探讨血清铁水平对血脂生化指标的影响及其临床意义。选取酒泉市二院2019-01-01-2019-05-31住院者575例作为研究对象,据血清铁测定结果将患者分为铁正常组(191例)、高铁组(192例)和低铁组(192例);对3组患者血脂生化指标总胆固醇(Total ch...探讨血清铁水平对血脂生化指标的影响及其临床意义。选取酒泉市二院2019-01-01-2019-05-31住院者575例作为研究对象,据血清铁测定结果将患者分为铁正常组(191例)、高铁组(192例)和低铁组(192例);对3组患者血脂生化指标总胆固醇(Total cholesterol,TCH),甘油三酯(Glycerin three fat,TG),高密度脂蛋白(High density lipoprotein,HDL-C),低密度脂蛋白(Low density lipoprotein,LDL-C),载脂蛋白-A1(Apolipoprotein A1,APOA1),载脂蛋白-B(Apolipoprotein B,APOB)检测结果进行比较分析;并对各组项目异常发生率进行统计比较。低铁组与铁正常组、高铁组TCH浓度(3.67mmol/L、4.24mmol/L、4.26mmol/L)、TG浓度(1.26mmol/L、1.50mmol/L、1.55mmol)、HDL-C浓度((1.21mmol/L、1.35mmol/L、1.40mmol/L)、LDL-C浓度(2.13mmol/L、2.40mmol/L、2.38mmol/L)、APOA1浓度(0.81g/L、0.94g/L、1.04g/L)、APOB浓度(0.67g/L、0.78g/L、0.74g/L)相比较明显增高,差异有显著统计学意义(p<0.001);低铁组与铁正常组、高铁组的TCH、LDL-C异常增高发生率比较,差异无统计学意义(P=0.232,P=0.649);TG异常增高发生率比较差异有统计学意义(χ2=36.799,p<0.001);HDL-C、APOA1、APOB异常降低发生率比较,差异有统计学意义(p<0.001)。患者体内血脂代谢指标和异常发生率随着血清铁水平不同而增加或降低,低铁时血脂指标降低且APOA1低于生理水平尤为突出。展开更多
AIM:To investigate the effects of the Chinese herbal decoction,Yi-Qi-Zeng-Min-Tang(YQZMT),on insulin resistance in type 2 diabetic rats.METHODS:Sprague-Dawley rats were divided into two dietary regiments by feeding ei...AIM:To investigate the effects of the Chinese herbal decoction,Yi-Qi-Zeng-Min-Tang(YQZMT),on insulin resistance in type 2 diabetic rats.METHODS:Sprague-Dawley rats were divided into two dietary regiments by feeding either normal pellet diet(NPD) or high fat diet(HFD).Four weeks later,the HFD-fed rats were injected intraperitoneally with lowdose streptozotocin(STZ).Rats with non-fasting blood glucose level ≥ 16.67 mmol/L were considered type 2 diabetic and further divided into five subgroups:the type 2 diabetes model group,low-dose,medium-doseand high-dose YQZMT groups,and rosiglitazone group.Age-matched NPD-fed rats served as controls.YQZMT or rosiglitazone were administered for 8 wk.Intraperitoneal glucose and insulin tolerance tests were performed before and after the treatment to measure the glucose tolerance and insulin sensitivity.Serum levels of biochemical parameters,adipocytokines,such as tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),as well as free fatty acids(FFAs),were also analyzed.RESULTS:There was significant elevation of insulin resistance and serum levels of fasting glucose(12.82 ± 1.08 mmol/L vs 3.60 ± 0.31 mmol/L,P < 0.01),insulin(7197.36 ± 253.89 pg/mL vs 4820.49 ± 326.89 pg/mL,P < 0.01),total cholesterol(TC)(8.40 ± 0.49 mmol/L vs 2.14 ± 0.06 mmol/L,P < 0.01),triglyceride(2.24 ± 0.12 mmol/L vs 0.78 ± 0.05 mmol/L,P < 0.01),low-density lipoprotein cholesterol(LDL-c)(7.84 ± 0.51 mmol/L vs 0.72 ± 0.04 mmol/L,P < 0.01) and decrease in high-density lipoprotein cholesterol(HDL-c)(0.57 ± 0.03 mmol/L vs 1.27 ± 0.03 mmol/L,P < 0.01) in the low-dose STZ and high-fat diet induced type 2 diabetic group when compared with the control group.Administration of YQZMT induced dose-and timedependent changes in insulin resistance,glucose and lipid profile,and reduced levels of FFA,TNF-α and IL-6 in the type 2 diabetic rats.After the treatment,compared with the diabetic group,the insulin resistance was ameliorated in the high-dose YQZMT(2.82 g/100 g per day) group,with a significant reduction in serum glucose(12.16 ± 1.00 mmol/L vs 17.65 ± 2.22 mmol/L,P < 0.01),homeostasis model assessment of basal insulin resistance(22.68 ± 2.37 vs 38.79 ± 9.02,P < 0.05),triglyceride(0.87 ± 0.15 mmol/L vs 1.99 ± 0.26 mmol/L,P < 0.01),TC(3.31 ± 0.52 mmol/L vs 6.50 ± 1.04 mmol/L,P < 0.01) and LDL-c(2.47 ± 0.50 mmol/L vs 6.00 ± 1.07 mmol/L,P < 0.01),and a signif icant increase in HDL-c(0.84 ± 0.08 mmol/L vs 0.50 ± 0.03 mmol/L,P < 0.01).But the body weight was not changed signif icantly.CONCLUSION:YQZMT,which ameliorates insulin resistance and does not cause increase in body weight,may be a suitable therapeutic adjunct for the treatment of type 2 diabetes.展开更多
文摘探讨血清铁水平对血脂生化指标的影响及其临床意义。选取酒泉市二院2019-01-01-2019-05-31住院者575例作为研究对象,据血清铁测定结果将患者分为铁正常组(191例)、高铁组(192例)和低铁组(192例);对3组患者血脂生化指标总胆固醇(Total cholesterol,TCH),甘油三酯(Glycerin three fat,TG),高密度脂蛋白(High density lipoprotein,HDL-C),低密度脂蛋白(Low density lipoprotein,LDL-C),载脂蛋白-A1(Apolipoprotein A1,APOA1),载脂蛋白-B(Apolipoprotein B,APOB)检测结果进行比较分析;并对各组项目异常发生率进行统计比较。低铁组与铁正常组、高铁组TCH浓度(3.67mmol/L、4.24mmol/L、4.26mmol/L)、TG浓度(1.26mmol/L、1.50mmol/L、1.55mmol)、HDL-C浓度((1.21mmol/L、1.35mmol/L、1.40mmol/L)、LDL-C浓度(2.13mmol/L、2.40mmol/L、2.38mmol/L)、APOA1浓度(0.81g/L、0.94g/L、1.04g/L)、APOB浓度(0.67g/L、0.78g/L、0.74g/L)相比较明显增高,差异有显著统计学意义(p<0.001);低铁组与铁正常组、高铁组的TCH、LDL-C异常增高发生率比较,差异无统计学意义(P=0.232,P=0.649);TG异常增高发生率比较差异有统计学意义(χ2=36.799,p<0.001);HDL-C、APOA1、APOB异常降低发生率比较,差异有统计学意义(p<0.001)。患者体内血脂代谢指标和异常发生率随着血清铁水平不同而增加或降低,低铁时血脂指标降低且APOA1低于生理水平尤为突出。
基金Supported by The Fok Ying-Tong Education Foundation, China, No. 114036Leading Academic Discipline Project of Shanghai Municipal Education Commission, No. J50307State Administration of Traditional Chinese Medicine
文摘AIM:To investigate the effects of the Chinese herbal decoction,Yi-Qi-Zeng-Min-Tang(YQZMT),on insulin resistance in type 2 diabetic rats.METHODS:Sprague-Dawley rats were divided into two dietary regiments by feeding either normal pellet diet(NPD) or high fat diet(HFD).Four weeks later,the HFD-fed rats were injected intraperitoneally with lowdose streptozotocin(STZ).Rats with non-fasting blood glucose level ≥ 16.67 mmol/L were considered type 2 diabetic and further divided into five subgroups:the type 2 diabetes model group,low-dose,medium-doseand high-dose YQZMT groups,and rosiglitazone group.Age-matched NPD-fed rats served as controls.YQZMT or rosiglitazone were administered for 8 wk.Intraperitoneal glucose and insulin tolerance tests were performed before and after the treatment to measure the glucose tolerance and insulin sensitivity.Serum levels of biochemical parameters,adipocytokines,such as tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),as well as free fatty acids(FFAs),were also analyzed.RESULTS:There was significant elevation of insulin resistance and serum levels of fasting glucose(12.82 ± 1.08 mmol/L vs 3.60 ± 0.31 mmol/L,P < 0.01),insulin(7197.36 ± 253.89 pg/mL vs 4820.49 ± 326.89 pg/mL,P < 0.01),total cholesterol(TC)(8.40 ± 0.49 mmol/L vs 2.14 ± 0.06 mmol/L,P < 0.01),triglyceride(2.24 ± 0.12 mmol/L vs 0.78 ± 0.05 mmol/L,P < 0.01),low-density lipoprotein cholesterol(LDL-c)(7.84 ± 0.51 mmol/L vs 0.72 ± 0.04 mmol/L,P < 0.01) and decrease in high-density lipoprotein cholesterol(HDL-c)(0.57 ± 0.03 mmol/L vs 1.27 ± 0.03 mmol/L,P < 0.01) in the low-dose STZ and high-fat diet induced type 2 diabetic group when compared with the control group.Administration of YQZMT induced dose-and timedependent changes in insulin resistance,glucose and lipid profile,and reduced levels of FFA,TNF-α and IL-6 in the type 2 diabetic rats.After the treatment,compared with the diabetic group,the insulin resistance was ameliorated in the high-dose YQZMT(2.82 g/100 g per day) group,with a significant reduction in serum glucose(12.16 ± 1.00 mmol/L vs 17.65 ± 2.22 mmol/L,P < 0.01),homeostasis model assessment of basal insulin resistance(22.68 ± 2.37 vs 38.79 ± 9.02,P < 0.05),triglyceride(0.87 ± 0.15 mmol/L vs 1.99 ± 0.26 mmol/L,P < 0.01),TC(3.31 ± 0.52 mmol/L vs 6.50 ± 1.04 mmol/L,P < 0.01) and LDL-c(2.47 ± 0.50 mmol/L vs 6.00 ± 1.07 mmol/L,P < 0.01),and a signif icant increase in HDL-c(0.84 ± 0.08 mmol/L vs 0.50 ± 0.03 mmol/L,P < 0.01).But the body weight was not changed signif icantly.CONCLUSION:YQZMT,which ameliorates insulin resistance and does not cause increase in body weight,may be a suitable therapeutic adjunct for the treatment of type 2 diabetes.
