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Slit2-Tg小鼠行为异常的病理表型
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作者 黎帅 吴玉娥 +3 位作者 刘书华 张钰 黄韧 王丽京 《广东医学》 CAS 北大核心 2015年第22期3430-3433,共4页
目的观察Slit2-Tg转基因小鼠类似神经退行性变行为的病理表型特征。方法利用Morris水迷宫及避暗实验装置检测Slit2-Tg小鼠的学习记忆能力,HE染色观察Slit2-Tg小鼠大脑皮层与海马神经元病理改变情况,免疫组化检测小鼠脑组织皮层和海马神... 目的观察Slit2-Tg转基因小鼠类似神经退行性变行为的病理表型特征。方法利用Morris水迷宫及避暗实验装置检测Slit2-Tg小鼠的学习记忆能力,HE染色观察Slit2-Tg小鼠大脑皮层与海马神经元病理改变情况,免疫组化检测小鼠脑组织皮层和海马神经元核抗原、乙酰胆碱酯酶(Ach E)、β-淀粉样蛋白(Aβ)的表达情况,Western blot检测小鼠脑组织Aβ、Ach E的表达水平,并与野生型C57BL/6J小鼠比较。结果与野生型C57BL/6J小鼠比较,Slit2-Tg小鼠行为出现异常,表现记忆力明显下降;病理学观察发现皮层与海马区有明显的神经元损伤,神经元空泡变性,数目减少;同时发现皮层和海马区毒性蛋白Aβ的沉积增多(P<0.05),Ach E的活性明显增强(P<0.01)。结论 Slit2-Tg小鼠脑部有明显的损伤,并出现类神经退行性变的病理学特点,对进一步研究Slit2蛋白过表达对脑神经系统的影响提供指导意义。 展开更多
关键词 SLIT2 转基因小鼠 行为学异常 神经元损伤 β-淀粉样蛋白沉积
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儿童行为异常与情绪障碍40例病因分析 被引量:1
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作者 徐兰芹 《陕西医学杂志》 CAS 北大核心 2008年第9期1251-1252,共2页
关键词 行为异常/病因 情绪障碍/病因 行为异常/诊断 情绪障碍/诊断 儿童
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Approach to Anomaly Traffic Detection in a Local Network
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作者 王秀英 肖立中 邵志清 《Journal of Donghua University(English Edition)》 EI CAS 2009年第6期656-661,共6页
The research intends to solve the problem of the occupation of bandwidth of local network by abnormal traffic which affects normal user's network behaviors.Firstly,a new algorithm in this paper named danger-theory... The research intends to solve the problem of the occupation of bandwidth of local network by abnormal traffic which affects normal user's network behaviors.Firstly,a new algorithm in this paper named danger-theory-based abnormal traffic detection was presented.Then an advanced ID3 algorithm was presented to classify the abnormal traffic.Finally a new model of anomaly traffic detection was built upon the two algorithms above and the detection results were integrated with firewall.The firewall limits the bandwidth based on different types of abnormal traffic.Experiments show the outstanding performance of the proposed approach in real-time property,high detection rate,and unsupervised learning. 展开更多
关键词 clanger theory information enlropy ID3 algorithm abnormal traffic
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Study of Structural, Electrical and Magnetic Properties of Manganese Doped Cobalt Ferrite Nanoparticles with Non-stoichiometric Composition
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作者 M. Z. Ahsan F. A. Khan 《Journal of Physical Science and Application》 2017年第6期30-37,共8页
The nanoparticles of Co1+xMnxFe2-xO4 (0≤x ≤ 0.5) ferrite system are synthesized by solid-state reaction route using planetary ball milling technique to investigate structural, electrical and magnetic properties. ... The nanoparticles of Co1+xMnxFe2-xO4 (0≤x ≤ 0.5) ferrite system are synthesized by solid-state reaction route using planetary ball milling technique to investigate structural, electrical and magnetic properties. The X-ray diffraction patterns confirm the inverse spinel structure with residual oxide phases. Three distinct regions of frequency response on dielectric constant are observed Co1.2sMn0.5Fe1.75O4 as determined by the Wayne Kerr Impedance Analyzer. The first two regions of frequency response 1.13-4.5 MHz and 4.5-6.5 MHz exhibit the normal behavior but the last region 6.5-10.5 MHz indicates its anomalous behavior due to concurrent contribution of O^2-, Fe^3+, Co^2+ and Mn^3+ ions in the relaxation process for sintering effects (sintered at 700℃). This anomalous behavior is found to be pronounced and significant for the sample of composition Co1.25Mn0.25Fe1.75O4, which may be suitable to be used in the frequency band filter over wide range of frequencies. The single peak of imaginary part of dielectric constant (ε") indicates that the conduction process in this sample is due to the grain boundary resistance. The pronounced increase of capacitance (C) as observed from 100 ℃ to 125 ~C in temperature dependent measurement (30-125℃) is expected to eause from the change of polarization across the grain boundary due to redistribution of ions by the thermal agitation. The variation of resistance (R) with temperature (30-125 ℃) is found to exhibit semieonducting behavior that resulted from the p-type carriers (Co^2+/Co^3+). A significant increase of Z from 105 ℃ with the increase of temperature indicates the signature of phase transition from ferrimagnetic-to-ferromagnetic, which may be ascribed to the increase of Co content. The appearance of the single semicircular arc in the Cole-Cole plot may be attributed to the contribution of grain boundary resistance and correspond to the parallel equivalent circuit of resistor-capacitor (R-C) combination with single relaxation time. Saturation magnetization of Co1.25Mn0.25Fe1.75O4 and Co1.375Mn0.375Fe1.625O4 is found to be greater than the literature value (61.5 emu/g) of un-doped cobalt ferrite in the measurement of their initial magnetization using Lakeshore vibrating sample magnetometer. The negative real part of AC permeability of Co1.5Mn0.5Fe1.5O4 signifies the diamagnetic behavior in the frequency range 0.13-25.2 MHz and expected to cause from the formation of magnetic dipoles opposite to the applied field due to Mn^2+ in the B site. The samples are expected to be suitable for dielectric heating and high frequency applications. 展开更多
关键词 Cobalt ferrite dielectric constant CAPACITANCE resistance impedance cole-cole plot magnetization.
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