The paper addresses the formulation of rate equations, via objective time derivatives, within continuum physics. The concept of objectivity is reviewed and distinction is made with material frame-indifference whose me...The paper addresses the formulation of rate equations, via objective time derivatives, within continuum physics. The concept of objectivity is reviewed and distinction is made with material frame-indifference whose meaning is restricted to the invariance of the balance equations relative to Galilean frames. Objective time derivatives are defined to leave the tensor character of the appropriate field invariant within the set of Euclidean frames. Rate equations are required to involve objective time derivatives and to be consistent with the second law of thermodynamics. Here the general structure of objective time derivatives is established and the known derivatives of the physical literature are shown to be particular cases. Next, to fix ideas, a rate equation is considered for the model of heat conduction via a generalization of the Maxwell-Cattaneo equation with higher-order gradients as in the Guyer-Krumhansl equation. The thermodynamic restrictions are investigated and the expected effects, of the selected derivative of the heat flux, on the stress tensor are derived.展开更多
Fucoidan, a group of sulfated heteropolysaccharides, was extracted from Laminaria japonica, an important economic alga species in China. The anticoagulant activity of fucoidan and its derivatives (including sulfated, ...Fucoidan, a group of sulfated heteropolysaccharides, was extracted from Laminaria japonica, an important economic alga species in China. The anticoagulant activity of fucoidan and its derivatives (including sulfated, phosphorylated, and aminated fucoidan) was examined using in-vitro anticoagulant systems. The correlation between chemical variations within the fucoidan group and anticoagulant activity was determined. The in-vitro anticoagulant properties of fucoidan and its derivatives were determined by measuring activated partial thromboplastin time (APTT), prothrombin time (PT), and thrombin time (TT). The results indicate anticoagulant activity in all samples using APTT and TT assays; however, only the fucoidan derivatives affected the PT assay. Thus, the fucoidan derivatives were able to inhibit both intrinsic and extrinsic blood coagulants. Fucoidan (FPS) and its derivatives presented better anticoagulant activity than low molecular weight fucoidan (DFPS) and its derivatives, suggesting that molecular weight and proper conformation are contributing factors for anticoagulant activity of polysaccharides. Amino groups have a positive charge and can thus change the charge density of fucoidan. Accordingly, among the tested samples, aminated fucoidan (NF) was the most active reflecting the importance of charge density for anticoagulant activity. Available data obtained using in-vitro models suggest that the sulfate content, sulfate/total-sugar ratio, molecular weight, and the substituted group of fucoidan are important factors for anticoagulant activity but that the influence of sulfate, phosphate and amino groups on anticoagulant activity was different.展开更多
Pulsars are good clocks in the universe. One fundamental question is that why they are good clocks? This is related to the braking mechanism of pulsars. Nowadays pulsar timing is done with unprecedented accuracy. More...Pulsars are good clocks in the universe. One fundamental question is that why they are good clocks? This is related to the braking mechanism of pulsars. Nowadays pulsar timing is done with unprecedented accuracy. More pulsars have braking indices measured.The period derivative of intermittent pulsars and magnetars can vary by a factor of several. However, during pulsar studies, the magnetic dipole braking in vacuum is still often assumed. It is shown that the fundamental assumption of magnetic dipole braking(vacuum condition) does not exist and it is not consistent with the observations. The physical torque must consider the presence of the pulsar magnetosphere. Among various efforts, the wind braking model can explain many observations of pulsars and magnetars in a unified way. It is also consistent with the up-to-date observations. It is time for a paradigm shift in pulsar studies: from magnetic dipole braking to wind braking. As one alternative to the magnetospheric model, the fallback disk model is also discussed.展开更多
The properties of norfloxacin(NFX)and its 4?-N-acetyl derivative(ANFX)are investigated in different pH aqueous solutions and H2O-CH3CN mixed solutions,to determine the effects of pH and polarity on their ground and ex...The properties of norfloxacin(NFX)and its 4?-N-acetyl derivative(ANFX)are investigated in different pH aqueous solutions and H2O-CH3CN mixed solutions,to determine the effects of pH and polarity on their ground and excited states.The triplet states of NFX and ANFX are affected more by pH than by polarity.The pH dependence of the NFX and ANFX triplet states is likely due to the different quantum yields of different protonated forms.Steady-state fluorescence,time-resolved fluorescence,and laser flash photolysis experiments at different pH values provide clear evidence of the involvement of different intramolecular charge-transfer pathways in the singlet states of NFX and ANFX.The different electron-donating capacities of 1-N,1?-N,and 4?-N under different conditions determine the major pathway.展开更多
The cationic reagent 1-(3-aminopropyl)-3-butylimidazolium bromide(BAPI) was exploited for the derivatization of carboxyl groups on peptides.Nearly 100% derivatization efficiency was achieved with the synthetic peptide...The cationic reagent 1-(3-aminopropyl)-3-butylimidazolium bromide(BAPI) was exploited for the derivatization of carboxyl groups on peptides.Nearly 100% derivatization efficiency was achieved with the synthetic peptide RVYVHPI(RI-7).Furthermore,the peptide derivative was stable in a 0.1% TFA/water solution or a 0.1%(v/v) TFA/acetonitrile/water solution for at least one week.The effect of BAPI derivatization on the ionization of the peptide RI-7 was further investigated,and the detection sensitivity was improved >42-fold via matrix-assisted laser desorption/ionization time-of-flight mass spectrometry(MALDI-TOF MS),thus outperforming the commercial piperazine derivatization approach.Moreover,the charge states of the peptide were largely increased via BAPI derivatization by electrospray ionization(ESI) MS.The results indicate the potential merits of BAPI derivatization for high sensitivity peptide analysis by MS.展开更多
文摘The paper addresses the formulation of rate equations, via objective time derivatives, within continuum physics. The concept of objectivity is reviewed and distinction is made with material frame-indifference whose meaning is restricted to the invariance of the balance equations relative to Galilean frames. Objective time derivatives are defined to leave the tensor character of the appropriate field invariant within the set of Euclidean frames. Rate equations are required to involve objective time derivatives and to be consistent with the second law of thermodynamics. Here the general structure of objective time derivatives is established and the known derivatives of the physical literature are shown to be particular cases. Next, to fix ideas, a rate equation is considered for the model of heat conduction via a generalization of the Maxwell-Cattaneo equation with higher-order gradients as in the Guyer-Krumhansl equation. The thermodynamic restrictions are investigated and the expected effects, of the selected derivative of the heat flux, on the stress tensor are derived.
基金Supported by the Ocean Public Welfare Scientific Research Project, State Oceanic Administration of the People's Republic of China (No. 201005024)
文摘Fucoidan, a group of sulfated heteropolysaccharides, was extracted from Laminaria japonica, an important economic alga species in China. The anticoagulant activity of fucoidan and its derivatives (including sulfated, phosphorylated, and aminated fucoidan) was examined using in-vitro anticoagulant systems. The correlation between chemical variations within the fucoidan group and anticoagulant activity was determined. The in-vitro anticoagulant properties of fucoidan and its derivatives were determined by measuring activated partial thromboplastin time (APTT), prothrombin time (PT), and thrombin time (TT). The results indicate anticoagulant activity in all samples using APTT and TT assays; however, only the fucoidan derivatives affected the PT assay. Thus, the fucoidan derivatives were able to inhibit both intrinsic and extrinsic blood coagulants. Fucoidan (FPS) and its derivatives presented better anticoagulant activity than low molecular weight fucoidan (DFPS) and its derivatives, suggesting that molecular weight and proper conformation are contributing factors for anticoagulant activity of polysaccharides. Amino groups have a positive charge and can thus change the charge density of fucoidan. Accordingly, among the tested samples, aminated fucoidan (NF) was the most active reflecting the importance of charge density for anticoagulant activity. Available data obtained using in-vitro models suggest that the sulfate content, sulfate/total-sugar ratio, molecular weight, and the substituted group of fucoidan are important factors for anticoagulant activity but that the influence of sulfate, phosphate and amino groups on anticoagulant activity was different.
基金supported by the Xinjiang Bairen project,West Light Foundation of Chinese Academy of Sciences (Grant No. LHXZ201201)National Program on Key Basic Research Project (Grant No. 2015CB857100), Qing Cu Hui of Chinese Academy of Sciences
文摘Pulsars are good clocks in the universe. One fundamental question is that why they are good clocks? This is related to the braking mechanism of pulsars. Nowadays pulsar timing is done with unprecedented accuracy. More pulsars have braking indices measured.The period derivative of intermittent pulsars and magnetars can vary by a factor of several. However, during pulsar studies, the magnetic dipole braking in vacuum is still often assumed. It is shown that the fundamental assumption of magnetic dipole braking(vacuum condition) does not exist and it is not consistent with the observations. The physical torque must consider the presence of the pulsar magnetosphere. Among various efforts, the wind braking model can explain many observations of pulsars and magnetars in a unified way. It is also consistent with the up-to-date observations. It is time for a paradigm shift in pulsar studies: from magnetic dipole braking to wind braking. As one alternative to the magnetospheric model, the fallback disk model is also discussed.
基金supported by the National Natural Science Foundation of China(10675158)
文摘The properties of norfloxacin(NFX)and its 4?-N-acetyl derivative(ANFX)are investigated in different pH aqueous solutions and H2O-CH3CN mixed solutions,to determine the effects of pH and polarity on their ground and excited states.The triplet states of NFX and ANFX are affected more by pH than by polarity.The pH dependence of the NFX and ANFX triplet states is likely due to the different quantum yields of different protonated forms.Steady-state fluorescence,time-resolved fluorescence,and laser flash photolysis experiments at different pH values provide clear evidence of the involvement of different intramolecular charge-transfer pathways in the singlet states of NFX and ANFX.The different electron-donating capacities of 1-N,1?-N,and 4?-N under different conditions determine the major pathway.
基金supported by National Basic Research Program of China (2012CB910604)National Natural Science Foundation of China (21205027,21005079,20935004)+1 种基金Analytical Method Innovation Program of Ministry of Science and Technology of China (2010IM030500)Natural Science Foundation of Hebei Province (B2012201095)
文摘The cationic reagent 1-(3-aminopropyl)-3-butylimidazolium bromide(BAPI) was exploited for the derivatization of carboxyl groups on peptides.Nearly 100% derivatization efficiency was achieved with the synthetic peptide RVYVHPI(RI-7).Furthermore,the peptide derivative was stable in a 0.1% TFA/water solution or a 0.1%(v/v) TFA/acetonitrile/water solution for at least one week.The effect of BAPI derivatization on the ionization of the peptide RI-7 was further investigated,and the detection sensitivity was improved >42-fold via matrix-assisted laser desorption/ionization time-of-flight mass spectrometry(MALDI-TOF MS),thus outperforming the commercial piperazine derivatization approach.Moreover,the charge states of the peptide were largely increased via BAPI derivatization by electrospray ionization(ESI) MS.The results indicate the potential merits of BAPI derivatization for high sensitivity peptide analysis by MS.
