蛙粪霉病1例

报告1例来自江苏省的蛙粪霉病临床经过：包括皮质类固醇和伊曲康唑作用下的病理生理学、组织病理学演变过程；光镜和电镜下，真菌的形态和结构特征。调查了可疑传染源。研究结果表明：(1)蟾蜍是可能的传染源，真菌反复接种于破损皮肤是可能的入侵途径。(2)使用皮质类固醇期间，由于炎症反应被抑制，临床表现相对静止。机体虽有防御反应，病灶内致病菌仍然繁殖旺盛，一定条件下发生了病灶播散。(3)伊曲康唑治疗3天见效，3周真菌被清除，8周显效，6个月治愈。药物破坏真菌细胞膜，引起抑菌和杀菌。大量真菌崩解后，促发强烈的急性炎症反应，因而真菌被清除，病灶吸收和修复。演变过程q一形成的脓肿干¨纤维化结节，辅助相应的手术治疗，缩短了疗程。

肾移植后皮下和内脏蛙粪霉病1例

Basidiobolomycosis is a chronic inflammatory disease that occurs exclusively in healthy individuals.Clinically, the infection is generally restricted to subcutaneous tissue; however, the disease has been documented to emerge in visceral organs but seldom spreads to cause disseminated infection We describe the first culture confirmed case of systemic Basidiobolus ranarum infection in an immunosuppressed patient A 55 yearold female renal transplant recipient developed chronic hard nonpitting oedema of the right lower extremity and abdominal wall concurrent with the infection from the same organism involving the uterus, urinary bladder and intra abdominal lymph nodes The patient responded successfully, both clinically and radiographically, to medical therapy without surgical resection The treatment regimen consisted of potassium iodide and trimethoprim/sulfamethoxazole for 3 months, and the patient remains clear of symptoms after 10 monthsfollow

蛙粪霉病一例报告(附超微结构观察)

对1例蛙粪霉病的临床经过作了报道,并作了组织病理、超微结构和真菌学检查。结果表明:①使用皮质类固醇期间,由于炎症反应被部分抑制,临床表现相对静止,机体虽有防御反应,病灶内致病菌仍然生长良好,繁殖旺盛,一定条件下发生了病灶播散。②使用伊曲康唑期间,药物通过破坏真菌细胞膜,导致抑菌和杀菌;发挥与机体防御系统的协同性而增强疗效。在药物作用下,大量真菌崩解,促发较强烈的急性炎症反应,继之,真菌被清除,病灶吸收和修复,在其演变过程中形成脓肿和纤维化结节,辅以相应的手术治疗,缩短了疗程。