Nasopharyngeal carcinoma(NPC)has been a focus of medical research for more than 100 years,with significant interest emerging over the last 58 years following the identification of the link between the disease and Epst...Nasopharyngeal carcinoma(NPC)has been a focus of medical research for more than 100 years,with significant interest emerging over the last 58 years following the identification of the link between the disease and Epstein-Barr virus(EBV)infection.NPC possesses several distinctive characteristics among human cancers,notably its well-documented global epidemiology,which reveals localized high-incidence regions primarily in Southeast Asia,particularly in the Southern provinces of China near the Pearl river,as well as in Greenland and North Africa.Epidemiological data indicate a marked male predominance,early disease onset,and a nearly 100%prevalence of latent EBV infection in the tumors.Due to lack of consistent pattern of cancer-related mutations in NPC genomes and excessive DNA-methylation in the tumor cells,NPC can be considered"an epigenetic cancer".Despite extensive researches,convincing biological explanations for these unique characteristics remain elusive.Recently,suggestive evidence has been published that specific local variants of EBV may represent major high risk factors.In spite of tumor and virus specific immunity,it has not been possible to use this for improved treatment.Ongoing studies on the role of the local microflora and tumor microenvironment are essential for a comprehensive understanding of host-EBV-tumor interactions.Ultimately,this knowledge aims to enhance diagnosis,disease fractionation,treatment strategies,and potentially prevention of NPC.展开更多
This paper examines the explorations and practices of environmental- economic accounting in the international community, provides a comprehensive overview and evaluation of the nature and research progress of China＇s...This paper examines the explorations and practices of environmental- economic accounting in the international community, provides a comprehensive overview and evaluation of the nature and research progress of China＇s natural resources balance sheet, reviews the relevant systems of China＇s natural resources balance sheet and the development of ecological civilization, identifies the issues in the formulation of natural resources balance sheet and makes suggestions for improvement.展开更多
A kind of thermosetting asphalt binder designated as epoxy asphalt, which is composed of two components： maleated asphalt with curing agents and accelerant of epoxy resin and epoxy resin, was prepared. Its paving fea...A kind of thermosetting asphalt binder designated as epoxy asphalt, which is composed of two components： maleated asphalt with curing agents and accelerant of epoxy resin and epoxy resin, was prepared. Its paving feasibility and concrete performances were investigated using Brookfield viscosimeter, direct tensile test （DTT）, Marshall testing and the MTS 810 hydraulic servos-system, respectively. Although only 50% to 60% of added maleic anhydride （MAH） reacted with the base asphalt irreversibly （probably by Diels-Alder mechanism）, the curing rate, rupture elongation and tensile strength of maleated epoxy asphalt were enhanced more evidently than those of unmaleated epoxy asphalt. As a result, an epoxy asphalt made from 4% MAH modified asphalt and other curing agents was featured to have an average rupture elongation of 281.9%, an average tensile strength of 2. 63 MPa, and the Marshall stability of its cured concrete reached 37. 0 kN, while that of uncured concrete was 10. 2 kN and the combined beam of fatigue test was still found to behave well after 12 × 10^6 cycles load.展开更多
RpoS protein is a σ factor of RNA polymerase that can control the expression of a group-specific gene, thus playing a vital role in bacteria. In bacteria, RpoS expression is under strict control and is mainly regulat...RpoS protein is a σ factor of RNA polymerase that can control the expression of a group-specific gene, thus playing a vital role in bacteria. In bacteria, RpoS expression is under strict control and is mainly regulated at three levels： transcription level, translation level and post-translational level. Environmental stress enters bacterial cells through signal transduction and leads to a series of variations in microenvironment, thereby causing changes of regulator and controlling its levels based on the direct and indirect interaction between regulator and RpoS protein. In addition, RpoS protein has played special roles in bacteria, therefore the changes of RpoS protein levels will lead to variations in expression levels of a large number of genes, thereby causing variations of bacterial response to different environmental stress and changes of certain characteristics of bacteria, which provides a new strategy for the control of bacterial diseases in the future. This paper reviewed the recent progress on the regulation of RpoS protein expression and its function in several common bacteria. Due to the functional complexity of RpoS protein, there are still a lot of unknown functions to be further identified.展开更多
The concentrations, accumulation and sources of 15 polycyclic aromatic hydrocarbons （PAHs） had been studied or evaluated in the surface layer sediments of Taizhou Bay, China. It showed that the concentrations of PAH...The concentrations, accumulation and sources of 15 polycyclic aromatic hydrocarbons （PAHs） had been studied or evaluated in the surface layer sediments of Taizhou Bay, China. It showed that the concentrations of PAHs ranged from 85.4 to 167.6 ng/g （averaged 138.62 ng/g）, and the highest level was found in Jiao Jiang Dock. Percentages of 2-, 3-, 4-, 5- and 6-cyclic aromatic hydrocarbons were 7.8 %, 42.1%, 33.3 %, 9.6 % and 7.2 % respectively. The accumulation indices of PAHs ranged from 532.7 to 1068.9 （averaged 807.5）, and the index of Phenanthrene was the highest （122.7）, while that of Benzo （a） Pyrene was the lowest （2.7） among them. In Taizhou Bay, PAHs in surface layer sediments came mainly from coal burning, partly from direct pollution of petroleum hydrocarbons.展开更多
文摘Nasopharyngeal carcinoma(NPC)has been a focus of medical research for more than 100 years,with significant interest emerging over the last 58 years following the identification of the link between the disease and Epstein-Barr virus(EBV)infection.NPC possesses several distinctive characteristics among human cancers,notably its well-documented global epidemiology,which reveals localized high-incidence regions primarily in Southeast Asia,particularly in the Southern provinces of China near the Pearl river,as well as in Greenland and North Africa.Epidemiological data indicate a marked male predominance,early disease onset,and a nearly 100%prevalence of latent EBV infection in the tumors.Due to lack of consistent pattern of cancer-related mutations in NPC genomes and excessive DNA-methylation in the tumor cells,NPC can be considered"an epigenetic cancer".Despite extensive researches,convincing biological explanations for these unique characteristics remain elusive.Recently,suggestive evidence has been published that specific local variants of EBV may represent major high risk factors.In spite of tumor and virus specific immunity,it has not been possible to use this for improved treatment.Ongoing studies on the role of the local microflora and tumor microenvironment are essential for a comprehensive understanding of host-EBV-tumor interactions.Ultimately,this knowledge aims to enhance diagnosis,disease fractionation,treatment strategies,and potentially prevention of NPC.
文摘This paper examines the explorations and practices of environmental- economic accounting in the international community, provides a comprehensive overview and evaluation of the nature and research progress of China＇s natural resources balance sheet, reviews the relevant systems of China＇s natural resources balance sheet and the development of ecological civilization, identifies the issues in the formulation of natural resources balance sheet and makes suggestions for improvement.
文摘A kind of thermosetting asphalt binder designated as epoxy asphalt, which is composed of two components： maleated asphalt with curing agents and accelerant of epoxy resin and epoxy resin, was prepared. Its paving feasibility and concrete performances were investigated using Brookfield viscosimeter, direct tensile test （DTT）, Marshall testing and the MTS 810 hydraulic servos-system, respectively. Although only 50% to 60% of added maleic anhydride （MAH） reacted with the base asphalt irreversibly （probably by Diels-Alder mechanism）, the curing rate, rupture elongation and tensile strength of maleated epoxy asphalt were enhanced more evidently than those of unmaleated epoxy asphalt. As a result, an epoxy asphalt made from 4% MAH modified asphalt and other curing agents was featured to have an average rupture elongation of 281.9%, an average tensile strength of 2. 63 MPa, and the Marshall stability of its cured concrete reached 37. 0 kN, while that of uncured concrete was 10. 2 kN and the combined beam of fatigue test was still found to behave well after 12 × 10^6 cycles load.
基金Supported by Science and Technology Program of Shandong Province (No. 2010GHY10501)National Department Public Benefit Research Fond of China (No. 200909020)~~
文摘RpoS protein is a σ factor of RNA polymerase that can control the expression of a group-specific gene, thus playing a vital role in bacteria. In bacteria, RpoS expression is under strict control and is mainly regulated at three levels： transcription level, translation level and post-translational level. Environmental stress enters bacterial cells through signal transduction and leads to a series of variations in microenvironment, thereby causing changes of regulator and controlling its levels based on the direct and indirect interaction between regulator and RpoS protein. In addition, RpoS protein has played special roles in bacteria, therefore the changes of RpoS protein levels will lead to variations in expression levels of a large number of genes, thereby causing variations of bacterial response to different environmental stress and changes of certain characteristics of bacteria, which provides a new strategy for the control of bacterial diseases in the future. This paper reviewed the recent progress on the regulation of RpoS protein expression and its function in several common bacteria. Due to the functional complexity of RpoS protein, there are still a lot of unknown functions to be further identified.
文摘The concentrations, accumulation and sources of 15 polycyclic aromatic hydrocarbons （PAHs） had been studied or evaluated in the surface layer sediments of Taizhou Bay, China. It showed that the concentrations of PAHs ranged from 85.4 to 167.6 ng/g （averaged 138.62 ng/g）, and the highest level was found in Jiao Jiang Dock. Percentages of 2-, 3-, 4-, 5- and 6-cyclic aromatic hydrocarbons were 7.8 %, 42.1%, 33.3 %, 9.6 % and 7.2 % respectively. The accumulation indices of PAHs ranged from 532.7 to 1068.9 （averaged 807.5）, and the index of Phenanthrene was the highest （122.7）, while that of Benzo （a） Pyrene was the lowest （2.7） among them. In Taizhou Bay, PAHs in surface layer sediments came mainly from coal burning, partly from direct pollution of petroleum hydrocarbons.
