螺旋结构的曲率和挠率分析及其在工艺上的应用

研究自然界的螺旋现象及其在工艺上的运用.利用微分几何的曲率、挠率及广义相对论的理论知识分析了螺旋形结构,指出自然选择这种螺旋结构的益处,探讨了螺旋造型的一些奥秘,并给出其在工艺上的一些应用例子.

16排螺旋CT血管成像在肺动脉栓塞诊断中的应用及其临床意义

目的探讨16排螺旋CT血管成像在肺动脉栓塞诊断中的临床应用价值。方法18例疑为肺栓塞的病人使用GELightSpeed16型多层螺旋CT设备行CT平扫和对比剂增强扫描检查,并通过最大密度投影(MIP)、多平面重组(MPR)及容积再现(VR)等影像后处理技术进行肺动脉三维成像。结果在18例病人中肺动脉分支栓塞者6例,肺段及段以下动脉栓塞者12例,且可见11支亚段肺动脉栓塞,18例病例中单支肺动脉栓塞者4例,2支及多支栓塞者14例,多层螺旋CT血管成像(SCTA)的直接征像为中心型充盈缺损、偏心型充盈缺损和完全阻塞。结论16排螺旋CT是诊断肺动脉栓塞的快速、有效、无创的诊断方法,可能成为诊断肺动脉栓塞的首选影像学检查手段。

64排128螺旋CT在早期结肠癌诊断中的应用探究

目的探讨64排128螺旋CT对早期结肠癌的诊断价值。方法病例筛选收治的结肠癌患者70例为本次研究对象,进行回顾性分析,所有患者均实施纤维结肠镜检查和64排128螺旋CT检查;对两种检测方法的诊断结果与病理确诊结果进行对比分析,比较诊断分期准确率。结果 64排128螺旋CT检查与纤维结肠镜检查Ⅰ期准确率无差异,P>0.05。64排128螺旋CT检查在Ⅱ期,Ⅲ期,Ⅳ期的准确率较纤维结肠镜检查均不同程度提高,P<0.05,差异有统计学意义。结论 64排128螺旋CT在早期结肠癌的检查中具有较高的检查准确率,同时对疾病的分期检查效果较好,为手术治疗方案的设计提供较可靠的依据,值得临床推广。

旋转式压缩机和泵用螺旋槽端面密封

叙述了旋转式压缩机和泵采用螺旋槽端面密封的结构、密封原理、特性、应用实例、选用和注意点及今后的展望。

复合病因性急腹症多层螺旋CT诊断价值

目的通过探讨和研究多层螺旋CT对急性腹痛患者临床诊断及应用价值,与术后病理学的对比可以为复合病因性急腹症患者的治疗提供更佳依据。方法回顾性分析该院自2015年9月-2017年12月11例经手术病理证实的复合病因性急腹症患者的病历资料,11例中仅3例行平扫及增强扫描,其余均行CT平扫及多平面重建。结果对照临床及手术病理结果,11例急腹症患者病变CT检出率为100.0%,误诊率为27.3%(3/11),诊断符合率约72.7%(7/9),上述病例均存在两种病因由两种或两种以上病因引起的急性腹痛、呕吐。CT诊断符合病例:横结肠扭转合并肠梗阻,脾曲结肠综合征(1例);乙状结肠Ca伴肠破裂,胆总管下段结石伴急性胆囊炎,全腹膜炎(1例);小肠破裂、左上腹小肠广泛粘连伴肠梗阻(1例);小肠系膜扭转伴肠梗阻,腹腔黏连(1例);空肠粘液腺Ca合并肠套叠,高位小肠梗阻(1例);结肠Ca合并肠套叠,肠梗阻(1例);过敏性紫癜、阑尾穿孔合并肠梗阻(1例)。结论多排螺旋CT在多种病因导致的急腹症的检查和诊断中有明显的优势,强大的工作站后处理功能使诊断过程快捷且具有较高的特异性和准确性,具有很好的临床推广价值。

多层螺旋CT冠状动脉成像诊断价值

近年来，冠状动脉的无创性三维成像技术已率先在16层或64层螺旋CT上得以实现，为冠心病的诊断和随访带来了极大的方便。自20世纪60年代选择性冠状动脉造影问世以来，这种有创的技术一直被认为是冠状动脉成像和冠心病诊断的“金标准”。

胃的螺旋CT检查及其对胃癌诊断的评价

目的 研究胃的螺旋CT检查方法及其对胃癌诊断的价值。方法 采用饮水螺旋CT扫描方法与经病理证实的 2 5例胃癌进行回顾性分析。结果 该方法能清晰显示解剖结构及邻近器管的毗邻关系。诊断为胃癌的所有病例胃壁均增厚 ,显示有肿块者 2 0例 ,有肝转移者 3例 ,有淋巴结转移者 8例。结论 螺旋CT能清晰显示胃解剖和病变的位置、大小、形态、分型及肿瘤扩散范围 ,对临床治疗方法的选择有很大帮助。

乙酰螺旋霉素联合口泰漱口液治疗牙龈出血的临床效果研究

目的研究乙酰螺旋霉素联合口泰漱口液治疗牙龈出血的临床效果。方法选取该院2014年4月至2015年5月收治的牙龈出血患者90例,采用随机数字表法将其平均分为对照组和观察组,每组45例。对照组单独应用乙酰螺旋霉素片治疗,观察组应用乙酰螺旋霉素片联合口泰漱口液治疗。观察两组患者临床疗效和满意度,并进行相关分析。结果对照组总有效率[91.11%(41/45)]与观察组[100.00%(45/45)]比较,差异无统计学意义(P=0.759 7);对照组患者总体满意度为84.44%(38/45),观察组总体满意度为95.56%(43/45);对照组患者中1个月内复发3例,观察组患者中无一例复发。结论单独应用乙酰螺旋霉素治疗牙龈出血效果有限,乙酰螺旋霉素联合口泰漱口液治疗牙龈出血效果显著,患者满意度高,复发率低,值得临床推广应用。

E-cadherin in gastric cancer

Cadherin is an adhesion molecule and a superfamily of calcium-mediated membrane glycoproteins. E-cadherin is the prototype of the class E-cadherin that links to catenins to form the cytoskeleton. Recent evidence has shown that E-cadherin not only acts as an adhesive, but also plays important roles in growth development and carcinogenesis. It has been recently viewed as an invasion as well as a growth suppressor gene. This review summarizes the recent discoveries on E-cadherin and its role in gastric cancer. In particular, our work on E-cadherin in gastric cancer, including its relation with Helicobacter pylori and clinical applications, are described in detail.

Application of CT perfusion imaging in detection of tumor angiogenesis in osteosarcoma

Objective： The aim of the study was to explore the application of 64-slice spiral computed tomography perfusion imaging （CTPI） in evaluating angiogenesis in human osteosarcoma. Methods： Twenty-six patients （18 males and 8 females ranging from 9 to 56 years old, with an average of 19 years） with osteosarcoma underwent 64-slice spiral CTPI. We analyzed the correlations of CTPI parameters including blood flow （BF）, blood volume （BV）, time to peak （TTP）, and permeability surface （PS） with the expression of markers of angiogenesis. Statistical analysis was performed with paired-samples t test, and Pearson correlation analysis was employed to investigate the correlations of CTPI parameters with microvessel density （MVD）. Results： Mean BF, BV, TTP, and PS values of osteosarcoma group were （46.6 ± 25.1） mL/100 g/min, （61.8 ± 29.5） mL/100 g, （122.9 ± 26.2） seconds, and （44.5 ± 14.6） mL/100 g/min, respectively. Those in the normal muscle group were （5.2 ± 6.6） mL/100 g/min, （9.6 ± 7.3） mL/100 g, （115.5 ± 33.1） seconds and （17.0 ± 29.3） mL/100 g/min, respectively. Osteosarcoma group showed higher BF, BV and PS compared with the normal muscle group （P = 0.000, P = 0.000, and P = 0.000, respectively）. However, no significant difference was found in TTP between osteosarcoma tissue and normal adjacent muscle tissue （P = 0.273）. BF, BV, and PS were positively correlated with MVD （r = 0.83, P = 0.000; r = 0.87, P = 0.000; and r = 0.63, P = 0.001, respectively）. No correlation was found between TTP and MVD （r = –0.02, P = 0.93）. Conclusion： CTPI is useful for assessing tumor vascularity of osteosarcoma and CTPI parameters are positively correlated with MVD.

传承伟人志 敢为天下先——广东省中山市人民医院倾力打造现代化名牌医院

院长简介 余元龙，主任医师，享受国务院特殊津贴专家，现任中山市人民医院院长、中山市肿瘤研究所常务副所长。武汉大学肝胆外科硕士、中山大学高级工商行政管理硕士（EMBA），在肝胆外科、器官移植、肿瘤防治、医院信息化建设及人力资源管理方面成绩显著。2001年他主持创建了器官移植中心，中山市人民医院的心脏移植、肝移植、自体干细胞移植、异种胰岛细胞移植、角膜移植等技术，在他的带领下获得蓬勃发展。他以开拓进取的创新精神在1999年建成中山市人民医院博士后科研基地，引进中山市首批博士后，为中山市树立了一个专业技术人才引进模式；他带领的中山市肿瘤研究所，被评为“广东省五个一工程重点专科”，连续多次参加鼻咽癌国家攻关课题。作为主要完成人，“大规模集成化医院信息系统的建设”项目先后荣获“广东省科学技术一等奖”和“国家倍增计划优秀项目”；他还承担多项厅级、市级课题，在核心期刊发表论文四十余篇。任副主编出版专著《多层螺旋CT原理和临床应用》。先后被聘任为中山市医学会外科学分会主任委员、中山市医学会肿瘤学分会主任委员、中山市青年科技工作者协会副会长、广东省医学会微创外科分会内镜外科组成员、广东省医学会外科学会委员、广东省医学会器官移植分会委员、中山市医学学术带头人、中山大学硕士生导师、《中华实验外科》特约编委、《普通外科学文献》编委。由于在学术及卫生管理方面成绩显著，荣获中山市政府授予的2004年度中山市十杰市民的称号。

Characterized the Microalgae （Chlorella and Spirulina） and Macro Algae by Using TGA and Bomb Calorific Meter for the Biomass Energy Application

Biomass usually is noticed a composition of various types of waste materials that can be utilized as useful form of energy alternative to the conventional fossil fuels. However, this new kind of energy has not met its full potential in production of energy, especially electricity generation due to its lower performance in terms of thermal efficiency. Algae （included Microalgae ＆ Macroalgae） are widely used for multi-application developments such as fishery aquaculture, food/nutrient supplement, cosmetics, and biomass energy. Microalgae have been treated as the source of bio-fuel. In this paper, we selected the two types of freshwater microalgae ＂Chlorella Vulgaris＂ ＆ ＂Spirulina＂ and macro algae （Laminariaceae） as the main materials and we analyzed TGA （thermal gravity analysis） and calorific values （heat of combustion）. We found the calorific values are 1,000-5,000 KC/KG and TGA results show that the microalgae decrease rapidly after reached 300 ℃. The results in this paper will be used as a reference material for microalgae multi-oriental energy application and biomass composition proximate and ultimate research development in the future.

Clinical study of stomach neoplasm CT perfusion imaging

Objection:The purpose of this study is preliminarily to discuss stomach perfusion imaging technique with Multi-slice CT and its clinical application value in stomach neoplasm.Methods:Fifteen patients with known stomach neoplasm performed perfusion imaging with 4 or 16 slice CT.Performing perfusion imaging in central slice of neoplasm,using CT cine scan,slice thick 10 mm/2i;with high pressure syringe,injecting quickly from right elbow-front vein,dosage 45-50 mL,injec-tion rate 3.5-4.0 mL/s,scanning delay time 5 s,scanning total time 45 s.We performed perfusion CT post-processing using pancreatic mode of perfusion CT software.Blood flow(BF),blood volume(BV),mean transit time(MTT),and permeability surface(PS) of gastric wall and tumor were computed for every case.Results:BF,BV,MTT and PS of gastric tumor were 116.68 ± 90.09 mL/(min·100 g),9.57 ± 8.12 mL/100 g,10.07 ± 7.74 s,20.78 ± 19.68 mL/(min·100g),respectively.The P values for each CT perfusion parameters between gastric tumor and normal gastric wall were 0.001,0.021,0.155 and 0.031,respectively.Conclusion:Perfusion CT can provide hemodynamics of gastric tumors and play a key role in the diagnosis of gastric tumors.It's clinical application prospect will be fully broad.

Magnetic Helical Micro-and Nanorobots:Toward Their Biomedical Applications

Magnetic helical micro- and nanorobots can perform 3D navigation in various liquids with a sub- micrometer precision under low-strength rotating magnetic fields （〈 10 rer）. Since magnetic fields with low strengths are harmless to cells and tissues, magnetic helical micro/ nanorobots are promising tools for biomedical applications, such as minimally invasive surgery, cell manipulation and analysis, and targeted therapy. This review provides general information on magnetic helical micro/nanorobots, including their fabrication, motion control, and further functionalization for biomedical applications.

鼻咽癌的CT诊断分析

目的探讨鼻咽癌的CT表现,加深对鼻咽癌CT表现的认识。方法 CT诊断为鼻咽癌患者的影像资料12例,参照组织学活检病理结果进行分析。结果 12例CT诊断为鼻咽癌的患者中11例为低分化鳞状细胞癌,1例为肉芽肿性炎。结论螺旋CT可以显示鼻咽癌的部位、范围及周围侵犯情况,还可以更好的进行TNM分期,为临床治疗提供有效依据。

Calculation method of sliding ratios for conjugate-curve gear pair and its application

The calculation method of sliding ratios for conjugate-curve gear pair, generated based on the theory of conjugate curves,is proposed. The theoretical model of conjugate-curve gear drive is briefly introduced. The general calculation formulas of sliding ratios are developed according to the conjugate curves. The applications to the circular arc gears based on conjugate curves and the novel involute-helix gears are studied. A comparison on the sliding coefficient with the conventional corresponding gear drive is also carried out. The influences of gear parameters such as spiral parameter, gear ratio and modulus on the sliding ratios of gear drive are discussed. Brief description of manufacturing method for conjugate-curve gear pair is given. The research results show that the sliding ratios of gear pair become smaller with the increase of spiral parameter and gear ratio, respectively. And it will be greater with the increase of modulus for the tooth profiles. The meshing characteristics of conjugate-curve gears are further reflected and the optimization design of tooth profiles with high performance may be obtained.

Cloning and Expression of the Tpp17 Gene of Treponema pallidum And Clinical Application

Objective: To obtain recombinant Treponema pallidumsubsp pallidum (TP 17KD) lipoprotein in large quantities byamplification and to further purify antigens for laboratorydiagnosis of syphilis and development of a syphilis vaccine. Method: The Tpp17 lipoprotein gene was amplified fromthe TP(strain Nichols), and then it was recombinated into aplasmid pMAL-2c and cloned within E coli l2-TB1. The hostbacteria containing recombinant plasmids were induced withIPTG. The Tpp 17KD lipoprotein gene was amplified by us-ing PCR and positive clones were screened with double diges-tion and PCR. Recombinant plasmids were transformed intoE. coli and the E coli carrying recombinant plasmids wereinduced. The expression of TP 17KD was detected by sodiumdedecyl sulfate-polyacrylamide gel electrophoresis(SDS-PAGE) and immunoblot. Results:Gel staining with Coomassie blue G-250 showedthat the induced E coli carrying recombinant plasmid couldproduce 60KD fusion protein at high levels. Gel scanningshowed that 17KD protein expression in E coli accounted for10% of total cellular protein. The recombinant protein antigenreacted with the sera of syphilis patients. Conclusion: Our study lays a cornerstone for developingnew techniques of laboratory diagnosis for syphilis and newvaccines. Preliminary clinical application showed that thefusion protein could be used for the diagnosis of syphilis.

《中华五新创世消化》肝肿瘤154例诊断分析

目的观察中药螺旋藻和血管内激光照射对肝肿瘤晚期病变的治疗效果方法154例全部经JH—3型电脑诊断：①查出原发良性恶变者共57例，其中：男34例（22％），女23例（15％），患病时间：90d～2920d，平均1505d．②继发恶性晚期共97例，其中：男性晚期53例（34．4％），女性晚期44例（28．5％）．时间分别是90d～2415d，平均1252d．按高新电脑（JH－3）型查后结果，①用最新量的螺旋藻鼻饲或口服用药，根据患者的体征、病情程度，垂危患者开始24g／d分四次用．②用中科院激光研究所生产的He－Ne血管内照射仪照射，垂危患者开始用4．8mw×90mn每天一次，二方联用至病情基本恢复后再慢慢减药，减光量．结果用以上方法诊治，90d～180d治愈共63例（40．9％），180d～240d治愈47例（30．5％），240d～300d38例（24．7％），好转4例（2．6％），死亡2例（1．3％）．结论按上方用于患者，能够充分发挥激光和螺旋藻最有效地抑制自由基活性．从而达到防癌、治癌的最高最新目的．

N-cap helix nucleation： methods and their applications

Recapitulation of well-defined α-helices could result in constrained peptide mimetics with preferable secondary structures and enhanced therapeutic properties for various purposes. Among the helix-stabilizing strategies, the nucleation strategies are able to maximize recognition specificity of the original sequence without compromising the molecular recognition surface. In this review,current methodologies of helix nucleation are introduced including their constructing strategies, structure features and proof of concept biological applications.