鞘内注射右美托咪啶对大鼠皮下蜜蜂毒诱导所致的持续性痛反应的抑制作用

右美托咪啶是高选择性的α2肾上腺素能受体激动剂,静脉应用具有镇静、镇痛及抗焦虑作用,应用于临床麻醉和重症监护病房（ICU）时,患者的血流动力学稳定,无明显呼吸抑制[1-3]及＂可唤醒＂镇静,

THE ROLES OF SPINAL N- AND L-TYPE VOLTAGE-DEPENDENT CALCIUM CHANNELS IN DEVELOPING AND MAINTAINING PROCESSES OF BEE VENOM-INDUCED PERSISTENT SPONTANEOUS NOCICEPTION AND HYPERALGESIA IN RATS

Aim: To further study the roles of spinal N-or L-type voltage-dependent calcium channel (VDCC) in induction and maintenance of both persistent spontaneous nociception (PSN) and hyperalgesia induced by subcutaneous (s.c.) bee venom injection, the effects of intrathecal (i.t.) pre- or post-treatment with VDCC blockers of N-type (ω-Conotoxin-GVIA) and L-type (verapamil) were evaluated in conscious rats.