In order to study the uplifting effect of compensation grouting on ground surface and the upper structures,the ground heave induced by stratum expansion was considered as a stochastic process and the stochastic medium...In order to study the uplifting effect of compensation grouting on ground surface and the upper structures,the ground heave induced by stratum expansion was considered as a stochastic process and the stochastic medium theory was applied to determine the heave and deformation of ground surface under uniform and non-uniform expansion models of spherical grout bulb.The corresponding calculating formulas and simplified methods were derived based on the hypotheses of radial expansion.Then,a numerical model,in which radial velocity was imposed on the outer nodes of grout bulb to simulate the expansion process reaching a required volume strain,was established simultaneously.This new method avoids repeated trial calculation needed in the traditional method which applies a "fictitious" expanding pressure in the grouting elements.The results show that the numerical solutions have good consistency with the theoretical ones.Meanwhile,though the heave resulting from non-uniform expansion is larger than that from uniform expansion for shallow grouting,both of them tend to be convergent with the increasing of grouting depth.展开更多
The alkylation of p-cresol with tert-butanol(TBA)to 2-tert-butyl-p-cresol(TBC)catalyzed by a novel multiple-SO3H functioned ionic liquid(IL1)was investigated.Meanwhile,the catalytic activity of this novel ionic ...The alkylation of p-cresol with tert-butanol(TBA)to 2-tert-butyl-p-cresol(TBC)catalyzed by a novel multiple-SO3H functioned ionic liquid(IL1)was investigated.Meanwhile,the catalytic activity of this novel ionic liquid was compared with other four traditional ionic liquids.The results showed that IL1 has superior catalytic activity to other four traditional ionic liquids with the conversion of 85.3%and selectivity of 95.2%.Also,the reaction conditions were investigated to obtain the optimum conditions.Operational simplicity,small amount of usage,high activity,reusability and selectivity are the key features of this methodology.展开更多
Epilepsy is one of the most common neurological disorders characterized by epileptic seizures.The anti-epileptic drugs(AEDs)are the main form of treatment for people with epilepsy.Classically,people thought that AEDs ...Epilepsy is one of the most common neurological disorders characterized by epileptic seizures.The anti-epileptic drugs(AEDs)are the main form of treatment for people with epilepsy.Classically,people thought that AEDs modify the activities of ion channels to suppress epileptic seizures.However,accumulating evidence suggests that targeting at ion channels cannot completely account for the numerous effects of the AEDs on its broad clinical activity in epileptic patients.In our study,proteomic methods were used to quantify the proteome of hippocampal tissues from patients who were treated or not treated by AEDs(Carbamazepine).Further bioinformatics methods,including Gene Ontology(GO)annotation and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis,were utilized to analyze the differences between two patient groups.We found that more than 400 proteins,including metabolism and immune related proteins,had a higher expression level in the carbamazepine-treated group compared with the controls.These altered proteins were considered to be involved in many different biological pathways.Among these pathways,immune-system related pathway modulated by complement C3 and microglia was highly remarkable,which regulated the synapses elimination in physiological condition.In epilepsy,the carbamazepine induced up-regulation of complement C3 might decrease the abnormal synaptic connections between neurons and thus contribute to the therapeutic role of carbamazepine.The results of our study suggested that apart from ion channels,carbamazepine exerted numerous effects on human epileptic foci,which might be the fundamental mechanisms of AEDs for treatment,adverse-effects and pharmacoresistance of epilepsy.展开更多
For low power dielectric barrier discharge (DBD) used in small-size material treatment or portable devices, high- step transformer parasitic capacitance greatly influences the performance of the resonant converter a...For low power dielectric barrier discharge (DBD) used in small-size material treatment or portable devices, high- step transformer parasitic capacitance greatly influences the performance of the resonant converter as it is of the same order of magnitude as the equivalent capacitance of DBD load. In this paper, steady-state analysis of the low power DBD is presented, considering the inevitable parasitic capacitance of the high-step transformer. The rectifier-compensated first harmonic approxi- mation (RCFHA) is applied to linearize the equivalent load circuit of DBD at low frequency and the derived expressions are accurate and convenient for the analysis and design of the power supply. Based on the proposed linear equivalent load circuit, the influence of transformer parasitic capacitance on the key parameters, including the frequency range and the applied electrode voltage, is discussed when the power is regulated with pulse frequency modulation (PFM). Also, a design procedure is presented based on the derived expressions. A prototype is constructed according to the design results and the accuracy of the design is verified by experimental results.展开更多
基金Project(2007AA11Z134) supported by the National High Technology Research and Development Program of ChinaProject(10JJ4035) supported by the Natural Science Foundation of Hunan Province,China Project(2010ybfz046) supported by the Fund of Excellent Doctoral Dissertation of Central South University,China
文摘In order to study the uplifting effect of compensation grouting on ground surface and the upper structures,the ground heave induced by stratum expansion was considered as a stochastic process and the stochastic medium theory was applied to determine the heave and deformation of ground surface under uniform and non-uniform expansion models of spherical grout bulb.The corresponding calculating formulas and simplified methods were derived based on the hypotheses of radial expansion.Then,a numerical model,in which radial velocity was imposed on the outer nodes of grout bulb to simulate the expansion process reaching a required volume strain,was established simultaneously.This new method avoids repeated trial calculation needed in the traditional method which applies a "fictitious" expanding pressure in the grouting elements.The results show that the numerical solutions have good consistency with the theoretical ones.Meanwhile,though the heave resulting from non-uniform expansion is larger than that from uniform expansion for shallow grouting,both of them tend to be convergent with the increasing of grouting depth.
基金Supported by the National High Technology Research and Development Program of China(2006BAE03B06)Shanghai Leading Academic Discipline Project(B409)Shanghai International Cooperation of Science and Technology Project(06SR07101)
文摘The alkylation of p-cresol with tert-butanol(TBA)to 2-tert-butyl-p-cresol(TBC)catalyzed by a novel multiple-SO3H functioned ionic liquid(IL1)was investigated.Meanwhile,the catalytic activity of this novel ionic liquid was compared with other four traditional ionic liquids.The results showed that IL1 has superior catalytic activity to other four traditional ionic liquids with the conversion of 85.3%and selectivity of 95.2%.Also,the reaction conditions were investigated to obtain the optimum conditions.Operational simplicity,small amount of usage,high activity,reusability and selectivity are the key features of this methodology.
基金The Ministry of Science and Technology of China(Grant No.2015CB559200)the National Natural Science Foundation of China(Grant No.81371432).
文摘Epilepsy is one of the most common neurological disorders characterized by epileptic seizures.The anti-epileptic drugs(AEDs)are the main form of treatment for people with epilepsy.Classically,people thought that AEDs modify the activities of ion channels to suppress epileptic seizures.However,accumulating evidence suggests that targeting at ion channels cannot completely account for the numerous effects of the AEDs on its broad clinical activity in epileptic patients.In our study,proteomic methods were used to quantify the proteome of hippocampal tissues from patients who were treated or not treated by AEDs(Carbamazepine).Further bioinformatics methods,including Gene Ontology(GO)annotation and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis,were utilized to analyze the differences between two patient groups.We found that more than 400 proteins,including metabolism and immune related proteins,had a higher expression level in the carbamazepine-treated group compared with the controls.These altered proteins were considered to be involved in many different biological pathways.Among these pathways,immune-system related pathway modulated by complement C3 and microglia was highly remarkable,which regulated the synapses elimination in physiological condition.In epilepsy,the carbamazepine induced up-regulation of complement C3 might decrease the abnormal synaptic connections between neurons and thus contribute to the therapeutic role of carbamazepine.The results of our study suggested that apart from ion channels,carbamazepine exerted numerous effects on human epileptic foci,which might be the fundamental mechanisms of AEDs for treatment,adverse-effects and pharmacoresistance of epilepsy.
基金supported by the National Natural Science Foundation of China(No.51107115)the China Postdoctoral Science Foundation(No.20110491766)
文摘For low power dielectric barrier discharge (DBD) used in small-size material treatment or portable devices, high- step transformer parasitic capacitance greatly influences the performance of the resonant converter as it is of the same order of magnitude as the equivalent capacitance of DBD load. In this paper, steady-state analysis of the low power DBD is presented, considering the inevitable parasitic capacitance of the high-step transformer. The rectifier-compensated first harmonic approxi- mation (RCFHA) is applied to linearize the equivalent load circuit of DBD at low frequency and the derived expressions are accurate and convenient for the analysis and design of the power supply. Based on the proposed linear equivalent load circuit, the influence of transformer parasitic capacitance on the key parameters, including the frequency range and the applied electrode voltage, is discussed when the power is regulated with pulse frequency modulation (PFM). Also, a design procedure is presented based on the derived expressions. A prototype is constructed according to the design results and the accuracy of the design is verified by experimental results.