目的:分析在中心型肺癌诊断中应用CT诊断的准确性与MRI的补充诊断意义。方法:选在我院治疗的中心型肺癌患者42例,全部患者都采取CT诊断,同时在CT诊断基础上实施M R I补充诊断,观察诊断的情况。结果:联合两种诊断方式诊断准确率与单用CT...目的:分析在中心型肺癌诊断中应用CT诊断的准确性与MRI的补充诊断意义。方法:选在我院治疗的中心型肺癌患者42例,全部患者都采取CT诊断,同时在CT诊断基础上实施M R I补充诊断,观察诊断的情况。结果:联合两种诊断方式诊断准确率与单用CT诊断的准确率相比,数值明显比单用CT诊断的准确率高,两种诊断方式诊断的准确率相比有显著的差异,P<0.05。结论:在中心型肺癌患者诊断中,应用CT诊断与M R I补充诊断,准确率比较高,值得应用。展开更多
Multislice computed tomography(MSCT) has recently evolved as a modality for noninvasive coronary imaging. Abstract: To assess the accuracy and robustness of MSCT vs the criterion standard of invasive coronary angiogra...Multislice computed tomography(MSCT) has recently evolved as a modality for noninvasive coronary imaging. Abstract: To assess the accuracy and robustness of MSCT vs the criterion standard of invasive coronary angiography for detection of obstructive coronary artery disease. Design, Setting, and Patients: Prospective, single-center study conducted in a referral center setting in Germany and enrolling 103 consecutive patients(mean age, 61.5[SD, 9.7] years) from November 2003- August 2004 who were undergoing both invasive coronary angiography and MSCT using a scanner with 16 detector rows. Main Outcome Measures: Blinded results for both modalities compared using the patient as the primary unit of analysis, with supplementary segment and vessel-based analyses. Results: One thousand three hundred eighty-four segments(≥ 1.5 mm diameter) were identified by invasive coronary angiography; nondiagnostic image quality of MSCT was identified for only 88(6.4% ) of these segments, mainly due to faster heart rates. Compared with invasive coronary angiography for detection of significant lesions( >50% stenosis), segment-based sensitivity, specificity, and positive and negative predictive values of MSCT were 95% , 98% , 87% , and 99% , respectively. Quantitative comparison of MSCT and invasive coronary angiography showed good correlation(r=0.87,P< .001), with MSCT systematically measuring greater-per- centage stenoses(bias,+ 12% ). In the patient-based analysis, the area under the receiver operating characteristic curve was 0.97(95% confidence interval, 0.90- 1.00), indicating high discriminative power to identify patients who might be candidates for revascularization(>50% left main artery stenosis and/or >70% stenosis in any other epicardial vessel). Threshold optimization allowed either detection of these patients with 100% sensitivity at a reasonable false-positive rate(specificity, 76.5% ; MSCT stenosis, >66% ) or optimization of both the sensitivity and specificity( >90% ; MSCT stenosis, >76% ). Conclusions: Multislice computed tomography provides high accuracy for noninvasive detection of suspected obstructive coronary artery disease. This promising technology has potential to complement diagnostic invasive coronary angiography in routine clinical care.展开更多
PURPOSE: To evaluate the role of optical coherence tomography (OCT) in determining choroidal neovascularization (CNV) activity before and after photodynamic therapy (PDT)-in patients with age-related macular degenerat...PURPOSE: To evaluate the role of optical coherence tomography (OCT) in determining choroidal neovascularization (CNV) activity before and after photodynamic therapy (PDT)-in patients with age-related macular degeneration (ARMD). DESIGN: Prospective observational case series. METHODS: setting: Institutional study. patient population: Fiftythree patients (62 eyes) with ARMD. observation procedure: Prospective observational case study. main outcome measures: Presence or absence of leakage on fluorescein angiography, presence of intraretinal or sub-retinal fluid on OCT, and macular and choroidal neovascular complex thickness on OCT. RESULTS: The macular thickness decreased significantly after PDT (P=.001). However, no significant changes in CNVthickness were measured after PDT (P=.567). Once the diagnosis of ARMD was established before treatment, OCT had a sensitivity of 96.77% for detecting CNV activity. After treatment, OCT had a good sensitivity (95.65% ) and a moderate specificity (59.01% ) in determining CNV activity, which resulted in a diagnostic efficiency (proportion of correct results) of 82.95% . CONCLUSIONS:OCT appears to be useful for indicating CNV activity. Therefore, it may serve as a complementary technique for deciding the need for PDT and re-treatment in patients with ARMD.展开更多
文摘目的:分析在中心型肺癌诊断中应用CT诊断的准确性与MRI的补充诊断意义。方法:选在我院治疗的中心型肺癌患者42例,全部患者都采取CT诊断,同时在CT诊断基础上实施M R I补充诊断,观察诊断的情况。结果:联合两种诊断方式诊断准确率与单用CT诊断的准确率相比,数值明显比单用CT诊断的准确率高,两种诊断方式诊断的准确率相比有显著的差异,P<0.05。结论:在中心型肺癌患者诊断中,应用CT诊断与M R I补充诊断,准确率比较高,值得应用。
文摘Multislice computed tomography(MSCT) has recently evolved as a modality for noninvasive coronary imaging. Abstract: To assess the accuracy and robustness of MSCT vs the criterion standard of invasive coronary angiography for detection of obstructive coronary artery disease. Design, Setting, and Patients: Prospective, single-center study conducted in a referral center setting in Germany and enrolling 103 consecutive patients(mean age, 61.5[SD, 9.7] years) from November 2003- August 2004 who were undergoing both invasive coronary angiography and MSCT using a scanner with 16 detector rows. Main Outcome Measures: Blinded results for both modalities compared using the patient as the primary unit of analysis, with supplementary segment and vessel-based analyses. Results: One thousand three hundred eighty-four segments(≥ 1.5 mm diameter) were identified by invasive coronary angiography; nondiagnostic image quality of MSCT was identified for only 88(6.4% ) of these segments, mainly due to faster heart rates. Compared with invasive coronary angiography for detection of significant lesions( >50% stenosis), segment-based sensitivity, specificity, and positive and negative predictive values of MSCT were 95% , 98% , 87% , and 99% , respectively. Quantitative comparison of MSCT and invasive coronary angiography showed good correlation(r=0.87,P< .001), with MSCT systematically measuring greater-per- centage stenoses(bias,+ 12% ). In the patient-based analysis, the area under the receiver operating characteristic curve was 0.97(95% confidence interval, 0.90- 1.00), indicating high discriminative power to identify patients who might be candidates for revascularization(>50% left main artery stenosis and/or >70% stenosis in any other epicardial vessel). Threshold optimization allowed either detection of these patients with 100% sensitivity at a reasonable false-positive rate(specificity, 76.5% ; MSCT stenosis, >66% ) or optimization of both the sensitivity and specificity( >90% ; MSCT stenosis, >76% ). Conclusions: Multislice computed tomography provides high accuracy for noninvasive detection of suspected obstructive coronary artery disease. This promising technology has potential to complement diagnostic invasive coronary angiography in routine clinical care.
文摘PURPOSE: To evaluate the role of optical coherence tomography (OCT) in determining choroidal neovascularization (CNV) activity before and after photodynamic therapy (PDT)-in patients with age-related macular degeneration (ARMD). DESIGN: Prospective observational case series. METHODS: setting: Institutional study. patient population: Fiftythree patients (62 eyes) with ARMD. observation procedure: Prospective observational case study. main outcome measures: Presence or absence of leakage on fluorescein angiography, presence of intraretinal or sub-retinal fluid on OCT, and macular and choroidal neovascular complex thickness on OCT. RESULTS: The macular thickness decreased significantly after PDT (P=.001). However, no significant changes in CNVthickness were measured after PDT (P=.567). Once the diagnosis of ARMD was established before treatment, OCT had a sensitivity of 96.77% for detecting CNV activity. After treatment, OCT had a good sensitivity (95.65% ) and a moderate specificity (59.01% ) in determining CNV activity, which resulted in a diagnostic efficiency (proportion of correct results) of 82.95% . CONCLUSIONS:OCT appears to be useful for indicating CNV activity. Therefore, it may serve as a complementary technique for deciding the need for PDT and re-treatment in patients with ARMD.
