The ice cap Ulugh Muztagh in the central Kunlun Shan at the northern fringe of the Tibetan Plateau is a very isolated region with arid cold conditions. No observational, meteorological or glaciological ground truth da...The ice cap Ulugh Muztagh in the central Kunlun Shan at the northern fringe of the Tibetan Plateau is a very isolated region with arid cold conditions. No observational, meteorological or glaciological ground truth data is available. Using the Moderate-resolution Imaging Spectroradiometer(MODIS) Level 1 radiance Swath Data(MOD02QKM) with a spatial resolution of 250 m, transient snow lines during the months of July to September in 2001 to 2014 are derived. Results are used to calibrate the physical based Coupled Snowpack and Ice surface energy and Mass balance model(COSIMA). The model runs on a representative detail region of Ulugh Muztagh(UM) on a digital elevation model with the same spatial resolution as the MODIS bands. In the absence of field observations, the model is driven solely by dynamically downscaled global analysis data from the High Asia Refined analysis(HAR). We compare remote sensing derived and modelled mean regional transient snow line altitudes in the course of consecutive summer seasons in 2008 to 2010. The resulting snow line altitude(SLA) and annual equilibrium line altitude(ELA) proxy of both methods coincide very well in their interannual variability in accordance with interannual variability of climatic conditions. Since SLAs of both methods do notconsistently agree on a daily basis a usage of remote sensing derived SLAs for model calibration in the absence of field observation data is only limitedly feasible for daily analysis. ELA approximation using the highest SLA at the end of ablation period may not be applied to UM because the negative winter mass balance(MB) is not reflected in the summer SLA. The study reveals moderate negative MB for UM throughout the modelling period. The mean regional MB of UM accounts for-523±410 mm w.e. a-1 in the modelling period. Hence UM seems not to belong to the area of the ‘Karakorum anomaly' comprising a region of positive mass balances in recent years which has its centre presumably in the Western Kunlun Shan.展开更多
Photolysis rate (J1) and reaction rate constants (kl) for the biacetyl (butane-2,3-dione) were evaluated in aqueous phase using a continuous photolysis system with a conventional Xe-Hg arc lamp as a light source...Photolysis rate (J1) and reaction rate constants (kl) for the biacetyl (butane-2,3-dione) were evaluated in aqueous phase using a continuous photolysis system with a conventional Xe-Hg arc lamp as a light source. The OH radicals was generated by H2OE/UV process and biacetyl (CH3C(O)C(O)CH3) concentrations were monitored using 2,4-DNPH derivatization method. 2,3-butanedione molecule is widely present in the atmosphere, it have been detected in hydrometeors (fogs, rain, and clouds) and at a significant yield (up to 10μmolar). The measurements were performed at 294 K and with free pH values. Our results lead to the following obtained values: J1= 3×10^-4 S^-1 and k1 = (6.17±0.95)×10^8 M^-1·s^-1.The uncertainty listed above is ±15%.展开更多
The AFO (activating private forest owners to increase forest fuel supply) project was set up to discover the best tools for activating an important fraction of the 12 million PFOs (private forest owners) in Europe...The AFO (activating private forest owners to increase forest fuel supply) project was set up to discover the best tools for activating an important fraction of the 12 million PFOs (private forest owners) in Europe to supply wood fuel, especially to small and medium-sized heating plants. It aimed to increase the utilization of Europe's vast forest fuel reserves. This was expected to benefit both the economy of the forest owners and rural areas and increase the use of renewable energy sources. The project was carried out between 2009 and 2012. The project operated in selected target regions that have a high proportion of private forest ownership (France, Slovenia, Latvia and the UK). It started by analyzing the potential wood fuel supply and use in relation to current regional markets. After assessing through inquiries the potential wood fuel supply and demand and the parties involved, the next step was to initiate and support the formation of wood fuel supply clusters and organize supply chains. This was followed by the dissemination of best practice examples from Austria and Finland--countries with the most expertise and long traditions of forest fuel production. In the last phase of the project, results and approved activation methods were disseminated to all 27 EU (European Union) countries.展开更多
Let SH be a sub-fractional Brownian motion with index 0 〈 H 〈 1/2. In this paper we study the existence of the generalized quadratic eovariation [f(SH), SH](W) defined by[f(SH),SH]t(W)=lim ε↓0 1/ ε2H ∫t...Let SH be a sub-fractional Brownian motion with index 0 〈 H 〈 1/2. In this paper we study the existence of the generalized quadratic eovariation [f(SH), SH](W) defined by[f(SH),SH]t(W)=lim ε↓0 1/ ε2H ∫t 0 {f(SH s+ε)-f(SH s+ε)-f(SH s)}(SH s+ε -SH s)ds2H, provided the limit exists in probability, where x → f(x) is a measurable function. We construct a Banach space X of measurable functions such that the generalized quadratic covariation exists in L2 provided f ∈ X. Moreover, the generalized Bouleau-Yor identity takes the form -∫R f(x) H(dx,t)=(2-2 2H-1)[f(SH ),SH]t(w) for all f ∈ where H (X, t) is the weighted local time of SH. This allows us to write the generalized ItS's formula for absolutely continuous functions with derivative belonging to .展开更多
Gene therapy targeted to vascular cells repre- sents a promising approach for prevention and treatment of pathological conditions such as intimal hyperplasia, in-stent and post-angioplasty restenosis. In this context,...Gene therapy targeted to vascular cells repre- sents a promising approach for prevention and treatment of pathological conditions such as intimal hyperplasia, in-stent and post-angioplasty restenosis. In this context, polymeric non-viral gene delivery systems are a safe alternative to viral vectors but a further improvement in efficiency and cytocom- patibility is needed to improve their clinical success. Herein, a library of 24 branched polyethylenimine (bPEI) derivatives modified with hydrophobic moieties was synthesised, char- acterised and tested in vitro on primary vascular cells, aim- ing to identify delivery agents with superior transfection effi- ciency and low cytotoxicity. Low molecular weight PEIs (0.6, 1.2 and 2 kDa) were grafted with long (C18) and short (C3) aliphatic chains, featuring different unsaturation degrees and degrees of substitution. 0.6 kDa bPEI-based derivatives were generally ineffective in transfection on vascular smooth mus- cle cells (VSMCs), while among the other derivatives some promising vectors were identified. Forcing polyplexes on the cell surface by means of centrifugation invariably boosted transfection levels but increased cytotoxicity as well. Of note, a propionyl-snbstituted derivative (PEI2-PrA1, C3:0) was the most effective on both VSMCs and endothelial cells (ECs), with higher and more sustained gene expression in combi- nation with markedly lower cytotoxicity with respect to the gold standard 25 kDa bPEI. In addition, a linoleoyl-substi- tuted derivative (PEI1.2-LA6, C18:2) owing to its high effi- ciency in VSMCs and relative inefficacy in ECs, combined with tolerable cytotoxicity was proposed as a vector for spe- cific VSMCs targeting.展开更多
We assembled a ternary blend bulk heterojunction polymer solar cell(PSCs) containing P3HT(donor) and PC61BM(acceptor) incorporated with a small molecule oligomer, dihexyl-quaterthiophene(DH4T) as a third component. By...We assembled a ternary blend bulk heterojunction polymer solar cell(PSCs) containing P3HT(donor) and PC61BM(acceptor) incorporated with a small molecule oligomer, dihexyl-quaterthiophene(DH4T) as a third component. By optimizing the contents of DH4 T, we increased the power conversion efficiency of ternary P3HT:DH4T:PC61BM PSCs to 4.17% from 3.44% of binary P3HT:PC61BM PSCs under AM 1.5 G of 100 m W/cm2 intensity. The major improvement is from the increase of the short circuit current and fill factor that is due to the increased light absorption at short wavelength, the balanced charge carrier transportation and the enhanced hole evacuation by a DH4T-enriched layer at the anode interface. In this work, we demonstrated that the efficiency of the PSCs can be enhanced by using low-bandgap conjugated polymer and its oligomer as donors and fullerene derivatives as acceptors.展开更多
基金supported by the German Research Foundation(DFG)Priority Programme 1372,‘Tibetan Plateau:Formation Climate Ecosystems’through the DynRG-TiP(‘Dynamic Response of Glaciers on the Tibetan Plateau to Climate Change’)project under codes SCHN 680/3-3 and SCHE 750/4-3the German Federal Ministry of Education and Research(BMBF)Central Asia Monsoon Dynamics and GeoEcosystems(CAME)program,through the WET project(‘Variability and Trends in Water Balance Components of Benchmark Drainage Basins on the Tibetan Plateau’)under code 03G0804A
文摘The ice cap Ulugh Muztagh in the central Kunlun Shan at the northern fringe of the Tibetan Plateau is a very isolated region with arid cold conditions. No observational, meteorological or glaciological ground truth data is available. Using the Moderate-resolution Imaging Spectroradiometer(MODIS) Level 1 radiance Swath Data(MOD02QKM) with a spatial resolution of 250 m, transient snow lines during the months of July to September in 2001 to 2014 are derived. Results are used to calibrate the physical based Coupled Snowpack and Ice surface energy and Mass balance model(COSIMA). The model runs on a representative detail region of Ulugh Muztagh(UM) on a digital elevation model with the same spatial resolution as the MODIS bands. In the absence of field observations, the model is driven solely by dynamically downscaled global analysis data from the High Asia Refined analysis(HAR). We compare remote sensing derived and modelled mean regional transient snow line altitudes in the course of consecutive summer seasons in 2008 to 2010. The resulting snow line altitude(SLA) and annual equilibrium line altitude(ELA) proxy of both methods coincide very well in their interannual variability in accordance with interannual variability of climatic conditions. Since SLAs of both methods do notconsistently agree on a daily basis a usage of remote sensing derived SLAs for model calibration in the absence of field observation data is only limitedly feasible for daily analysis. ELA approximation using the highest SLA at the end of ablation period may not be applied to UM because the negative winter mass balance(MB) is not reflected in the summer SLA. The study reveals moderate negative MB for UM throughout the modelling period. The mean regional MB of UM accounts for-523±410 mm w.e. a-1 in the modelling period. Hence UM seems not to belong to the area of the ‘Karakorum anomaly' comprising a region of positive mass balances in recent years which has its centre presumably in the Western Kunlun Shan.
文摘Photolysis rate (J1) and reaction rate constants (kl) for the biacetyl (butane-2,3-dione) were evaluated in aqueous phase using a continuous photolysis system with a conventional Xe-Hg arc lamp as a light source. The OH radicals was generated by H2OE/UV process and biacetyl (CH3C(O)C(O)CH3) concentrations were monitored using 2,4-DNPH derivatization method. 2,3-butanedione molecule is widely present in the atmosphere, it have been detected in hydrometeors (fogs, rain, and clouds) and at a significant yield (up to 10μmolar). The measurements were performed at 294 K and with free pH values. Our results lead to the following obtained values: J1= 3×10^-4 S^-1 and k1 = (6.17±0.95)×10^8 M^-1·s^-1.The uncertainty listed above is ±15%.
文摘The AFO (activating private forest owners to increase forest fuel supply) project was set up to discover the best tools for activating an important fraction of the 12 million PFOs (private forest owners) in Europe to supply wood fuel, especially to small and medium-sized heating plants. It aimed to increase the utilization of Europe's vast forest fuel reserves. This was expected to benefit both the economy of the forest owners and rural areas and increase the use of renewable energy sources. The project was carried out between 2009 and 2012. The project operated in selected target regions that have a high proportion of private forest ownership (France, Slovenia, Latvia and the UK). It started by analyzing the potential wood fuel supply and use in relation to current regional markets. After assessing through inquiries the potential wood fuel supply and demand and the parties involved, the next step was to initiate and support the formation of wood fuel supply clusters and organize supply chains. This was followed by the dissemination of best practice examples from Austria and Finland--countries with the most expertise and long traditions of forest fuel production. In the last phase of the project, results and approved activation methods were disseminated to all 27 EU (European Union) countries.
基金supported by National Natural Science Foundation of China(Grant No.11171062)Innovation Program of Shanghai Municipal Education Commission(Grant No.12ZZ063)
文摘Let SH be a sub-fractional Brownian motion with index 0 〈 H 〈 1/2. In this paper we study the existence of the generalized quadratic eovariation [f(SH), SH](W) defined by[f(SH),SH]t(W)=lim ε↓0 1/ ε2H ∫t 0 {f(SH s+ε)-f(SH s+ε)-f(SH s)}(SH s+ε -SH s)ds2H, provided the limit exists in probability, where x → f(x) is a measurable function. We construct a Banach space X of measurable functions such that the generalized quadratic covariation exists in L2 provided f ∈ X. Moreover, the generalized Bouleau-Yor identity takes the form -∫R f(x) H(dx,t)=(2-2 2H-1)[f(SH ),SH]t(w) for all f ∈ where H (X, t) is the weighted local time of SH. This allows us to write the generalized ItS's formula for absolutely continuous functions with derivative belonging to .
基金financially supported by the Natural Science and Engineering Research Council of Canada, (Discovery Grant to UludagH and Mantovani D)the Canadian Institute for Health Research (Operating grant to Uludag H)the Fonds de Recherche du Quebec sur les Natures et Technologies (Bilateral Grant to Mantovani D)
文摘Gene therapy targeted to vascular cells repre- sents a promising approach for prevention and treatment of pathological conditions such as intimal hyperplasia, in-stent and post-angioplasty restenosis. In this context, polymeric non-viral gene delivery systems are a safe alternative to viral vectors but a further improvement in efficiency and cytocom- patibility is needed to improve their clinical success. Herein, a library of 24 branched polyethylenimine (bPEI) derivatives modified with hydrophobic moieties was synthesised, char- acterised and tested in vitro on primary vascular cells, aim- ing to identify delivery agents with superior transfection effi- ciency and low cytotoxicity. Low molecular weight PEIs (0.6, 1.2 and 2 kDa) were grafted with long (C18) and short (C3) aliphatic chains, featuring different unsaturation degrees and degrees of substitution. 0.6 kDa bPEI-based derivatives were generally ineffective in transfection on vascular smooth mus- cle cells (VSMCs), while among the other derivatives some promising vectors were identified. Forcing polyplexes on the cell surface by means of centrifugation invariably boosted transfection levels but increased cytotoxicity as well. Of note, a propionyl-snbstituted derivative (PEI2-PrA1, C3:0) was the most effective on both VSMCs and endothelial cells (ECs), with higher and more sustained gene expression in combi- nation with markedly lower cytotoxicity with respect to the gold standard 25 kDa bPEI. In addition, a linoleoyl-substi- tuted derivative (PEI1.2-LA6, C18:2) owing to its high effi- ciency in VSMCs and relative inefficacy in ECs, combined with tolerable cytotoxicity was proposed as a vector for spe- cific VSMCs targeting.
基金financially supported by the National Natural Science Foundation of China(21374120)support by 100 Talents Program of the Chinese Academy of Sciences
文摘We assembled a ternary blend bulk heterojunction polymer solar cell(PSCs) containing P3HT(donor) and PC61BM(acceptor) incorporated with a small molecule oligomer, dihexyl-quaterthiophene(DH4T) as a third component. By optimizing the contents of DH4 T, we increased the power conversion efficiency of ternary P3HT:DH4T:PC61BM PSCs to 4.17% from 3.44% of binary P3HT:PC61BM PSCs under AM 1.5 G of 100 m W/cm2 intensity. The major improvement is from the increase of the short circuit current and fill factor that is due to the increased light absorption at short wavelength, the balanced charge carrier transportation and the enhanced hole evacuation by a DH4T-enriched layer at the anode interface. In this work, we demonstrated that the efficiency of the PSCs can be enhanced by using low-bandgap conjugated polymer and its oligomer as donors and fullerene derivatives as acceptors.