血尿酸、血液物化及胆红素联合检测对冠心病患者的临床价值评估

目的:评估血尿酸、血液物化及胆红素联合检测对冠心病患者的临床价值。方法:回顾性分析2014年1月-2015年1月在笔者所在医院心血管内科住院的152例冠心病患者的临床资料,所有患者均采用全自动血液流变系统和全自动生化分析仪检测血液物化、血尿酸及胆红素水平,选取同时期在笔者所在医院进行体检的健康人群作为正常对照组,并进行对比分析。结果:与正常对照组比较,冠心病组患者其直接胆红素、总胆红素和间接胆红素水平明显降低,而其血尿酸水平显著升高,差异均有统计学意义(P<0.05);冠心病组患者血浆黏度,全血黏度低、中、高切,全血还原黏度,红细胞刚性指数,红细胞聚集指数,纤维蛋白原及细胞比容均高于对照组,而红细胞变形指数则低于对照组,差异均有统计学意义(P<0.05)。结论:血尿酸、血液物化及胆红素联合检测对冠心病患者的临床诊断具有重要研究价值。

冠心病患者联合检测血尿酸、血液物化及胆红素的价值分析

目的:分析血尿酸、胆红素及血液物化的相互变化对冠心病患者的影响。方法:采用CI8200生化分析仪和MVIS-2022全自动血液流变系统,分别对患者的血液进行检测。结果:被检测的152例冠心病患者的血尿酸及血流动力学均明显升高,胆红素降低。结论:联合检测血尿酸、胆红素及血液物化对冠心病的诊治具有重要价值。

冠心病患者联合检测血尿酸、血液物化及胆红素的价值分析

目的研究冠心病患者联合检测血尿酸、血液物化及胆红素的价值。方法随机筛选本院体检人员中的150例冠心病患者作为冠心病组;同时筛选正常健康者150例作为正常组。检测两组的血尿酸、血液物化及胆红素水平,观察比较两组的血液检查结果。结果冠心病组的血尿酸为(398.60±88.50)μmol/L,总胆红素为(10.60±2.54)mmol/L,直接胆红素为(3.00±1.07)mmol/L,间接胆红素为(8.80±3.78)mmol/L,全血粘度低切为(13.78±2.85)m Pa·s,全血粘度中切为(6.55±0.83)m Pa·s,全血粘度高切为(5.06±0.56)m Pa·s,血浆粘度为(1.58±0.26)m Pa·s,全血还原粘度为(26.79±7.03)m Pa·s,红细胞比容为(47.66±6.72)%,纤维蛋白原为(3.39±1.01)g/L,红细胞聚集指数为(1.90±0.50),红细胞刚性指数为(3.50±0.60),红细胞变形指数为(0.50±0.30)。正常组的血尿酸为(266.80±70.60)μmol/L,总胆红素为(14.70±4.68)mmol/L,直接胆红素为(2.74±1.15)mmol/L,间接胆红素为(11.80±4.65)mmol/L,全血粘度低切为(9.45±1.45)m Pa·s,全血粘度中切为(5.16±0.41)m Pa·s,全血粘度高切为(4.23±0.53)m Pa·s,血浆粘度为(1.44±0.20)m Pa·s,全血还原粘度为(20.28±3.69)m Pa·s,红细胞比容为(43.57±5.67)%,纤维蛋白原为(2.79±0.72)g/L,红细胞聚集指数为(2.60±0.80),红细胞刚性指数为(6.80±0.60),红细胞变形指数为(0.77±0.32)。冠心病组的血尿酸、直接胆红素、全血粘度低切、全血粘度中切、全血粘度高切、血浆粘度、全血还原粘度、红细胞比容、纤维蛋白原高于正常组,总胆红素、间接胆红素、红细胞聚集指数、红细胞刚性指数、红细胞变形指数低于正常组,差异具有统计学意义(P<0.05)。结论联合检测血尿酸、血液物化及胆红素对于冠心病的诊治具有重要临床研究价值,值得临床推广。

雷公藤治疗肾小球疾病

雷公藤为卫矛科雷公藤属植物,其学名为Triperytjgium WilfordiiHook。其味苦,研究发现其有较强的非特异性抗炎作用与免疫抑制作用,并具有抗凝、改善血液物化性质与微循环作用等。自70年代以来,将雷公藤应用于肾炎的治疗研究日趋受到临床学者的重视,不仅治疗肾脏病越来越广泛,且在减少肾炎患者的蛋白尿方面具有肯定的效果,据有关资料表明其临床有效率在64—96％之间。

Pegylated-interferon alpha 2a treatment for chronic hepatitis C in patients on chronic haemodialysis

AIM： To evaluate the response to pegylated-interferon alpha 2a in chronic hepatitis C patients on chronic haemodialysis. METHODS： Ten patients with chronic C hepatitis were enrolled in this study. All had increased aminotransferases for more than 6 too, positive antiHCV antibodies and positive PCR HCV-RNA. We administrated Peg-Interferon alpha 2a 180 μg/wk for 48 wk. After 12 wk of treatment we evaluated the biochemical and early virological response （EVR）. At the end of the treatment we evaluated the biochemical response and 24 wk after the end of the treatment we evaluated the sustained virological response （SVR）. We monitored the sideeffects during the treatment. RESULTS： Two patients dropped out in the first 12 wk of treatment and 2 after the first 12 wk of treatment. After 12 wk of treatment, 7 out of 8 patients had biochemical response and EVR and 1 had biochemical response but persistent viremia. We had to reduce the dose of pegylated-interferon to 135 μg/wk in 2 cases. Three out of 6 （50%） patients had SVR 24 wk after the end of the treatment. Intention-to-treat analysis showed that 3 out of 10 patients （30%） had SVR. Side-effects occurred in most of the patients （flu-like syndrome, thrombocytopenia or leucopoenia）, but they did not impose the discontinuation of treatment. CONCLUSION： After 12 wk of treatment with Peg-Interferon alpha 2a （40 ku） in patients on chronic haemodialysis with chronic C hepatitis, EVR was obtained in 87.5% （7/8） of the cases. SVR was achieved in 50% of the cases （3/6 patients） that finished the 48 wk of treatment.

Physical-Chemical Aggressiveness of Solutions of Medicines as a Factor in the Rheology of the Blood inside Veins and Catheters

In experiments in vitro and observations in the clinic in vivo studied the state of the lumen of subcutaneous veins and blood rheology of patients after their interaction with vascular catheters and solutions of medicines based on the values of temperature, volume, concentration, osmotic activity and pH. It is shown that heparin injection in blood not prevent, but solution of 4% sodium bicarbonate injection prevents blood clotting, blood clots and blockage blood clots of veins and of catheters. It is shown that the heating to a temperature of＋42 ℃ with the solution of 4% sodium bicarbonate provides softening action on old dry blood clots in 1 min, and their subsequent irrigation with a warm solution of 4% sodium bicarbonate and 3% hydrogen peroxide provides complete destruction and discoloration of the remaining spots of blood during 2 s. Proposed new medicines and hygiene products for the protection of the veins and installed in them vascular catheters from blockage of blood clots, and for removing blood stains from clothes and body surface patients.

Acute toxicity study of Aspidopterys obcordata aqueous extract in Sprague-Dawley rats

OBJECTIVE: To examine the acute toxicity of an aqueous extract of Aspidopterys obcordata(A. obcordata) in Sprague Dawley rats.METHODS: The rats were orally administered a dose of 5000 mg/kg body weight and observed continuously for 6 h and then daily for 14 days. Control rats were administered distilled water. The effect of the extract on general behavior, body weight, and food and water intake were measured.After 14 days, the rats were sacrificed and their organs(liver, heart, spleen, lungs, kidney, adrenal glands, ovaries, and testes) were removed for macroscopic examination. The body and organ weights in addition to hematology(e.g., hemoglobin and white blood cell counts) and clinical blood biochemistry(e.g., albumin and bilirubin) were also examined.RESULTS: There were no deaths recorded, and the rats treated with A. obcordata showed no signs of toxicity. All measured parameters in rats treated with A. obcordata were unaffected when compared with those in control rats. The acute toxicity(LD_(50))was estimated to be > 5000 mg/kg body weight.CONCLUSION: Our results demonstrate the safety of an acute oral administration of an aqueous extract of A. obcordata in rats and indicate that future subacute and long-term toxicity testing of A. obcordata is warranted.

Natural products against hematological malignancies and identification of their targets

Naturally occurring molecules derived from higher plants, animals, microorganisms and minerals play an important role in the discovery and development of novel therapeutic agents. The identification of molecular targets is of interest to elucidate the mode of action of these compounds, and it may be employed to set up target-based assays and allow structure-activity relationship studies to guide medicinal chemistry efforts toward lead optimization. In recent years, plant-derived natural compounds possessing potential anti-tumor activities have been garnering much interest and efforts are underway to identify their molecular targets. Here, we attempt to summarize the discoveries of several natural compounds with activities against hematological malignancies, such as adenanthin, oridonin, gambogic acid and wogonoside, the identification of their targets, and their modes of actions.