目的回顾性分析低剂量单采血小板预防性输注疗效,探索低剂量单采血小板预防性输注的可行性。方法选取2020年11月至2021年9月本院输注血小板的住院患者392名,输注常规剂量(1治疗量)单采血小板为对照组,输注低剂量(0.5治疗量)单采血小板...目的回顾性分析低剂量单采血小板预防性输注疗效,探索低剂量单采血小板预防性输注的可行性。方法选取2020年11月至2021年9月本院输注血小板的住院患者392名,输注常规剂量(1治疗量)单采血小板为对照组,输注低剂量(0.5治疗量)单采血小板为试验组。以输注前后血小板计数、血小板增高值(△PLT)以及24 h血小板计数纠正增加指数(CCI)为观测指标,按病种和性别分析低剂量血小板输注疗效。结果对照组血小板△PLT值和24 h CCI有效输注率均高于试验组(16±16)×10^(9)vs(7±10)×10^(9),71.94%vs 60.46%(P<0.05)。对照组△PLT值约为试验组1.4~3.5倍,有效率约为1~1.4倍。对照组,血小板增高值△PLT为AML(20±14)>AA(14±14)>ALL(13±12)>NHL(9±8)>MDS(7±6);试验组,血小板增高值△PLT(×10^(9))为AA(11±18)>AML(8±8)>ALL(5±7)>NHL(5±7)>MDS(5±16)。24 h CCI,对照组,AML(163/188,86.70%)>AA(23/32,71.88%)>ALL(65/98,66.33%)>MDS(9/17,52.94%)>NHL(12/22,51.55%);试验组,AML(133/188,70.74%)>AA(19/32,59.38%)>NHL(12/22,51.55%)>ALL(47/98,47.96%)>MDS(8/17,47.06%)。AML和ALL 2种疾病的试验组有效输注率分别为70.74%(133/188)、47.96%(47/98),明显低于对照组86.7%(163/188)、66.33%(65/98),差异有统计学意义(P<0.05);其它病种试验组与对照组有效输注率间的差异无统计学意义(P>0.05)。结论低剂量单采血小板预防性输注可缓解供需矛盾,能达到60.46%(237/392)的有效输注率,具有一定的临床应用价值。推荐临床在应用低剂量血小板时,优先选择AML、AA或ALL的患者,尽量避免MDS、NHL患者。展开更多
Hemosuccus pancreaticus is a rare cause of intermittent upper gastrointestinal bleeding. We report two cases of hemosuccus pancreaticus with multiple episodes of upper gastrointestinal bleeding. The causes of hemorrha...Hemosuccus pancreaticus is a rare cause of intermittent upper gastrointestinal bleeding. We report two cases of hemosuccus pancreaticus with multiple episodes of upper gastrointestinal bleeding. The causes of hemorrhage were rupture of pseudoaneurysm of the splenic artery and bleeding from the wall of pancreatic pseudocyst. Interventional radiology is the first modality for early diagnosis and possible treatment of hemosuccus pancreaticus. When angiography shows no abnormal findings or interventional radiological therapy can not be successful, surgery should be considered without delay. Our patients herein underwent surgery without recurrence or sequelae. Intraoperative ultrasonography and pancreatoscopy were helpful modalities for confirming the source of hemorrhage and determining the cutting line of the pancreas. When we encounter intermittent upper gastrointestinal bleeding with an obscure source, hemosuccus pancreaticus should be included in differential diagnoses especially in patients with chronic pancreatitis, which would lead to a prompt and proper treatment.展开更多
To explore the therapeutic effects of the method of promoting blood circulation and removing blood stasis on hemorrhagic apoplexy of acute stage, 45 cases were treated by the method and observed for their conscious st...To explore the therapeutic effects of the method of promoting blood circulation and removing blood stasis on hemorrhagic apoplexy of acute stage, 45 cases were treated by the method and observed for their conscious state and motor function, which were compared with 40 cases treated with regular western drugs. The results showed that the effective rate in the treated group was 82.2% and that in control group 60% with a significant difference (P<0.05) between the two groups. In the treated group, the scores of the conscious state and the motor function after treatment were elevated dramatically (P<0.01), indicating a much better effect in the treated group than in the control group.展开更多
The above therapeutic results show that TCM drugs have excellent effects in counteracting the metastasis of tumors. They can produce a synergistic effect when used together with surgery, radio- and chemotherapy. In an...The above therapeutic results show that TCM drugs have excellent effects in counteracting the metastasis of tumors. They can produce a synergistic effect when used together with surgery, radio- and chemotherapy. In analyzing the relationship between the factors that affect the distant metastasis, the authors strongly recommend that the FDM-survival rate be used, i.e. the survival rate free from distant metastasis as suggested by Hong Minghuang et al in their article. An analysis based on FDM-survival rate in a duration of three or five years with the data treated with the Kaplan-Meier and/or Life Table would be rational and convincible.展开更多
OBJECTIVE： To evaluate the medium- to long-term efficacy of ligustrazine plus conventional medicine treating ischemic stroke. METHODS： Randomized controlled trials （RCTs） testing ligustrazine in the treatment of a...OBJECTIVE： To evaluate the medium- to long-term efficacy of ligustrazine plus conventional medicine treating ischemic stroke. METHODS： Randomized controlled trials （RCTs） testing ligustrazine in the treatment of acute isch- emic stroke were retrieved from Cochrane Library, PubMed, Excerpta Medica Database, Chinese Medi- cal Journal Database, Chinese Biomedical Data- base, China National Knowledge Infrastructure Da- tabase, and Chinese Clinical Trial Register, and then identified by the inclusive and exclusive criteria. The quality of trials was assessed with the Co- chrane Handbook 5.1, a risk of bias assessment toot. RevMan 5.1 was used for meta-analysis.RESULTS： Three RCTs involving 643 patients were included. Compared to conventional medicine treatment alone, ligustrazine plus conventional medicine treatment showed significant difference in reduction of stroke recurrence either at the end of 1-year follow-up [RR=0.42, 95% CI （0.18, 0.94）, P〈 0.05] or 3-years observation [RR=0.48, 95% C/（0.27, 0.83）, P〈0.05]. The ligustrazine group also showed higher survival rate [RR=1.67, 95% CI （1.02, 0.2.71）, P〈0.05] and significantly better effective rate [RR= 1.28, 95% CI（1.10, 1.50）, P〈0.05] than that of the control group at the end of 1 year visit. Only one tri- al conducted safety assessment and no adverse events were reported. The methodological quality of all the trials included was generally poor. CONCLUSION： The findings provided evidence that the combination of ligustrazine and conven- tional medication was medium- and long-term ben- eficial to the patients suffering ischemic stroke. But more RCTs of high quality are needed to further prove the efficacy and safety of using ligustrazine for ischemic stroke.展开更多
OBJECTIVE： To test the clinical curative effect of Jiutengzhuyu tablets, a patented Chinese vine-de- rived drug used for promoting blood circulation, on women with oviducal obstruction. METHODS Patients with tubal in...OBJECTIVE： To test the clinical curative effect of Jiutengzhuyu tablets, a patented Chinese vine-de- rived drug used for promoting blood circulation, on women with oviducal obstruction. METHODS Patients with tubal infertility were di- vided randomly into two groups： 58 patients in the treatment group and 57 in a control group. The treated patients took Jiutengzhuyu tablets orally for 25 days. The control group received an intrauter- ine infusion of 5 mg dexamethasone sodium phos- phate, 4000 units of chymotrypsin, 80 000 units of gentamicin sulfate dissolved in 20 mL of normal sa- line at I mL/min. After 3 months of treatment, the curative effect on tubal patency was assessed and a l-year follow-up visit was used to document any pregnancies. RESULTS The total effective rate was 78% in the treatment group and 32% in the control group with a statistically significant difference （x2=24.57, P〈0.01）.CONCLUSION： Jiutengzhuyu was effective in treat- ing infertility caused by tubal infertility with a Traditional Chinese Medicine diagnosis of blood stasis.展开更多
文摘目的回顾性分析低剂量单采血小板预防性输注疗效,探索低剂量单采血小板预防性输注的可行性。方法选取2020年11月至2021年9月本院输注血小板的住院患者392名,输注常规剂量(1治疗量)单采血小板为对照组,输注低剂量(0.5治疗量)单采血小板为试验组。以输注前后血小板计数、血小板增高值(△PLT)以及24 h血小板计数纠正增加指数(CCI)为观测指标,按病种和性别分析低剂量血小板输注疗效。结果对照组血小板△PLT值和24 h CCI有效输注率均高于试验组(16±16)×10^(9)vs(7±10)×10^(9),71.94%vs 60.46%(P<0.05)。对照组△PLT值约为试验组1.4~3.5倍,有效率约为1~1.4倍。对照组,血小板增高值△PLT为AML(20±14)>AA(14±14)>ALL(13±12)>NHL(9±8)>MDS(7±6);试验组,血小板增高值△PLT(×10^(9))为AA(11±18)>AML(8±8)>ALL(5±7)>NHL(5±7)>MDS(5±16)。24 h CCI,对照组,AML(163/188,86.70%)>AA(23/32,71.88%)>ALL(65/98,66.33%)>MDS(9/17,52.94%)>NHL(12/22,51.55%);试验组,AML(133/188,70.74%)>AA(19/32,59.38%)>NHL(12/22,51.55%)>ALL(47/98,47.96%)>MDS(8/17,47.06%)。AML和ALL 2种疾病的试验组有效输注率分别为70.74%(133/188)、47.96%(47/98),明显低于对照组86.7%(163/188)、66.33%(65/98),差异有统计学意义(P<0.05);其它病种试验组与对照组有效输注率间的差异无统计学意义(P>0.05)。结论低剂量单采血小板预防性输注可缓解供需矛盾,能达到60.46%(237/392)的有效输注率,具有一定的临床应用价值。推荐临床在应用低剂量血小板时,优先选择AML、AA或ALL的患者,尽量避免MDS、NHL患者。
文摘Hemosuccus pancreaticus is a rare cause of intermittent upper gastrointestinal bleeding. We report two cases of hemosuccus pancreaticus with multiple episodes of upper gastrointestinal bleeding. The causes of hemorrhage were rupture of pseudoaneurysm of the splenic artery and bleeding from the wall of pancreatic pseudocyst. Interventional radiology is the first modality for early diagnosis and possible treatment of hemosuccus pancreaticus. When angiography shows no abnormal findings or interventional radiological therapy can not be successful, surgery should be considered without delay. Our patients herein underwent surgery without recurrence or sequelae. Intraoperative ultrasonography and pancreatoscopy were helpful modalities for confirming the source of hemorrhage and determining the cutting line of the pancreas. When we encounter intermittent upper gastrointestinal bleeding with an obscure source, hemosuccus pancreaticus should be included in differential diagnoses especially in patients with chronic pancreatitis, which would lead to a prompt and proper treatment.
文摘To explore the therapeutic effects of the method of promoting blood circulation and removing blood stasis on hemorrhagic apoplexy of acute stage, 45 cases were treated by the method and observed for their conscious state and motor function, which were compared with 40 cases treated with regular western drugs. The results showed that the effective rate in the treated group was 82.2% and that in control group 60% with a significant difference (P<0.05) between the two groups. In the treated group, the scores of the conscious state and the motor function after treatment were elevated dramatically (P<0.01), indicating a much better effect in the treated group than in the control group.
文摘The above therapeutic results show that TCM drugs have excellent effects in counteracting the metastasis of tumors. They can produce a synergistic effect when used together with surgery, radio- and chemotherapy. In analyzing the relationship between the factors that affect the distant metastasis, the authors strongly recommend that the FDM-survival rate be used, i.e. the survival rate free from distant metastasis as suggested by Hong Minghuang et al in their article. An analysis based on FDM-survival rate in a duration of three or five years with the data treated with the Kaplan-Meier and/or Life Table would be rational and convincible.
基金Supported by Joint Special Project of Guangdong Provincial Department of Science and Technology-Guangdong Provincial Academy of Chinese Medical Sciences:Construction and Application of Evidence-Based Knowledge Management System for Traditional Chinese Medicine(No.2012A032500009)
文摘OBJECTIVE： To evaluate the medium- to long-term efficacy of ligustrazine plus conventional medicine treating ischemic stroke. METHODS： Randomized controlled trials （RCTs） testing ligustrazine in the treatment of acute isch- emic stroke were retrieved from Cochrane Library, PubMed, Excerpta Medica Database, Chinese Medi- cal Journal Database, Chinese Biomedical Data- base, China National Knowledge Infrastructure Da- tabase, and Chinese Clinical Trial Register, and then identified by the inclusive and exclusive criteria. The quality of trials was assessed with the Co- chrane Handbook 5.1, a risk of bias assessment toot. RevMan 5.1 was used for meta-analysis.RESULTS： Three RCTs involving 643 patients were included. Compared to conventional medicine treatment alone, ligustrazine plus conventional medicine treatment showed significant difference in reduction of stroke recurrence either at the end of 1-year follow-up [RR=0.42, 95% CI （0.18, 0.94）, P〈 0.05] or 3-years observation [RR=0.48, 95% C/（0.27, 0.83）, P〈0.05]. The ligustrazine group also showed higher survival rate [RR=1.67, 95% CI （1.02, 0.2.71）, P〈0.05] and significantly better effective rate [RR= 1.28, 95% CI（1.10, 1.50）, P〈0.05] than that of the control group at the end of 1 year visit. Only one tri- al conducted safety assessment and no adverse events were reported. The methodological quality of all the trials included was generally poor. CONCLUSION： The findings provided evidence that the combination of ligustrazine and conven- tional medication was medium- and long-term ben- eficial to the patients suffering ischemic stroke. But more RCTs of high quality are needed to further prove the efficacy and safety of using ligustrazine for ischemic stroke.
文摘OBJECTIVE： To test the clinical curative effect of Jiutengzhuyu tablets, a patented Chinese vine-de- rived drug used for promoting blood circulation, on women with oviducal obstruction. METHODS Patients with tubal infertility were di- vided randomly into two groups： 58 patients in the treatment group and 57 in a control group. The treated patients took Jiutengzhuyu tablets orally for 25 days. The control group received an intrauter- ine infusion of 5 mg dexamethasone sodium phos- phate, 4000 units of chymotrypsin, 80 000 units of gentamicin sulfate dissolved in 20 mL of normal sa- line at I mL/min. After 3 months of treatment, the curative effect on tubal patency was assessed and a l-year follow-up visit was used to document any pregnancies. RESULTS The total effective rate was 78% in the treatment group and 32% in the control group with a statistically significant difference （x2=24.57, P〈0.01）.CONCLUSION： Jiutengzhuyu was effective in treat- ing infertility caused by tubal infertility with a Traditional Chinese Medicine diagnosis of blood stasis.
