The WNK kinases are a recently discovered family of serine-threonine kinases that have been shown to play an essential role in the regulation of electrolyte homeostasis. Intronic deletions in the WNK1 gene result in i...The WNK kinases are a recently discovered family of serine-threonine kinases that have been shown to play an essential role in the regulation of electrolyte homeostasis. Intronic deletions in the WNK1 gene result in its overexpression and lead to pseudohypoaldosteronism type II, a disease with salt-sensitive hypertension and hyperkalemia. This review focuses on the recent evidence elucidating the structure of the kinase domain of WNK1 and functions of these kinases in normal and disease physiology. Their functions have implications for understanding the biochemical mechanism that could lead to the retention or insertion of proteins in the plasma membrane. The WNK kinases may be able to influence ion homeostasis through its effects on synaptotagmin function.展开更多
[Objective] This study aimed to further explore the relationship between tea and health. [Method] Different experimental groups were designed to preliminarily investigate the effects of ＂Plateau Bright Pearl＂ commix...[Objective] This study aimed to further explore the relationship between tea and health. [Method] Different experimental groups were designed to preliminarily investigate the effects of ＂Plateau Bright Pearl＂ commixed green tea on blood pressure, myocardial ultrastructure and level of plasma angiotensin Ⅱ （Ang Ⅱ） in spontaneous hypertensive rats. [Result] The results showed that ＂Plateau Bright Pearl＂ commixed green tea could significantly decrease blood pressure and level of plasma angiotensin Ⅱ （ang Ⅱ） in spontaneous hypertensive rats and improve ultrastructures of left ventricular mitochondrion and myofibrillae. [Conclusion] ＂Plateau Bright Pearl＂ commixed green tea has many physiological health functions including losing weight, protecting the heart and lowering blood pressure.展开更多
文摘The WNK kinases are a recently discovered family of serine-threonine kinases that have been shown to play an essential role in the regulation of electrolyte homeostasis. Intronic deletions in the WNK1 gene result in its overexpression and lead to pseudohypoaldosteronism type II, a disease with salt-sensitive hypertension and hyperkalemia. This review focuses on the recent evidence elucidating the structure of the kinase domain of WNK1 and functions of these kinases in normal and disease physiology. Their functions have implications for understanding the biochemical mechanism that could lead to the retention or insertion of proteins in the plasma membrane. The WNK kinases may be able to influence ion homeostasis through its effects on synaptotagmin function.
基金Supported by Major Special Science and Technology Project of Guizhou Province "Key Technology Research and Demonstration of Tea Industry in Guizhou" [(2008) 6015]Project of Guizhou Provincial Department of Science and Technology "Core Technology Research and New Product Development of 'Plateau Bright Pearl' Antihypertensive Health Tea" [(2010) 4002]~~
文摘[Objective] This study aimed to further explore the relationship between tea and health. [Method] Different experimental groups were designed to preliminarily investigate the effects of ＂Plateau Bright Pearl＂ commixed green tea on blood pressure, myocardial ultrastructure and level of plasma angiotensin Ⅱ （Ang Ⅱ） in spontaneous hypertensive rats. [Result] The results showed that ＂Plateau Bright Pearl＂ commixed green tea could significantly decrease blood pressure and level of plasma angiotensin Ⅱ （ang Ⅱ） in spontaneous hypertensive rats and improve ultrastructures of left ventricular mitochondrion and myofibrillae. [Conclusion] ＂Plateau Bright Pearl＂ commixed green tea has many physiological health functions including losing weight, protecting the heart and lowering blood pressure.
