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影响乳剂基质——中药原粉栓剂的融变时间与耐热性因素的探讨 被引量:1
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作者 钱春梅 李融来 敬欣 《药品评价》 CAS 2004年第5期347-349,共3页
目的探讨影响乳剂(O/W型)基质-中药原粉栓剂融变时间与耐热性的因素及其变化规律。方法采用正交设计方法,改变乳剂基质中甘油-水的比例和中药原粉加入量,制得4种基质、16组栓剂样品;检查栓剂外观、重量差异;测定栓剂的融变时间与放置37... 目的探讨影响乳剂(O/W型)基质-中药原粉栓剂融变时间与耐热性的因素及其变化规律。方法采用正交设计方法,改变乳剂基质中甘油-水的比例和中药原粉加入量,制得4种基质、16组栓剂样品;检查栓剂外观、重量差异;测定栓剂的融变时间与放置37℃未软化时间。结果16组栓剂的外观适宜、重量差异符合规定,栓剂的融变时间和37℃耐热时间随着基质中甘油-水的比例减少及栓剂中药材原粉用量增加程度不同地延长。结论基质中甘油-水的比例与栓剂中药材原粉用量都明显影响栓剂的融变时间和耐热性,中药材原粉用量尤其明显。融变时间与耐热性均较适宜的乳剂基质-中药原粉栓剂中的明胶-甘油-水比例是2:14:2,栓剂中药原粉不宜多于0.3g。 展开更多
关键词 中药原粉栓剂 乳剂基质 融变时间 耐热性
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甘油明胶栓剂基质组方的改进研究 被引量:16
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作者 钱春梅 季龙凤 李进旺 《西安交通大学学报(医学版)》 CAS CSCD 北大核心 2002年第6期541-543,共3页
目的 设计耐热性较好、融变时间适宜的甘油明胶栓剂基质新组方。方法 以甘油明胶栓剂基质的融变时间与受热软化温度为考察指标 ,依次改变基质中明胶的用量、筛选加入其他辅料 (聚乙二醇、β 环糊精、尿素、甘露醇 ) ,通过正交设计试... 目的 设计耐热性较好、融变时间适宜的甘油明胶栓剂基质新组方。方法 以甘油明胶栓剂基质的融变时间与受热软化温度为考察指标 ,依次改变基质中明胶的用量、筛选加入其他辅料 (聚乙二醇、β 环糊精、尿素、甘露醇 ) ,通过正交设计试验确定甘油明胶栓剂基质新组方。结果 明胶用量能改变基质的融变时间 ,但对其耐热性无显著影响 ;添加的 5种辅料中 ,甘露醇提高基质的耐热性效果最好 ,也能缩短基质的融变时间。结论 耐热性与融变时间均适宜的甘油明胶栓剂基质新组方为明胶 2 0 g、甘油 5 0g、甘露醇 6 0 g ,控制基质含水量为 10 %。 展开更多
关键词 甘油明胶 栓剂基质 组方 改进 耐热性 融变时间
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An improvement to the simulation of phase-change heat-transfer during soil freezing and thawing 被引量:6
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作者 YANG Tao ZHENG Mao-yu 《Mining Science and Technology》 EI CAS 2009年第2期262-268,共7页
A new variable time step method,which is called the backwards calculating time step method,is presented in this paper.It allows numerical simulation of soil freezing and thawing while avoiding "phase change missi... A new variable time step method,which is called the backwards calculating time step method,is presented in this paper.It allows numerical simulation of soil freezing and thawing while avoiding "phase change missing and overflowing".A sensitive heat capacity model is introduced through which the calculation errors are analyzed.Then the equation using the self-adjusted time step is presented and solved using finite differences.Through this equation,the time needed for a space cell to reach the phase change point temperature is calculated.Using this time allows the time step to be adjusted so that errors caused by "phase change missing and overflowing" are successfully eliminated.Above all,the obvious features of this method are an accelerated rate for adjusting the time step and simplifing the computations.An actual example proves that this method can accurately calculate the temperature fields during soil freezing and thawing.It is an improvement over traditional methods and can be widely used on complicated multi-dimensional phase change problems. 展开更多
关键词 backwards calculating time step method phase change missing phase change overflowing
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A Novel Method for Banks to Monitor the Cumulative Loss Due to Defaults
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作者 KSS lyer 《Journal of Mathematics and System Science》 2014年第4期244-250,共7页
Banking institutions all over the world face significant challenge due to the cumulative loss due to defaults of borrowers of different types of loans. The cumulative default loss built up over a period of time could ... Banking institutions all over the world face significant challenge due to the cumulative loss due to defaults of borrowers of different types of loans. The cumulative default loss built up over a period of time could wipe out the capital cushion of the banks. The aim of this paper is to help the banks to forecast the cumulative loss and its volatility. Defaulting amounts are random and defaults occur at random instants of time. A non Markovian time dependent random point process is used to model the cumulative loss. The expected loss and volatility are evaluated analytically. They are functions of probability of default, probability of loss amount, recovery rate and time. Probability of default being the important contributor is evaluated using Hidden Markov modeling. Numerical results obtained validate the model. 展开更多
关键词 Random point process expected cumulative loss non Markovian hidden Markov model
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小儿用布洛芬中空栓剂的制备及其质量评价 被引量:6
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作者 陈鹏浩 乔瑾 +2 位作者 王晨曦 隋小宇 姜帆 《中国医药工业杂志》 CAS CSCD 北大核心 2016年第10期1280-1283,共4页
以熔点、融变时间、外观与硬度为指标,考察了聚乙二醇(PEG)的种类(PEG 400、PEG 600和PEG 1000)和组成比例对空白栓剂基质的影响。结果表明,以PEG 400和PEG 1000(25∶75)为混合基质的空白栓剂熔点和融变时间为30.3℃和19.3 min,外观呈... 以熔点、融变时间、外观与硬度为指标,考察了聚乙二醇(PEG)的种类(PEG 400、PEG 600和PEG 1000)和组成比例对空白栓剂基质的影响。结果表明,以PEG 400和PEG 1000(25∶75)为混合基质的空白栓剂熔点和融变时间为30.3℃和19.3 min,外观呈均匀白色,硬度适宜。在此基础上,采用直接加入原料药粉末的方式,制备了空腔直径3 mm、距栓尾深度为1.8或2.3 cm的载布洛芬50 mg的两种小儿用中空栓。结果所得载药中空栓外观和硬度与空白栓剂相似,融变时间为18.4 min。以市售小儿布洛芬栓为对照,考察自制中空栓的体外溶出情况。结果显示,两种中空栓在20 min内均达到溶出平衡,溶出率大于90%;而市售品70 min时溶出率为79%,提示中空栓能达到快速释药的目的。 展开更多
关键词 布洛芬 中空栓剂 聚乙二醇 融变时间 体外溶出 儿科用药
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A Hyper-Erlang Jump-Diffusion Process and Applications in Finance
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作者 DONG Yinghui HAN Min 《Journal of Systems Science & Complexity》 SCIE EI CSCD 2016年第2期557-572,共16页
This paper studies the first passage time problem for a reflected two-sided jump-diffusion risk model with the jumps having a hyper-Erlang distribution.The authors give the explicit closed-form expression for the join... This paper studies the first passage time problem for a reflected two-sided jump-diffusion risk model with the jumps having a hyper-Erlang distribution.The authors give the explicit closed-form expression for the joint Laplace transform of the first passage time and the overshoot for the reflected process.Finally,the formula is applied to the ruin problem under the barrier dividend strategy and the pricing of the Russian option. 展开更多
关键词 Barrier strategy first passage time hyper-Erlang distribution reflected jump-diffusion process Russian option.
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Smoothing Non-Stationary Time Series Using the Discrete Cosine Transform
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作者 THOMAKOS Dimitrios 《Journal of Systems Science & Complexity》 SCIE EI CSCD 2016年第2期382-404,共23页
This paper considers the problem of smoothing a non-stationary time series(having either deterministic and/or stochastic trends) using the discrete cosine transform(DCT).The DCT is a powerful tool which has found frui... This paper considers the problem of smoothing a non-stationary time series(having either deterministic and/or stochastic trends) using the discrete cosine transform(DCT).The DCT is a powerful tool which has found fruitful applications in filtering and smoothing as it can closely approximate the optimal Karhunen-Loeve transform(KLT).In fact,it is known that it almost corresponds to the KLT for first-order autoregressive processes with a root close to unity:This is the case with most economic and financial time series.A number of new results are derived in the paper:(a) The explicit form of the linear smoother based on the DCT,which is found to have time-varying weights and that uses all observations;(b) the extrapolation of the DCT-smoothed series;(c) the form of the average frequency response function,which is shown to approximate the frequency response of the ideal low pass filter;(d) the asymptotic distribution of the DCT coefficients under the assumptions of deterministic or stochastic trends;(e) two news method for selecting an appropriate degree of smoothing,in general and under the assumptions in(d).These findings are applied and illustrated using several real world economic and financial time series.The results indicate that the DCT-based smoother that is proposed can find many useful applications in economic and financial time series. 展开更多
关键词 Discrete cosine transform non-stationary time series order selection singular spectrumanalysis SMOOTHING trend extraction unit root.
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