目的:研究血中性粒细胞/淋巴细胞比值(neutrophil-lymphocyte ratio,NLR)及其变化率与重症医学科(intensive care unit,ICU)脓毒症患者预后之间的关系。方法 :选择入住ICU的脓毒症患者94例,根据预后分为死亡组(25例)和存活组(69例),评...目的:研究血中性粒细胞/淋巴细胞比值(neutrophil-lymphocyte ratio,NLR)及其变化率与重症医学科(intensive care unit,ICU)脓毒症患者预后之间的关系。方法 :选择入住ICU的脓毒症患者94例,根据预后分为死亡组(25例)和存活组(69例),评估两组NLR水平及其变化率与预后的关系。结果:ICU脓毒症患者死亡组和存活组入科时NLR分别为16.69±13.99和16.27±15.72,差异无统计学意义(P>0.05);48 h NLR分别为24.31±15.53和12.53±10.64,差异有统计学意义(P<0.05);NLR变化率分别为0.92±1.57和-0.11±0.62,差异有统计学意义(P<0.01);急性生理学与慢性健康状况评分系统Ⅱ(score of acute pathologic and chronic health evaluationⅡ,APACHEⅡ)评分分别为27.00±5.81和19.99±4.41,差异有统计学意义(P<0.01)。结论:ICU脓毒症患者48 h NLR、NLR变化率与预后相关。展开更多
Active ulcerative colitis (UC) is associated with elevated granulocytes and mo nocytes/macrophages (GM) which show activation behavior and increased survival t ime. Further, fecal calprotectin (a stable neutrophil pro...Active ulcerative colitis (UC) is associated with elevated granulocytes and mo nocytes/macrophages (GM) which show activation behavior and increased survival t ime. Further, fecal calprotectin (a stable neutrophil protein) level parallels i ntestinal inflammation and can predict UC relapse. Since GM are major sources of inflammatory cytokines and chemokines, they are suspected to have roles in the initiation and perpetuation of UC. Our objective was to investigated relationshi ps between peripheral blood (PB) neutrophils, calprotectin, and UC disease activ ity. Full PB and calprotectin were determined in 69 healthy controls and 31 pati ents with UC, then 7 randomly selected patients received GM adsorptive apheresis (GMA) with Adacolumn, 10 sessions of 60-min duration each. Patients with UC ha d higher neutrophil counts (P < 0.001), but lower lymphocyte counts (P < 0.001) compared with controls. Further, fecal calprotectin levels showed a correlation with UC clinical activity index (CAI; P < 0.001) and mucosal inflammation (P < 0 .001) . Following GMA, there were falls in neutrophils (P < 0.02), CAI (P < 0.02 ) and calprotectin (P < 0.02). In conclusion, GM appear to contribute to intesti nal inflammation and UC activity and reduction of these cells by GMA should bene fit patients with active UC. Further, the correlations among calprotectin, UC ac tivities, and PB neutrophils should serve as the basis for preemptive actions to control this disease.展开更多
文摘目的:研究血中性粒细胞/淋巴细胞比值(neutrophil-lymphocyte ratio,NLR)及其变化率与重症医学科(intensive care unit,ICU)脓毒症患者预后之间的关系。方法 :选择入住ICU的脓毒症患者94例,根据预后分为死亡组(25例)和存活组(69例),评估两组NLR水平及其变化率与预后的关系。结果:ICU脓毒症患者死亡组和存活组入科时NLR分别为16.69±13.99和16.27±15.72,差异无统计学意义(P>0.05);48 h NLR分别为24.31±15.53和12.53±10.64,差异有统计学意义(P<0.05);NLR变化率分别为0.92±1.57和-0.11±0.62,差异有统计学意义(P<0.01);急性生理学与慢性健康状况评分系统Ⅱ(score of acute pathologic and chronic health evaluationⅡ,APACHEⅡ)评分分别为27.00±5.81和19.99±4.41,差异有统计学意义(P<0.01)。结论:ICU脓毒症患者48 h NLR、NLR变化率与预后相关。
文摘Active ulcerative colitis (UC) is associated with elevated granulocytes and mo nocytes/macrophages (GM) which show activation behavior and increased survival t ime. Further, fecal calprotectin (a stable neutrophil protein) level parallels i ntestinal inflammation and can predict UC relapse. Since GM are major sources of inflammatory cytokines and chemokines, they are suspected to have roles in the initiation and perpetuation of UC. Our objective was to investigated relationshi ps between peripheral blood (PB) neutrophils, calprotectin, and UC disease activ ity. Full PB and calprotectin were determined in 69 healthy controls and 31 pati ents with UC, then 7 randomly selected patients received GM adsorptive apheresis (GMA) with Adacolumn, 10 sessions of 60-min duration each. Patients with UC ha d higher neutrophil counts (P < 0.001), but lower lymphocyte counts (P < 0.001) compared with controls. Further, fecal calprotectin levels showed a correlation with UC clinical activity index (CAI; P < 0.001) and mucosal inflammation (P < 0 .001) . Following GMA, there were falls in neutrophils (P < 0.02), CAI (P < 0.02 ) and calprotectin (P < 0.02). In conclusion, GM appear to contribute to intesti nal inflammation and UC activity and reduction of these cells by GMA should bene fit patients with active UC. Further, the correlations among calprotectin, UC ac tivities, and PB neutrophils should serve as the basis for preemptive actions to control this disease.
