Isoflavonoids possess broad activities besides cardiovascular activity.3 phenyl 4(1H)quinolinone derivatives are isosteres of isoflavonoids.They have similar spatial structures.Eight 3 phenyl 4(1H)quinolinone halide d...Isoflavonoids possess broad activities besides cardiovascular activity.3 phenyl 4(1H)quinolinone derivatives are isosteres of isoflavonoids.They have similar spatial structures.Eight 3 phenyl 4(1H)quinolinone halide derivatives were synthesised for studying their biological activities especially cardiovascular activity.Their chemical structures were confirmed by 1 H NMR,MS and IR.The preliminary tests with isolated heart of rabbits indicated that both mixtures,A 1B 1,A 2B 2,had more positive inotropic effect than vesnarinone which appeared on the market in Japanese.The results of the pharmacological tests showed that the two mixtures did not affect the blood pressure and respiration of the dogs.展开更多
目的探讨血管活性-正性肌力药物评分(vasoactive inotropic score,VIS)对新生儿持续肺动脉高压(persistent pulmonary hypertension of the newborn,PPHN)患儿死亡的早期预测价值。方法回顾性分析2017年7月至2020年11月入住南京医科大...目的探讨血管活性-正性肌力药物评分(vasoactive inotropic score,VIS)对新生儿持续肺动脉高压(persistent pulmonary hypertension of the newborn,PPHN)患儿死亡的早期预测价值。方法回顾性分析2017年7月至2020年11月入住南京医科大学附属儿童医院新生儿医疗中心的PPHN患儿(胎龄≥34周、入院日龄<7 d),根据预后分为存活组和死亡组。收集两组患儿的一般资料、死亡相关影响因素及入院12 h内各时间段的VIS值等。比较两组患儿相关指标的差异,采用Logistic回归校正混杂因素得出VIS与患儿死亡的独立关联程度,采用受试者工作特征曲线计算VIS对PPHN患儿死亡的预测价值。结果共纳入105例PPHN患儿,其中存活组75例,死亡组30例,病死率28.6%(30/105)。死亡组胎龄大于存活组[(39.1±1.8)周比(37.9±2.0)周],1 min Apgar评分低于存活组[8.0(6.0,9.3)分比9.0(8.0,10.0)分],入院12 h内最低PaO2/FiO2低于存活组[40(30,50)比80(60,100)]。在校正了胎龄、1 min Apgar评分、入院12 h内最低PaO2/FiO2后,入院12 h内VIS最大值>27.8与患儿死亡独立相关(OR=23.055,95%CI 4.885~108.800,P<0.001)。受试者工作特征曲线分析提示,入院12 h内VIS最大值预测患儿死亡的截断值为27.8,对应的敏感度、特异度分别为70.0%、90.7%,曲线下面积0.828,约登指数0.607。结论VIS可以作为PPHN患儿死亡的早期预测指标,入院12 h内VIS最大值>27.8的PPHN患儿为死亡高危儿,需引起重视。展开更多
文摘Isoflavonoids possess broad activities besides cardiovascular activity.3 phenyl 4(1H)quinolinone derivatives are isosteres of isoflavonoids.They have similar spatial structures.Eight 3 phenyl 4(1H)quinolinone halide derivatives were synthesised for studying their biological activities especially cardiovascular activity.Their chemical structures were confirmed by 1 H NMR,MS and IR.The preliminary tests with isolated heart of rabbits indicated that both mixtures,A 1B 1,A 2B 2,had more positive inotropic effect than vesnarinone which appeared on the market in Japanese.The results of the pharmacological tests showed that the two mixtures did not affect the blood pressure and respiration of the dogs.
文摘目的探讨血管活性-正性肌力药物评分(vasoactive inotropic score,VIS)对新生儿持续肺动脉高压(persistent pulmonary hypertension of the newborn,PPHN)患儿死亡的早期预测价值。方法回顾性分析2017年7月至2020年11月入住南京医科大学附属儿童医院新生儿医疗中心的PPHN患儿(胎龄≥34周、入院日龄<7 d),根据预后分为存活组和死亡组。收集两组患儿的一般资料、死亡相关影响因素及入院12 h内各时间段的VIS值等。比较两组患儿相关指标的差异,采用Logistic回归校正混杂因素得出VIS与患儿死亡的独立关联程度,采用受试者工作特征曲线计算VIS对PPHN患儿死亡的预测价值。结果共纳入105例PPHN患儿,其中存活组75例,死亡组30例,病死率28.6%(30/105)。死亡组胎龄大于存活组[(39.1±1.8)周比(37.9±2.0)周],1 min Apgar评分低于存活组[8.0(6.0,9.3)分比9.0(8.0,10.0)分],入院12 h内最低PaO2/FiO2低于存活组[40(30,50)比80(60,100)]。在校正了胎龄、1 min Apgar评分、入院12 h内最低PaO2/FiO2后,入院12 h内VIS最大值>27.8与患儿死亡独立相关(OR=23.055,95%CI 4.885~108.800,P<0.001)。受试者工作特征曲线分析提示,入院12 h内VIS最大值预测患儿死亡的截断值为27.8,对应的敏感度、特异度分别为70.0%、90.7%,曲线下面积0.828,约登指数0.607。结论VIS可以作为PPHN患儿死亡的早期预测指标,入院12 h内VIS最大值>27.8的PPHN患儿为死亡高危儿,需引起重视。
