用血白细胞计数和血清C反应蛋白联合检测鉴别诊断小儿感染类型的效果分析

目的:探讨用血白细胞计数(WBC)和血清C反应蛋白(CRP)联合检测法鉴别诊断小儿感染类型的效果。方法:选取2018年9月至2020年9月期间山东省东平县中医院收治的61例细菌感染性疾病患儿和61例病毒感染性疾病患几作为研究对象。将其中的61例细菌感染性疾病患儿设为研究组,将其中的61例病毒感染性疾病患儿设为对照组。两纽患儿入院后,均对其进行血WBC检查和血清CRP检测。然后比较两组患儿的检测结果。结果:研究组患儿的血MBC、血清CRP的水平均高于对照纽患儿,P<0.05。对研究组患儿进行血WBC检查、血清CRP检测的阳性率均低于对其进行血WBC检查联合血清CRP检测的阳性率,P<0.05。对研究组患儿进行血WBC检查、血清CRP检测及血WBC检查联合血清CRP检测的阳性率均高于对对照组患儿进行血WBC检查、血清CRP检测及血WBC检查联合血清CRP检测的阳性率,P<0.05。结论:用血W6C和血清CRP联合检测法鉴别诊断小儿感染类型的效果较为理想。

血白细胞、血糖血脂等检查指标与结肠息肉良恶性的关联研究

探讨分析血白细胞、血糖血脂等检查指标和结肠息肉良恶性之间的关联性,将这一数据作为基础,对结肠息肉良恶性患者的个体状况进行判断。方法 选择2016年1月至2022年3月作为研究时段,在该时段内录入我院中收入的265名结肠息肉恶性患者,作为恶性组进行研究,同时录入2000名结肠息肉良性患者,作为良性组,本次研究选择对照实验,对两组研究对象的个体状况进行评估。对两组研究对象的血白细胞、血糖血脂等检查指标进行评估,分析两组数据之间的差异。结果 两组研究对象的血白细胞指标数据对比。恶性组的血白细胞计数、中性粒细胞计数和淋巴细胞计数均显著高于良性组和健康组,而健康组的指标值最低。,差异显著(P<0.05)。两组患者的血脂指标对比。恶性组的总胆固醇、甘油三酯、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇水平均显著高于良性组和健康组,而健康组的血脂水平最低,差异显著(P<0.05)。两组患者的血糖指标对比。恶性组的空腹血糖、2小时餐后血糖和糖化血红蛋白水平均显著高于良性组和健康组,而健康组的血糖水平最低,差异显著(P<0.05)。结论 本研究的结果,血白细胞、血脂和血糖等检查指标与结肠息肉的良恶性之间存在明显的关联。恶性组的血白细胞计数、中性粒细胞计数和淋巴细胞计数较高,血脂和血糖水平也显著升高,而良性组和健康组的指标值较低。这表明这些指标可以作为评估结肠息肉良恶性以及患者个体状况的重要指标,有助于指导临床诊断和治疗决策。进一步的研究可能需要扩大样本量和考虑其他相关因素,以更全面地了解血白细胞、血糖和血脂等指标在结肠息肉良恶性评估中的作用和价值。

Diagnostic role of serum interleukin-18 in gastric cancer patients

AIM： To determine the current status in various aspects of gastric cancer patients and to find out the clinical correlation with prognostic role of serum interleukins in Thai patients. METHODS： Sixty-eight patients were enrolled in this study at King Chulalongkorn Memorial Hospital during April 2003 to May 2005. Gastric cancer was histologically proven in 51 patients and gastric ulcer in 17 patients. Serum IL-6, IL-10, IL-12, and IL-18 levels were measured by enzyme-linked immunosorbent assay （ELISA）. RESULTS： There were 26 males （55.32%） and 21 females （44.68%） with their age ranging from 33 to 85 years （mean age 64.49 ± 13.83 years）. The common presentations were weight loss （41.2%）, dyspepsia （39.2%）, and upper gastrointestinal bleeding （15.7%）. A total of 35.3% gastric cancer patients and 6.3% of gastric ulcer patients were smokers （P = 0.029）. Moreover, 32.4% of gastric cancer patients and 6.3% of gastric ulcer patients were alcoholic drinkers （P = 0.044）. Lesion location was pyloric-antrum in 39.4%, gastric body in 39.4%, upper stomach in 12.2% and entire stomach in 6.1% of the patients. H pylori infection was detected in 44.4%. The poorly-differentiated adenocarcinoma was the most common pathologic finding （60.7%）. Surgical treatment was performed in 44.1% patients （total gastrectomy in 5.9%, subtotal gastrectomy in 32.4% and palliative bypass surgery in 5.9%）. Systemic chemotherapy was given as an adjuvant therapy in 8.8% patients. Carcinomatosis peritoneii were found in 18.8% patients. The mean survival time was 13.03 ± 9.75 mo. The IL-18 level in gastric cancer patient group （58.54 ± 43.96 pg/mL） was significantly higher than that in gastric ulcer patient group （30.84± 11.18 pg/mL） （P = 0.0001） （95% CI was 42.20, 13.19）. The cut point of IL-18 for diagnosis of gastric cancer was 40 pg/mL, the positive predictive value was 92.31%. The IL-6 level in gastric cancer patients with distant metastasis （20.21 ±9.37 pg/mL） was significantly higher than that in those with no metastasis （10.13 ± 7.83 pg/mL） （P = 0.037） （95% CI was 19.51, 0.65）. The role of IL-10 and IL-12 levels in gastric cancer patients was to provide data with no significant difference.CONCLUSION： These findings demonstrate that serum IL-6 and IL-18, but not IL-10 and IL-12 levels may be the useful biological markers of clinical correlation and prognostic factor in patients with gastric cancer. Moreover, IL-18 could serve as a diagnostic marker for gastric cancer with a high positive predictive value.