Background: Basidiobolomycosis is a rare chronic subcutaneous infection caused by Basidiobolus ranarum, which is usually treated with potassium iodide. Extensive deforming lesions in children can occur owing to lack o...Background: Basidiobolomycosis is a rare chronic subcutaneous infection caused by Basidiobolus ranarum, which is usually treated with potassium iodide. Extensive deforming lesions in children can occur owing to lack of early diagnosis and/or inappropriate treatment. Case report: An 8- year- old girl child presented to us with extensive deforming plaque- like lesions over the left thigh and leg with multiple ulcerations of 1 year’ s duration. Histopathology was suggestive of subcutaneous zygomycosis with Splendore Hoeppli phenomenon. Microscopic examination of the tissue showed branching, sparsely septate fungal hyphae on a 10% KOH mount, and culture yielded Basidiobolus ranarum. The patient was initially treated with potassium iodide for 6 weeks to which only a poor response was observed. Itraconazole therapy resulted in rapid regression of the lesions and complete resolution after 15 weeks of therapy. She continues to be disease- free at 1 year of follow up. Conclusions: This case report highlights that in an older child even longstanding extensive basidiobolomycosis can be safely treated with itraconazole. Surgery is not usually necessary in these patients.展开更多
Basidiobolomycosis is a chronic inflammatory disease that occurs exclusively in healthy individuals.Clinically, the infection is generally restricted to subcutaneous tissue; however, the disease has been documented to...Basidiobolomycosis is a chronic inflammatory disease that occurs exclusively in healthy individuals.Clinically, the infection is generally restricted to subcutaneous tissue; however, the disease has been documented to emerge in visceral organs but seldom spreads to cause disseminated infection We describe the first culture confirmed case of systemic Basidiobolus ranarum infection in an immunosuppressed patient A 55 yearold female renal transplant recipient developed chronic hard nonpitting oedema of the right lower extremity and abdominal wall concurrent with the infection from the same organism involving the uterus, urinary bladder and intra abdominal lymph nodes The patient responded successfully, both clinically and radiographically, to medical therapy without surgical resection The treatment regimen consisted of potassium iodide and trimethoprim/sulfamethoxazole for 3 months, and the patient remains clear of symptoms after 10 monthsfollow展开更多
文摘Background: Basidiobolomycosis is a rare chronic subcutaneous infection caused by Basidiobolus ranarum, which is usually treated with potassium iodide. Extensive deforming lesions in children can occur owing to lack of early diagnosis and/or inappropriate treatment. Case report: An 8- year- old girl child presented to us with extensive deforming plaque- like lesions over the left thigh and leg with multiple ulcerations of 1 year’ s duration. Histopathology was suggestive of subcutaneous zygomycosis with Splendore Hoeppli phenomenon. Microscopic examination of the tissue showed branching, sparsely septate fungal hyphae on a 10% KOH mount, and culture yielded Basidiobolus ranarum. The patient was initially treated with potassium iodide for 6 weeks to which only a poor response was observed. Itraconazole therapy resulted in rapid regression of the lesions and complete resolution after 15 weeks of therapy. She continues to be disease- free at 1 year of follow up. Conclusions: This case report highlights that in an older child even longstanding extensive basidiobolomycosis can be safely treated with itraconazole. Surgery is not usually necessary in these patients.
文摘Basidiobolomycosis is a chronic inflammatory disease that occurs exclusively in healthy individuals.Clinically, the infection is generally restricted to subcutaneous tissue; however, the disease has been documented to emerge in visceral organs but seldom spreads to cause disseminated infection We describe the first culture confirmed case of systemic Basidiobolus ranarum infection in an immunosuppressed patient A 55 yearold female renal transplant recipient developed chronic hard nonpitting oedema of the right lower extremity and abdominal wall concurrent with the infection from the same organism involving the uterus, urinary bladder and intra abdominal lymph nodes The patient responded successfully, both clinically and radiographically, to medical therapy without surgical resection The treatment regimen consisted of potassium iodide and trimethoprim/sulfamethoxazole for 3 months, and the patient remains clear of symptoms after 10 monthsfollow
