目的探讨高血压患者晨峰睡-谷值与血管紧张素Ⅱ(AngⅡ)、醛固酮(ALD)、生长激素(GH)、皮质醇(COR)之间的相关性。方法 306例高血压患者,依据晨峰变异>10 mm Hg(1 mm Hg=0.133 kPa)规定分为非晨峰组(214例)与晨峰组(92例),检测患者血...目的探讨高血压患者晨峰睡-谷值与血管紧张素Ⅱ(AngⅡ)、醛固酮(ALD)、生长激素(GH)、皮质醇(COR)之间的相关性。方法 306例高血压患者,依据晨峰变异>10 mm Hg(1 mm Hg=0.133 kPa)规定分为非晨峰组(214例)与晨峰组(92例),检测患者血液中的AngⅡ、ALD、GH、COR水平,分析高血压患者晨峰睡-谷值与血液中AngⅡ、ALD、GH、COR之间的关系。结果晨峰组患者AngⅡ(162.8±82.3)ng/(ml·h)、ALD(210.4±40.0)ρ/(pg·ml)、GH(3.8±1.9)ρ/(pg·ml)、COR(18.7±5.3)ρ/(ng·ml)显著高于非晨峰组的(137.8±73.9)ng/(ml·h)、(140.1±47.1)ρ/(pg·ml)、(1.4±0.7)ρ/(pg·ml)、(14.2±4.2)ρ/(ng·ml),两组数据比较差异有统计学意义(t=2.62、12.51、16.13、7.92,P<0.05)。晨峰组晨峰睡-谷值与AngⅡ、ALD、GH、COR呈正相关(r=0.43、0.27、0.46、0.33,P=<0.01或0.05)。结论高血压患者在晨间的血压升高与AngⅡ、ALD、GH、COR有着密切的关系。展开更多
The mechanisms of regulation, activation and signal transduction of the angiotensin II (Ang II) type 1 (AT1) receptor have been studied extensively in the decade after its cloning. The AT1 receptor is a major componen...The mechanisms of regulation, activation and signal transduction of the angiotensin II (Ang II) type 1 (AT1) receptor have been studied extensively in the decade after its cloning. The AT1 receptor is a major component of the renin-angiotensin system (RAS). It mediates the classical biological actions of Ang II. Among the structures required for regulation and activation of the receptor, its carboxyl- terminal region plays crucial roles in receptor internalization, desensitization and phosphorylation. The mechanisms involved in heterotrimeric G-protein coupling to the receptor, activation of the downstream signaling pathway by G proteins and the Ang II signal transduction pathways leading to specific cellular responses are discussed. In addition, recent work on the identification and characterization of novel proteins associated with carboxy1-terminus of the AT1 receptor is presented. These novel proteins will advance our understanding of how the receptor is internalized and recycled as they provide molecular mechanisms for the activation and regulation of G-protein-coupled receptors.展开更多
文摘目的探讨高血压患者晨峰睡-谷值与血管紧张素Ⅱ(AngⅡ)、醛固酮(ALD)、生长激素(GH)、皮质醇(COR)之间的相关性。方法 306例高血压患者,依据晨峰变异>10 mm Hg(1 mm Hg=0.133 kPa)规定分为非晨峰组(214例)与晨峰组(92例),检测患者血液中的AngⅡ、ALD、GH、COR水平,分析高血压患者晨峰睡-谷值与血液中AngⅡ、ALD、GH、COR之间的关系。结果晨峰组患者AngⅡ(162.8±82.3)ng/(ml·h)、ALD(210.4±40.0)ρ/(pg·ml)、GH(3.8±1.9)ρ/(pg·ml)、COR(18.7±5.3)ρ/(ng·ml)显著高于非晨峰组的(137.8±73.9)ng/(ml·h)、(140.1±47.1)ρ/(pg·ml)、(1.4±0.7)ρ/(pg·ml)、(14.2±4.2)ρ/(ng·ml),两组数据比较差异有统计学意义(t=2.62、12.51、16.13、7.92,P<0.05)。晨峰组晨峰睡-谷值与AngⅡ、ALD、GH、COR呈正相关(r=0.43、0.27、0.46、0.33,P=<0.01或0.05)。结论高血压患者在晨间的血压升高与AngⅡ、ALD、GH、COR有着密切的关系。
文摘The mechanisms of regulation, activation and signal transduction of the angiotensin II (Ang II) type 1 (AT1) receptor have been studied extensively in the decade after its cloning. The AT1 receptor is a major component of the renin-angiotensin system (RAS). It mediates the classical biological actions of Ang II. Among the structures required for regulation and activation of the receptor, its carboxyl- terminal region plays crucial roles in receptor internalization, desensitization and phosphorylation. The mechanisms involved in heterotrimeric G-protein coupling to the receptor, activation of the downstream signaling pathway by G proteins and the Ang II signal transduction pathways leading to specific cellular responses are discussed. In addition, recent work on the identification and characterization of novel proteins associated with carboxy1-terminus of the AT1 receptor is presented. These novel proteins will advance our understanding of how the receptor is internalized and recycled as they provide molecular mechanisms for the activation and regulation of G-protein-coupled receptors.
