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大鼠体内大豆苷元及其代谢物分布影响因素研究 被引量:2
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作者 徐海燕 苏芳铭 +3 位作者 蒋唤 张亮 邵楠 袁波 《沈阳药科大学学报》 CSCD 北大核心 2017年第9期768-775,共8页
目的研究大鼠灌胃给予大豆苷元后,多剂量与性别对大豆苷元及其代谢物在大鼠血浆中分布的影响。方法雌、雄大鼠分别单次或多次灌胃给予大豆苷元1.0 mg·kg-1,血浆样品经沉淀蛋白处理,采用LC-MS/MS方法测定血浆样品中大豆苷元及其II... 目的研究大鼠灌胃给予大豆苷元后,多剂量与性别对大豆苷元及其代谢物在大鼠血浆中分布的影响。方法雌、雄大鼠分别单次或多次灌胃给予大豆苷元1.0 mg·kg-1,血浆样品经沉淀蛋白处理,采用LC-MS/MS方法测定血浆样品中大豆苷元及其II相代谢物的质量浓度,采用Winnolin6.4计算各化合物的主要药动学参数,并对获得的药动学参数进行统计分析。结果大鼠多次灌胃给予大豆苷元后,血浆中大豆苷元及其代谢物的AUC_(0-24)明显高于单次给药。多次给药后雌鼠血浆中大豆苷元主要以大豆苷元-7-葡萄糖醛酸结合物和大豆苷元-7-硫酸结合物形式存在,雄鼠血浆中主要以大豆苷元-7-葡萄糖醛酸结合物、大豆苷元-7-硫酸结合物和大豆苷元-7-葡萄糖醛酸-4'-硫酸结合物形式存在。结论多次给药及性别差异明显影响大豆苷元在大鼠血浆中的分布。 展开更多
关键词 大豆苷元 Ⅱ相代谢物 液相色谱-串联质谱法 血浆分布 性别差异
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慢性心力衰竭患者中红细胞分布宽度与尿酸、左室舒张末径相关性分析
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作者 宿海峰 魏士刚 《实用老年医学》 CAS 2014年第9期761-763,共3页
目的探讨慢性心力衰竭(心衰)患者血浆红细胞分布宽度(RDW)的水平变化及其与尿酸、左室舒张末期内径的相关性分析。方法入选59例慢性心衰患者,根据超声心动图中左室收缩功能减低的程度(轻、中、重度)分为3组,观察各组RDW、尿酸及左室舒... 目的探讨慢性心力衰竭(心衰)患者血浆红细胞分布宽度(RDW)的水平变化及其与尿酸、左室舒张末期内径的相关性分析。方法入选59例慢性心衰患者,根据超声心动图中左室收缩功能减低的程度(轻、中、重度)分为3组,观察各组RDW、尿酸及左室舒张末期内径情况,并进行比较分析。结果左室收缩功能重度减低的心衰患者RDW、尿酸明显高于轻度患者(P<0.05),RDW与左室舒张末期内径有显著相关性(r=0.282,P<0.05)。结论 RDW水平可作为CHF患者评价心衰进程及预后的重要指标。 展开更多
关键词 慢性心力衰竭 血浆红细胞分布宽度 尿酸 左室舒张末期内径
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Ordinary Mode Instability in a Cairns Distributed Electron Plasma
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作者 K.Azra Z.Iqbal G.Murtaza 《Communications in Theoretical Physics》 SCIE CAS CSCD 2018年第6期699-703,共5页
Employing the linearized Vlasov-Maxwell equations, a generalized dispersion relation for the ordinary mode is derived by employing the Cairns distribution function. The instability of the mode and its threshold condit... Employing the linearized Vlasov-Maxwell equations, a generalized dispersion relation for the ordinary mode is derived by employing the Cairns distribution function. The instability of the mode and its threshold condition is investigated. It is found that the temperature anisotropy χ= TⅡ I⊥〉 1 required to excite the instability varies with density values whereas the growth rate is dependent on various parameters like non-thermMity A, equilibrium number density no and temperature anisotropy. It is found that with the increase in the values of any of the parameters A, no and X, the growth rate is enhanced and the k-domain is enlarged. The results are applicable for space plasma environments like solar wind. 展开更多
关键词 ordinary mode Cairns distribution temperature anisotropy INSTABILITY
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Solitary Potential in a Space Plasma Containing Dynamical Heavy Ions and Bi-Kappa Distributed Electrons of Two Distinct Temperatures
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作者 M.Sarker B.Hosen +1 位作者 M.R.Hossen A.A.Mamun 《Communications in Theoretical Physics》 SCIE CAS CSCD 2018年第1期107-114,共8页
The heavy ion-acoustic solitary waves(HIASWs) in a magnetized, collisionless, space plasma system(containing dynamical heavy ions and bi-kappa distributed electrons of two distinct temperatures) have been theoreticall... The heavy ion-acoustic solitary waves(HIASWs) in a magnetized, collisionless, space plasma system(containing dynamical heavy ions and bi-kappa distributed electrons of two distinct temperatures) have been theoretically investigated. The Korteweg-de Vries(K-dV), modified K-dV(MK-dV), and higher-order MK-dV(HMK-dV) equations are derived by employing the reductive perturbation method. The basic features of HIASWs(viz. speed, polarity,amplitude, width, etc.) are found to be significantly modified by the effects of number density and temperature of different plasma species, and external magnetic field(obliqueness). The K-dV and HM-Kd V equations give rise to both compressive and rarefactive solitary structures, whereas the MK-dV equation supports only the compressive solitary structures. The implication of our results in some space and laboratory plasma situations are briefly discussed. 展开更多
关键词 heavy ion acoustic waves solitary waves superthermal electrons higher order nonlinear equations
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