目的：观察补肾地黄汤加减口服治疗老年性高血压的临床疗效及其对血压变应性的影响。方法：将130例老年性高血压患者采用随机数字表法分为对照组和观察组各65例。对照组采用苯磺酸氨氯地平片口服,每次2.5~10 mg,1次·d-1,观察组在...目的：观察补肾地黄汤加减口服治疗老年性高血压的临床疗效及其对血压变应性的影响。方法：将130例老年性高血压患者采用随机数字表法分为对照组和观察组各65例。对照组采用苯磺酸氨氯地平片口服,每次2.5~10 mg,1次·d-1,观察组在对照组治疗的基础上加用补肾地黄汤加减口服。疗程均为8周。治疗前后采用动态血压监测仪对患者进行24 h血压监测,记录24 h SSD、24 h DSD、24h SBP及DBP均值,并计算血压昼夜节律,评价临床疗效;治疗前后抽取患者空腹静脉血,送检血脂水平;记录治疗期间的不良反应。结果：观察组有效率为90.77%,高于对照组的72.31%（t=5.13,P〈0.05）;治疗后,观察组SBP及DBP均明显下降（P〈0.05）,观察组SBP下调幅度优于对照组（P〈0.01）;治疗后,观察组杓型血压例数明显增多,并多于对照组（t=4.74,P〈0.05）;疗程结束后两组患者24 h SSD及24 h DSD均明显下降,观察组下降幅度更加明显,差异有统计学意义（P〈0.05）;经治疗,观察组患者TG及TC水平均下降,并较对照组下降明显（P〈0.05）;两组患者治疗期间均无明显不良反应出现,安全性相比差异无统计学意义（P〉0.05）。结论：补肾地黄汤加减口服治疗老年性高血压,可明显改善患者血压变异性及血脂水平,有效缓解患者临床症状及体征,提高生存质量,且具有稳定性。展开更多
目的：观察补肾地黄汤联合葡萄糖酸锌治疗脾肾不足型儿童锌缺乏致身材矮小伴智力低下的临床疗效.方法：将69例儿童锌缺乏症致身材矮小同时伴有智力低下的患儿采用随机数字表法分为两组.对照组给予葡萄糖酸锌（元素锌）,1 d 1μg/g,口服...目的：观察补肾地黄汤联合葡萄糖酸锌治疗脾肾不足型儿童锌缺乏致身材矮小伴智力低下的临床疗效.方法：将69例儿童锌缺乏症致身材矮小同时伴有智力低下的患儿采用随机数字表法分为两组.对照组给予葡萄糖酸锌（元素锌）,1 d 1μg/g,口服.治疗组在对照组治疗基础上给予补肾地黄汤（党参、黄芪、白术、茯苓、熟地黄、山茱萸、构杞子、龟板胶、益智仁、怀牛膝）加减,每次煎服50～100 mL,1d1剂,分2次口服.两组均每周服药5d,休息2d,治疗3个月后判定疗效.结果：治疗组在3个月后血清锌浓度上升及6个月后身高增长和生长速率、IQ值、操作分数及语言分数均优于对照组（P＜0.05）.结论：补肾地黄汤治疗脾肾不足型锌缺乏症致儿童身材矮小伴智力低下疗效确切.展开更多
Stroke is the leading cause of human disability with limited effective drugs availability. The disruption of multiple signaling pathways in stroke makes developing new drugs be difficult. Traditional Chinese medicine(...Stroke is the leading cause of human disability with limited effective drugs availability. The disruption of multiple signaling pathways in stroke makes developing new drugs be difficult. Traditional Chinese medicine(TCM) has its unique advantage in targeting multiple signaling pathways with multiple components. Many TCM formulas have the potential for neuroprotection and neurogenesis, but well-designed clinical trials are insufficient and underlying mechanisms unclear. Herein, we introduce the commonly used TCM formulas for stroke treatment and selectively introduce two classic formulas, An Gong Niu Huang(AGNH) pill and Bu Yang Huan Wu Decoction(BYHWD) for neuroprotection and neurogenesis, respectively. Current scientific evidence and clinical trials indicate AGNH pill could be an effective neuroprotective formula as adjunct therapy with relative safety. On the other hand, as a representative TCM formula for post stroke disability, BYHWD could improve the neurological outcome with its neuroprotective and neurogenic effects. The underlying mechanisms could be attributed to the modulation of multiple molecular targets with its multiple components. In conclusion, TCM formulas could be potential adjunct therapies for stroke treatment. The clinical efficacies and molecular mechanisms of promoting neuroprotection and neurogenesis remain to be further studies.展开更多
Diabetic acromelic gangrene is a kind of ischemic necrosis developed in extremities of the diabetic patients. It occurs frequently in the lower extremities, hence known as 'diabetic foot'. According to the rep...Diabetic acromelic gangrene is a kind of ischemic necrosis developed in extremities of the diabetic patients. It occurs frequently in the lower extremities, hence known as 'diabetic foot'. According to the reports in China, the incidence rate is about 0.9-1.7% in the diabetic patients, and ac-展开更多
文摘目的：观察补肾地黄汤加减口服治疗老年性高血压的临床疗效及其对血压变应性的影响。方法：将130例老年性高血压患者采用随机数字表法分为对照组和观察组各65例。对照组采用苯磺酸氨氯地平片口服,每次2.5~10 mg,1次·d-1,观察组在对照组治疗的基础上加用补肾地黄汤加减口服。疗程均为8周。治疗前后采用动态血压监测仪对患者进行24 h血压监测,记录24 h SSD、24 h DSD、24h SBP及DBP均值,并计算血压昼夜节律,评价临床疗效;治疗前后抽取患者空腹静脉血,送检血脂水平;记录治疗期间的不良反应。结果：观察组有效率为90.77%,高于对照组的72.31%（t=5.13,P〈0.05）;治疗后,观察组SBP及DBP均明显下降（P〈0.05）,观察组SBP下调幅度优于对照组（P〈0.01）;治疗后,观察组杓型血压例数明显增多,并多于对照组（t=4.74,P〈0.05）;疗程结束后两组患者24 h SSD及24 h DSD均明显下降,观察组下降幅度更加明显,差异有统计学意义（P〈0.05）;经治疗,观察组患者TG及TC水平均下降,并较对照组下降明显（P〈0.05）;两组患者治疗期间均无明显不良反应出现,安全性相比差异无统计学意义（P〉0.05）。结论：补肾地黄汤加减口服治疗老年性高血压,可明显改善患者血压变异性及血脂水平,有效缓解患者临床症状及体征,提高生存质量,且具有稳定性。
文摘目的：观察补肾地黄汤联合葡萄糖酸锌治疗脾肾不足型儿童锌缺乏致身材矮小伴智力低下的临床疗效.方法：将69例儿童锌缺乏症致身材矮小同时伴有智力低下的患儿采用随机数字表法分为两组.对照组给予葡萄糖酸锌（元素锌）,1 d 1μg/g,口服.治疗组在对照组治疗基础上给予补肾地黄汤（党参、黄芪、白术、茯苓、熟地黄、山茱萸、构杞子、龟板胶、益智仁、怀牛膝）加减,每次煎服50～100 mL,1d1剂,分2次口服.两组均每周服药5d,休息2d,治疗3个月后判定疗效.结果：治疗组在3个月后血清锌浓度上升及6个月后身高增长和生长速率、IQ值、操作分数及语言分数均优于对照组（P＜0.05）.结论：补肾地黄汤治疗脾肾不足型锌缺乏症致儿童身材矮小伴智力低下疗效确切.
基金funding support from the Hong Kong Innovation and Technology Commission ITF grant (UIM/289)Grant from National Natural Science Foundation of China (No. 31570855)Contract Research Project of Beijing Tong Ren Tang Chinese Medicine Co. Ltd.
文摘Stroke is the leading cause of human disability with limited effective drugs availability. The disruption of multiple signaling pathways in stroke makes developing new drugs be difficult. Traditional Chinese medicine(TCM) has its unique advantage in targeting multiple signaling pathways with multiple components. Many TCM formulas have the potential for neuroprotection and neurogenesis, but well-designed clinical trials are insufficient and underlying mechanisms unclear. Herein, we introduce the commonly used TCM formulas for stroke treatment and selectively introduce two classic formulas, An Gong Niu Huang(AGNH) pill and Bu Yang Huan Wu Decoction(BYHWD) for neuroprotection and neurogenesis, respectively. Current scientific evidence and clinical trials indicate AGNH pill could be an effective neuroprotective formula as adjunct therapy with relative safety. On the other hand, as a representative TCM formula for post stroke disability, BYHWD could improve the neurological outcome with its neuroprotective and neurogenic effects. The underlying mechanisms could be attributed to the modulation of multiple molecular targets with its multiple components. In conclusion, TCM formulas could be potential adjunct therapies for stroke treatment. The clinical efficacies and molecular mechanisms of promoting neuroprotection and neurogenesis remain to be further studies.
文摘Diabetic acromelic gangrene is a kind of ischemic necrosis developed in extremities of the diabetic patients. It occurs frequently in the lower extremities, hence known as 'diabetic foot'. According to the reports in China, the incidence rate is about 0.9-1.7% in the diabetic patients, and ac-
