Sudden earthquakes pose a threat to the running safety of trains on high-speed railway bridges,and the stiffness of piers is one of the factors affecting the dynamic response of train-track-bridge system.In this paper...Sudden earthquakes pose a threat to the running safety of trains on high-speed railway bridges,and the stiffness of piers is one of the factors affecting the dynamic response of train-track-bridge system.In this paper,a experiment of a train running on a high-speed railway bridge is performed based on a dynamic experiment system,and the corresponding numerical model is established.The reliability of the numerical model is verified by experiments.Then,the experiment and numerical data are analyzed to reveal the pier height effects on the running safety of trains on bridges.The results show that when the pier height changes,the frequency of the bridge below the 30 m pier height changes greater;the increase of pier height causes the transverse fundamental frequency of the bridge close to that of the train,and the shaking angle and lateral displacement of the train are the largest for bridge with 50 m pier,which increases the risk of derailment;with the pier height increases from 8 m to 50 m,the derailment coefficient obtained by numerical simulations increases by 75% on average,and the spectral intensity obtained by experiments increases by 120% on average,two indicators exhibit logarithmic variation.展开更多
Running safety assessment and tracking irregularity parametric sensitivity analysis of high-speed maglev train-bridge system are of great concern,especially need perfect refinement models in which all properties can b...Running safety assessment and tracking irregularity parametric sensitivity analysis of high-speed maglev train-bridge system are of great concern,especially need perfect refinement models in which all properties can be well characterized based on various stochastic excitations.A three-dimensional refined spatial random vibration analysis model of high-speed maglev train-bridge coupled system is established in this paper,in which multi-source uncertainty excitation can be considered simultaneously,and the probability density evolution method(PDEM)is adopted to reveal the system-specific uncertainty dynamic characteristic.The motion equation of the maglev vehicle model is composed of multi-rigid bodies with a total 210-degrees of freedom for each vehicle,and a refined electromagnetic force-air gap model is used to account for the interaction and coupling effect between the moving train and track beam bridges,which are directly established by using finite element method.The model is proven to be applicable by comparing with Monte Carlo simulation.By applying the proposed stochastic framework to the high maglev line,the random dynamic responses of maglev vehicles running on the bridges are studied for running safety and stability assessment.Moreover,the effects of track irregularity wavelength range under different amplitude and running speeds on the coupled system are investigated.The results show that the augmentation of train speed will move backward the sensitive wavelength interval,and track irregularity amplitude influences the response remarkably in the sensitive interval.展开更多
Aiming at prevalent violations of non-motorists at urban intersections in China, this paper intends to clarify the characteristics and risks of non-motorist violations at signalized intersections through questionnaire...Aiming at prevalent violations of non-motorists at urban intersections in China, this paper intends to clarify the characteristics and risks of non-motorist violations at signalized intersections through questionnaires and video recordings, which may serve as a basis for non-motorized vehicle management. It can help improve the traffic order and enhance the degree of safety at signalized intersections. To obtain the perception information, a questionaire survey on the Internet was conducted and 972 valid questionnaires were returned. It is found that academic degree contributes little to non-motorist violations, while electrical bicyclists have a relatively higher frequency of violations compared with bicyclists. The video data of 18 228 non-motorist behaviors indicate that the violation rate of all non-motorists is 26.5%; the number of conflicts reaches 1 938, among which violation conflicts account for 66.8%. The study shows that the violation rates and the violation behavior at three types of surveyed intersections are markedly different. It is also concluded that the conflict rates and the violation rates are positively correlated. Furthermore, signal violation, traveling in the wrong direction, and overspeeding to cross the intersection are the most dangerous among traffic violation behaviors.展开更多
In order to effectively separate galena and jamesonite and improve the recovery during the mixing flotation, the interaction mechanisms between the minerals and the collector of diethyl dithiocarbamate (DDTC) were i...In order to effectively separate galena and jamesonite and improve the recovery during the mixing flotation, the interaction mechanisms between the minerals and the collector of diethyl dithiocarbamate (DDTC) were investigated. Single mineral flotation test was organized to research the effect of pulp pH value on the flotation behavior of galena and jamesonite. Electrochemistry property of the interaction of these two minerals with DDTC was investigated by cyclic voltammetry and Tafel tests. Flotation test shows that the recovery of jamesonite in high alkaline pulp is strongly depressed by lime (Ca(OH)2). The cyclic voltammetry and Tafel tests results show that the interaction between galena and DDTC is an electrochemical process. High pH value has little influence on the interaction between galena and DDTC, while it has great effect on jamesonite due to self-oxidation and specific adsorption of OH^- and CaOH^+ on jamesonite surface. Non-electroactive hydroxyl compound and low-electroconductive calcium compounds cover the surface of jamesonite, which impedes electron transfer and DDTC adsorption, thus leads to very low floatability of jamesonite.展开更多
The low altitude airspace will be open in China, general aviation flights are tremendously increased. Whether aircrafts can fly safely and how to determine the requirements of safety flight are the problems needed to ...The low altitude airspace will be open in China, general aviation flights are tremendously increased. Whether aircrafts can fly safely and how to determine the requirements of safety flight are the problems needed to be confirmed. Under this circumstances, based on the international Civil Aviation Organization(ICAO) criteria and the standards made by CAAC, this paper adopts the "See and Avoid" principle. Under the binding conditions of flight rules, visibility requirements, responding time, the aircraft speed, circle banking angle or the climbing angle, based on its study on aircraft dynamics principles, this paper establishes a mathematical collision avoidance model for head-to-head traffic and crossing converging traffic at the same level. And the safety separation requirements of the aircrafts in low altitude flight are equantitatively analyzed. Finally, the Matlab software is used to analyze the above method. The result shows that the safe traffic avoidance of the converging traffic at the same level meets certain flight conditions, while intersecting the traffic at the same level can safely avoid the collision.展开更多
By means of the relationship between speed and distance headway, this paperattempts to directly determine the road capacity based on a new concept. At first it makes acomprehensive analysis of distance headway, includ...By means of the relationship between speed and distance headway, this paperattempts to directly determine the road capacity based on a new concept. At first it makes acomprehensive analysis of distance headway, including safe distance headway and desired one. Theformer is decided by the demand for the degree of safety, and the latter depends on the motorists'behavior, i.e. the model of traffic flow. Both of them are functions of speed. According to thecharacteristics of their curves, we can find a crossing point that is the capacity of a roadsegment. This capacity represents the maximum flow rate meeting the minimum safety requirement.展开更多
This paper discusses some issues on human reliability model of time dependent human behavior. Some results of the crew reliability experiment on Tsinghua training simulator in China are given, Meanwhile, a case of ca...This paper discusses some issues on human reliability model of time dependent human behavior. Some results of the crew reliability experiment on Tsinghua training simulator in China are given, Meanwhile, a case of calculation for human error probability during anticipated transient without scram (ATWS) based on the data drew from the recent experiment is offered.展开更多
A new emergency evacuation car-following model (EECM) is proposed. The model aims to capture the main characteristics of traffic flow and driver behavior under an emergency evacuation, and it is developed on the bas...A new emergency evacuation car-following model (EECM) is proposed. The model aims to capture the main characteristics of traffic flow and driver behavior under an emergency evacuation, and it is developed on the basis of minimum safety distances with parts of the drivers' abnormal behavior in a panic emergency situation. A thorough questionnaire survey is undertaken among drivers of different ages. Based on the results from the survey, a safety-distance car-following model is formulated by taking into account two new parameters: a differential distributing coefficient and a driver' s experiential decision coefficient, which are used to reflect variations of driving behaviors under an emergency evacuation situation when compared with regular conditions. The formulation and derivation of the new model, as well as its properties and applicability are discussed. A case study is presented to compare the car-following trajectories using observed data under regular peak-hour traffic conditions and theoretical EECM results. The results indicate the consistency of the analysis of assumptions on the EECM and observations.展开更多
Background Hyperuricemia is frequently present in patients with heart failure. Many pathological conditions, such as tissue ischemia, renal function impairment, cardiac function impairment, metabolic syndrome, and inf...Background Hyperuricemia is frequently present in patients with heart failure. Many pathological conditions, such as tissue ischemia, renal function impairment, cardiac function impairment, metabolic syndrome, and inflammatory status, may impact uric acid (UA) metabolism. This study was to assess their potential relations to UA metabolism in heart failure. Methods We retrospectively assessed clinical charac- teristics, echocardiological, renal, metabolic and inflammatory variables selected on the basis of previous evidence of their involvement in cardiovascular diseases and UA metabolism in a large cohort of randomly selected adults with congestive heart failure (n = 553). By clustering of indices, those variables were explored using factor analysis. Results In factor analysis, serum uric acid (SUA) formed part of a principal cluster of renal functional variables which included serum creatinine (SCr) and blood urea nitrogen (BUN). Univariate correlation coefficients between variables of patients with congestive heart failure showed that the strongest correlations for SUA were with BUN (r = 0.48, P 〈 0.001) and SCr (r = 0.47, P 〈 0.001). Conclusions There was an inverse relationship between SUA levels and measures of renal function in patients with congestive heart failure. The strong correlation between SUA and SCr and BUN levels suggests that elevated SUA concentrations reflect an impairment of renal function in heart failure.展开更多
Due to the wide railway network and different characteristics of many earthquake zones in China,considering the running safety performance of trains(RSPT)in the design of high-speed railway bridge structures is very n...Due to the wide railway network and different characteristics of many earthquake zones in China,considering the running safety performance of trains(RSPT)in the design of high-speed railway bridge structures is very necessary.In this study,in order to provide the seismic design and evaluation measure of the bridge structure based on the RSPT,a calculation model of RSPT on bridge under earthquake was established,and the track surface response measure when the derailment coefficient reaches the limit value was calculated by referring to 15 commonly used ground motion(GM)intensity measures.Based on the coefficient of variation of the limit value obtained from multiple GM samples,the optimal measures were selected.Finally,the limit value of bridge seismic response based on RSPT with different train speeds and structural periods was determined.展开更多
Bridges crossing active faults are more likely to suffer serious damage or even collapse due to the wreck capabilities of near-fault pulses and surface ruptures under earthquakes.Taking a high-speed railway simply-sup...Bridges crossing active faults are more likely to suffer serious damage or even collapse due to the wreck capabilities of near-fault pulses and surface ruptures under earthquakes.Taking a high-speed railway simply-supported girder bridge with eight spans crossing an active strike-slip fault as the research object,a refined coupling dynamic model of the high-speed train-CRTS III slab ballastless track-bridge system was established based on ABAQUS.The rationality of the established model was thoroughly discussed.The horizontal ground motions in a fault rupture zone were simulated and transient dynamic analyses of the high-speed train-track-bridge coupling system under 3-dimensional seismic excitations were subsequently performed.The safe running speed limits of a high-speed train under different earthquake levels(frequent occurrence,design and rare occurrence)were assessed based on wheel-rail dynamic(lateral wheel-rail force,derailment coefficient and wheel-load reduction rate)and rail deformation(rail dislocation,parallel turning angle and turning angle)indicators.Parameter optimization was then investigated in terms of the rail fastener stiffness and isolation layer friction coefficient.Results of the wheel-rail dynamic indicators demonstrate the safe running speed limits for the high-speed train to be approximately 200 km/h and 80 km/h under frequent and design earthquakes,while the train is unable to run safely under rare earthquakes.In addition,the rail deformations under frequent,design and rare earthquakes meet the safe running requirements of the high-speed train for the speeds of 250,100 and 50 km/h,respectively.The speed limits determined for the wheel-rail dynamic indicators are lower due to the complex coupling effect of the train-track-bridge system under track irregularity.The running safety of the train was improved by increasing the fastener stiffness and isolation layer friction coefficient.At the rail fastener lateral stiffness of 60 kN/mm and isolation layer friction coefficients of 0.9 and 0.8,respectively,the safe running speed limits of the high-speed train increased to 250 km/h and 100 km/h under frequent and design earthquakes,respectively.展开更多
An integrated model is presented to schedule the container handling system. The objective is to improve the coop- eration between different types of equipments, and to increase the productivity of the terminal. The pr...An integrated model is presented to schedule the container handling system. The objective is to improve the coop- eration between different types of equipments, and to increase the productivity of the terminal. The problem is formulated as a Hybrid Flow Shop Scheduling problem with precedence constraint, setup times and blocking (HFSS-B). A tabu search algorithm is proposed to solve this problem. The quality and efficiency of the proposed algorithm is analyzed from the computational point of view.展开更多
To study the influence of rainfall on pavement skid-resistance performance and driving safety,the water film thickness(WFT)concept considering the longitudinal and transverse slopes of the pavement was utilized based ...To study the influence of rainfall on pavement skid-resistance performance and driving safety,the water film thickness(WFT)concept considering the longitudinal and transverse slopes of the pavement was utilized based on the total discharge formulation and turbulence theory of slope flow.Using experimental data measured using the British pendulum test under varying WFT levels,a model for calculating the skid resistance,namely the British pendulum number(BPN),was formulated and used to quantitatively evaluate the effects of rainfall intensity,transverse,and longitudinal slopes on the computed BPN.The study results reveal that skid resistance is linearly proportional to the pavement transverse slope and inversely proportional to the rainfall intensity and the pavement longitudinal slope.In particular,rainfall intensity,along with pavement texture depth,exhibited a significant impact on the tire-pavement friction and skid-resistance performance.The results further indicate that driving safety under wet weather is predominantly governed by skid resistance and visibility.The BPN and sideway force coefficient(SFC60)values for new asphalt pavements under different rainfall intensities are provided along with some modification to the stopping sight distance(SSD)criteria.Safe driving speed limits are also determined using a safe-driving model to develop the appropriate speed limit strategies.The overall study results provide some insights,methodology approach,and reference data for the evaluation of pavement skid-resistance performance and driving safety conditions under different pavement slopes and rainfall intensities.展开更多
Under high-level earthquakes,bridge piers and bearings are prone to be damaged and the elastoplastic state of bridge structural components is easily accessible in the train-track-bridge interaction(TTBI)system.Conside...Under high-level earthquakes,bridge piers and bearings are prone to be damaged and the elastoplastic state of bridge structural components is easily accessible in the train-track-bridge interaction(TTBI)system.Considering the complexity and structural non-linearity of the TTBI system under earthquakes,a single software is not adequate for the coupling analysis.Therefore,in this paper,an interactive method for the TTBI system is proposed by combining the multi-body dynamics software Simpack and the seismic simulation software OpenSees based on the Client-Server architecture,which takes full advantages of the powerful wheel-track contact analysis capabilities of Simpack and the sophisticated nonlinear analysis capabilities of OpenSees.Based on the proposed Simpack and OpenSees co-simulating train-track-bridge(SOTTB)method,a single-span bridge analysis under the earthquake was conducted and the accuracy of co-simulation method was verified by comparing it with results of the finite element model.Finally,the TTBI model is built utilizing the SOTTB method to further discuss the running safety of HST on multi-span simply supported bridges under earthquakes.The results show that the SOTTB method has the advantages of usability,high versatility and accuracy which can be further used to study the running safety of HST under earthquakes with high intensities.展开更多
AIM: To provide scientific evidence for prevention and controlling of cryptosporidiosis, the infection of Cryptosporidium parvum and its epidemiological characteristics were studied in some areas of Anhui Province. ME...AIM: To provide scientific evidence for prevention and controlling of cryptosporidiosis, the infection of Cryptosporidium parvum and its epidemiological characteristics were studied in some areas of Anhui Province. METHODS: The oocyst of Cryptosporidium parvum in 5421 fresh stool samples from eleven areas of Anhui Province was tested by auramine-phenol stain and improved anti-acid stain respectively. The specific antibody of IgG, IgM and T subsets of 41 patients with positive Cryptosporidium parvum in stools were detected by ELISA and biotin-streptavidin (BSA) respectively. RESULTS: The total infective rate of Cryptosporidium parvum was 1.33% (74/5421). Among them, the positive rates of oocyst in the areas of Huaibei (1.82%) and Fuyang (1.80%) were higher. The positive rates of oocyst in stools of infants, pupils, middle school students, college students, adults, patients with diarrhea, and those with immunodeficiency were 3.15%(28/889), 0.82% (9/1098), 0.82%(9/1092), 0.83%(8/969), 0.85% (9/1095), 2.88%(8/278) and 8.33%(3/36)% respectively. The positive rates of oocyst in infants and the patients with diarrhea and immunodeficiency were significantly higher than those in controls (P【0.01). The positive rate of oocyst in males was similar to that in females (P】0.05). The positive rate of oocyst in urban areas (1.13%) was significantly lower than those in rural areas (1.72%, P【0.01). The positive rates of specific IgG, IgM and IgG+IgM in sera of the patients with positive oocyst in stool were 63.4% (26/41), 17.1% (7/41), 19.5% (8/41) respectively. The number fractions of T subsets of CD(3)(+), CD(4)(+), CD(8)(+) and CD(4)(+)/CD(8)(+) of the patients were 0.66+/-0.07, 0.44+/-0.06, 0.28+/-0.04 and 1.58+/-0.32 respectively. The difference between the patients and the controls was significant (P【0.05). The main manifestations of the patients were subclinical infection, in forms of slight abdominal pain, mild diarrhea, and loose stool. CONCLUSION: There are two infection peaks in infection of Cryptosporidium parvum and its infection can be found more often in infants, patients with diarrhea or immunodeficiency, and in rural areas. Subclinical infection is the main manifestation and might be easily misdiagnosed. When the therapeutic effectiveness is low for diarrhea, the infection of Cryptosporidium parvum should be considered, concerning their age and immune function.展开更多
基金Projects(52022113,52278546)supported by the National Natural Science Foundation of ChinaProject(2020EEEVL0403)supported by the China Earthquake Administration。
文摘Sudden earthquakes pose a threat to the running safety of trains on high-speed railway bridges,and the stiffness of piers is one of the factors affecting the dynamic response of train-track-bridge system.In this paper,a experiment of a train running on a high-speed railway bridge is performed based on a dynamic experiment system,and the corresponding numerical model is established.The reliability of the numerical model is verified by experiments.Then,the experiment and numerical data are analyzed to reveal the pier height effects on the running safety of trains on bridges.The results show that when the pier height changes,the frequency of the bridge below the 30 m pier height changes greater;the increase of pier height causes the transverse fundamental frequency of the bridge close to that of the train,and the shaking angle and lateral displacement of the train are the largest for bridge with 50 m pier,which increases the risk of derailment;with the pier height increases from 8 m to 50 m,the derailment coefficient obtained by numerical simulations increases by 75% on average,and the spectral intensity obtained by experiments increases by 120% on average,two indicators exhibit logarithmic variation.
基金Project(2023YFB4302500)supported by the National Key R&D Program of ChinaProject(52078485)supported by the National Natural Science Foundation of ChinaProjects(2021-Major-16,2021-Special-08)supported by the Science and Technology Research and Development Program Project of China Railway Group Limited。
文摘Running safety assessment and tracking irregularity parametric sensitivity analysis of high-speed maglev train-bridge system are of great concern,especially need perfect refinement models in which all properties can be well characterized based on various stochastic excitations.A three-dimensional refined spatial random vibration analysis model of high-speed maglev train-bridge coupled system is established in this paper,in which multi-source uncertainty excitation can be considered simultaneously,and the probability density evolution method(PDEM)is adopted to reveal the system-specific uncertainty dynamic characteristic.The motion equation of the maglev vehicle model is composed of multi-rigid bodies with a total 210-degrees of freedom for each vehicle,and a refined electromagnetic force-air gap model is used to account for the interaction and coupling effect between the moving train and track beam bridges,which are directly established by using finite element method.The model is proven to be applicable by comparing with Monte Carlo simulation.By applying the proposed stochastic framework to the high maglev line,the random dynamic responses of maglev vehicles running on the bridges are studied for running safety and stability assessment.Moreover,the effects of track irregularity wavelength range under different amplitude and running speeds on the coupled system are investigated.The results show that the augmentation of train speed will move backward the sensitive wavelength interval,and track irregularity amplitude influences the response remarkably in the sensitive interval.
基金The National Key Technology R&D Program during the 11th Five-Year Plan Period(No.2009BAG13A05)the National Natural Science Foundation of China(No.51078086)
文摘Aiming at prevalent violations of non-motorists at urban intersections in China, this paper intends to clarify the characteristics and risks of non-motorist violations at signalized intersections through questionnaires and video recordings, which may serve as a basis for non-motorized vehicle management. It can help improve the traffic order and enhance the degree of safety at signalized intersections. To obtain the perception information, a questionaire survey on the Internet was conducted and 972 valid questionnaires were returned. It is found that academic degree contributes little to non-motorist violations, while electrical bicyclists have a relatively higher frequency of violations compared with bicyclists. The video data of 18 228 non-motorist behaviors indicate that the violation rate of all non-motorists is 26.5%; the number of conflicts reaches 1 938, among which violation conflicts account for 66.8%. The study shows that the violation rates and the violation behavior at three types of surveyed intersections are markedly different. It is also concluded that the conflict rates and the violation rates are positively correlated. Furthermore, signal violation, traveling in the wrong direction, and overspeeding to cross the intersection are the most dangerous among traffic violation behaviors.
基金Projects(5110417951374247)supported by the National Natural Science Foundation of China
文摘In order to effectively separate galena and jamesonite and improve the recovery during the mixing flotation, the interaction mechanisms between the minerals and the collector of diethyl dithiocarbamate (DDTC) were investigated. Single mineral flotation test was organized to research the effect of pulp pH value on the flotation behavior of galena and jamesonite. Electrochemistry property of the interaction of these two minerals with DDTC was investigated by cyclic voltammetry and Tafel tests. Flotation test shows that the recovery of jamesonite in high alkaline pulp is strongly depressed by lime (Ca(OH)2). The cyclic voltammetry and Tafel tests results show that the interaction between galena and DDTC is an electrochemical process. High pH value has little influence on the interaction between galena and DDTC, while it has great effect on jamesonite due to self-oxidation and specific adsorption of OH^- and CaOH^+ on jamesonite surface. Non-electroactive hydroxyl compound and low-electroconductive calcium compounds cover the surface of jamesonite, which impedes electron transfer and DDTC adsorption, thus leads to very low floatability of jamesonite.
文摘The low altitude airspace will be open in China, general aviation flights are tremendously increased. Whether aircrafts can fly safely and how to determine the requirements of safety flight are the problems needed to be confirmed. Under this circumstances, based on the international Civil Aviation Organization(ICAO) criteria and the standards made by CAAC, this paper adopts the "See and Avoid" principle. Under the binding conditions of flight rules, visibility requirements, responding time, the aircraft speed, circle banking angle or the climbing angle, based on its study on aircraft dynamics principles, this paper establishes a mathematical collision avoidance model for head-to-head traffic and crossing converging traffic at the same level. And the safety separation requirements of the aircrafts in low altitude flight are equantitatively analyzed. Finally, the Matlab software is used to analyze the above method. The result shows that the safe traffic avoidance of the converging traffic at the same level meets certain flight conditions, while intersecting the traffic at the same level can safely avoid the collision.
文摘By means of the relationship between speed and distance headway, this paperattempts to directly determine the road capacity based on a new concept. At first it makes acomprehensive analysis of distance headway, including safe distance headway and desired one. Theformer is decided by the demand for the degree of safety, and the latter depends on the motorists'behavior, i.e. the model of traffic flow. Both of them are functions of speed. According to thecharacteristics of their curves, we can find a crossing point that is the capacity of a roadsegment. This capacity represents the maximum flow rate meeting the minimum safety requirement.
文摘This paper discusses some issues on human reliability model of time dependent human behavior. Some results of the crew reliability experiment on Tsinghua training simulator in China are given, Meanwhile, a case of calculation for human error probability during anticipated transient without scram (ATWS) based on the data drew from the recent experiment is offered.
基金The National Key Technology R&D Program of China during the 10th Five-Year Plan Period(No.2005BA41B11)the National Natural Science Foundation of China(No.50578003)
文摘A new emergency evacuation car-following model (EECM) is proposed. The model aims to capture the main characteristics of traffic flow and driver behavior under an emergency evacuation, and it is developed on the basis of minimum safety distances with parts of the drivers' abnormal behavior in a panic emergency situation. A thorough questionnaire survey is undertaken among drivers of different ages. Based on the results from the survey, a safety-distance car-following model is formulated by taking into account two new parameters: a differential distributing coefficient and a driver' s experiential decision coefficient, which are used to reflect variations of driving behaviors under an emergency evacuation situation when compared with regular conditions. The formulation and derivation of the new model, as well as its properties and applicability are discussed. A case study is presented to compare the car-following trajectories using observed data under regular peak-hour traffic conditions and theoretical EECM results. The results indicate the consistency of the analysis of assumptions on the EECM and observations.
文摘Background Hyperuricemia is frequently present in patients with heart failure. Many pathological conditions, such as tissue ischemia, renal function impairment, cardiac function impairment, metabolic syndrome, and inflammatory status, may impact uric acid (UA) metabolism. This study was to assess their potential relations to UA metabolism in heart failure. Methods We retrospectively assessed clinical charac- teristics, echocardiological, renal, metabolic and inflammatory variables selected on the basis of previous evidence of their involvement in cardiovascular diseases and UA metabolism in a large cohort of randomly selected adults with congestive heart failure (n = 553). By clustering of indices, those variables were explored using factor analysis. Results In factor analysis, serum uric acid (SUA) formed part of a principal cluster of renal functional variables which included serum creatinine (SCr) and blood urea nitrogen (BUN). Univariate correlation coefficients between variables of patients with congestive heart failure showed that the strongest correlations for SUA were with BUN (r = 0.48, P 〈 0.001) and SCr (r = 0.47, P 〈 0.001). Conclusions There was an inverse relationship between SUA levels and measures of renal function in patients with congestive heart failure. The strong correlation between SUA and SCr and BUN levels suggests that elevated SUA concentrations reflect an impairment of renal function in heart failure.
基金Projects(U1934207,51778630,11972379)supported by the National Natural Science Foundation of ChinaProject(2020zzts148)supported by the Fundamental Research Funds for the Central Universities,ChinaProject(GJJ200657)supported the Research Project of Jiangxi Provincial Education Department,China。
文摘Due to the wide railway network and different characteristics of many earthquake zones in China,considering the running safety performance of trains(RSPT)in the design of high-speed railway bridge structures is very necessary.In this study,in order to provide the seismic design and evaluation measure of the bridge structure based on the RSPT,a calculation model of RSPT on bridge under earthquake was established,and the track surface response measure when the derailment coefficient reaches the limit value was calculated by referring to 15 commonly used ground motion(GM)intensity measures.Based on the coefficient of variation of the limit value obtained from multiple GM samples,the optimal measures were selected.Finally,the limit value of bridge seismic response based on RSPT with different train speeds and structural periods was determined.
基金Project(51378050) supported by the National Natural Science Foundation of ChinaProject(B13002) supported by the “111” Project,China+2 种基金Project (8192035) supported by the Beijing Municipal Natural Science Foundation,ChinaProject(P2019G002) supported by the Science and Technology Research and Development Program of China RailwayProject(2019YJ193) supported by the State Key Laboratory for Track Technology of High-speed Railway,China。
文摘Bridges crossing active faults are more likely to suffer serious damage or even collapse due to the wreck capabilities of near-fault pulses and surface ruptures under earthquakes.Taking a high-speed railway simply-supported girder bridge with eight spans crossing an active strike-slip fault as the research object,a refined coupling dynamic model of the high-speed train-CRTS III slab ballastless track-bridge system was established based on ABAQUS.The rationality of the established model was thoroughly discussed.The horizontal ground motions in a fault rupture zone were simulated and transient dynamic analyses of the high-speed train-track-bridge coupling system under 3-dimensional seismic excitations were subsequently performed.The safe running speed limits of a high-speed train under different earthquake levels(frequent occurrence,design and rare occurrence)were assessed based on wheel-rail dynamic(lateral wheel-rail force,derailment coefficient and wheel-load reduction rate)and rail deformation(rail dislocation,parallel turning angle and turning angle)indicators.Parameter optimization was then investigated in terms of the rail fastener stiffness and isolation layer friction coefficient.Results of the wheel-rail dynamic indicators demonstrate the safe running speed limits for the high-speed train to be approximately 200 km/h and 80 km/h under frequent and design earthquakes,while the train is unable to run safely under rare earthquakes.In addition,the rail deformations under frequent,design and rare earthquakes meet the safe running requirements of the high-speed train for the speeds of 250,100 and 50 km/h,respectively.The speed limits determined for the wheel-rail dynamic indicators are lower due to the complex coupling effect of the train-track-bridge system under track irregularity.The running safety of the train was improved by increasing the fastener stiffness and isolation layer friction coefficient.At the rail fastener lateral stiffness of 60 kN/mm and isolation layer friction coefficients of 0.9 and 0.8,respectively,the safe running speed limits of the high-speed train increased to 250 km/h and 100 km/h under frequent and design earthquakes,respectively.
文摘An integrated model is presented to schedule the container handling system. The objective is to improve the coop- eration between different types of equipments, and to increase the productivity of the terminal. The problem is formulated as a Hybrid Flow Shop Scheduling problem with precedence constraint, setup times and blocking (HFSS-B). A tabu search algorithm is proposed to solve this problem. The quality and efficiency of the proposed algorithm is analyzed from the computational point of view.
基金The National Natural Science Foundation of China(No.51478114)
文摘To study the influence of rainfall on pavement skid-resistance performance and driving safety,the water film thickness(WFT)concept considering the longitudinal and transverse slopes of the pavement was utilized based on the total discharge formulation and turbulence theory of slope flow.Using experimental data measured using the British pendulum test under varying WFT levels,a model for calculating the skid resistance,namely the British pendulum number(BPN),was formulated and used to quantitatively evaluate the effects of rainfall intensity,transverse,and longitudinal slopes on the computed BPN.The study results reveal that skid resistance is linearly proportional to the pavement transverse slope and inversely proportional to the rainfall intensity and the pavement longitudinal slope.In particular,rainfall intensity,along with pavement texture depth,exhibited a significant impact on the tire-pavement friction and skid-resistance performance.The results further indicate that driving safety under wet weather is predominantly governed by skid resistance and visibility.The BPN and sideway force coefficient(SFC60)values for new asphalt pavements under different rainfall intensities are provided along with some modification to the stopping sight distance(SSD)criteria.Safe driving speed limits are also determined using a safe-driving model to develop the appropriate speed limit strategies.The overall study results provide some insights,methodology approach,and reference data for the evaluation of pavement skid-resistance performance and driving safety conditions under different pavement slopes and rainfall intensities.
基金Project(2020EEEVL0403)supported by the China Earthquake AdministrationProjects(51878674,52022113)supported by the National Natural Science Foundation of ChinaProject(2022ZZTS0670)supported by the Fundamental Research Funds for the Central Universities,China。
文摘Under high-level earthquakes,bridge piers and bearings are prone to be damaged and the elastoplastic state of bridge structural components is easily accessible in the train-track-bridge interaction(TTBI)system.Considering the complexity and structural non-linearity of the TTBI system under earthquakes,a single software is not adequate for the coupling analysis.Therefore,in this paper,an interactive method for the TTBI system is proposed by combining the multi-body dynamics software Simpack and the seismic simulation software OpenSees based on the Client-Server architecture,which takes full advantages of the powerful wheel-track contact analysis capabilities of Simpack and the sophisticated nonlinear analysis capabilities of OpenSees.Based on the proposed Simpack and OpenSees co-simulating train-track-bridge(SOTTB)method,a single-span bridge analysis under the earthquake was conducted and the accuracy of co-simulation method was verified by comparing it with results of the finite element model.Finally,the TTBI model is built utilizing the SOTTB method to further discuss the running safety of HST on multi-span simply supported bridges under earthquakes.The results show that the SOTTB method has the advantages of usability,high versatility and accuracy which can be further used to study the running safety of HST under earthquakes with high intensities.
文摘AIM: To provide scientific evidence for prevention and controlling of cryptosporidiosis, the infection of Cryptosporidium parvum and its epidemiological characteristics were studied in some areas of Anhui Province. METHODS: The oocyst of Cryptosporidium parvum in 5421 fresh stool samples from eleven areas of Anhui Province was tested by auramine-phenol stain and improved anti-acid stain respectively. The specific antibody of IgG, IgM and T subsets of 41 patients with positive Cryptosporidium parvum in stools were detected by ELISA and biotin-streptavidin (BSA) respectively. RESULTS: The total infective rate of Cryptosporidium parvum was 1.33% (74/5421). Among them, the positive rates of oocyst in the areas of Huaibei (1.82%) and Fuyang (1.80%) were higher. The positive rates of oocyst in stools of infants, pupils, middle school students, college students, adults, patients with diarrhea, and those with immunodeficiency were 3.15%(28/889), 0.82% (9/1098), 0.82%(9/1092), 0.83%(8/969), 0.85% (9/1095), 2.88%(8/278) and 8.33%(3/36)% respectively. The positive rates of oocyst in infants and the patients with diarrhea and immunodeficiency were significantly higher than those in controls (P【0.01). The positive rate of oocyst in males was similar to that in females (P】0.05). The positive rate of oocyst in urban areas (1.13%) was significantly lower than those in rural areas (1.72%, P【0.01). The positive rates of specific IgG, IgM and IgG+IgM in sera of the patients with positive oocyst in stool were 63.4% (26/41), 17.1% (7/41), 19.5% (8/41) respectively. The number fractions of T subsets of CD(3)(+), CD(4)(+), CD(8)(+) and CD(4)(+)/CD(8)(+) of the patients were 0.66+/-0.07, 0.44+/-0.06, 0.28+/-0.04 and 1.58+/-0.32 respectively. The difference between the patients and the controls was significant (P【0.05). The main manifestations of the patients were subclinical infection, in forms of slight abdominal pain, mild diarrhea, and loose stool. CONCLUSION: There are two infection peaks in infection of Cryptosporidium parvum and its infection can be found more often in infants, patients with diarrhea or immunodeficiency, and in rural areas. Subclinical infection is the main manifestation and might be easily misdiagnosed. When the therapeutic effectiveness is low for diarrhea, the infection of Cryptosporidium parvum should be considered, concerning their age and immune function.