目的研究理疗联合五福饮对椎间盘相关腰痛患者血清β-catenin、疼痛和生活水平的影响。方法选取2017年6月~2018年6月于我院就诊的椎间盘相关腰痛患者126例,按随机数字表法分为实验组(n=63)和对照组(n=63),对照组患者给予常规理疗,实验...目的研究理疗联合五福饮对椎间盘相关腰痛患者血清β-catenin、疼痛和生活水平的影响。方法选取2017年6月~2018年6月于我院就诊的椎间盘相关腰痛患者126例,按随机数字表法分为实验组(n=63)和对照组(n=63),对照组患者给予常规理疗,实验组患者在对照组的基础上给予五福饮治疗,观察两组患者血清β-catenin和DKK1、VAS评分、Oswestry功能障碍指数问卷表(ODI)评分、世界卫生组织生存质量调查表简表(WHOQOL-BREF)评分以及不良反应发生情况。结果治疗后两组患者血清β-catenin和DKK1均显著下降,且实验组血清β-catenin和DKK1显著低于对照组,差异具有统计学意义(P<0.05);治疗后2周、4周和2个月两组患者VAS评分均显著降低,且实验组VAS评分显著低于对照组,差异具有统计学意义(P<0.05);治疗后2周、4周和2个月两组患者ODI评分均显著降低,且实验组ODI评分显著低于对照组,差异具有统计学意义(P<0.05);治疗后两组患者生理领域、心理领域、社会关系领域和环境领域评分均显著升高,且实验组各项评分显著高于对照组,差异具有统计学意义(P<0.05);实验组和对照组不良反应发生率无统计学差异(4.76% vs 1.59%,χ^2=0.529,P=0.427)。结论理疗联合五福饮能显著降低患者血清β-catenin水平,缓解患者疼痛,改善患者生活水平,且具有较高的安全性,值得临床推广。展开更多
Liver cancer,and in particular hepatocellular carcinoma(HCC)is a disease of rising prevalence and incidence.To date,definitive treatment options include either surgical excision or ablation of the affected area.With i...Liver cancer,and in particular hepatocellular carcinoma(HCC)is a disease of rising prevalence and incidence.To date,definitive treatment options include either surgical excision or ablation of the affected area.With increasing research on several pathways that could be involved in the progression of HCC,new elements within these pathways emerge as potential targets for novel therapies.The WNT/β-catenin pathway favors the presence of M2 tumor-associated macrophages which in turn promote tumor growth and metastasis.The inhibition of this pathway is considered a good candidate for such targeted therapeutic interventions.Interestingly,as Huang et al show in their recently published article,Calculus bovis which is used in traditional Chinese medicine can exert an inhibitory effect on theβ-catenin pathway and become a potential candidate for targeted pharmacotherapy against liver cancer.展开更多
文摘目的研究理疗联合五福饮对椎间盘相关腰痛患者血清β-catenin、疼痛和生活水平的影响。方法选取2017年6月~2018年6月于我院就诊的椎间盘相关腰痛患者126例,按随机数字表法分为实验组(n=63)和对照组(n=63),对照组患者给予常规理疗,实验组患者在对照组的基础上给予五福饮治疗,观察两组患者血清β-catenin和DKK1、VAS评分、Oswestry功能障碍指数问卷表(ODI)评分、世界卫生组织生存质量调查表简表(WHOQOL-BREF)评分以及不良反应发生情况。结果治疗后两组患者血清β-catenin和DKK1均显著下降,且实验组血清β-catenin和DKK1显著低于对照组,差异具有统计学意义(P<0.05);治疗后2周、4周和2个月两组患者VAS评分均显著降低,且实验组VAS评分显著低于对照组,差异具有统计学意义(P<0.05);治疗后2周、4周和2个月两组患者ODI评分均显著降低,且实验组ODI评分显著低于对照组,差异具有统计学意义(P<0.05);治疗后两组患者生理领域、心理领域、社会关系领域和环境领域评分均显著升高,且实验组各项评分显著高于对照组,差异具有统计学意义(P<0.05);实验组和对照组不良反应发生率无统计学差异(4.76% vs 1.59%,χ^2=0.529,P=0.427)。结论理疗联合五福饮能显著降低患者血清β-catenin水平,缓解患者疼痛,改善患者生活水平,且具有较高的安全性,值得临床推广。
文摘Liver cancer,and in particular hepatocellular carcinoma(HCC)is a disease of rising prevalence and incidence.To date,definitive treatment options include either surgical excision or ablation of the affected area.With increasing research on several pathways that could be involved in the progression of HCC,new elements within these pathways emerge as potential targets for novel therapies.The WNT/β-catenin pathway favors the presence of M2 tumor-associated macrophages which in turn promote tumor growth and metastasis.The inhibition of this pathway is considered a good candidate for such targeted therapeutic interventions.Interestingly,as Huang et al show in their recently published article,Calculus bovis which is used in traditional Chinese medicine can exert an inhibitory effect on theβ-catenin pathway and become a potential candidate for targeted pharmacotherapy against liver cancer.
