目的评估终末期肝病模型(model for end-stage liver disease,MELD)联合血清高密度脂蛋白胆固醇(HDL-C)水平对预测肝硬化肝功能失代偿期患者的短期、中期死亡危险的价值。方法入选57例非酒精性肝硬化肝功能失代偿期患者,分别根据随访6月...目的评估终末期肝病模型(model for end-stage liver disease,MELD)联合血清高密度脂蛋白胆固醇(HDL-C)水平对预测肝硬化肝功能失代偿期患者的短期、中期死亡危险的价值。方法入选57例非酒精性肝硬化肝功能失代偿期患者,分别根据随访6月及12月的存活情况分组,观察死亡者与存活者中血清HDL-C值、MELD评分。结果随访至6月及12月,死亡者血清HDL-C显著低于存活者,MELD评分显著高于存活者,均具有统计学差异(均P<0.01)。MELD评分与HDL-C密切相关(r=-0.96,P<0.01)。MELD评分联合血清HDL-C预测6个月死亡敏感性100.0%,特异性92.1%。结论MELD评分系统、血清HDL-C水平是预测非酒精性肝硬化患者6个月、12个月生存率的独立的较好预后指标。MELD评分联合血清HDL-C水平在预测非酒精性肝硬化肝功能失代偿期患者短、中期死亡率方面具有更好的作用。展开更多
Objective To observe the serum level of non-high density lipoprotein cholesterol(non-HDLC),and to evaluate the relationship between non-HDLC and atherosclerosis in Hangzhou occupational population.Methods 11668 people...Objective To observe the serum level of non-high density lipoprotein cholesterol(non-HDLC),and to evaluate the relationship between non-HDLC and atherosclerosis in Hangzhou occupational population.Methods 11668 people(7369 males,4299 females) who took physical examination in our hospital during 2006.1-2007.6 were detected the fast serum levels of total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C) and low density lipoprotein cholesterol(LDL-C) according to standard operating procedure.And then non-HDLC and atherogenic index of plasma(AIP) were calculated according to the formulae non-HDL-C =TC-HD-C and AIP=log(TG/HDL-C).Statistical analysis was performed to evaluate the correlation between non-HDLC and atherosclerosis.Results There was a significant difference of LDL-C between by direct assay and by Friedewald formula calculation(P<0.001).When TG<4.5mmol/L and TG without grouping,LDL-C calculated by Friedewald formula was higher than that by direct assay.When TG≧4.5mmol/L,LDL-C calculated by Friedewald formula was obviously lower than that by direct assay.Non-HDLC was more closely related to AIP than LDLC as comparing TC and TG on different levels.Conclusions Non-HDLC was more closely related to AIP,and it could be used to judge the chanciness of atherosclerosis.Therefore,we suggest that the value of non-HDLC and AIP should be combined on analyzing routine blood fat to elevate the accuracy of artherosclerosis evaluation and non-HDLC as the second target in blood fat treatment.展开更多
近年来,心血管疾病(cardiovascular diseases,CVD)的发病率及死亡率逐年升高,发病年龄趋于提前,因此心血管疾病防治的研究备受关注.研究表明,血清低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)可以导致CVD的发生...近年来,心血管疾病(cardiovascular diseases,CVD)的发病率及死亡率逐年升高,发病年龄趋于提前,因此心血管疾病防治的研究备受关注.研究表明,血清低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)可以导致CVD的发生和发展,使用降脂类药物调节血清LDL-C的水平,即使降至1.8mmol/L以下,CVD的发生率仍然较高[1].这种心血管疾病剩余风险存在的原因之一可能与血清低水平的HDL-C有关.他汀类药物IVUS试验的前瞻性随机试验的荟萃分析表明[2],血清低水平的HDL-C是动脉粥样硬化性疾病的独立危险因素.然而,最近对血清HDL-C水平和动脉粥样硬化性心血管疾病的这种负相关关系提出了异议.近年来,血清HDL-C对心血管疾病的防治作用及机制已成为研究的热点,综述如下.展开更多
文摘目的评估终末期肝病模型(model for end-stage liver disease,MELD)联合血清高密度脂蛋白胆固醇(HDL-C)水平对预测肝硬化肝功能失代偿期患者的短期、中期死亡危险的价值。方法入选57例非酒精性肝硬化肝功能失代偿期患者,分别根据随访6月及12月的存活情况分组,观察死亡者与存活者中血清HDL-C值、MELD评分。结果随访至6月及12月,死亡者血清HDL-C显著低于存活者,MELD评分显著高于存活者,均具有统计学差异(均P<0.01)。MELD评分与HDL-C密切相关(r=-0.96,P<0.01)。MELD评分联合血清HDL-C预测6个月死亡敏感性100.0%,特异性92.1%。结论MELD评分系统、血清HDL-C水平是预测非酒精性肝硬化患者6个月、12个月生存率的独立的较好预后指标。MELD评分联合血清HDL-C水平在预测非酒精性肝硬化肝功能失代偿期患者短、中期死亡率方面具有更好的作用。
文摘Objective To observe the serum level of non-high density lipoprotein cholesterol(non-HDLC),and to evaluate the relationship between non-HDLC and atherosclerosis in Hangzhou occupational population.Methods 11668 people(7369 males,4299 females) who took physical examination in our hospital during 2006.1-2007.6 were detected the fast serum levels of total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C) and low density lipoprotein cholesterol(LDL-C) according to standard operating procedure.And then non-HDLC and atherogenic index of plasma(AIP) were calculated according to the formulae non-HDL-C =TC-HD-C and AIP=log(TG/HDL-C).Statistical analysis was performed to evaluate the correlation between non-HDLC and atherosclerosis.Results There was a significant difference of LDL-C between by direct assay and by Friedewald formula calculation(P<0.001).When TG<4.5mmol/L and TG without grouping,LDL-C calculated by Friedewald formula was higher than that by direct assay.When TG≧4.5mmol/L,LDL-C calculated by Friedewald formula was obviously lower than that by direct assay.Non-HDLC was more closely related to AIP than LDLC as comparing TC and TG on different levels.Conclusions Non-HDLC was more closely related to AIP,and it could be used to judge the chanciness of atherosclerosis.Therefore,we suggest that the value of non-HDLC and AIP should be combined on analyzing routine blood fat to elevate the accuracy of artherosclerosis evaluation and non-HDLC as the second target in blood fat treatment.
文摘近年来,心血管疾病(cardiovascular diseases,CVD)的发病率及死亡率逐年升高,发病年龄趋于提前,因此心血管疾病防治的研究备受关注.研究表明,血清低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)可以导致CVD的发生和发展,使用降脂类药物调节血清LDL-C的水平,即使降至1.8mmol/L以下,CVD的发生率仍然较高[1].这种心血管疾病剩余风险存在的原因之一可能与血清低水平的HDL-C有关.他汀类药物IVUS试验的前瞻性随机试验的荟萃分析表明[2],血清低水平的HDL-C是动脉粥样硬化性疾病的独立危险因素.然而,最近对血清HDL-C水平和动脉粥样硬化性心血管疾病的这种负相关关系提出了异议.近年来,血清HDL-C对心血管疾病的防治作用及机制已成为研究的热点,综述如下.