血管内栓塞联合显微手术治疗中枢神经系统血管周细胞瘤

目的探讨中枢神经系统血管周细胞瘤（CNS-HPC）的治疗方法及临床效果。方法回顾性分析2010年1月至2013年10月收治的4例CNS-HPC患者的临床资料,4例患者术前均行全脑血管造影术确定肿瘤主要供血动脉,然后将肿瘤供血动脉栓塞,最后在显微镜下切除肿瘤。结果肿瘤全切除3例,次全切除1例。术中出血量为1 500-3 000 ml。4例患者术后均无明显并发症发生。术后2例患者行伽玛刀治疗,2例患者行外放射治疗。随访641个月均未见肿瘤复发和转移。结论对于巨大的、供血极其丰富的CNS-HPC术前行供血动脉栓塞可以明显减少术中出血,提高肿瘤全切率。全切除肿瘤并辅以放疗是CNS-HPC的主要治疗方案,术后随访观察肿瘤复发及转移非常必要。

小腿穴位区细胞外钙离子对血管的作用

探讨细胞外 Ca2 +对穴位区血管的作用 ,为进一步研究穴位的物质基础及穴位钙的作用提供资料。方法 :用不同浓度的钙离子溶液在体局部孵育大鼠胫前动脉 ,光镜下观测免疫组化染色的血管周降钙素基因相关肽、神经肽Y阳性神经纤维的密度改变。结果 :当细胞外 Ca2 +浓度为生理浓度的 10倍时 ,胫前动脉周降钙素基因相关肽、神经肽 Y阳性神经纤维的密度均有所下降 ,以降钙素基因相关肽阳性神经纤维表现最为显著。结论 :适度细胞外高钙可促进血管周神经释放降钙素基因相关肽等神经活性物质 。

大鼠回肠肌间神经丛的一种特殊类型神经元——初步酶组织化学观察

The myenteric plexus of ileum in 5 male or female wistar rats weighing 180-220g were studied by histochemical method for acetylcholinesterase (AChE)and nitric oxide synthase (NOS). We found that some neurons in myenteric plexus were located against the capillary or even closely contacted with the capillary. We refer them as pericapillary neurons The neurons were spindle, pear-like or polygonal in shape and all showed NOS positive reaction but AChE negative reaction. According to the close appositional relationship between the neurons and capillary, we infer that this peculiar type of neurons might be similar to the cerebrospinal fluid-contacting neurons in the central nervous system and might have the function of neurosecretion or reception of the changes of chemical composition in the blood.