To establish the empirical capacity model of an on- ramp merging section, the Erlang distribution is first selected to define the time headway distribution, and then the gap acceptance theory is applied to develop the...To establish the empirical capacity model of an on- ramp merging section, the Erlang distribution is first selected to define the time headway distribution, and then the gap acceptance theory is applied to develop the basic capacity model of the on-ramp merging section. Since not all the time headways on the shoulder lane can be made full use of by on- ramp vehicles, a modified capacity model is developed, which takes the usage probability of time headway into consideration. Then, a model of capacity discount coefficient ~： is developed. Finally, based on the modified capacity model and the model of capacity discount coefficient, an empirical merge capacity model which contains the shoulder lane volume, critical gap, and the distance from nose to merging point, is constructed. Results show that, compared with other models, the proposed model is more reasonable since it takes merging section geometry into consideration, and it is easy to apply. The merge capacity varies with the shoulder lane volume, the critical gap, the distance between the nose and the merging point, and the design velocity of the shoulder lane and ramp.展开更多
Celiac disease (CD) is a common autoimmune disorder characterized by an immune response to ingested gluten and has a strong HLA association with HLA- DQ2 and HLA-DQ8 molecules, but human HLA-DQ risk factors do not exp...Celiac disease (CD) is a common autoimmune disorder characterized by an immune response to ingested gluten and has a strong HLA association with HLA- DQ2 and HLA-DQ8 molecules, but human HLA-DQ risk factors do not explain the entire genetic susceptibility to gluten intolerance. CD is caused by the lack of immune tolerance (oral tolerance) to wheat gluten. In this sense, the expression of soluble HLA-G in CD is of special interest because the molecule plays an important role in the induction of immune tolerance. The enhanced expression of soluble HLA-G found in CD may be part of a mechanism to restore the gluten intolerance. In this editorial, we review recent progress in understanding CD in relation to its prevalence, diagnosis and possible mechanisms of pathogenesis.展开更多
The authors review the clinical outcome in patients with Crohn's disease(CD)based on studies describing the natural course of the disease.Population-based studies have demonstrated that the incidence rates and pre...The authors review the clinical outcome in patients with Crohn's disease(CD)based on studies describing the natural course of the disease.Population-based studies have demonstrated that the incidence rates and prevalence rates for CD have increased since the mid-1970s.The authors search for English language articles from 1980 until 2011.Geographical variations,incidence,prevalence,smoking habits,sex,mortality and medications are investigated.An increasing incidence and prevalence of CD have been found over the last three decades.The disease seems to be most common in northern Europe and North America,but is probably increasing also in Asia and Africa.Smoking is associated with an increased risk of developing CD.Age <40 at diagnosis,penetrating/stricturing complications,need for systemic steroids,and disease location in terminal ileum are factors associated with higher relapse rates.A slight predominance of women diagnosed with CD has been found.Ileocecal resection is the most commonly performed surgical procedure,and within the first five years after the diagnosis about one third of the patients have had intestinal surgery.Smoking is associated with a worse clinical course and withincreased risk of flare-ups.In most studies the overall mortality is comparable to the background population.To date,the most effective treatment options in acute flares are glucocorticosteroids and tumor necrosis factor(TNF)-α-blockers.Azathioprine/methotrexate and TNF-α-blockers are effective in maintaining remission.展开更多
Pedestrian's road-crossing model is the key part of micro-simulation for mixed traffic at signalized intersection.To reproduce the crossing behavior of pedestrians,the microscopic behaviors of the pedestrians pass...Pedestrian's road-crossing model is the key part of micro-simulation for mixed traffic at signalized intersection.To reproduce the crossing behavior of pedestrians,the microscopic behaviors of the pedestrians passing through the crosswalk at signalized intersection were analyzed.A pedestrian's decision making model based on gap acceptance theory was proposed.Based on the field data at three typical intersections in Beijing,China,the critical gaps and lags of pedestrians were calibrated.In addition,considering pedestrian's required space,a modification of the social force model that consists of a self-deceleration mechanism prevents a simulated pedestrian from continuously pushing over other pedestrians,making the simulation more realistic.After the simple change,the modified social force model is able to reproduce the fundamental diagram of pedestrian flows for densities less than 3.5 m-2 as reported in the literature.展开更多
In this paper, a deterministic delay differential pantograph equation （DDPE） with an unbounded memory is stochastically perturbed by an Ito-type noise. The contribution of white noise to the oscillatory behaviour of...In this paper, a deterministic delay differential pantograph equation （DDPE） with an unbounded memory is stochastically perturbed by an Ito-type noise. The contribution of white noise to the oscillatory behaviour of the new stochastic delay differential pantograph equation （SDDPE） is investigated. It is established that under certain conditions and with a highly positive probability, the new stochastic delay differential pantograph equation has an oscillatory solution influenced by the presence of the noise. This is not possible with the original deterministic system which has a non-oscillatory solution due to the absence of noise.展开更多
The prospect of employing Light Amplification by Stimulated Emission of Radiation(LASER) for well drilling in oil and gas industry was examined.In this work,the experimental works carried out on various oil well drill...The prospect of employing Light Amplification by Stimulated Emission of Radiation(LASER) for well drilling in oil and gas industry was examined.In this work,the experimental works carried out on various oil well drilling operations was discussed.The results show that,LASER or LASER-aided oil and gas well drilling has many potential advantages over conventional rotary drilling,including high penetration rate,reduction or elimination of tripping,casing,bit costs,enhanced well control,as well as perforating and side-tracking capabilities.The investigation also reveals that modern infrared LASERs have a higher rate of rock cuttings removal than that of conventional rotary drilling and flame-jet spallation.It also reveals that LASER can destroy rock without damaging formation permeability but rather,it enhances or improves permeability and that permeability and porosity increases in all rock types.The paper has therefore provided more knowledge on the potential value to drilling operations and techniques using LASER.展开更多
A design method for parallel processing application on multi-channel low-intermediate-frequency(LIF) digital receiver was presented. It is based on the DSP sub-array with a simple topology and operation timing to eval...A design method for parallel processing application on multi-channel low-intermediate-frequency(LIF) digital receiver was presented. It is based on the DSP sub-array with a simple topology and operation timing to evaluate and determine the processing capability and then construct the parallel processing array for multi-channel signals according to the restriction of operation timing. Using this method, the design of multi-channel digital receiver may be simplified. Finally, a design example was used to show how to apply this method.展开更多
Bone remodeling is performed under the joint action of osteoblasts and osteoclasts. Since the effect of osteoclasts has been gradually recognized on bone and joint diseases, targeted researches toward osteoclasts have...Bone remodeling is performed under the joint action of osteoblasts and osteoclasts. Since the effect of osteoclasts has been gradually recognized on bone and joint diseases, targeted researches toward osteoclasts have become a hot research field. This article reviews the relevant medical literature concerning the possible effects of the fluid shear stress (FSS) on the osteoclastogenesis chiefly from the aspects of RANKL-RANK-OPG system, the macrophage colony-stimulating factor (M-CSF), and calcitonin receptor (CTR). On the basis of the changes of the expression of osteoclastic activities, it is suggested that FSS is a potent, important regulator of bone metabolism.展开更多
In order to deeply analyze the differences in the acceptance of autonomous driving technology among different gender groups,a multiple indicators and multiple causes model was constructed by integrating a technology a...In order to deeply analyze the differences in the acceptance of autonomous driving technology among different gender groups,a multiple indicators and multiple causes model was constructed by integrating a technology acceptance model and theory of planned behavior to comprehensively reveal the gender differences in the influence mechanisms of subjective and objective factors.The analysis is based on data collected from Chinese urban residents.Among objective factors,age has a significant negative impact on women's perceived behavior control and a significant positive impact on perceived ease of use.Education has a significant positive impact on men's perceived behavior control,and has a strong positive impact on women's perceived usefulness(PU).For men,income and education are found to have strong positive impacts on perceived behavior control.Among subjective factors,perceived ease of use(PEU)has the greatest influence on women's behavior intention,and it is the only influential factor for women's intention to use autonomous driving technology,with an influence coefficient of 0.72.The influencing path of men's intention to use autonomous driving technology is more complex.It is not only directly affected by the significant and positive joint effects of attitude and PU,but also indirectly affected by perceived behavior controls,subjective norms,and PEU.展开更多
基金The National Natural Science Foundation of China(No.51278520 51278220)the Science and Technology Development Project of Jilin Province(No.20130206093SF)
文摘To establish the empirical capacity model of an on- ramp merging section, the Erlang distribution is first selected to define the time headway distribution, and then the gap acceptance theory is applied to develop the basic capacity model of the on-ramp merging section. Since not all the time headways on the shoulder lane can be made full use of by on- ramp vehicles, a modified capacity model is developed, which takes the usage probability of time headway into consideration. Then, a model of capacity discount coefficient ~： is developed. Finally, based on the modified capacity model and the model of capacity discount coefficient, an empirical merge capacity model which contains the shoulder lane volume, critical gap, and the distance from nose to merging point, is constructed. Results show that, compared with other models, the proposed model is more reasonable since it takes merging section geometry into consideration, and it is easy to apply. The merge capacity varies with the shoulder lane volume, the critical gap, the distance between the nose and the merging point, and the design velocity of the shoulder lane and ramp.
文摘Celiac disease (CD) is a common autoimmune disorder characterized by an immune response to ingested gluten and has a strong HLA association with HLA- DQ2 and HLA-DQ8 molecules, but human HLA-DQ risk factors do not explain the entire genetic susceptibility to gluten intolerance. CD is caused by the lack of immune tolerance (oral tolerance) to wheat gluten. In this sense, the expression of soluble HLA-G in CD is of special interest because the molecule plays an important role in the induction of immune tolerance. The enhanced expression of soluble HLA-G found in CD may be part of a mechanism to restore the gluten intolerance. In this editorial, we review recent progress in understanding CD in relation to its prevalence, diagnosis and possible mechanisms of pathogenesis.
文摘The authors review the clinical outcome in patients with Crohn's disease(CD)based on studies describing the natural course of the disease.Population-based studies have demonstrated that the incidence rates and prevalence rates for CD have increased since the mid-1970s.The authors search for English language articles from 1980 until 2011.Geographical variations,incidence,prevalence,smoking habits,sex,mortality and medications are investigated.An increasing incidence and prevalence of CD have been found over the last three decades.The disease seems to be most common in northern Europe and North America,but is probably increasing also in Asia and Africa.Smoking is associated with an increased risk of developing CD.Age <40 at diagnosis,penetrating/stricturing complications,need for systemic steroids,and disease location in terminal ileum are factors associated with higher relapse rates.A slight predominance of women diagnosed with CD has been found.Ileocecal resection is the most commonly performed surgical procedure,and within the first five years after the diagnosis about one third of the patients have had intestinal surgery.Smoking is associated with a worse clinical course and withincreased risk of flare-ups.In most studies the overall mortality is comparable to the background population.To date,the most effective treatment options in acute flares are glucocorticosteroids and tumor necrosis factor(TNF)-α-blockers.Azathioprine/methotrexate and TNF-α-blockers are effective in maintaining remission.
基金Project(70972041)supported by the National Natural Science Foundation of ChinaProject(20100009110010)supported by the PhD Programs Foundation of Ministry of Education of ChinaProject(2011YJS246)supported by Fundamental Research Funds for the Central Universities of China
文摘Pedestrian's road-crossing model is the key part of micro-simulation for mixed traffic at signalized intersection.To reproduce the crossing behavior of pedestrians,the microscopic behaviors of the pedestrians passing through the crosswalk at signalized intersection were analyzed.A pedestrian's decision making model based on gap acceptance theory was proposed.Based on the field data at three typical intersections in Beijing,China,the critical gaps and lags of pedestrians were calibrated.In addition,considering pedestrian's required space,a modification of the social force model that consists of a self-deceleration mechanism prevents a simulated pedestrian from continuously pushing over other pedestrians,making the simulation more realistic.After the simple change,the modified social force model is able to reproduce the fundamental diagram of pedestrian flows for densities less than 3.5 m-2 as reported in the literature.
文摘In this paper, a deterministic delay differential pantograph equation （DDPE） with an unbounded memory is stochastically perturbed by an Ito-type noise. The contribution of white noise to the oscillatory behaviour of the new stochastic delay differential pantograph equation （SDDPE） is investigated. It is established that under certain conditions and with a highly positive probability, the new stochastic delay differential pantograph equation has an oscillatory solution influenced by the presence of the noise. This is not possible with the original deterministic system which has a non-oscillatory solution due to the absence of noise.
文摘The prospect of employing Light Amplification by Stimulated Emission of Radiation(LASER) for well drilling in oil and gas industry was examined.In this work,the experimental works carried out on various oil well drilling operations was discussed.The results show that,LASER or LASER-aided oil and gas well drilling has many potential advantages over conventional rotary drilling,including high penetration rate,reduction or elimination of tripping,casing,bit costs,enhanced well control,as well as perforating and side-tracking capabilities.The investigation also reveals that modern infrared LASERs have a higher rate of rock cuttings removal than that of conventional rotary drilling and flame-jet spallation.It also reveals that LASER can destroy rock without damaging formation permeability but rather,it enhances or improves permeability and that permeability and porosity increases in all rock types.The paper has therefore provided more knowledge on the potential value to drilling operations and techniques using LASER.
文摘A design method for parallel processing application on multi-channel low-intermediate-frequency(LIF) digital receiver was presented. It is based on the DSP sub-array with a simple topology and operation timing to evaluate and determine the processing capability and then construct the parallel processing array for multi-channel signals according to the restriction of operation timing. Using this method, the design of multi-channel digital receiver may be simplified. Finally, a design example was used to show how to apply this method.
文摘Bone remodeling is performed under the joint action of osteoblasts and osteoclasts. Since the effect of osteoclasts has been gradually recognized on bone and joint diseases, targeted researches toward osteoclasts have become a hot research field. This article reviews the relevant medical literature concerning the possible effects of the fluid shear stress (FSS) on the osteoclastogenesis chiefly from the aspects of RANKL-RANK-OPG system, the macrophage colony-stimulating factor (M-CSF), and calcitonin receptor (CTR). On the basis of the changes of the expression of osteoclastic activities, it is suggested that FSS is a potent, important regulator of bone metabolism.
基金The National Key Research and Development Program of China(No.2018YFB1601304)the National Natural Science Foundation of China(No.71871107)Philosophy and Social Science Foundation Project of Universities in Jiangsu Province(No.2020SJA2059).
文摘In order to deeply analyze the differences in the acceptance of autonomous driving technology among different gender groups,a multiple indicators and multiple causes model was constructed by integrating a technology acceptance model and theory of planned behavior to comprehensively reveal the gender differences in the influence mechanisms of subjective and objective factors.The analysis is based on data collected from Chinese urban residents.Among objective factors,age has a significant negative impact on women's perceived behavior control and a significant positive impact on perceived ease of use.Education has a significant positive impact on men's perceived behavior control,and has a strong positive impact on women's perceived usefulness(PU).For men,income and education are found to have strong positive impacts on perceived behavior control.Among subjective factors,perceived ease of use(PEU)has the greatest influence on women's behavior intention,and it is the only influential factor for women's intention to use autonomous driving technology,with an influence coefficient of 0.72.The influencing path of men's intention to use autonomous driving technology is more complex.It is not only directly affected by the significant and positive joint effects of attitude and PU,but also indirectly affected by perceived behavior controls,subjective norms,and PEU.
