目的:分析小儿原发性肾病综合征(PNS)的临床特点及转归情况。方法:2016年10月-2017年10月收治PNS患者36例,纳入观察组;选取同期入院体检的健康儿童39例,纳入对照组。比较两组血尿生化指标水平,并对29例单纯性肾病(INS)患儿以血纤维蛋白...目的:分析小儿原发性肾病综合征(PNS)的临床特点及转归情况。方法:2016年10月-2017年10月收治PNS患者36例,纳入观察组;选取同期入院体检的健康儿童39例,纳入对照组。比较两组血尿生化指标水平,并对29例单纯性肾病(INS)患儿以血纤维蛋白原(FIB)为基准进行分组,对比各组尿蛋白阴转时间。结果:观察组载脂蛋白(APO)、FIB、总胆固醇(TC)、尿N-乙酰-L-半胱氨酸(NAC)酶活性、血浆清蛋白(Alb)及24 h尿蛋白定量(24 h UP)水平均高于对照组,差异有统计学意义(P<0.05)。观察组29例INS患儿中,FIB增高且用药治疗的患儿尿蛋白阴转天数更短。观察组患儿中,INS 29例,基本治愈27例(93.10%),显效2例(6.90%);肾炎性肾病7例,基本治愈3例(42.86%),显效3例(42.86%),无效1例(14.29%)。结论:PNS患儿的血尿生化指标水平明显异常,且合并免疫损伤,需要及时抗凝等对症处理,以保证预后。展开更多
Objective： Decompensated chronic hyperglycemia often leads to late microvascular complications such as retinopathy, diabetic foot syndrome, and diabetic kidney disease. The aim of this study was to determine the conc...Objective： Decompensated chronic hyperglycemia often leads to late microvascular complications such as retinopathy, diabetic foot syndrome, and diabetic kidney disease. The aim of this study was to determine the concentration of vascular endothelial growth factor A （VEGF-A） and its receptors in patients with well-controlled diabetes. Methods： The study was conducted on 31 patients with well-controlled type 2 diabetes without microor macroangiopathy. Thirty healthy volunteers were enrolled in a control group. Serum concentrations of VEGF-A, VEGF receptors 1 and 2 （VEGFR1 and VEGFR2）, fasting glucose, and lipid profiles were measured, and the plasma concentration of glycated hemoglobin （HbAlc） was determined. Results： No significant differences were observed between the concentration of VEGF-A, VEGFR1 or VEGFR2 in the subject group and that in the control group. Positive correlations were noted between the levels of VEGF-A, VEGFR2, and triglyceride, and there was a negative correlation between the levels of VEGFR2 and high-density lipoprotein （HDL）-cholesterel in the study group. Conclusions： The concentrations of VEGF-A and its receptors 1 and 2 in patients with well-controlled diabetes are comparable to those of healthy individuals, which may indicate that appropriate control of glucose levels delays the occurrence of vascular complications. A negative correlation between VEGFR2 and HDL-cholesterol levels, and positive correlations between VEGF-A, VEGFR2, and triglyceride levels, suggest that lipid abnormalities occurring in diabetes may be involved in the modulation of angiogenesis.展开更多
文摘目的:分析小儿原发性肾病综合征(PNS)的临床特点及转归情况。方法:2016年10月-2017年10月收治PNS患者36例,纳入观察组;选取同期入院体检的健康儿童39例,纳入对照组。比较两组血尿生化指标水平,并对29例单纯性肾病(INS)患儿以血纤维蛋白原(FIB)为基准进行分组,对比各组尿蛋白阴转时间。结果:观察组载脂蛋白(APO)、FIB、总胆固醇(TC)、尿N-乙酰-L-半胱氨酸(NAC)酶活性、血浆清蛋白(Alb)及24 h尿蛋白定量(24 h UP)水平均高于对照组,差异有统计学意义(P<0.05)。观察组29例INS患儿中,FIB增高且用药治疗的患儿尿蛋白阴转天数更短。观察组患儿中,INS 29例,基本治愈27例(93.10%),显效2例(6.90%);肾炎性肾病7例,基本治愈3例(42.86%),显效3例(42.86%),无效1例(14.29%)。结论:PNS患儿的血尿生化指标水平明显异常,且合并免疫损伤,需要及时抗凝等对症处理,以保证预后。
基金Project supported by the Collegium Medicum in Bydgoszcz,Nicolaus Copernicus University in Toruń,Poland
文摘Objective： Decompensated chronic hyperglycemia often leads to late microvascular complications such as retinopathy, diabetic foot syndrome, and diabetic kidney disease. The aim of this study was to determine the concentration of vascular endothelial growth factor A （VEGF-A） and its receptors in patients with well-controlled diabetes. Methods： The study was conducted on 31 patients with well-controlled type 2 diabetes without microor macroangiopathy. Thirty healthy volunteers were enrolled in a control group. Serum concentrations of VEGF-A, VEGF receptors 1 and 2 （VEGFR1 and VEGFR2）, fasting glucose, and lipid profiles were measured, and the plasma concentration of glycated hemoglobin （HbAlc） was determined. Results： No significant differences were observed between the concentration of VEGF-A, VEGFR1 or VEGFR2 in the subject group and that in the control group. Positive correlations were noted between the levels of VEGF-A, VEGFR2, and triglyceride, and there was a negative correlation between the levels of VEGFR2 and high-density lipoprotein （HDL）-cholesterel in the study group. Conclusions： The concentrations of VEGF-A and its receptors 1 and 2 in patients with well-controlled diabetes are comparable to those of healthy individuals, which may indicate that appropriate control of glucose levels delays the occurrence of vascular complications. A negative correlation between VEGFR2 and HDL-cholesterol levels, and positive correlations between VEGF-A, VEGFR2, and triglyceride levels, suggest that lipid abnormalities occurring in diabetes may be involved in the modulation of angiogenesis.
