包头地区孕妇碘营养状况分析及其对新生儿足跟血促甲状腺激素水平的影响分析

目的探究包头地区孕妇碘营养状况分析及其对新生儿足跟血促甲状腺激素水平的影响。方法采用随机分层按比例抽样的方法,于2017年1月—2018年1月选取包头市城市和农村共260名孕妇进行尿碘测定,并追踪测定其分娩的新生儿足跟血促甲状腺激素值。结果3组孕妇尿碘在<150μg/L、150～300μg/L、>300μg/L占比分别为53.86%、30.71%、15.43%,差异无统计学意义(P>0.05),不同尿碘指标(<150μg/L、150～300μg/L、>300μg/L)的孕妇所生新生儿在血促甲状腺激素水平分别为(2.15±0.23)、(2.13±0.25)、(1.91±0.19)μIU/mL,差异有统计学意义(P<0.05),在新生儿血促甲状腺激素水平>5 mU/L的比例占比上,虽不同尿碘指标的孕妇所生新生儿之间差异无统计学意义(P>0.05),但<150μg/L的孕妇所产的新生儿有部分高于3%。结论包头地区孕妇碘缺乏现象较为普遍,临床应针对性给予相关措施,扩大宣教力度,将尿碘检测纳入孕期常规检测,根据检验情况适量补充,以提升人口素质,减少新生儿智力发育异常等问题。

二甲双胍对2型糖尿病合并原发性亚临床甲状腺功能减退患者血促甲状腺激素水平的影响

目的探讨针对患有2型糖尿病合并原发性亚临床甲状腺功能减退的患者采用二甲双胍进行治疗后,对患者血清促甲状腺激素水平的影响结果分析。方法选取该院在2013年4月—2014年5月收治的患有2型糖尿病合并原发性亚临床甲状腺功能异常的患者80例作为研究对象,将甲状腺功能减退的患者32例作为观察组,将甲状腺功能亢进的患者48例作为对照组,对这两组患者均采用二甲双胍的方式进行治疗,比较这两组患者血清促甲状腺激素水平的变化。结果在经过治疗之后,这两组患者的血糖值水平均发生了明显的下降,差异有统计学意义(P<0.05);两组患者在治疗前后总三碘甲状腺原氨酸水平以及总甲状腺素水平均发生了显著的变化,差异有统计学意义(P<0.05);同时在治疗过后,对照组中患者的甲状腺素水平发生了明显的降低,差异有统计学意义(P<0.05)。结论针对患有2型糖尿病合并原发性亚临床甲状腺功能减退的患者采用二甲双胍进行治疗后,可以有效改善患者的血清促甲状腺激素的含量水平。

术前禁食对机体和肝脏代谢的影响

目的探讨术前短期和长期禁食状态对机体和肝脏代谢的影响。方法建立实验兔的短期禁食动物模型,比较饱食和禁食状态下,血激素水平、血生化指标和肝脏糖原含量的差异。进一步基于肝良性肿瘤患者和肝移植配型失败肝源的临床检查结果和肝糖原含量分析,比较术前短期和长期禁食对代谢的影响。结果在短期禁食动物模型中,过夜禁食后,兔血清中甲状腺素T4、皮质醇和多巴胺的水平增加约4倍,而肾上腺素水平降低约2.6倍,其余激素如胰高血糖素在禁食后略升高,而肾上腺素略有下降,血糖水平下降8.2倍,丙酮酸水平增加了15.6倍。而择期手术患者术后长期禁食比起术前短期禁食,血总胆固醇和总胆酸水平显著降低。兔肝和人肝样本均表现为禁食后肝糖原含量的显著下降。结论禁食是一种正常的生理状态,机体和肝脏的代谢改变源于体内和肝脏内大量代谢相关转录因子、酶表达水平和活性的改变。因此在临床工作和科研实践中应充分考虑并排除禁食对化验指标和基因表达的影响。

Androgen deficiency in elderly men with systolic chronic heart failure

Objective Several previous studies have shown androgens deficiency in men with CHF, and 2 studies on the prognostic significance of serum levels of androgens in CHF patients have yielded conflicting results. The aim of this study was to examine the relationship between serum concentration of testosterone and mortality in men with systolic CHE Methods A total of 175 elderly （age ≥ 60 years） men with CHF were recruited. Total testosterone fiT） and sex hormone binding globulin （SHBG） were measured, and free serum testosterone （eFT） was calculated. The median follow-up time was 1262 days. Results During follow-up 54 （30.9%） patients died. TT and eFF deficiency was found in 21.7% （38/175） and 27.4% （48/175） patients, respectively. Both TT and eFT were inversely associated with LVEF and NT-proBNP （all P〈0.01）. Kaplan-Meier curves for patients in low, medium and high tertiles according to TF and eFT level showed significantly different cumulative survival rate （both P〈0.01 by log-rank test）. However, after adjustment for clinical variables, there were no significant associations between either Tr or eFT levels or survival time （OR=0.97, 95% CI, 0.84-1.12, P--0.28; and OR=0.92, 95% CI, 0.82-1.06,/＇=0.14, respectively）. Conclusion Our study showed that although levels of TT and eFT are commonly decreased in elderly patients with systolic CHF and related to disease severity, they are not independent predictors for mortality

Second-trimester maternal β-human chorionic gonadotropin level associated with subsequent development of pregnancy-induced hypertension

Objective:To determine whether maternal β-human chorionic gonadotropin(β-hCG) level in second-trimester may be associated with subsequent development of pregnancy-induced hypertension(PIH).Methods:Seven hundred and sixty-two women in mid-trimester were to have maternal urine β-hCG standardized concentrations and maternal serum β-hCG measurements.Their case histories were recorded and reviewed from mid-trimester to delivery.The relation was observed between maternal urine,serum markers and subsequent development of PIH.Results:Among 762 women,504 cases were normal pregnancies,42 cases had PIH,94 cases had premature rupture of membrane (PROM),69 cases had preterm delivery (PD),53 other cases were excluded by various reasons.The levels of maternal urine,serum β-hCG in PIH were (61.75±9.78) IU/L and (304.56±54.17) ng/mg respectively,which were higher significantly than normal pregnancy group ([20.65±7.61] IU/L and [146.34±47.81] ng/mg,P<0.05).When maternal serum,urine β-hCG levels ≥2 MOM(multiple of mean),the incidences of developing PIH were increased significantly as compared with those of β-hCG <2 MOM women.The incidence of PIH increased from 5.1% in pregnancies with urine β-hCG ≥2 MOM to 11.7% in cases with urine β-hCG ≥4 MOM.Conclusion:The elevation of maternal mid-trimester urine,serum β-hCG levels is not only an early signal for dysfunction of placenta but also a dangerous signal for development of PIH.Second-trimester maternal urine β-hCG measurement proves to be superior to serum marker in clinical prediction.

经阴道超声引导介入治疗在终止瘢痕妊娠中的治疗效果分析

目的:分析经阴道超声引导介入治疗在终止瘢痕妊娠中的治疗效果。方法:选取2013年1月~2016年1月在我院进行诊治的104例瘢痕妊娠患者作为研究对象,采用随机抽签的方法分为研究组和对照组,每组52例。研究组采用经阴道超声引导介入治疗,对照组采用甲氨蝶呤肌内注射联合清宫术治疗。比较两组患者的整体疗效和血绒毛膜促性腺激素(β-HCG)恢复正常时间。结果:研究组的治疗有效率为96.15%,高于对照组的84.62%,差异有统计学意义,P<0.05;研究组的β-HCG恢复正常时间为(11.67±3.34)d,短于对照组的(19.72±4.72)d,差异有统计学意义,P<0.05。结论 :经阴道超声引导介入治疗在终止瘢痕妊娠中治疗效果显著,可快速恢复患者的β-HCG水平,并顺利终止妊娠。

Effects of heterotopic autotransplantation of cryopreserved-thawed ovarian tissues on sex hormone level

Objective: The aim of our study was to measure and compare the serum hormone level of transplant group with blank control and castrated control groups after heterotopic autotransplantation of cryopreserved-thawed ovarian tissues into back muscles. Methods: A total of 40 SPF-SD female rats(5–6 week-old) were randomly divided into three groups: blank control group(group A), castration control group(group B) and transplant group(group C). Ovaries were removed by surgical procedure, then after cryopreservation and thawing procedures the ovarian tissues were implanted into the back muscles of mice in group C. After 4 weeks of ovarian tissues transplantation, all rats blood sampling were measured for E2, LH and FSH hormone levels by ELISA. Results: E2 level was significantly higher in group C and group A than group B [(38.98 ± 5.66) pg/mL,(8.14 ± 3.24) pg/mL; P < 0.05) and [(36.30 ± 6.90) pg/mL,(8.14 ± 3.24) pg/mL; P < 0.05)]. However, E2 level in group C and group A had no significant difference. FSH level in group B, group A and group C was(18.87 ± 2.54) nmol/L,(7.77 ± 0.87) nmol/L and(9.39 ± 2.12) nmol/L respectively. FSH level increased significantly in group B compared with group A, and the difference had statistical significance(P < 0.05). FSH level was slightly increased in group C compared with group A, and the difference was not statistically significant(P > 0.05), but compared with group B, FSH level was significantly reduced and being statistically significant(P < 0.05). Conclusion: Autotransplantation of cryopreserved-thawed ovarian tissue into back muscles can sustain follicular development and re-establish endogenous hormone production by restoring the factors such as angiogenesis and innervations at the graft site.

A research on the relationship between ejaculation and serum testosterone level in men

The purpose of this study is to gain understanding of the relationshi p between ejaculation and serum testosterone level in men. The serum testosteron e concentrations of 28 volunteers were investigated daily during abstinence peri ods after ejaculation for two phases. The authors found that the fluctuations o f testosterone levels from the 2nd to 5th day of abstinence were minimal. On the 7th day of abstinence, however, a clear peak of serum testosterone appeared, re aching 145.7% of the baseline (P<0.01). No regular fluctuation was observed foll owing continuous abstinence after the peak. Ejaculation is the precondition and beginning of the special periodic serum testosterone level variations, which wou ld not occur without ejaculation. The results showed that ejaculation-caused va r iations were characterized by a peak on the 7th day of abstinence; and that the effective time of an ejaculation is 7 days minimum. These data are the first to document the phenomenon of the periodic change in serum testosterone level; the correlation between ejaculation and periodic change in the serum testosterone le vel, and the pattern and characteristics of the periodic change.