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Hb/SCr比值联合血尿酸对急性心肌梗死急诊PCI术后患者院内死亡的预测价值 被引量:1
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作者 鲍凤香 杨成俊 周国辉 《中华危重病急救医学》 CAS CSCD 北大核心 2023年第9期951-957,共7页
目的探讨血红蛋白与血肌酐比值(Hb/SCr)联合血尿酸(SUA)对急性心肌梗死(AMI)患者急诊经皮冠脉介入治疗(PCI)术后院内死亡的临床预测价值.方法回顾性分析2017年1月至2021年12月于南京医科大学康达学院第一附属医院急诊行PCI治疗的AMI患... 目的探讨血红蛋白与血肌酐比值(Hb/SCr)联合血尿酸(SUA)对急性心肌梗死(AMI)患者急诊经皮冠脉介入治疗(PCI)术后院内死亡的临床预测价值.方法回顾性分析2017年1月至2021年12月于南京医科大学康达学院第一附属医院急诊行PCI治疗的AMI患者的临床资料.收集患者一般资料、基础病史、血常规、肝肾功能、血凝常规、SUA等指标.主要复合终点定义为院内死亡,包括PCI期间及术后住院15d内院内全因死亡.单因素分析AMI患者急诊PCI术后院内死亡相关因素,多变量Logistic回归分析独立相关因素及构建风险预测模型,采用Hosmer-Lemeshow法和受试者工作特征曲线(ROC曲线)分别检验模型及相关因素的拟合优度、预测效果.结果最终纳入1976例患者,院内死亡92例,存活1884例.死亡组SUA高于存活组(μmol/L:476.88±132.04比354.87±105.31,P<0.01),Hb/SCr比值明显低于存活组(13.84±5.48比19.20±5.74,P<0.01).Pearson相关性分析显示,SUA与Hb/SCr比值呈直线负相关(r=-0.502,P<0.01).Logistic回归风险模型分析最终纳入年龄[优势比(OR)=0.916]、Hb/SCr比值(OR=0.182)、白细胞计数(WBC,OR=2.733)、C-反应蛋白(CRP,OR=3.611)、SUA(OR=4.667)、血糖(Glu,OR=2.726)、同型半胱氨酸(Hcy,OR=2.688)7个因素构建风险预测模型,为AMI患者急诊PCI术后发生院内死亡的独立相关因素(均P<0.05).Hosmer-Lemeshow检验模型拟合效果,结果显示P=0.447,该模型预测AMI患者急诊PCI术后发生院内死亡的ROC曲线下面积(AUC)为0.764[95%可信区间(95%CI)为0.712~0.816,P=0.001],当截断值为0.5658时,敏感度为70.7%,特异度为70.2%,约登指数为0.410.用Hb/SCr比值+SUA、SUA、Hb/SCr比值、Hb、SCr预测AMI患者急诊PCI术后发生院内死亡时,Hb/SCr比值+SUA的AUC最大,为0.810;最佳截断值为-0.847时,敏感度为77.7%,特异度为74.5%,约登指数为0.522.结论年龄、SUA、Hb/SCr比值、WBC、CRP、Glu、Hcy为AMI患者急诊PCI术后院内死亡的独立相关因素;入院时Hb/SCr比值越低、SUA越高,AMI患者急诊PCI术后院内死亡风险越高;Hb/SCr比值联合SUA较单一指标对AMI患者急诊PCI术后院内死亡的预测价值更高,有助于早期识别高危患者. 展开更多
关键词 血红蛋白/血肌酐比值 尿酸 急性心肌梗死 经皮冠脉介入治疗 院内死亡 预后
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Molecular Evolutionary Rate Calculation of Hemoglobin α Chain and γ Chain at Different Stages in Vertebrate Evolution Process
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作者 龙承星 张波 马绍宾 《Agricultural Science & Technology》 CAS 2010年第9期101-104,220,共5页
Pseudogene and fibrin peptide which has rapid evolve speed and good stability are used in this study to determine the divergence date among groups.Through calculating the evolutionary rate of hemoglobin α chain,γ ch... Pseudogene and fibrin peptide which has rapid evolve speed and good stability are used in this study to determine the divergence date among groups.Through calculating the evolutionary rate of hemoglobin α chain,γ chain in vertebrate(including birds and mammals),it is concluded that the evolutionary rate of hemoglobin α chain,γ chain is not invariable.It shows different evolutionary rates in different periods,that is,faster in early evolution stage and relatively slow in later stage. 展开更多
关键词 Molecular clock Evolutionary rate HEMOGLOBIN VERTEBRATE Fibrin peptide
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RELATIONSHIP BETWEEN HEMOGLOBIN A1C AND BLOOD GLUCOSE THROUGHOUT THE DAY IN WELL-GLYCEMIC-CONTROLLED MEDICAL NUTRITION THERAPY ALONE TYPE 2 DIABETIC PATIENTS 被引量:6
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作者 Wen-hui Li Xin-hua Xiao Qi Sun Guo-hua Yang Heng Wang 《Chinese Medical Sciences Journal》 CAS CSCD 2006年第2期90-94,共5页
Objective To investigate the relationship between glycosylated hemoglobin A1 c (HbA1 c) and blood glucose levels of eight different points throughout the day in well-glycemic-controlled medical nutrition therapy (... Objective To investigate the relationship between glycosylated hemoglobin A1 c (HbA1 c) and blood glucose levels of eight different points throughout the day in well-glycemic-controlled medical nutrition therapy (MNT) alone type 2 diabetic pafients. Methods Data were collected as" capillary blood glucose value of eight different sample points among sixteen observing days in thirty MNT alone type 2 diabetic patients. The correlation between HbAI c and capillary blood glucose value was evaluated by Pearson's correlation method. Results The r-values between HbA1c and capillary blood glucose of 3:00, 6:00, and bedtime (22:00-23:00) were 0. 81,0. 79, and 0. 78, respectively(P 〈0. 001 ). The best correlation was found between the mean value of 8- point blood glucose value throughout the day and HbA1c ( r=0. 84, P 〈0. 001 ). Conclustion Fasting blood glucose and postabsorptive blood glucose have better correlations with HbAlc compared with other points in this group of well-glycemic-controlled MNT alone type 2 diabetic patients. 展开更多
关键词 type 2 diabetes medical nutrition therapy hemoglobin Alc blood glucose
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Several factors including ITPA polymorphism influence ribavirin-induced anemia in chronic hepatitis C 被引量:1
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作者 Akihito Tsubota Noritomo Shimada +10 位作者 Hiroshi Abe Kai Yoshizawa Rie Agata Yoko Yumoto Makiko Ika Yoshihisa Namiki Keisuke Nagatsuma Hiroshi Matsudaira Kiyotaka Fujise Norio Tada Yoshio Aizawa 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第41期5879-5888,共10页
AIM: To construct formulae for predicting the likelihood of ribavirin-induced anemia in pegylated interferon plus ribavirin for chronic hepatitis C. METHODS: Five hundred and sixty-one Japanese patients with hepatit... AIM: To construct formulae for predicting the likelihood of ribavirin-induced anemia in pegylated interferon plus ribavirin for chronic hepatitis C. METHODS: Five hundred and sixty-one Japanese patients with hepatitis C virus genotype lb who had received combination treatment were enrolled and as- signed randomly to the derivation and confirmatory groups. Single nucleotide polymorphisms at or nearby ITPA were genotyped by real-time detection poly- merase chain reaction. Factors influencing significant anemia (hemoglobin concentration 〈 10.0 g/dL at week 4 of treatment) and significant hemoglobin decline (declining concentrations 〉 3.0 g/dL at week 4) were analyzed using multiple regression analyses. Prediction formulae were constructed by significantly independent factors. RESULTS: Multivariate analysis for the derivation group identified four independent factors associated with significant hemoglobin decline: hemoglobin decline at week 2 [P = 3.29× 10^4, odds ratio (OR) = 7.54 (g/dL)], estimated glomerular filtration rate [P = 2.16× 10^4, OR = 0.962 (ml/min/1.73 m2)], rs1127354 (P = 5.75 × 10^4, OR = 10.94) and baseline hemoglobin [P = 7.86 × 10^4, OR = 1.50 (g/alL)]. Using the model constructed by these factors, positive and negative predictive values and predictive accuracy were 79.8%, 88.8% and 86.2%, respectively. For the confirmatory group, they were 83.3%, 91.0% and 88.3%. These factors were closely correlated with significant anemia. However, the model could not be constructed, because no patients with rs1127354 minor genotype CA/AA had significant anemia. CONCLUSION: Reliable formulae for predicting the likelihood of ribavirin-induced anemia were constructed. Such modeling may be useful in developing individual tailoring and optimization of ribavirin dosage. 展开更多
关键词 Chronic hepatitis C virus infection Ribavi-rin Pegylated interferon Prediction model Hemolyticanemia Single nucleotide polymorphism
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Cross-reactivity of anti-H pylori antibodies with membrane antigens of human erythrocytes
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作者 Feng-Hua Guo Xiao-Mei Yan Chun-Xiang Fan Fei Zhao Yuan Hu Di Xiao Xun Zeng Mao-Jun Zhang Li-Hua He Fan-Ling Meng Jian-Zhong Zhang 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第27期3742-3746,共5页
AIM: To investigate whether anti-H pylori antibodies have cross-reaction with antigens of erythrocyte membrane. METHODS: Blood samples were collected from 14 volunteers (8 positive and 6 negative for Hpylori detect... AIM: To investigate whether anti-H pylori antibodies have cross-reaction with antigens of erythrocyte membrane. METHODS: Blood samples were collected from 14 volunteers (8 positive and 6 negative for Hpylori detected by ^13C-urea breath test) of the general population. Erythrocyte membrane proteins of the subjects were examined by Western blot using anti-H pylori serum. The proteins related to the positive bands were identified by mass spectrum analysis. RESULTS: Anti-Hpylori antibodies had cross-reaction with the proteins of about 50 kDa of erythrocyte membranes in all samples independent of H pylori infection. One protein in the positive band was identified as Chain S, the crystal structure of the cytoplasmic domain of human erythrocyte Band-3 protein. CONCLUSION: Anti-HpyloH antibodies cross-react with some antigens of human erythrocyte membrane, which may provide a clue for the relationship between Hpylori infection and vascular disorders. 展开更多
关键词 H pylori ANTIBODIES ERYTHROCYTE Crossreactivity
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Effect of hypoxia on the blood of large yellow croaker (Pseudosciaena crocea)
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作者 顾孝连 徐兆礼 《Chinese Journal of Oceanology and Limnology》 SCIE CAS CSCD 2011年第3期524-530,共7页
Large areas of hypoxic water have recently been reported in the East China Sea. It is hypothesized that hypoxia may be partially responsible for the decline of some fish stocks. We evaluated the effect of hypoxia on l... Large areas of hypoxic water have recently been reported in the East China Sea. It is hypothesized that hypoxia may be partially responsible for the decline of some fish stocks. We evaluated the effect of hypoxia on large yellow croaker (Pseudosciaena crocea). The fish were exposed to three concentrations of dissolved oxygen (DO; 1.5 mg/L and 2.0 mg/L, and 6.5 mg/L control). We collected blood after 6, 12, 24, 48, and 96 h exposure. There was a significant increase in red blood count, hematocrit, hemoglobin concentration, and mean corpuscular hemoglobin in the group exposed to 1.5 mg/L DO after 6 h or 12 h, and a delayed increase (only elevated after 48 h and 96 h) in these indices in the group exposed to 2.0 mg/L DO. Plasma glucose concentrations increased significantly in both hypoxic groups after 24 h. Furthermore, plasma lactate and lactate dehydrogenase activity increased significantly after the first 6 h exposure in both hypoxic groups. Our results suggest that large yellow croakers could not maintain the aerobic pathway and instead use anaerobic metabolism for survival when DO levels fall below 2.0 mg/L. We conclude that the occurrence of hypoxia (<2 mg/L DO) in the East China Sea could cause metabolic stress for large yellow croakers and may be partially responsible for the population decline of this species. 展开更多
关键词 Pseudosciaena crocea HEMATOLOGY GLUCOSE LACTATE lactate dehydrogenase
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Cardiovascular effects of hemoglobin response in patients receiving epoetin alfa and oral iron in heart failure with a preserved ejection fraction
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作者 Sirish Vullaganti Jeff Goldsmith +3 位作者 Sergio Teruya Julissa Alvarez Stephen Helmke Mathew S. Maurer 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2014年第2期100-105,共6页
Background Previous data from a recently conducted prospective, single blind randomized clinical trial among community dwelling older patients with heart failure with a preserved ejection fraction (HFPEF) and anemia... Background Previous data from a recently conducted prospective, single blind randomized clinical trial among community dwelling older patients with heart failure with a preserved ejection fraction (HFPEF) and anemia randomized to treatment with epoetin alfa (erythro-poiesis-stimulating agents, ESA) vs. placebo did not demonstrate significant benefits of therapy regarding left ventricular (LV) structure, functional capacity, or quality of life (QOL). However, several patients randomized to the treatment arm were non-responders with a subop-timal increase in hemoglobin. All patients in the trial also received oral ferrous gluconate, which could have contributed to increases in he-moglobin observed in those receiving placebo. Accordingly, we performed an analysis separating patients into responders vs. non-responders in order to determine if measured improvement in anemia would have any effect on clinical endpoints. Methods A total of 56 patients (age 77 ± 11 years, 68%female) were recruited who had anemia defined as a hemoglobin of≤12 g/dL (average, 10.4 ± 1 g/dL) with HFPEF defined as having NHANES-CHF (National Health And Nutrition Examination Survey:Congestive Heart Failure) criteria score of≥3 and an ejection fraction of&gt;40%(average EF=63%±15%). Patients were randomly allocated to receive either ESA and ferrous gluconate or ferrous gluconate only. In this analysis, a responder was defined as a patient with an increase of 1 g/dL in the first 4 weeks of the trial. Re-sults Nineteen subjects were classified as responders compared to 33 non-responders. While the average hemoglobin increased signifi-cantly at the end of 6 months for responders (1.8 ± 0.3 vs. 0.8 ± 0.2 g/dL, P = 0.004), 50% of the subjects assigned to ESA were non-responders. Left ventricular function including ejection fraction (P=0.32) and end diastolic volume (P=0.59) was unchanged in res-ponders compared to non-responders. Responders also showed no significant improvements in New York Heart Association (NYHA) class, Six Minute Walk Test (6 MWT) and peak VO2. Though QOL improved significantly within each group, there was no difference between the two. Conclusions A significant hemoglobin response to anemia treatment with ESA and oral iron does not lead to differences in LV re-modeling, functional status, or QOL. Additionally, a significant percent of older adults with HFPEF and anemia do not respond to ESA ther-apy. Given the results of this small trial, it appears as though using objective improvements in anemia as a marker in older adult subjects with HFPEF does not have significant clinical utility. 展开更多
关键词 Heart failure ANEMIA Erythropoetin stimulating agents
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Number of medications is associated with outcomes in the elderly patient with metabolic syndrome
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作者 Akshar Y. Patel Pratik Shah Joseph H. Flaherty 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2012年第3期213-219,共7页
Background The diagnosis of metabolic syndrome indicates a clustering of metabolic imbalances which in sum have been recognized as a major predictor of cardiovascular and all-cause mortality. The aim of this study was... Background The diagnosis of metabolic syndrome indicates a clustering of metabolic imbalances which in sum have been recognized as a major predictor of cardiovascular and all-cause mortality. The aim of this study was to assess the level of under-pharmacy and poly-pbarmacy and its prognostic impact in elderly patients with metabolic syndrome. Methods Retrospective chart-review at a tertiary medical center, of 324 patients greater than 65 years of age who met the International Diabetes Foundation criteria for metabolic syndrome diagnosis [Body Mass Index (BMI) 〉 30 kg/m2, diagnosis of type 2 diabetes, hypertension, and dyslipidemia]. Results There were 60 (18.5%) patients in the low (〈 5) medication burden group, 159 (49.1%) in the medium (〉 5 and 〈 10) medication burden group, and 105 (32.4%) in the high (〉 10) medication burden group. At baseline, the groups differed only by systolic blood pressure. At two years follow-up, the medium group had significantly better improvement in high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), HbAlc, and systolic blood pressure compared to the low medication burden group and significantly better improvement in triglycerides, Haemoglobin Alc (HbAlc) and systolic blood pressure compared to the high medication group. Decrease in HDL-C was the only variable associated with strokes. High medication burden predicted hospitalization burden. The number of anti-hypertensives, history of tobacco use, low and high medication burdens and decrease in HDL-C were all associated with death. Conclusions Both poly-pharmacy and under-pharmacy are associated with a decreased therapeutic benefit among patients with metabolic syndrome in terms of important laboratory measurements as well as clinical outcomes such as myocardial infarctions, hospitalization, and death. 展开更多
关键词 Cardiovascular outcomes Elderly patients Poly-pharmacy Metabolic syndrome Diabetes Mortality predictors
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Association of Thalassemia and Trait, Sickle Cell and Trait and Haemoglobin C with Iron-Deficiency Anemia in Colombians of African Descent
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作者 Martha Castillo Ana Lucia Oliveros Ana Isabel Mora Bautista 《Journal of Life Sciences》 2014年第11期861-864,共4页
The conditions of poverty and violence in Colombia have increased the displacement of people of African descent. The research group concerned with the health of these communities has performed research to find the ass... The conditions of poverty and violence in Colombia have increased the displacement of people of African descent. The research group concerned with the health of these communities has performed research to find the association of alterations in the hemoglobin molecule with the presence of iron deficiency anemia. This research was performed with the support of the epidemiological public health laboratory. The objective of the study is the association of sickle cell disease and sickle cell trait, and the presence of hemoglobin C and its trait, with iron deficiency anemia in Afro-Colombians between 18 and 50 years of age, by investigation of hemograms, peripheral blood study, serum ferritin, soluble receptor for transferrin (sTfR) and index of sTfR, and hemoglobin electrophoresis. This research is a descriptive, quantitative, transverse, structured, non-experimental and correlational study, with a total of 56 samples (10 men, 46 women). The results showed that ferritin in men had normal values, compared to 32% (15/46) of women who had low levels of ferritin. Men's sTfR levels were normal, while in women 2% (1/46) had iron deficiency in stage I, 41% (19/46) iron deficiency in stage If, and 9% (4/46) possibly without anemia iron deficiency. In hemoglobin electrophoresis, 84% (46/56) of the population presents hemoglobin A, 4% (2/56) increased hemoglobin A2 and fetal hemoglobin related to a possible thalassemia trait, 11% (6/56) had hemoglobin AS related to sickle cell trait, and 2% (1/56) show hemoglobin AC, related to hemoglobin AC trait. This project supports investigative and social projects, and also contributes to the improvement of the quality of life and dissemination of good health practices in these communities. 展开更多
关键词 Afro-descendant HEMOGLOBINOPATHIES iron deficiency anemia trait.
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Effects of Imidapril on Venous Blood Gas Values in Broiler Chickens Exposed to Low Ambient Temperature
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作者 Xueqin HAO Meng LI +2 位作者 Shouyan ZHANG Yongshu WANG Tongwen SUN 《Agricultural Science & Technology》 CAS 2013年第7期1002-1004,共3页
ObjectiveThis study was designed to evaluate the effects of imidapril on blood gas parameters in broiler chickens. MethodTwenty-four chickens were randomly divided into three groups (n=8), control group, low temperatu... ObjectiveThis study was designed to evaluate the effects of imidapril on blood gas parameters in broiler chickens. MethodTwenty-four chickens were randomly divided into three groups (n=8), control group, low temperature group and imidapril group. Chickens in low temperature group and imidapril group were exposed to low ambient temperature (12-18 ℃) from age at 14 d to 45 d, whereas the control group was exposed to 24-30 ℃; chickens in imidapril group were gavaged with imidapril (3 mg/kg) once daily for 30 d. At age of 45 d, blood was taken from wing vein and blood gas parameters were evaluated by blood gas analyzer in Luoyang Central Hospital Affiliated to Zhengzhou University. ResultImidapril significantly increased hematocrit (HCT) and total hemoglobin content (T HBC ) and blood Na concentration in broiler chickens exposed to low ambient temperature. No significant differences were observed in pH, P CO 2 , P O 2 , K + , Ca 2+ , HCO 3-, HCO 3std , T CO 2 , BE and SO 2c . ConclusionImidapril increases hematocrit, total hemoglobin content and blood Na + concentration in chickens exposed to low ambient temperature. 展开更多
关键词 IMIDAPRIL Blood gas value Broiler chicken Low ambient temperature
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Analysis on blood glucose excursions in well-controlled patients with type 2 diabetes mellitus
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作者 Deng Wuquan Yu Qiongwu +2 位作者 Wang Fuhua Ai Zhihua Chen Bing 《Journal of Medical Colleges of PLA(China)》 CAS 2009年第2期92-98,共7页
Objective:To probe glycemic excursions in type 2 diabetic patients whose hemoglobin A1c(HbA1c) was kept ≤6.0%.Methods:Totally 36 cases with type 2 diabetes(T2DM) with HbA1c≤6.0% and 30 cases with normal glucose tole... Objective:To probe glycemic excursions in type 2 diabetic patients whose hemoglobin A1c(HbA1c) was kept ≤6.0%.Methods:Totally 36 cases with type 2 diabetes(T2DM) with HbA1c≤6.0% and 30 cases with normal glucose tolerance(NGT) from December 2005 to December 2007 in our department were subjected prospectively.Continuous glucose monitoring system(CGMS) was employed to record their continuous blood glucose level for 3 d.The blood glucose profiles including the mean blood glucose(MBG),standard differentiation(SD),mean amplitude of glycemic excursions(MAGE) and absolute means of daily differences(MODD) were analyzed.Results:T2DM group had obviously postprandial hyperglycemia,in about 2 h after meal,especially after breakfast.Fifty-two hypoglycemic episodes occurred during the monitoring period in T2DM groups,of which 73.1%(38 episodes) were absence of symptomatic hypoglycemia with the lowest value of blood glucose only 2.0 mmol/L.And 20 episodes took place during the day hours,while 32 episodes observed during the night hours.Compared with NGT groups,SD,MAGE and MODD were all significantly higher in T2DM groups.MBG was significantly correlated with HbA1c in T2DM groups,but SD,MAGE,NGE and MODD were all independent of HbA1c.MAGE was independent of MODD.Conclusion:The amplitude of glycemic excursions is higher in normol-controlled T2DM groups than the NGT groups.Thus ideally glycemic control is not only to make HbA1c reach standard,but also to lessen glycemic excursions and reduce hypoglycemia episodes. 展开更多
关键词 Type 2 diabetes mellitus Hemoglobin A 1 c Glycemic excursions Continuous glucose monitoring system
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Diabetes onset before or after the age of 65 does it affect the progression of renal and cardiovascular diseases in the elderly patient?
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作者 Yassamine Bentata Haddiya Intissar +3 位作者 Karimi Ilham Benabdellah Nawal Chemlal Abdeljalil Redouane Abouqal 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2016年第3期267-269,共3页
Type 2 diabetes (T2D) is common in the elderly and more than half of the people with diabetes are over 65 years old. Elderly diabetic patients have a higher frequency of hypertension, coronary artery disease and chr... Type 2 diabetes (T2D) is common in the elderly and more than half of the people with diabetes are over 65 years old. Elderly diabetic patients have a higher frequency of hypertension, coronary artery disease and chronic kidney disease than non-diabetic elderly patients and the risk of these complications increases with patient age, duration of the dia- betes and glycated hemoglobin values. Besides the known classical factors of renal disease progression, 展开更多
关键词 Cardiovascular disease DIABETES Elderly patients Renal disease
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Infrared Spectra and X-ray Examination of the Complex Albumin Human with UO2^2+
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作者 Aibassov Yerkin Zhakenovlch Yemelyanova Valentina +6 位作者 Shakieva Tatyana Nakisbekov Narymzhan Tussupbaev Nessipbay Abenov Bakhyt Bulenbayev Maxat Dossumova Binara Blagikh Evgeniy 《Journal of Chemistry and Chemical Engineering》 2015年第5期324-328,共5页
Reaction dioxouraniun (VI) UO22+ ion with human serum albumin was prepared: human albumin with uranium UO22+ ion and the X-ray method of investigation of these complexes. The authors have shown that Human Albumin... Reaction dioxouraniun (VI) UO22+ ion with human serum albumin was prepared: human albumin with uranium UO22+ ion and the X-ray method of investigation of these complexes. The authors have shown that Human Albumin may be used to remove highly toxic uranyl UO22+ ions. 展开更多
关键词 Albumin serum human dioxouraniun (VI) UO22+ ion X-RAY complex.
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Hematologic toxicity of gemcitabine: a comparison between fixed-dose rate infusion and thirty-minute infusion in the treatment of malignancy
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作者 Chunyan Li Li Chu (Co-first author) +4 位作者 Hui Han Xi Liu Yuping Shen Mantang Qiu Qing Xu 《The Chinese-German Journal of Clinical Oncology》 CAS 2012年第7期414-418,共5页
Objective: The aim of the study was to compare the hematologic toxicity of gemcitabine between fixed-dose rate (FDR) infusion and 30-minute standard infusion in the treatment of malignancy. Methods: The 25 maligna... Objective: The aim of the study was to compare the hematologic toxicity of gemcitabine between fixed-dose rate (FDR) infusion and 30-minute standard infusion in the treatment of malignancy. Methods: The 25 malignancy patients confirmed by histopathology or cytology received single-agent gemcitabine or gemcitabine in combination with other chemo- therapeutic agents. These patients were randomly divided into gemcitabine 1000 mg/m2 on dl, d8 at a rate of 10 mg/m2/min arm (FDR arm) or 30 rain arm (standard arm), every 21 days one cycle. Hematologic toxicity was evaluated at the end of each cycle. Results: The 13 of 25 patients received gemcitabine FDR therapy, a total of 28 cycles was completed, and 32 cycles in the others (12 of 25 patients) with the standard arm. All patients were evaluable for hematologic toxicity. The result showed that the grades 3-4 leucopenia was significantly different between the two arms (14.3% vs 0, P 〈 0.05), and no significant differences of neutropenia, thrombocytopenia and hemoglobin suppression of grades 3-4 (14.3% vs 3.1%, 10.7% vs 3.1%, 3.6% vs 9.4%, P 〉 0.05, respectively) were observed between the two arms, no grade 4 of hemoglobin suppression was observed. Conclusion: Hematologic toxicity of gemcitabine therapy at a fixed-dose rate for malignancy is tolerable. 展开更多
关键词 GEMCITABINE fixed-dose rate (FDR) MALIGNANCY hematologic toxicity
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高职院校女学生贫血状况及其相关影响因素分析 被引量:2
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作者 乜金茹 王少康 +1 位作者 叶雨婷 邵晨昕 《中国校医》 2019年第2期95-97,110,共4页
目的了解南京地区高职护理专业女生的铁营养状况,贫血患病率,分析贫血相关因素,为进一步的膳食干预提供理论依据。方法采用分层整群抽样获取600名高职护理女学生对其进行问卷调查,同时抽取静脉血进行血红蛋白及血清铁等相关指标含量检... 目的了解南京地区高职护理专业女生的铁营养状况,贫血患病率,分析贫血相关因素,为进一步的膳食干预提供理论依据。方法采用分层整群抽样获取600名高职护理女学生对其进行问卷调查,同时抽取静脉血进行血红蛋白及血清铁等相关指标含量检测。结果本校高职护理女生贫血患病率为15.0%;贫血组女生血清铁(SI)和转铁蛋白饱和度(TS)显著低于非贫血组,未结合铁(UIBC)和总铁结合力(TIBC)显著高于非贫血组(P值均<0.05);非条件Logistic回归分析结果表明生源地为城市、母亲文化程度较高、正常吃晚餐、肉类食物摄入量较高的女学生贫血的患病率相对较低(P<0.05),且均为贫血的保护因素(OR>1)。结论南京地区高职护理专业女学生贫血发生率相对较高,贫血组女生血清铁贮备量显著少于非贫血组,需要进一步的指导与改善。 展开更多
关键词 年轻人 学生 护理 女性 /血 血红蛋白/血 营养状况
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Efficacy and safety of saxagliptin in patients with type 2 diabetes mellitus:a meta-analysis of randomized controlled trials 被引量:2
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作者 姚莉 范芳芳 +2 位作者 胡兰 赵生俊 郑丽丽 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2016年第2期128-139,共12页
As a new oral hypoglycemic agent, saxagliptin belongs to the class of dipeptidyl peptidase-4 (DPP-4) inhibitors. However, it remains inconclusive whether saxagliptin is associated with increased risk of adverse even... As a new oral hypoglycemic agent, saxagliptin belongs to the class of dipeptidyl peptidase-4 (DPP-4) inhibitors. However, it remains inconclusive whether saxagliptin is associated with increased risk of adverse events (AE) and efficacy as add-on treatment. Therefore, we performed an up-to-date meta-analysis to compare the efficacy and safety of saxagliptin with placebo and other oral hypoglycemic agents in adult patients with type 2 diabetes mellitus (T2DM). Randomized clinical trials (RCTs) comparing saxagliptin with comparators were retrieved by selecting articles from Pubmed, Embase, Cochrane Library and Clinical Trials Registry Platform up to Oct. 2013. Weighted mean difference (WMD) was used to analyze the effect of hypoglycemic agents on HbAlc, weight and fasting plasma glucose (FPG). While the patients who achieved HbAlc〈7.0% and had AE were analyzed as relative risks (RR). A total of 18 articles from 16 RCTs and one clinic trial from the WHO International Clinical Trials Registry Platform met the included criterion. Clinically significant decrease from baseline HbAlc compared with placebo was certified for 2.5 mg/day saxagliptin (WMD = -0.45%, 95% CI, -0.48% to -0.42%) and 5 mg/d saxagliptin (WMD = -0.52%, 95% CI, -0.60% to -0.44%). Saxagliptin as add-on therapy was superior to thiazolidinediones, up-titrated glyburide, up-titrated metformin or metformin monotherapy in achieving HbA1c〈7.0%. Treatment with saxagliptin had negligible effect on weight, and it was considered weight neutral. Saxagliptin treatment did not increase the risk of hypoglycemia (RR = 1.28, 95% CI 0.72 to 2.27, P = 0.40) and serious adverse experiences (RR = 1.25, 95% CI 0.94 to 1.66, P = 0.13). No statistically significant differences were observed between saxagliptin and comparators in terms of the risk of infections. The present study showed that saxagliptin was effective in improving glycaemic control in T2DM with a low risk of hypoglycaemia and incidence of infections in either monotherapy or add-on treatment. This founding should be further certified by large-sample size and good-designed RCT. 展开更多
关键词 DPP-4 inhibitor SAXAGLIPTIN META-ANALYSIS Type 2 diabetes mellitus Fasting plasma glucose Glycosylated hemoglobin Randomized controlled trial HYPOGLYCAEMIA
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Effects of 95%ethanol extract of Aquilaria sinensis leaves on hyperglycemia in diabetic db/db mice 被引量:8
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作者 姜珊 姜勇 +3 位作者 管又飞 屠鹏飞 汪科元 陈金明 《Journal of Chinese Pharmaceutical Sciences》 CAS 2011年第6期609-614,共6页
The leaves of Aquilaria sinensis(Lour.) Gilg have been used in folk medicine for the treatment of diabetes in Guangdong Province,China.In this study,effects of ethanol extract of Aquilaria sinensis leaves on hypergl... The leaves of Aquilaria sinensis(Lour.) Gilg have been used in folk medicine for the treatment of diabetes in Guangdong Province,China.In this study,effects of ethanol extract of Aquilaria sinensis leaves on hyperglycemia were investigated in diabetic db/db mice.After 4 weeks of administration,the 95%ethanol(EtOH) extract of Aquilaria sinensis leaves (AE),especially at high dose level(600 mg/kg),activated AMP-activated protein kinase(AMPK),resulting in reduced fasting blood glucose and glycosylated hemoglobin levels in db/db mice.In addition,the oral glucose tolerance test(OGTT test) showed that AE could remarkably improve insulin resistance.Compared to Thiazolinediones(TZDs),no weight gain was observed after AE administration,which is a severe side effect of TZDs.The data suggested that AE could act as an activator of AMPK,and might be used as an alternative to TZDs in the management of obesity-related diabetes. 展开更多
关键词 Aquilaria sinensis Diabetes db/db mice Fasting glucose level HBA1C OGTT AMPK
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Clinical Observations on the Dose-effect Relationship of Gegen Qin Lian Decoction (葛根芩连汤) on 54 Out-patients with Type 2 Diabetes 被引量:39
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作者 仝小林 赵林华 +5 位作者 连凤梅 周强 夏乐 张家成 陈欣燕 姬航宇 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2011年第1期56-59,共4页
Objective: To observe the therapeutic effect of different dosages of Gegen Qin Lian Decoction (葛根芩连汤) on type 2 diabetic patients. Methods: Fifty-four type 2 diabetic patients from low dosage group (20 cases), me... Objective: To observe the therapeutic effect of different dosages of Gegen Qin Lian Decoction (葛根芩连汤) on type 2 diabetic patients. Methods: Fifty-four type 2 diabetic patients from low dosage group (20 cases), medium dosage group (19 cases) and high dosage group (15 cases) were treated with different dosage of Gegen Qin Lian Decoction for 12 weeks. Fasting blood-glucose (FBG), postprandial blood sugar (PBG) and Hemoglobin A1c (HbAlc) were determined before and after treatment. Results: With the increase of dosage, the overall effective rate of glycaemic control increased, and FBG, PBG, HbAlc decreased. The overall effective rate of blood glucose control of high dosage, medium dosage and low dosage group were 80%, 47%, 30% respectively, and there were significant differences between high dosage group and low dosage group. The decrease of FBG, PBG and HbAlc of high dosage showed significant differences from low dosage too. These data was analyzed by trend χ2 test and covariance analysis. Conclusion: The result indicated that different dosage of Gegen Qin Lian Decoction has dose-effect relationship in reducing HbAlc and FBG. 展开更多
关键词 Gegen Qin Lian Decoction dose-effect relationship type2 diabetes
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Retrospective study of Traditional Chinese Medicine treatment of type 2 diabetes mellitus 被引量:11
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作者 Pang Bing Guo Jing +3 位作者 Zhao Linhua Zhao Xiyan Zhou Qiang Tong Xiaolin 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2016年第3期307-313,共7页
OBJECTIVE: To provide clinical evidence in support of Dahuang Huanglian Xiexin decoction(DHXD) to treat type 2 diabetes mellitus(T2DM) and to introduce a new treatment option for clinicians.METHODS: Retrospective anal... OBJECTIVE: To provide clinical evidence in support of Dahuang Huanglian Xiexin decoction(DHXD) to treat type 2 diabetes mellitus(T2DM) and to introduce a new treatment option for clinicians.METHODS: Retrospective analysis was used to evaluate DHXD for the treatment of T2DM by analyzing clinical records of 183 cases. Patients with T2DM who met the inclusion criteria between January 1,2013 and January 1, 2014 were enrolled. The effects of the treatment were evaluated by the changes in fasting blood-glucose(FBG), postprandial blood sugar(PBG), hemoglobin A1c(Hb Alc), blood lipid profiles and body mass index(BMI) at 1, 2, 3 and 6 months. The changes in main symptoms were alsoevaluated. The dosage of Huanglian(Rhizoma Coptidis) and related factors were analyzed.RESULTS: There was a significant improvement in mean Hb A1C at 3 and 6 months after DHXD treatment compared with the baseline level(P < 0.01).There were also significant improvements in FBG,PBG, blood lipid series and BMI. DHXD also improved the main symptoms of stomach and intestine excessive heat syndrome in patients with obese T2DM. Huanglian(Rhizoma Coptidis) was the most frequently used in 678 clinical visits, the dosage of Huanglian(Rhizoma Coptidis) was related to age, BMI, DM duration, the level of blood glucose,and use of Western hypoglycemic drugs.CONCLUSION: This study suggests that DHXD could decrease blood glucose and improve T2DM symptoms and reduce body weight. The use of DHXD may indicate a new optional treatment for T2 DM. 展开更多
关键词 Diabetes mellitus type 2 Blood glucose Body weight Dahuang Huanglian Xiexin decoction Retrospective studies
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A preliminary evaluation of VEGF-A, VEGFR1 and VEGFR2 in patients with well-controlled type 2 diabetes mellitus 被引量:3
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作者 Barbara RUSZKOWSKA-CIASTEK Alina SOKUP +6 位作者 Maciej W. SOCHA Zofia RUPRECHT Lidia HALAS Barbara GóRALCZYK Krzysztof GóRALCZYK Grazyna GADOMSKA Danuta ROSC 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2014年第6期575-581,共7页
Objective: Decompensated chronic hyperglycemia often leads to late microvascular complications such as retinopathy, diabetic foot syndrome, and diabetic kidney disease. The aim of this study was to determine the conc... Objective: Decompensated chronic hyperglycemia often leads to late microvascular complications such as retinopathy, diabetic foot syndrome, and diabetic kidney disease. The aim of this study was to determine the concentration of vascular endothelial growth factor A (VEGF-A) and its receptors in patients with well-controlled diabetes. Methods: The study was conducted on 31 patients with well-controlled type 2 diabetes without microor macroangiopathy. Thirty healthy volunteers were enrolled in a control group. Serum concentrations of VEGF-A, VEGF receptors 1 and 2 (VEGFR1 and VEGFR2), fasting glucose, and lipid profiles were measured, and the plasma concentration of glycated hemoglobin (HbAlc) was determined. Results: No significant differences were observed between the concentration of VEGF-A, VEGFR1 or VEGFR2 in the subject group and that in the control group. Positive correlations were noted between the levels of VEGF-A, VEGFR2, and triglyceride, and there was a negative correlation between the levels of VEGFR2 and high-density lipoprotein (HDL)-cholesterel in the study group. Conclusions: The concentrations of VEGF-A and its receptors 1 and 2 in patients with well-controlled diabetes are comparable to those of healthy individuals, which may indicate that appropriate control of glucose levels delays the occurrence of vascular complications. A negative correlation between VEGFR2 and HDL-cholesterol levels, and positive correlations between VEGF-A, VEGFR2, and triglyceride levels, suggest that lipid abnormalities occurring in diabetes may be involved in the modulation of angiogenesis. 展开更多
关键词 Type 2 Diabetes ANGIOGENESIS Lipid abnormalities Glycated hemoglobin (HbA1c)
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