The molecular mechanism of how hepatocytes maintain cholesterol homeostasis has become much more transparent with the discovery of sterol regulatory element binding proteins (SREBPs) in recent years. These membrane pr...The molecular mechanism of how hepatocytes maintain cholesterol homeostasis has become much more transparent with the discovery of sterol regulatory element binding proteins (SREBPs) in recent years. These membrane proteins aremembers of the basic helix-loop-helix-leucine zipper (bHLHZip) family of transcription factors. They activate the expression of at least 30 genes involved in the synthesis of cholesterol and lipids. SREBPs are synthesized as precursor proteins in the endoplasmic reticulum (ER), where they form a complex with another protein, SREBP cleavage activating protein (SCAP). The SCAP molecule contains a sterol sensory domain. In the presence of high cellular sterol concentrations SCAP confines SREBP to the ER. With low cellular concentrations, SCAP escorts SREBP to activation in the Golgi. There, SREBP undergoes two proteolytic cleavage steps to release the mature, biologically active transcription factor, nuclear SREBP (nSREBP). nSREBP translocates to the nucleus and binds to sterol response elements (SRE) in the promoter/enhancer regions of target genes. Additional transcription factors are required to activate transcription of these genes. Three different SREBPs are known, SREBPs-1a, -1c and -2. SREBP-1a and -1c are isoforms produced from a single gene by alternate splicing. SREBP-2 is encoded by a different gene and does not display any isoforms. It appears that SREBPs alone, in the sequence described above, can exert complete control over cholesterol synthesis, whereas many additional factors (hormones, cytokines, etc.) are required for complete control of lipid metabolism. Medicinal manipulation of the SREBP/SCAP system is expected to prove highly beneficial in the management of cholesterol-related disease.展开更多
Naturally occurring plants in agroecosystem evidently play an important role in ecosystem stability. Field studies on the ecological effects of native plants conserved in orchard and their resistance to adverse climat...Naturally occurring plants in agroecosystem evidently play an important role in ecosystem stability. Field studies on the ecological effects of native plants conserved in orchard and their resistance to adverse climatic stress, and soil erosion were conducted from 1998 to 2001 in a newly developed Changshan-huyou (Citrus changshan-huyou Y.B. Chang) orchard. The experimental area covered 150 ha in typical red soil hilly region in southeastern China. The experimental design was a randomized complete block with six combinations of twelve plant species with four replications. All species used were native in the orchard. Plots were 15×8m^2 and separated by 2m buffer strips. Precipitation, soil erosion in rainstorm days and aboveground biomass of plant community when rainstorm days ended, soil temperature and moisture under various plant covers during seasonal megathermal drought period, antiscourability of soil with different root density under various simulated rainfalls were measured. Plant cover significantly decreased the daily highest and mean soil temperature and its daily variation in hot-drought season, but there was no significant difference of the alleviation among various plant covers. Plant covers significantly increased the soil moisture in seasonal megathermal drought period. Better moisture maintenance and soil erosion reduction was found when the plant species numbers in cover plant communities increased from one to eight. Higher root density in plant communities with higher species richness increased significantly the antiscourability of the soil. It was suggested that conserving plant communities with diversified native species could produce the best positive ecological effects on citrus orchard ecosystem stability.展开更多
There are two states for the coal-mass on the goal-side which is in stress equilibrium： the state of limit equilibrium （the bearing stress in the coal-mass equals its ultimate bearing stress） and the state of non- ...There are two states for the coal-mass on the goal-side which is in stress equilibrium： the state of limit equilibrium （the bearing stress in the coal-mass equals its ultimate bearing stress） and the state of non- ultimate equilibrium （the bearing stress in the coal-mass is less than its ultimate bearing stress）. To ana- lyze the bearing characteristics of a coal pillar in the state of limit equilibrium and guide the design of pillar width, we established a mechanical analytical model of the non-ultimate equilibrium zone in the coal-mass on the goal-side combined with the limit equilibrium theory as well as adopting the methods of theory analysis and mechanical analysis based on the assumption of a state of non-ultimate equilibrium. The width correction coeffident of the limit equilibrium zone has been given. The influence of mining depth, stress concentration coefficient of the surrounding rock, the non-limit strength of the coal-mass and stability of the coal rock interface has been studied. On this basis, we have confirmed that when the width ofa longwall mining face roadway protection coal pillar is between 11.6 m and 13.16 m in No. 4 coal seam of Xinrui coal mine in Lvliang in Shanxi province the elastic core region in the coal pillar can be assured and the roadway will be located in the area of lower stress which is outside the peak stress. So the revised width of the limit eauilibrium zone is more oractical.展开更多
From the 1960s, the increasingly serious ecological crisis gave rise to ecocriticism. William Wordsworth （1770-1850）, a representative of romantic poets, composes substantial poems to eulogize nature and to encourag...From the 1960s, the increasingly serious ecological crisis gave rise to ecocriticism. William Wordsworth （1770-1850）, a representative of romantic poets, composes substantial poems to eulogize nature and to encourage equality and harmony between nature and human beings. From the angle of deep ecology, a branch of ecological study, this paper aims to analyze the ecological consciousness conveyed in Wordsworth＇s poetry. It analyzes the adverse impacts of industrialization on nature and man in Wordsworth＇s poetry. It elaborates further on ecological thoughts in Wordsworth＇s poetry. And finally, it summarizes how Wordsworth criticizes industrialization in his poetry and how he expresses his ecological thoughts--ecological equilibrium, social equality and harmony, and nature preservation展开更多
CDM will reduce the global GHG emissions with lower costs while promoting sustainable development of the developing countries.However,the lack of distribution equilibrium has been a problem not solved for a long time....CDM will reduce the global GHG emissions with lower costs while promoting sustainable development of the developing countries.However,the lack of distribution equilibrium has been a problem not solved for a long time.In order to increase CDM distribution equilibrium in China,CDM support requirement extent of different areas is analyzed based on the study on the economic development and sustainable development capability.At the same time,registered and issued projects are analyzed to have an assessment on the CDM distribution equilibrium in China.Based on the study,it is concluded that there is a lack of CDM distribution equilibrium in China as most of CDM support has gone to the relatively more developed areas.Based on the reason analysis from the sector development,CDM market and information circulation aspects,suggestions are given to support CDM development in western areas by the"sector development guidance+CDM capability construction+market support"mode in this paper.展开更多
The purpose of the paper is to develop a solution for application of PV （photovoltaic） generators in MV （medium voltage） distribution system without unacceptable voltage changes due to drops of PV power output. Th...The purpose of the paper is to develop a solution for application of PV （photovoltaic） generators in MV （medium voltage） distribution system without unacceptable voltage changes due to drops of PV power output. The proposed solution includes operation of PV with predetermined leading power factor and addition of a capacitor bank in parallel to PV plant in order to compensate the reactive power absorbed by the PV inverters. The analytical expression of required power factor angle is derived. Adding a capacitor bank in parallel to PV power plant may pose a problem because of space limitations. The dimensions and cost of small MV capacitor banks depend significantly on the capacitor bank protection against internal faults. Application of the developed negative-sequence current difference method for the unbalance protection of the capacitor banks enables to achieve a compact and cost-reduced design of the banks connected in parallel to PV power plants. A real-world example of operation of the PV plant in parallel to the capacitor bank with the novel protection scheme is described.展开更多
文摘The molecular mechanism of how hepatocytes maintain cholesterol homeostasis has become much more transparent with the discovery of sterol regulatory element binding proteins (SREBPs) in recent years. These membrane proteins aremembers of the basic helix-loop-helix-leucine zipper (bHLHZip) family of transcription factors. They activate the expression of at least 30 genes involved in the synthesis of cholesterol and lipids. SREBPs are synthesized as precursor proteins in the endoplasmic reticulum (ER), where they form a complex with another protein, SREBP cleavage activating protein (SCAP). The SCAP molecule contains a sterol sensory domain. In the presence of high cellular sterol concentrations SCAP confines SREBP to the ER. With low cellular concentrations, SCAP escorts SREBP to activation in the Golgi. There, SREBP undergoes two proteolytic cleavage steps to release the mature, biologically active transcription factor, nuclear SREBP (nSREBP). nSREBP translocates to the nucleus and binds to sterol response elements (SRE) in the promoter/enhancer regions of target genes. Additional transcription factors are required to activate transcription of these genes. Three different SREBPs are known, SREBPs-1a, -1c and -2. SREBP-1a and -1c are isoforms produced from a single gene by alternate splicing. SREBP-2 is encoded by a different gene and does not display any isoforms. It appears that SREBPs alone, in the sequence described above, can exert complete control over cholesterol synthesis, whereas many additional factors (hormones, cytokines, etc.) are required for complete control of lipid metabolism. Medicinal manipulation of the SREBP/SCAP system is expected to prove highly beneficial in the management of cholesterol-related disease.
基金Projects (Nos. 30228005, 39870143 and 30030030) supported by the National Natural Science Foundation of China Author for correspondence
文摘Naturally occurring plants in agroecosystem evidently play an important role in ecosystem stability. Field studies on the ecological effects of native plants conserved in orchard and their resistance to adverse climatic stress, and soil erosion were conducted from 1998 to 2001 in a newly developed Changshan-huyou (Citrus changshan-huyou Y.B. Chang) orchard. The experimental area covered 150 ha in typical red soil hilly region in southeastern China. The experimental design was a randomized complete block with six combinations of twelve plant species with four replications. All species used were native in the orchard. Plots were 15×8m^2 and separated by 2m buffer strips. Precipitation, soil erosion in rainstorm days and aboveground biomass of plant community when rainstorm days ended, soil temperature and moisture under various plant covers during seasonal megathermal drought period, antiscourability of soil with different root density under various simulated rainfalls were measured. Plant cover significantly decreased the daily highest and mean soil temperature and its daily variation in hot-drought season, but there was no significant difference of the alleviation among various plant covers. Plant covers significantly increased the soil moisture in seasonal megathermal drought period. Better moisture maintenance and soil erosion reduction was found when the plant species numbers in cover plant communities increased from one to eight. Higher root density in plant communities with higher species richness increased significantly the antiscourability of the soil. It was suggested that conserving plant communities with diversified native species could produce the best positive ecological effects on citrus orchard ecosystem stability.
基金supported by the National Programs for Fundamental Research and Development (No. 2013CB227900)the National Natural Science Foundation of China (Nos. 51204166, 51174195 and 51474209)the Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
文摘There are two states for the coal-mass on the goal-side which is in stress equilibrium： the state of limit equilibrium （the bearing stress in the coal-mass equals its ultimate bearing stress） and the state of non- ultimate equilibrium （the bearing stress in the coal-mass is less than its ultimate bearing stress）. To ana- lyze the bearing characteristics of a coal pillar in the state of limit equilibrium and guide the design of pillar width, we established a mechanical analytical model of the non-ultimate equilibrium zone in the coal-mass on the goal-side combined with the limit equilibrium theory as well as adopting the methods of theory analysis and mechanical analysis based on the assumption of a state of non-ultimate equilibrium. The width correction coeffident of the limit equilibrium zone has been given. The influence of mining depth, stress concentration coefficient of the surrounding rock, the non-limit strength of the coal-mass and stability of the coal rock interface has been studied. On this basis, we have confirmed that when the width ofa longwall mining face roadway protection coal pillar is between 11.6 m and 13.16 m in No. 4 coal seam of Xinrui coal mine in Lvliang in Shanxi province the elastic core region in the coal pillar can be assured and the roadway will be located in the area of lower stress which is outside the peak stress. So the revised width of the limit eauilibrium zone is more oractical.
文摘From the 1960s, the increasingly serious ecological crisis gave rise to ecocriticism. William Wordsworth （1770-1850）, a representative of romantic poets, composes substantial poems to eulogize nature and to encourage equality and harmony between nature and human beings. From the angle of deep ecology, a branch of ecological study, this paper aims to analyze the ecological consciousness conveyed in Wordsworth＇s poetry. It analyzes the adverse impacts of industrialization on nature and man in Wordsworth＇s poetry. It elaborates further on ecological thoughts in Wordsworth＇s poetry. And finally, it summarizes how Wordsworth criticizes industrialization in his poetry and how he expresses his ecological thoughts--ecological equilibrium, social equality and harmony, and nature preservation
基金supported by National Key Project of Scientific and Technical Supporting Programs Funded by Ministry of Science and Technology of China in the 11th Five-Year Plan (Grant No. 2007BAC03A04)
文摘CDM will reduce the global GHG emissions with lower costs while promoting sustainable development of the developing countries.However,the lack of distribution equilibrium has been a problem not solved for a long time.In order to increase CDM distribution equilibrium in China,CDM support requirement extent of different areas is analyzed based on the study on the economic development and sustainable development capability.At the same time,registered and issued projects are analyzed to have an assessment on the CDM distribution equilibrium in China.Based on the study,it is concluded that there is a lack of CDM distribution equilibrium in China as most of CDM support has gone to the relatively more developed areas.Based on the reason analysis from the sector development,CDM market and information circulation aspects,suggestions are given to support CDM development in western areas by the"sector development guidance+CDM capability construction+market support"mode in this paper.
文摘The purpose of the paper is to develop a solution for application of PV （photovoltaic） generators in MV （medium voltage） distribution system without unacceptable voltage changes due to drops of PV power output. The proposed solution includes operation of PV with predetermined leading power factor and addition of a capacitor bank in parallel to PV plant in order to compensate the reactive power absorbed by the PV inverters. The analytical expression of required power factor angle is derived. Adding a capacitor bank in parallel to PV power plant may pose a problem because of space limitations. The dimensions and cost of small MV capacitor banks depend significantly on the capacitor bank protection against internal faults. Application of the developed negative-sequence current difference method for the unbalance protection of the capacitor banks enables to achieve a compact and cost-reduced design of the banks connected in parallel to PV power plants. A real-world example of operation of the PV plant in parallel to the capacitor bank with the novel protection scheme is described.
