[Objective] In the Xinjiang new era from October 2012 to February 2013, agricultural and animal husbandry Co. Ltd. feedlot Yining Tuogelake village used tethered and scattered feeding methods to conduct fattening youn...[Objective] In the Xinjiang new era from October 2012 to February 2013, agricultural and animal husbandry Co. Ltd. feedlot Yining Tuogelake village used tethered and scattered feeding methods to conduct fattening young Xinjiang brown cattle experiment. [Method] The 16-month-old young Xinjiang brown bulls were se- lected totaling 68 heads, divided into scattered group and tethered group. Male claves were taken as test subjects from October to February of following year and body conformation linear evaluation were made, followed by measurement of body size indexes and Regular collection of Blood samples. [Result] In the two feeding ways, scattered group feeding improved the ADG of youth Xinjiang brown cattle bull calf （P〈0.01）, and the whole calf ADG 845.58g was significantly higher than that in tethered group at 619.11g, increasing by 36.58%; furthermore, scattered group in the December, January and February average daily weight gain was significantly higher compared with the tethered group at 13.61%, 32.32%, 53.47%, respectively. Scattered group feeding significantly increased the young calf serum phosphorus content （P〈0.01）, higher than the tethered group at 0.62%, 7.89%, 14.29% in February, December and January respectively. But the tethered feeding young cattle serum phosphorus content gradually declined. Of the two groups, male calf serum calcium content had little effects on the serum calcium with insignificant difference （P〉0.05）. Bulls by scattered feeding method was proved faster and better in the whole growth period, in terms of body height, body length, circumference, leg cir- cumference, rump length, waist high, sciatic wide, hip width basically in the contin- ued growth trend. [Conclusion] Scattered feeding can significantly improve the young Xinjiang brown cattle＇s daily gain, and accelerate the body height, heart girth and body length etc body growth. What＇s more, scattered feeding serum calcium and phosphorus content are significantly higher than tethered feeding.展开更多
Objective： Bisphosphonates were widely used with the rate of malignant tumor with bone metastases increasing rapidly. The aim of this study was to evaluate zoledronic acid and pamidronic acid on treating ostealgia of...Objective： Bisphosphonates were widely used with the rate of malignant tumor with bone metastases increasing rapidly. The aim of this study was to evaluate zoledronic acid and pamidronic acid on treating ostealgia of malignant tumor with bone metastases and serum calcium, phosphorus and alkaline phosphorus movement. Methods： One Hundred cancer patients with bone metastases were diagnosed according to pathological and imaging methods. After zoledronic acid or pamidronic acid intravenous infusion one and two months, ostealgia degree, serum calcium, serum phosphorus and alkaline phosphorus were observed before bisphosphonates treatment, one and two months after treatment, respectively. Results： Ostealgia degree did not change significantly after diphosphonates treatment from one to two months （P 〉 0.05）. The linear correlation between serum calcium and serum phosphorus on bone metastases cancer patients before therapy was dismissed after bisphosphonates treatment one month and did not recover in two months. The incidence of hypo-calcium after diphosphonate treatment one month （54%） and two months （56%） were significantly increased than that before treatment （36%） （X2 = 6.55, P = 0.011; X2 = 8.05, P = 0.005）. Serum calcium and serum phosphorus were both decreased after treatment one month （t = 4.39, P = 0.000; t = 2.50, P = 0.014） and two months （t = 4.32, P = 0.000; t = 2.49, P = 0.010）. There had no difference between zoledronic acid and pamidronic acid on treating of ostealgia and serum calcium and phosphorus changing. Conclusion： Zoledronic acid and pamidronic acid can relief ostealgia of cancer patients with bone metastases and induce hypo-calcium, break the linear relationship between calcium and phosphorus. There have no difference between zoledronic acid and pamidronic acid on treating ostealgia and inducing hypo-calcium and hypo-phosphorus.展开更多
Objective：We investigated whether disturbance of calcium and phosphate metabolism is associated with the presence and severity of calcific aortic valve disease （CAVD） in patients with normal or mildly impaired rena...Objective：We investigated whether disturbance of calcium and phosphate metabolism is associated with the presence and severity of calcific aortic valve disease （CAVD） in patients with normal or mildly impaired renal function. Methods：We measured serum levels of calcium, phosphate, alkaline phosphatase （AKP）, intact parathyroid hormone （iPTH）, 25-hydroxyvitamin D （25-OHD）, and biomarkers of bone turnover in 260 consecutive patients with normal or mildly impaired renal function and aortic valve sclerosis （AVSc） （n=164） or stenosis （AVS） （n=96） and in 164 age- and gender-matched controls. Logistic regression models were used to determine the association of mineral metabolism parameters with the presence and severity of CAVD. Results：Stepwise increases were observed in serum levels of calcium, phosphate, AKP, and iPTH from the control group to patients with AVS, and with reverse changes for 25-OHD levels （al P〈0.001）. Similarly, osteocalcin, procol agen I N-terminal peptide, andβ-isomerized type I col agen C-telopeptide breakdown products were significantly increased stepwise from the control group to patients with AVS （al P〈0.001）. In patients with AVS, serum levels of iPTH were positively, in contrast 25-OHD levels were negatively, related to trans-aortic peak flow velocity and mean pressure gradient. After adjusting for relevant confounding varia-bles, increased serum levels of calcium, phosphate, AKP, and iPTH and reduced serum levels of 25-OHD were in-dependently associated with the presence and severity of CAVD. Conclusions： This study suggests an association between mineral metabolism disturbance and the presence and severity of CAVD in patients with normal or mildly impaired renal function. Abnormal bone turnover may be a potential mechanism.展开更多
基金Supported by the NationalTechnology Support Program(2011BAD47B02)~~
文摘[Objective] In the Xinjiang new era from October 2012 to February 2013, agricultural and animal husbandry Co. Ltd. feedlot Yining Tuogelake village used tethered and scattered feeding methods to conduct fattening young Xinjiang brown cattle experiment. [Method] The 16-month-old young Xinjiang brown bulls were se- lected totaling 68 heads, divided into scattered group and tethered group. Male claves were taken as test subjects from October to February of following year and body conformation linear evaluation were made, followed by measurement of body size indexes and Regular collection of Blood samples. [Result] In the two feeding ways, scattered group feeding improved the ADG of youth Xinjiang brown cattle bull calf （P〈0.01）, and the whole calf ADG 845.58g was significantly higher than that in tethered group at 619.11g, increasing by 36.58%; furthermore, scattered group in the December, January and February average daily weight gain was significantly higher compared with the tethered group at 13.61%, 32.32%, 53.47%, respectively. Scattered group feeding significantly increased the young calf serum phosphorus content （P〈0.01）, higher than the tethered group at 0.62%, 7.89%, 14.29% in February, December and January respectively. But the tethered feeding young cattle serum phosphorus content gradually declined. Of the two groups, male calf serum calcium content had little effects on the serum calcium with insignificant difference （P〉0.05）. Bulls by scattered feeding method was proved faster and better in the whole growth period, in terms of body height, body length, circumference, leg cir- cumference, rump length, waist high, sciatic wide, hip width basically in the contin- ued growth trend. [Conclusion] Scattered feeding can significantly improve the young Xinjiang brown cattle＇s daily gain, and accelerate the body height, heart girth and body length etc body growth. What＇s more, scattered feeding serum calcium and phosphorus content are significantly higher than tethered feeding.
基金Supported by grants from the Minhang District Science and Technology Foundation and Health Bureau Foundation (No. 2008MW23, 2009MW17, 2010MHZ042)
文摘Objective： Bisphosphonates were widely used with the rate of malignant tumor with bone metastases increasing rapidly. The aim of this study was to evaluate zoledronic acid and pamidronic acid on treating ostealgia of malignant tumor with bone metastases and serum calcium, phosphorus and alkaline phosphorus movement. Methods： One Hundred cancer patients with bone metastases were diagnosed according to pathological and imaging methods. After zoledronic acid or pamidronic acid intravenous infusion one and two months, ostealgia degree, serum calcium, serum phosphorus and alkaline phosphorus were observed before bisphosphonates treatment, one and two months after treatment, respectively. Results： Ostealgia degree did not change significantly after diphosphonates treatment from one to two months （P 〉 0.05）. The linear correlation between serum calcium and serum phosphorus on bone metastases cancer patients before therapy was dismissed after bisphosphonates treatment one month and did not recover in two months. The incidence of hypo-calcium after diphosphonate treatment one month （54%） and two months （56%） were significantly increased than that before treatment （36%） （X2 = 6.55, P = 0.011; X2 = 8.05, P = 0.005）. Serum calcium and serum phosphorus were both decreased after treatment one month （t = 4.39, P = 0.000; t = 2.50, P = 0.014） and two months （t = 4.32, P = 0.000; t = 2.49, P = 0.010）. There had no difference between zoledronic acid and pamidronic acid on treating of ostealgia and serum calcium and phosphorus changing. Conclusion： Zoledronic acid and pamidronic acid can relief ostealgia of cancer patients with bone metastases and induce hypo-calcium, break the linear relationship between calcium and phosphorus. There have no difference between zoledronic acid and pamidronic acid on treating ostealgia and inducing hypo-calcium and hypo-phosphorus.
基金Project supported by the Science and Technology Commission of Shanghai Municipality(No.114119a8800),China
文摘Objective：We investigated whether disturbance of calcium and phosphate metabolism is associated with the presence and severity of calcific aortic valve disease （CAVD） in patients with normal or mildly impaired renal function. Methods：We measured serum levels of calcium, phosphate, alkaline phosphatase （AKP）, intact parathyroid hormone （iPTH）, 25-hydroxyvitamin D （25-OHD）, and biomarkers of bone turnover in 260 consecutive patients with normal or mildly impaired renal function and aortic valve sclerosis （AVSc） （n=164） or stenosis （AVS） （n=96） and in 164 age- and gender-matched controls. Logistic regression models were used to determine the association of mineral metabolism parameters with the presence and severity of CAVD. Results：Stepwise increases were observed in serum levels of calcium, phosphate, AKP, and iPTH from the control group to patients with AVS, and with reverse changes for 25-OHD levels （al P〈0.001）. Similarly, osteocalcin, procol agen I N-terminal peptide, andβ-isomerized type I col agen C-telopeptide breakdown products were significantly increased stepwise from the control group to patients with AVS （al P〈0.001）. In patients with AVS, serum levels of iPTH were positively, in contrast 25-OHD levels were negatively, related to trans-aortic peak flow velocity and mean pressure gradient. After adjusting for relevant confounding varia-bles, increased serum levels of calcium, phosphate, AKP, and iPTH and reduced serum levels of 25-OHD were in-dependently associated with the presence and severity of CAVD. Conclusions： This study suggests an association between mineral metabolism disturbance and the presence and severity of CAVD in patients with normal or mildly impaired renal function. Abnormal bone turnover may be a potential mechanism.
