PURPOSE: Radiotherapy alone or with combined chemot-herapy is the first therapeutic option for epidermoid carcinoma of the anal canal. Failure of this conservative treatment may benefit of salvage abdominoperineal res...PURPOSE: Radiotherapy alone or with combined chemot-herapy is the first therapeutic option for epidermoid carcinoma of the anal canal. Failure of this conservative treatment may benefit of salvage abdominoperineal resection. This study was designed to analyze postoperative outcome and oncologic results in a single anticancer institution. METHODS: Medical charts of 36 patients (median age, 57.9 years) who underwent salvage abdominoperineal resection after failure of conservative treatment between 1987 and 2002 were reviewed retrospectively. There were 15 patients treated for immediate failure (Group I) and 21 patients for recurrence (Group II). Twenty-two patients have undergone primary use of flap reconstruction of the perineal wound. There were ten rectus abdominis myocutaneous flaps, nine omental flaps, two gracilis muscular flaps, and one combined flap. RESULTS: There was no postoperative mortality. Median follow-up was 67 (range, 15-155) months. Primary closure of the perineum was obtained in 33 patients (92 percent). Secondary wound breakdown occurred in 23 of 33 patients (70 percent). Complications unrelated to the perineal wound occurred in 13 patients. The overall crude five-year survival after salvage abdominoperineal resection was 69.4 percent. The crude five-year survival in Group I and Group II was 60.7 and 71.5 percent respectively (P = 0.28). The crude five-year, disease-free survival in Groups I and II was 31.1 and 48.2 percent respectively (P = 0.10). Twenty-three patients experienced recurrences after salvage abdominoperineal resection (64 percent) with a mean delay of 30 months. CONCLUSIONS: Despite high incidence of perineal morbidity, salvage abdominoperineal resection for epidermoid carcinomas of the anal canal has a high long-term survival rate.展开更多
黏液表皮样癌通常发生在唾液腺,是唾液腺最常见的恶性肿瘤,但极少原发于甲状腺^([1])。原发性甲状腺黏液表皮样癌(primary mucoepidermoid carcinoma of the thyroid gland, TMEC)是一种罕见的甲状腺恶性肿瘤,通常以恶性鳞状细胞和黏液...黏液表皮样癌通常发生在唾液腺,是唾液腺最常见的恶性肿瘤,但极少原发于甲状腺^([1])。原发性甲状腺黏液表皮样癌(primary mucoepidermoid carcinoma of the thyroid gland, TMEC)是一种罕见的甲状腺恶性肿瘤,通常以恶性鳞状细胞和黏液细胞混合为特征^([2])。国内暂无相关报道。本文报道1例罕见的高度恶性TMEC,同时结合国外相关文献总结该疾病的临床特点、组织病理学特征、诊疗方法及预后。展开更多
文摘PURPOSE: Radiotherapy alone or with combined chemot-herapy is the first therapeutic option for epidermoid carcinoma of the anal canal. Failure of this conservative treatment may benefit of salvage abdominoperineal resection. This study was designed to analyze postoperative outcome and oncologic results in a single anticancer institution. METHODS: Medical charts of 36 patients (median age, 57.9 years) who underwent salvage abdominoperineal resection after failure of conservative treatment between 1987 and 2002 were reviewed retrospectively. There were 15 patients treated for immediate failure (Group I) and 21 patients for recurrence (Group II). Twenty-two patients have undergone primary use of flap reconstruction of the perineal wound. There were ten rectus abdominis myocutaneous flaps, nine omental flaps, two gracilis muscular flaps, and one combined flap. RESULTS: There was no postoperative mortality. Median follow-up was 67 (range, 15-155) months. Primary closure of the perineum was obtained in 33 patients (92 percent). Secondary wound breakdown occurred in 23 of 33 patients (70 percent). Complications unrelated to the perineal wound occurred in 13 patients. The overall crude five-year survival after salvage abdominoperineal resection was 69.4 percent. The crude five-year survival in Group I and Group II was 60.7 and 71.5 percent respectively (P = 0.28). The crude five-year, disease-free survival in Groups I and II was 31.1 and 48.2 percent respectively (P = 0.10). Twenty-three patients experienced recurrences after salvage abdominoperineal resection (64 percent) with a mean delay of 30 months. CONCLUSIONS: Despite high incidence of perineal morbidity, salvage abdominoperineal resection for epidermoid carcinomas of the anal canal has a high long-term survival rate.
文摘黏液表皮样癌通常发生在唾液腺,是唾液腺最常见的恶性肿瘤,但极少原发于甲状腺^([1])。原发性甲状腺黏液表皮样癌(primary mucoepidermoid carcinoma of the thyroid gland, TMEC)是一种罕见的甲状腺恶性肿瘤,通常以恶性鳞状细胞和黏液细胞混合为特征^([2])。国内暂无相关报道。本文报道1例罕见的高度恶性TMEC,同时结合国外相关文献总结该疾病的临床特点、组织病理学特征、诊疗方法及预后。
