The myenteric plexus of ileum in 5 male or female wistar rats weighing 180-220g were studied by histochemical method for acetylcholinesterase (AChE)and nitric oxide synthase (NOS). We found that some neurons in myente...The myenteric plexus of ileum in 5 male or female wistar rats weighing 180-220g were studied by histochemical method for acetylcholinesterase (AChE)and nitric oxide synthase (NOS). We found that some neurons in myenteric plexus were located against the capillary or even closely contacted with the capillary. We refer them as pericapillary neurons The neurons were spindle, pear-like or polygonal in shape and all showed NOS positive reaction but AChE negative reaction. According to the close appositional relationship between the neurons and capillary, we infer that this peculiar type of neurons might be similar to the cerebrospinal fluid-contacting neurons in the central nervous system and might have the function of neurosecretion or reception of the changes of chemical composition in the blood.展开更多
Sensory or motor peripheral neuropathy may be observed in a significant proportion of hepatitis C virus (HCV)-infected patients.However,central nervous system (CNS) involvement is uncommon,especially in cryoglobulin-n...Sensory or motor peripheral neuropathy may be observed in a significant proportion of hepatitis C virus (HCV)-infected patients.However,central nervous system (CNS) involvement is uncommon,especially in cryoglobulin-negative subjects.We describe a case of peripheral neuropathy combined with an ischemic CNS event as primary manifestations of chronic HCV infection without cryoglobulinemia.Significant improvement was observed after antiviral therapy.We discuss the spectrum of neurological manifestations of HCV infection and review the literature.展开更多
Objective：To study the survival and ability of inducing axonal regeneration of the Schwann cells after the peripheral nerve being grafted into spinal cord. Methods：A total of 30 adult female Wistar rats were randoml...Objective：To study the survival and ability of inducing axonal regeneration of the Schwann cells after the peripheral nerve being grafted into spinal cord. Methods：A total of 30 adult female Wistar rats were randomly divided into the VN （vascularized peripheral nerve） and PN （peripheral nerve） groups. A 5-mm spinal cord defect of the left posterior column was made at the T1-3 vertebral level. The defect was grafted with the vascularized or isolated peripheral nerve respectively. The survival and proliferation of the Schwann cells were assessed by histological and morphometric analysis 8 weeks after the operation. Resuits：In the VN group, the peripheral nerve grew into the cord with lots of Schwann cells survived and proliferated, and had more NF and S-100 positive fibers than in the PN group. Conclusion：The vascularized peripheral nerve enhances the survival and proliferation of the Schwann cells and prompts the regener- ation of injured axon of the central nerve system to certain degree.展开更多
Perivascular space(PVS) is a crevice between two slices of cerebral pia maters,filled with tissue fluid,which be formed by pia mater emboling in the surrounding of cerebral perforating branch(excluding micrangium). No...Perivascular space(PVS) is a crevice between two slices of cerebral pia maters,filled with tissue fluid,which be formed by pia mater emboling in the surrounding of cerebral perforating branch(excluding micrangium). Normal PVS(diameter < 2 mm) can be found in almost all healthy adults; however enlarged PVS(diameter > 2 mm) has correlation with neurological disorders probably. The article reviews the formation mechanism,imageology characteristics and the relation with neurological disorders of PVS,which...展开更多
Objective：To evaluate the local effect of vascular endothelial growth factor （VEGF） on transected sciatic nerve regeneration.Methods：Sixty male white Wistar rats were divided into four experimental groups randomly...Objective：To evaluate the local effect of vascular endothelial growth factor （VEGF） on transected sciatic nerve regeneration.Methods：Sixty male white Wistar rats were divided into four experimental groups randomly （n=15）.In transected group the left sciatic nerve was transected and the stump was fixed to adjacent muscle.In treatment group the defect was bridged using a silicone graft filled with 10μL VEGF.In silicone group the graft was filled with phosphate-buffered saline.In sham-operated group the sciatic nerve was exposed and manipulated.Each group was subdivided into three subgroups with five animals in each and nerve fibers were studied 4,8 and 12 weeks after operation.Results：Behavioral test,functional study of sciatic nerve,gastrocnemius muscle mass and morphometric indices confirmed a faster recovery of regenerated axons in VEGF group than in silicone group （P〈0.05）.In immunohistochemical assessment,reactions to S-100 in VEGF group were more positive than that in silicone group.Conclusion：Local administration of VEGF will improve functional recovery and morphometric indices of sciatic nerve.展开更多
文摘The myenteric plexus of ileum in 5 male or female wistar rats weighing 180-220g were studied by histochemical method for acetylcholinesterase (AChE)and nitric oxide synthase (NOS). We found that some neurons in myenteric plexus were located against the capillary or even closely contacted with the capillary. We refer them as pericapillary neurons The neurons were spindle, pear-like or polygonal in shape and all showed NOS positive reaction but AChE negative reaction. According to the close appositional relationship between the neurons and capillary, we infer that this peculiar type of neurons might be similar to the cerebrospinal fluid-contacting neurons in the central nervous system and might have the function of neurosecretion or reception of the changes of chemical composition in the blood.
文摘Sensory or motor peripheral neuropathy may be observed in a significant proportion of hepatitis C virus (HCV)-infected patients.However,central nervous system (CNS) involvement is uncommon,especially in cryoglobulin-negative subjects.We describe a case of peripheral neuropathy combined with an ischemic CNS event as primary manifestations of chronic HCV infection without cryoglobulinemia.Significant improvement was observed after antiviral therapy.We discuss the spectrum of neurological manifestations of HCV infection and review the literature.
文摘Objective：To study the survival and ability of inducing axonal regeneration of the Schwann cells after the peripheral nerve being grafted into spinal cord. Methods：A total of 30 adult female Wistar rats were randomly divided into the VN （vascularized peripheral nerve） and PN （peripheral nerve） groups. A 5-mm spinal cord defect of the left posterior column was made at the T1-3 vertebral level. The defect was grafted with the vascularized or isolated peripheral nerve respectively. The survival and proliferation of the Schwann cells were assessed by histological and morphometric analysis 8 weeks after the operation. Resuits：In the VN group, the peripheral nerve grew into the cord with lots of Schwann cells survived and proliferated, and had more NF and S-100 positive fibers than in the PN group. Conclusion：The vascularized peripheral nerve enhances the survival and proliferation of the Schwann cells and prompts the regener- ation of injured axon of the central nerve system to certain degree.
文摘Perivascular space(PVS) is a crevice between two slices of cerebral pia maters,filled with tissue fluid,which be formed by pia mater emboling in the surrounding of cerebral perforating branch(excluding micrangium). Normal PVS(diameter < 2 mm) can be found in almost all healthy adults; however enlarged PVS(diameter > 2 mm) has correlation with neurological disorders probably. The article reviews the formation mechanism,imageology characteristics and the relation with neurological disorders of PVS,which...
文摘Objective：To evaluate the local effect of vascular endothelial growth factor （VEGF） on transected sciatic nerve regeneration.Methods：Sixty male white Wistar rats were divided into four experimental groups randomly （n=15）.In transected group the left sciatic nerve was transected and the stump was fixed to adjacent muscle.In treatment group the defect was bridged using a silicone graft filled with 10μL VEGF.In silicone group the graft was filled with phosphate-buffered saline.In sham-operated group the sciatic nerve was exposed and manipulated.Each group was subdivided into three subgroups with five animals in each and nerve fibers were studied 4,8 and 12 weeks after operation.Results：Behavioral test,functional study of sciatic nerve,gastrocnemius muscle mass and morphometric indices confirmed a faster recovery of regenerated axons in VEGF group than in silicone group （P〈0.05）.In immunohistochemical assessment,reactions to S-100 in VEGF group were more positive than that in silicone group.Conclusion：Local administration of VEGF will improve functional recovery and morphometric indices of sciatic nerve.
