目的探讨血液透析治疗患者按照0-1-2月免疫程序接种乙型肝炎(乙肝)疫苗(Hepatitis B vaccine,HepB)的依从性和免疫原性。方法采用两种乙肝免疫程序完成率和免疫原性比较的随机对照临床试验,在北京市朝阳区8家医疗机构招募接受血液透析...目的探讨血液透析治疗患者按照0-1-2月免疫程序接种乙型肝炎(乙肝)疫苗(Hepatitis B vaccine,HepB)的依从性和免疫原性。方法采用两种乙肝免疫程序完成率和免疫原性比较的随机对照临床试验,在北京市朝阳区8家医疗机构招募接受血液透析治疗且乙肝表面抗原、乙肝表面抗体(Hepatitis B surface antibody,HBsAb)和乙肝核心抗体均阴性的18-70岁患者,随机分为试验组和对照组,分别按照0-1-2月和0-1-6月免疫程序接种20μg HepB,检测免疫前和免疫后1个月血清HBsAb,比较两组HepB全程接种完成率、HBsAb阳转率和几何平均浓度(GMC)。结果试验组、对照组受试者HepB全程接种完成率分别为94.39%(101/107)、90.83%(99/109)(χ^(2)=1.00,P=0.316);两组全程免疫后HBsAb阳转率分别为70.10%(68/97)、87.76%(86/98)(率差=-17.66%,95%CI下限:-28.84%);GMC分别为60.81mIU/mL、247.08mIU/mL(t=-3.68,P=0.000)。结论血液透析治疗患者HepB 0-1-2月免疫程序的依从性较好,但免疫原性弱于0-1-6月免疫程序。展开更多
Investigation of depression prevalence in end stage renal disease （ESRD） patients treated with two different methods, hemodialysis （HD） and continuous ambulatory peritoneal dialysis （CAPD） is conducted. We inves...Investigation of depression prevalence in end stage renal disease （ESRD） patients treated with two different methods, hemodialysis （HD） and continuous ambulatory peritoneal dialysis （CAPD） is conducted. We investigated whether the dialysis adequacy （Kt/v） and serum hemoglobin level had any correlation with depression severity. Psychiatric interview was performed on 30 HD and 30 CAPD patients. Hamilton depression rating scale （HAMD） was used to evaluate depression symptoms. Kt/v and serum hemoglobin level were detected. Half of HD patients were depressive, while depression wasn＇t found in any CAPD patient. Hemoglobin was in positive correlation with the HAMD, while Kt/v was in negative correlation with the HAMD. Patients on CAPD had less depressive symptoms. Good dialysis adequacy diminish depressive symptoms.展开更多
The large prevalence of respiratory acid-base disordersoverlapping metabolic acidosis in hemodialysis popu-lation should prompt nephrologists to deal with the partial pressure of carbon dioxide （pCO2） complying with...The large prevalence of respiratory acid-base disordersoverlapping metabolic acidosis in hemodialysis popu-lation should prompt nephrologists to deal with the partial pressure of carbon dioxide （pCO2） complying with the reduced bicarbonate concentration. What the most suitable formula to compute pCO2 is reviewed. Then, the neglected issue of CO2 content in the dialysis fluid is under the spotlight. In fact, a considerable amount of CO2 comes to patients’ bloodstream every hemodialysis treatment and “acidosis by dialysate” may occur if lungs do not properly clear away this burden of CO2. Moreover, vascular access recirculation may be easy diagnosed by detecting CO2 in the arterial line of extracorporeal circuit if CO2-enriched blood from the flter reenters arterial needle.展开更多
文摘目的探讨血液透析治疗患者按照0-1-2月免疫程序接种乙型肝炎(乙肝)疫苗(Hepatitis B vaccine,HepB)的依从性和免疫原性。方法采用两种乙肝免疫程序完成率和免疫原性比较的随机对照临床试验,在北京市朝阳区8家医疗机构招募接受血液透析治疗且乙肝表面抗原、乙肝表面抗体(Hepatitis B surface antibody,HBsAb)和乙肝核心抗体均阴性的18-70岁患者,随机分为试验组和对照组,分别按照0-1-2月和0-1-6月免疫程序接种20μg HepB,检测免疫前和免疫后1个月血清HBsAb,比较两组HepB全程接种完成率、HBsAb阳转率和几何平均浓度(GMC)。结果试验组、对照组受试者HepB全程接种完成率分别为94.39%(101/107)、90.83%(99/109)(χ^(2)=1.00,P=0.316);两组全程免疫后HBsAb阳转率分别为70.10%(68/97)、87.76%(86/98)(率差=-17.66%,95%CI下限:-28.84%);GMC分别为60.81mIU/mL、247.08mIU/mL(t=-3.68,P=0.000)。结论血液透析治疗患者HepB 0-1-2月免疫程序的依从性较好,但免疫原性弱于0-1-6月免疫程序。
文摘Investigation of depression prevalence in end stage renal disease （ESRD） patients treated with two different methods, hemodialysis （HD） and continuous ambulatory peritoneal dialysis （CAPD） is conducted. We investigated whether the dialysis adequacy （Kt/v） and serum hemoglobin level had any correlation with depression severity. Psychiatric interview was performed on 30 HD and 30 CAPD patients. Hamilton depression rating scale （HAMD） was used to evaluate depression symptoms. Kt/v and serum hemoglobin level were detected. Half of HD patients were depressive, while depression wasn＇t found in any CAPD patient. Hemoglobin was in positive correlation with the HAMD, while Kt/v was in negative correlation with the HAMD. Patients on CAPD had less depressive symptoms. Good dialysis adequacy diminish depressive symptoms.
文摘The large prevalence of respiratory acid-base disordersoverlapping metabolic acidosis in hemodialysis popu-lation should prompt nephrologists to deal with the partial pressure of carbon dioxide （pCO2） complying with the reduced bicarbonate concentration. What the most suitable formula to compute pCO2 is reviewed. Then, the neglected issue of CO2 content in the dialysis fluid is under the spotlight. In fact, a considerable amount of CO2 comes to patients’ bloodstream every hemodialysis treatment and “acidosis by dialysate” may occur if lungs do not properly clear away this burden of CO2. Moreover, vascular access recirculation may be easy diagnosed by detecting CO2 in the arterial line of extracorporeal circuit if CO2-enriched blood from the flter reenters arterial needle.
