Recently, there has been an increased recognition of neoplasms of the pancreas other than ductal adenocarcinorna. Although not as well studied or characterized as pancreatic adenocarcinorna there are many distinct les...Recently, there has been an increased recognition of neoplasms of the pancreas other than ductal adenocarcinorna. Although not as well studied or characterized as pancreatic adenocarcinorna there are many distinct lesions which exhibit diverse biological behaviors and varying degrees of malignancy. These lesions include： endocrine neoplasms, cystic tumors, solid pseudopapillary tumors, acinar cell carcinoma, squamous cell carcinoma, primary lymphoma of the pancreas, and metastatic lesions to the pancreas. These less common neoplasms are being diagnosed more frequently as the number and sensitivity of diagnostic imaging studies increase. This review article discusses the clinical course, diagnosis, and treatment of these less common, but quite relevant, neoplasms of the pancreas.展开更多
Synapsins are a family of phosphoproteins specifically associated with the cytoplasmic surface of the synaptic vesicle membrane, appearing to regulate neurotransmitter release, the formation and maintenance of synapti...Synapsins are a family of phosphoproteins specifically associated with the cytoplasmic surface of the synaptic vesicle membrane, appearing to regulate neurotransmitter release, the formation and maintenance of synaptic contacts. They could induce the change of the synaptic plasticity to regulate various adaptation reactions, and change the cognitive behaviors. So we presume that if some cognitive behavior are damaged, synapsins would be changed as well. This gives us a new recognition of better diagnosis and therapy of cognitive disorder desease.展开更多
Objective In order to characterize the feature of stress response induced by stressor with both physical and psychological natures, the effect of water restriction performed in different experimental modes on the phys...Objective In order to characterize the feature of stress response induced by stressor with both physical and psychological natures, the effect of water restriction performed in different experimental modes on the physiological parameters, psychological behavioral manifestations and brain c-Fos expressions were observed and compared. Methods 58 male Wistar rats were used and randomly divided into three experimental groups （n=18 for each） and a control group （n=4）. In control group, the rats were allowed to access drinking water freely at all experimental period. In the experimental groups the water supply to the rats was restricted. In timed water supply （TW） group, the water was supplied twice a day, 10 min for each in fixed hours every day. In empty bottle-served （EB） and water-restricted （WR） groups, the water was served only once a day for 10 min, either in the early morning or evening, and in the other time point scheduled for water supply only an empty bottle without water was provided in the EB group and nothing was given in the WR group. The quantities of drank water and eaten food, weight-gaining, and behavior score were observed every day. The serum level of corticosterone was assayed and the rats were sacrificed with fixative perfusion of 3 d, 7 d or 14 d respectively, following water restriction （n=6 for each time point in each group）. The brain c-Fos expressions were examined with immunohistochemistry. Results The slowing down of weight-gaining, rise of serum corticosterone level, occurrence of psychological behavioral manifestations of unpeaceful restlessness such as exploring and attacking, enhance of c-Fos expression in the subfomical organ （SFO）, median preoptic nucleus （MnPO）, area postrema （AP）, hypothalamic paraventricular nucleus （PVN）, supraoptic nucleus （SON）, medial （MeA） and central （CeA） amygdaloid nucleus and ventrolateral septum （LSV） were noticed in both EB and WR groups, except the nucleus of solitary tract （NTS） in which the Fos expression was decreased. The changes of Fos expression in most of nuclei in EB group began at day 3, at least persisted till day 7, and backed down at day 14. While in WR group, similar changes started at day 7 and reached its peak at day 14. In TW group, only the concentration of corticosterone at day 7 was slightly increased and the rest indexes observed were unchanged. Conclusion The results indicate that water restriction induces physical as well as psychological stress responses. And the water restrictions experimentally executed in different modes result in different manifestations of behavioral response and brain immediately early gene expression in discrete brain nuclei/regions.展开更多
Network has not only become a habit and lifestyle for university student, but also brought all sorts of ethical misconducts and ethical issues in society. Based on the analysis of college students＇ frustrations, this...Network has not only become a habit and lifestyle for university student, but also brought all sorts of ethical misconducts and ethical issues in society. Based on the analysis of college students＇ frustrations, this paper explores the causes of network behavior anomie for college students, which mainly include： dissatisfaction in real communication, game addiction to the network, craving online pornography, and hooking on online shopping. In addition, it also investigates the ways to wipe out mental frustration in such a cyber era. These ways mainly are to strenzthen online education and management, to make psychological counseling, and to carry on frustration education.展开更多
Haemangiopericytoma(HPC) is a rare vascular tumor with borderline malignancy, considerable histological variability, and unpredictable clinical and biological behavior. HPC can present a diagnostic challenge because o...Haemangiopericytoma(HPC) is a rare vascular tumor with borderline malignancy, considerable histological variability, and unpredictable clinical and biological behavior. HPC can present a diagnostic challenge because of its indeterminate clinical, radiological, and pathological features. HPC generally presents in adulthood and is equally frequent in both sexes. HPC can arise in any site in the body as a slowly growing and painless mass. The precise cell type origin of HPC is uncertain. One third of HPCs occur in the head and neck areas. Exceptional cases of hemangioblastoma arising outside the head and neck areas have been reported, but little is known about their clinicopathologic and immunohistochemical features. This study reports on a case of a large sacro-anterior HPC in a 65-year-old male.展开更多
This study investigates Chinese elementary, middle, and high school students＇ L2 perceptual learning styles, imagination, ideal L2 self, and motivated L2 behavior. A perceptual learning style and L2 learning motivati...This study investigates Chinese elementary, middle, and high school students＇ L2 perceptual learning styles, imagination, ideal L2 self, and motivated L2 behavior. A perceptual learning style and L2 learning motivation questionnaire was administered to 1,667 students from elementary to high school. Statistical results revealed that Chinese elementary, middle, and high school students were more in favor of a visual learning style in comparison to their auditory and kinesthetic learning styles. This visually oriented style was significantly correlated with their ideal L2 self and motivated L2 behavior. The sequential regression analysis results indicated that the ideal L2 self and visual learning style were the most meaningful predictors for Chinese students＇ motivated L2 behavior. This study suggests that teachers need to help students create and maintain their ideal L2 self and facilitate their L2 learning motivation by providing more adequate visual teaching materials.展开更多
Clinical medicine and experiments have shown that electrophysiological activities on neuronal disease systems such as the epilepsy and Parkinson can exhibit the evolutions of complex dynamical behaviors and their tran...Clinical medicine and experiments have shown that electrophysiological activities on neuronal disease systems such as the epilepsy and Parkinson can exhibit the evolutions of complex dynamical behaviors and their transitions, which are closely related to the generation mechanism of neuronal diseases. Traditionally, electrophysiological activities have been analyzed from the statistical methods. Although some ideal results have been obtained, mechanisms of complex electrophysiological activities in neuronal systems cannot yet be disclosed. Dynamics modelling can help researchers to explore the mechanisms of electro- physiological activities of neuronal disease systems. By constructing reasonable physiological dynamical model, inner relation between the dynamics model and representation behaviors of the neuronal disease systems can be further studied. In addition, based on the constructed network model, we can also explore mechanisms of the evolutions of dynamical behaviors and their transitions of the initiation, propagation and termination of different kinds of the seizures. Finally, we can design the feasible control method to regulate dynamics behaviors of the seizures so as to realize the healthy neuronal firings.展开更多
文摘Recently, there has been an increased recognition of neoplasms of the pancreas other than ductal adenocarcinorna. Although not as well studied or characterized as pancreatic adenocarcinorna there are many distinct lesions which exhibit diverse biological behaviors and varying degrees of malignancy. These lesions include： endocrine neoplasms, cystic tumors, solid pseudopapillary tumors, acinar cell carcinoma, squamous cell carcinoma, primary lymphoma of the pancreas, and metastatic lesions to the pancreas. These less common neoplasms are being diagnosed more frequently as the number and sensitivity of diagnostic imaging studies increase. This review article discusses the clinical course, diagnosis, and treatment of these less common, but quite relevant, neoplasms of the pancreas.
文摘Synapsins are a family of phosphoproteins specifically associated with the cytoplasmic surface of the synaptic vesicle membrane, appearing to regulate neurotransmitter release, the formation and maintenance of synaptic contacts. They could induce the change of the synaptic plasticity to regulate various adaptation reactions, and change the cognitive behaviors. So we presume that if some cognitive behavior are damaged, synapsins would be changed as well. This gives us a new recognition of better diagnosis and therapy of cognitive disorder desease.
文摘Objective In order to characterize the feature of stress response induced by stressor with both physical and psychological natures, the effect of water restriction performed in different experimental modes on the physiological parameters, psychological behavioral manifestations and brain c-Fos expressions were observed and compared. Methods 58 male Wistar rats were used and randomly divided into three experimental groups （n=18 for each） and a control group （n=4）. In control group, the rats were allowed to access drinking water freely at all experimental period. In the experimental groups the water supply to the rats was restricted. In timed water supply （TW） group, the water was supplied twice a day, 10 min for each in fixed hours every day. In empty bottle-served （EB） and water-restricted （WR） groups, the water was served only once a day for 10 min, either in the early morning or evening, and in the other time point scheduled for water supply only an empty bottle without water was provided in the EB group and nothing was given in the WR group. The quantities of drank water and eaten food, weight-gaining, and behavior score were observed every day. The serum level of corticosterone was assayed and the rats were sacrificed with fixative perfusion of 3 d, 7 d or 14 d respectively, following water restriction （n=6 for each time point in each group）. The brain c-Fos expressions were examined with immunohistochemistry. Results The slowing down of weight-gaining, rise of serum corticosterone level, occurrence of psychological behavioral manifestations of unpeaceful restlessness such as exploring and attacking, enhance of c-Fos expression in the subfomical organ （SFO）, median preoptic nucleus （MnPO）, area postrema （AP）, hypothalamic paraventricular nucleus （PVN）, supraoptic nucleus （SON）, medial （MeA） and central （CeA） amygdaloid nucleus and ventrolateral septum （LSV） were noticed in both EB and WR groups, except the nucleus of solitary tract （NTS） in which the Fos expression was decreased. The changes of Fos expression in most of nuclei in EB group began at day 3, at least persisted till day 7, and backed down at day 14. While in WR group, similar changes started at day 7 and reached its peak at day 14. In TW group, only the concentration of corticosterone at day 7 was slightly increased and the rest indexes observed were unchanged. Conclusion The results indicate that water restriction induces physical as well as psychological stress responses. And the water restrictions experimentally executed in different modes result in different manifestations of behavioral response and brain immediately early gene expression in discrete brain nuclei/regions.
文摘Network has not only become a habit and lifestyle for university student, but also brought all sorts of ethical misconducts and ethical issues in society. Based on the analysis of college students＇ frustrations, this paper explores the causes of network behavior anomie for college students, which mainly include： dissatisfaction in real communication, game addiction to the network, craving online pornography, and hooking on online shopping. In addition, it also investigates the ways to wipe out mental frustration in such a cyber era. These ways mainly are to strenzthen online education and management, to make psychological counseling, and to carry on frustration education.
文摘Haemangiopericytoma(HPC) is a rare vascular tumor with borderline malignancy, considerable histological variability, and unpredictable clinical and biological behavior. HPC can present a diagnostic challenge because of its indeterminate clinical, radiological, and pathological features. HPC generally presents in adulthood and is equally frequent in both sexes. HPC can arise in any site in the body as a slowly growing and painless mass. The precise cell type origin of HPC is uncertain. One third of HPCs occur in the head and neck areas. Exceptional cases of hemangioblastoma arising outside the head and neck areas have been reported, but little is known about their clinicopathologic and immunohistochemical features. This study reports on a case of a large sacro-anterior HPC in a 65-year-old male.
文摘This study investigates Chinese elementary, middle, and high school students＇ L2 perceptual learning styles, imagination, ideal L2 self, and motivated L2 behavior. A perceptual learning style and L2 learning motivation questionnaire was administered to 1,667 students from elementary to high school. Statistical results revealed that Chinese elementary, middle, and high school students were more in favor of a visual learning style in comparison to their auditory and kinesthetic learning styles. This visually oriented style was significantly correlated with their ideal L2 self and motivated L2 behavior. The sequential regression analysis results indicated that the ideal L2 self and visual learning style were the most meaningful predictors for Chinese students＇ motivated L2 behavior. This study suggests that teachers need to help students create and maintain their ideal L2 self and facilitate their L2 learning motivation by providing more adequate visual teaching materials.
文摘Clinical medicine and experiments have shown that electrophysiological activities on neuronal disease systems such as the epilepsy and Parkinson can exhibit the evolutions of complex dynamical behaviors and their transitions, which are closely related to the generation mechanism of neuronal diseases. Traditionally, electrophysiological activities have been analyzed from the statistical methods. Although some ideal results have been obtained, mechanisms of complex electrophysiological activities in neuronal systems cannot yet be disclosed. Dynamics modelling can help researchers to explore the mechanisms of electro- physiological activities of neuronal disease systems. By constructing reasonable physiological dynamical model, inner relation between the dynamics model and representation behaviors of the neuronal disease systems can be further studied. In addition, based on the constructed network model, we can also explore mechanisms of the evolutions of dynamical behaviors and their transitions of the initiation, propagation and termination of different kinds of the seizures. Finally, we can design the feasible control method to regulate dynamics behaviors of the seizures so as to realize the healthy neuronal firings.
