The stability of Candida rugosa lipase coated with glutamic acid didodecyl ester ribitol amide was investigated taking esterification of lauryl alcohol and lauric acid in isooctane as a model reaction. At 30C, the hal...The stability of Candida rugosa lipase coated with glutamic acid didodecyl ester ribitol amide was investigated taking esterification of lauryl alcohol and lauric acid in isooctane as a model reaction. At 30C, the half-life of the activity of the coated lipase was ca 10 h, the enzyme activity became less changed after 12 h and the residual activity was 39% of the initial value. The coated lipase obeyed a first-order deactivation model with a deactivation energy of 29.9J.mol-1.展开更多
Effects of four coating formulations on maize production were studied.The results showed that all coating formulations had some effects on improving maize seedlings,strengthening the resistance againt diseases and pes...Effects of four coating formulations on maize production were studied.The results showed that all coating formulations had some effects on improving maize seedlings,strengthening the resistance againt diseases and pests and increasing the yields in different degrees,especially Paxil which increased the corn yield by 12.0%,significantly higher than the control.展开更多
Aloe vera is being identified as a potential medicinal plant for its application in industries as well as traditional usage. The gel obtained from the leaves of A. vera has numerous properties. In this study, using th...Aloe vera is being identified as a potential medicinal plant for its application in industries as well as traditional usage. The gel obtained from the leaves of A. vera has numerous properties. In this study, using the gel to extend the shelf life of Ampalavi mango fruits was studied. Even sized, uniform coloured, matured Ampalavi cultivar mango fruits were surface cleaned and coated with 33%, 66% and 100% gel, respectively. Results revealed that the ripening was delayed due to the coating. The total soluble solid （TSS）, pH and weight loss were high in uncoated fruits. The mean pH of the pulp from fruits kept as control was 4.94 at 4 d fruit preservation period （FPP） and was slightly increased to 5.43 within 12 d FPP, whereas the minimal pH （4.69 at 4 d FPP and 5.03 at 9 d FPP） was noticed in 100% gel coated fruits. The TSS （brix） was significantly in higher levels （13.67°Bx within 4 d FPP and 20.77°Bx within 12 d FPP） in control fruits, whereas the minimum TSS value was 9.27°Bx and 18.03° Bx within 4 d and 12 d FPP, respectively, recorded from the 100% gel coated fruits in storage. The weight loss percentage （WLP） was significantly （P 〈 0.05） higher in control fruits （8.46%）, whereas the lower WLP （1.13%） was found in 100% gel coated fruits after 12 d of storage. This low-scale gel coating technique prolonged the fruits shelf life by delaying the fruit ripening. This effect has to be further investigated to commercialize the natural product for large scale ready-made application.展开更多
Solid dispersion of fenofibrate （FNB）, a poorly water-soluble drug, was prepared by a fluid-bed coating technique with PEG 6000 as the carrier. The physical state was characterized by DSC and X-ray powder diffractom...Solid dispersion of fenofibrate （FNB）, a poorly water-soluble drug, was prepared by a fluid-bed coating technique with PEG 6000 as the carrier. The physical state was characterized by DSC and X-ray powder diffractometry, which indicated the existence of fenofibrate in crystalline form in the solid dispersion. In vitro dissolution was studied in water containing 1% sodium lauryl sulfate, FASSIF and FESSIF. Significant enhancement in dissolution was achieved at PEG/FNB ratio of 4/1 with near complete dissolution within 30 min. Moderate improvement in dissolution rate was observed at smaller PEG/FNB ratios. Oral bioavailability was studied in beagle dogs after oral administration of fenofibrate solid dispersion pellets by monitoring fenofibric acid in plasma. The oral bioavailability of PEG/FNB 3/1 and 4/1 solid dispersion pellets was improved by 3.4 and 4.4-fold as compared to Lipanthyl, a commercial micronized fenotibrate formulation. There was a strong dependence of oral bioavailability on the in vitro dissolution rate. Good correlation was observed between the in vivo absorption fraction and the in vitro dissolution rate in each of the dissolution media, water containing 1% sodium lauryl sulfate, FASSIF and FESSIF. It could be concluded that PEG/FNB solid dispersion pellets were able to improve the dissolution and oral bioavailability of fenofibrate.展开更多
β-Carotene is one of the most abundant natural pigments in foods;however,usage of β-carotene is limited because of its instability.Microencapsulation techniques are usually applied to protect microencapsulated p-car...β-Carotene is one of the most abundant natural pigments in foods;however,usage of β-carotene is limited because of its instability.Microencapsulation techniques are usually applied to protect microencapsulated p-carotene from oxidization.In this study,β-carotene was microencapsulated using different drying processes:spray-drying,spray freeze-dryi ng,coati ng,and spray granulation.The properties of morphology,particle size,water con tent,thermal characteristic,and chemical stability have been explored and compared.Scanning electron microscopy measure?ments showed that the coated powder had a dense surface surro un ded by starch and suggested that the coati ng process gave a microencapsulated powder with the smallest bulk density and the best compressibility among the prepared powders.The chemical stabilities of microcapsules were evaluated during six months of storage at different temperatures.The coated powder had the highest mass fraction of β-carotene,which indicated that the coating process was superior to the three other drying processes.展开更多
基金Supported by the National Natural Science Foundation of China(No.29876031)
文摘The stability of Candida rugosa lipase coated with glutamic acid didodecyl ester ribitol amide was investigated taking esterification of lauryl alcohol and lauric acid in isooctane as a model reaction. At 30C, the half-life of the activity of the coated lipase was ca 10 h, the enzyme activity became less changed after 12 h and the residual activity was 39% of the initial value. The coated lipase obeyed a first-order deactivation model with a deactivation energy of 29.9J.mol-1.
文摘Effects of four coating formulations on maize production were studied.The results showed that all coating formulations had some effects on improving maize seedlings,strengthening the resistance againt diseases and pests and increasing the yields in different degrees,especially Paxil which increased the corn yield by 12.0%,significantly higher than the control.
文摘Aloe vera is being identified as a potential medicinal plant for its application in industries as well as traditional usage. The gel obtained from the leaves of A. vera has numerous properties. In this study, using the gel to extend the shelf life of Ampalavi mango fruits was studied. Even sized, uniform coloured, matured Ampalavi cultivar mango fruits were surface cleaned and coated with 33%, 66% and 100% gel, respectively. Results revealed that the ripening was delayed due to the coating. The total soluble solid （TSS）, pH and weight loss were high in uncoated fruits. The mean pH of the pulp from fruits kept as control was 4.94 at 4 d fruit preservation period （FPP） and was slightly increased to 5.43 within 12 d FPP, whereas the minimal pH （4.69 at 4 d FPP and 5.03 at 9 d FPP） was noticed in 100% gel coated fruits. The TSS （brix） was significantly in higher levels （13.67°Bx within 4 d FPP and 20.77°Bx within 12 d FPP） in control fruits, whereas the minimum TSS value was 9.27°Bx and 18.03° Bx within 4 d and 12 d FPP, respectively, recorded from the 100% gel coated fruits in storage. The weight loss percentage （WLP） was significantly （P 〈 0.05） higher in control fruits （8.46%）, whereas the lower WLP （1.13%） was found in 100% gel coated fruits after 12 d of storage. This low-scale gel coating technique prolonged the fruits shelf life by delaying the fruit ripening. This effect has to be further investigated to commercialize the natural product for large scale ready-made application.
基金Shanghai Municipal Committee of Science and Technology (Grant No. 0852nm04400)
文摘Solid dispersion of fenofibrate （FNB）, a poorly water-soluble drug, was prepared by a fluid-bed coating technique with PEG 6000 as the carrier. The physical state was characterized by DSC and X-ray powder diffractometry, which indicated the existence of fenofibrate in crystalline form in the solid dispersion. In vitro dissolution was studied in water containing 1% sodium lauryl sulfate, FASSIF and FESSIF. Significant enhancement in dissolution was achieved at PEG/FNB ratio of 4/1 with near complete dissolution within 30 min. Moderate improvement in dissolution rate was observed at smaller PEG/FNB ratios. Oral bioavailability was studied in beagle dogs after oral administration of fenofibrate solid dispersion pellets by monitoring fenofibric acid in plasma. The oral bioavailability of PEG/FNB 3/1 and 4/1 solid dispersion pellets was improved by 3.4 and 4.4-fold as compared to Lipanthyl, a commercial micronized fenotibrate formulation. There was a strong dependence of oral bioavailability on the in vitro dissolution rate. Good correlation was observed between the in vivo absorption fraction and the in vitro dissolution rate in each of the dissolution media, water containing 1% sodium lauryl sulfate, FASSIF and FESSIF. It could be concluded that PEG/FNB solid dispersion pellets were able to improve the dissolution and oral bioavailability of fenofibrate.
基金Project supported by the Hubei Province Technology Innovation Project(No.2017ACA083),China
文摘β-Carotene is one of the most abundant natural pigments in foods;however,usage of β-carotene is limited because of its instability.Microencapsulation techniques are usually applied to protect microencapsulated p-carotene from oxidization.In this study,β-carotene was microencapsulated using different drying processes:spray-drying,spray freeze-dryi ng,coati ng,and spray granulation.The properties of morphology,particle size,water con tent,thermal characteristic,and chemical stability have been explored and compared.Scanning electron microscopy measure?ments showed that the coated powder had a dense surface surro un ded by starch and suggested that the coati ng process gave a microencapsulated powder with the smallest bulk density and the best compressibility among the prepared powders.The chemical stabilities of microcapsules were evaluated during six months of storage at different temperatures.The coated powder had the highest mass fraction of β-carotene,which indicated that the coating process was superior to the three other drying processes.
