目的:使用定量超声骨密度仪诊断骨远端骨折患者的骨密度值,并观察血糖、血脂水平对其发生骨质疏松的影响。方法:选取2014年6月—2017年6月期间我院收治的50例桡骨远端骨折患者按有/无骨质疏松分为观察组(n=25)与对照组(n=25),两组患者...目的:使用定量超声骨密度仪诊断骨远端骨折患者的骨密度值,并观察血糖、血脂水平对其发生骨质疏松的影响。方法:选取2014年6月—2017年6月期间我院收治的50例桡骨远端骨折患者按有/无骨质疏松分为观察组(n=25)与对照组(n=25),两组患者均检测空腹血糖(FBG)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平,同时用定量超声骨密度仪测定桡骨远端骨密度(BMD)。并以FBG、TC、TG水平对桡骨远端骨折患者骨质疏松的诊断绘制R O C曲线。结果:观察组FBG、TC、TG水平均显著高于对照组(P均<0.01),而BMD值显著低于对照组(P<0.05);两组患者LDL-C、HDL-C水平比较无显著差异(P=0.615、0.718);直线相关分析发现,观察组患者FBG、TC、TG水平与其BMD值均呈负相关(r=-0.985、-0.943、-0.941,P均<0.01)。ROC曲线分析:FBG、TC、TG水平与桡骨远端骨折患者BMD值关系密切。结论:血糖血脂异常是桡骨远端骨折患者骨质疏松发生的危险因素。FBG、TC、TG水平是监测桡骨远端骨折患者骨质疏松的预先指标。展开更多
Objective： Decompensated chronic hyperglycemia often leads to late microvascular complications such as retinopathy, diabetic foot syndrome, and diabetic kidney disease. The aim of this study was to determine the conc...Objective： Decompensated chronic hyperglycemia often leads to late microvascular complications such as retinopathy, diabetic foot syndrome, and diabetic kidney disease. The aim of this study was to determine the concentration of vascular endothelial growth factor A （VEGF-A） and its receptors in patients with well-controlled diabetes. Methods： The study was conducted on 31 patients with well-controlled type 2 diabetes without microor macroangiopathy. Thirty healthy volunteers were enrolled in a control group. Serum concentrations of VEGF-A, VEGF receptors 1 and 2 （VEGFR1 and VEGFR2）, fasting glucose, and lipid profiles were measured, and the plasma concentration of glycated hemoglobin （HbAlc） was determined. Results： No significant differences were observed between the concentration of VEGF-A, VEGFR1 or VEGFR2 in the subject group and that in the control group. Positive correlations were noted between the levels of VEGF-A, VEGFR2, and triglyceride, and there was a negative correlation between the levels of VEGFR2 and high-density lipoprotein （HDL）-cholesterel in the study group. Conclusions： The concentrations of VEGF-A and its receptors 1 and 2 in patients with well-controlled diabetes are comparable to those of healthy individuals, which may indicate that appropriate control of glucose levels delays the occurrence of vascular complications. A negative correlation between VEGFR2 and HDL-cholesterol levels, and positive correlations between VEGF-A, VEGFR2, and triglyceride levels, suggest that lipid abnormalities occurring in diabetes may be involved in the modulation of angiogenesis.展开更多
文摘目的:使用定量超声骨密度仪诊断骨远端骨折患者的骨密度值,并观察血糖、血脂水平对其发生骨质疏松的影响。方法:选取2014年6月—2017年6月期间我院收治的50例桡骨远端骨折患者按有/无骨质疏松分为观察组(n=25)与对照组(n=25),两组患者均检测空腹血糖(FBG)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平,同时用定量超声骨密度仪测定桡骨远端骨密度(BMD)。并以FBG、TC、TG水平对桡骨远端骨折患者骨质疏松的诊断绘制R O C曲线。结果:观察组FBG、TC、TG水平均显著高于对照组(P均<0.01),而BMD值显著低于对照组(P<0.05);两组患者LDL-C、HDL-C水平比较无显著差异(P=0.615、0.718);直线相关分析发现,观察组患者FBG、TC、TG水平与其BMD值均呈负相关(r=-0.985、-0.943、-0.941,P均<0.01)。ROC曲线分析:FBG、TC、TG水平与桡骨远端骨折患者BMD值关系密切。结论:血糖血脂异常是桡骨远端骨折患者骨质疏松发生的危险因素。FBG、TC、TG水平是监测桡骨远端骨折患者骨质疏松的预先指标。
基金Project supported by the Collegium Medicum in Bydgoszcz,Nicolaus Copernicus University in Toruń,Poland
文摘Objective： Decompensated chronic hyperglycemia often leads to late microvascular complications such as retinopathy, diabetic foot syndrome, and diabetic kidney disease. The aim of this study was to determine the concentration of vascular endothelial growth factor A （VEGF-A） and its receptors in patients with well-controlled diabetes. Methods： The study was conducted on 31 patients with well-controlled type 2 diabetes without microor macroangiopathy. Thirty healthy volunteers were enrolled in a control group. Serum concentrations of VEGF-A, VEGF receptors 1 and 2 （VEGFR1 and VEGFR2）, fasting glucose, and lipid profiles were measured, and the plasma concentration of glycated hemoglobin （HbAlc） was determined. Results： No significant differences were observed between the concentration of VEGF-A, VEGFR1 or VEGFR2 in the subject group and that in the control group. Positive correlations were noted between the levels of VEGF-A, VEGFR2, and triglyceride, and there was a negative correlation between the levels of VEGFR2 and high-density lipoprotein （HDL）-cholesterel in the study group. Conclusions： The concentrations of VEGF-A and its receptors 1 and 2 in patients with well-controlled diabetes are comparable to those of healthy individuals, which may indicate that appropriate control of glucose levels delays the occurrence of vascular complications. A negative correlation between VEGFR2 and HDL-cholesterol levels, and positive correlations between VEGF-A, VEGFR2, and triglyceride levels, suggest that lipid abnormalities occurring in diabetes may be involved in the modulation of angiogenesis.
