Diffusion-weighted magnetic resonance imaging(DWI)is a well established method for the evaluation of intracranial diseases,such as acute stroke.DWI for extracranial application is more difficult due to physiological m...Diffusion-weighted magnetic resonance imaging(DWI)is a well established method for the evaluation of intracranial diseases,such as acute stroke.DWI for extracranial application is more difficult due to physiological motion artifacts and the heterogeneous composition of the organs.However,thanks to the newer technical development of DWI,DWI has become increasingly used over the past few years in extracranial organs including the abdomen and pelvis.Most previous studies of DWI have been limited to the evaluation of diffuse parenchymal abnormalities and focal lesions in abdominal organs,whereas there are few studies about DWI for the evaluation of the biliopancreatic tract.Although further studies are needed to determine its performance in evaluating bile duct,gallbladder and pancreas diseases,DWI has potential in the assessment of the functional information on the biliopancreatic tract concerning the status of tissue cellularity,because increased cellularity is associated with impeded diffusion,as indicated by a reduction in the apparent diffusion coefficient.The detection of malignant lesions and their differentiation from benign tumor-like lesions in the biliopancreatic tract could be improved using DWI in conjunction with findings obtained with conventional magnetic resonance cholagiopancreatography.Additionally,DWI can be useful for the assessment of the biliopancreatic tract in patients with renal impairment because contrast-enhanced computed tomography or magnetic resonance scans should be avoided in these patients.展开更多
Objective： The aim of our study was to investigate the value of Diffusion-weighted MR imaging （DWl） for evaluating differential diagnosis of pulmonary isolated lesions. Methods： Twenty-seven consecutive patients e...Objective： The aim of our study was to investigate the value of Diffusion-weighted MR imaging （DWl） for evaluating differential diagnosis of pulmonary isolated lesions. Methods： Twenty-seven consecutive patients enrolled in this study, all of whom underwent single direction DWl examinations and received a histologic and clinical diagnosis. Diffusion factor B value was 300, 500, 800 s/mm2, respectively. DWl images of twenty cases could be satisfied to measurement and diagnosis and success rate was percent 74. Among these, lung tuberculoma 5 cases, harmatoma 3 cases, peripheral lung cancer 12 cases. The apparent diffusion coefficient （ADC） values of the lesions were measured. Statistical analyses were performed with the independent samples t test for comparing difference of ADC values between malignant nodules and benign nodules at different 8 value. Results： DWI images of twenty cases could be satisfied and its success rate was percent 74. When B value was 300 s/mm2, ADC values of malignant nodules and benign nodules were 0.002192±0.0006091 mm2/s, 0.002454 ± 0.0007892 mm2/s, respectively, and P = 0.442. When B value was 500 s/mm2, ADC value of malignant nodules and benign nodules were 0.002065 ± 0.0006769 mm2/s, 0.002871± 0.0007746 mm2/s, respectively, and P = 0.033. When B value was 800 s/mm2, ADC value of malignant nodules and benign nodules were 0.001646 ± 0.0004292 mm2/s, 0.002651 ＋ 0.0008041 mm2/s, respectively, and P = 0.009. There were the most different between malignant nodules and benign nodules at B value 800 and statistical significance. Conclusion： Lung DWl imaging is helpful to diagnosis and differential diagnosis between malignant and benign isolated nodules. The ADC value of benign lesions was statistically higher than that of malignant tumors.展开更多
Objective： The relationship between apparent diffusion coefficient （ADC） and chemotherapy has been established. However, whether ADC could be considered as a measure for monitoring response to sorafenib in hepatoce...Objective： The relationship between apparent diffusion coefficient （ADC） and chemotherapy has been established. However, whether ADC could be considered as a measure for monitoring response to sorafenib in hepatocellular carcinoma （HCC） has not been demonstrated. This study was to investigate the ADC changes of ad- vanced HCC under sorafenib treatment. Methods： Athymic mice with HepG2 xenografts were allocated to two groups： control and sorafenib （40 mg/kg, bid）. T2 and diffusion images were acquired at each time point （0, 10, 14, and 18 d post-therapy）. Tumor volume and changes in ADC were calculated. Results： Tumor volumes on Days 10, 14, and 18 after treatment showed significant decreases in the sorafenib-treated group compared with the control. Pretreatment ADC values were not significantly different between the control and treated groups. A slow increase in ADC in the peripheral zone of tumors appeared in the treated group, which was significantly higher compared with the control group on Days 10, 14, and 18. In the central part of tumors on Day 10 after treatment, an increase in ADC appeared in the treated and control groups, the ADC of the control group being significantly lower compared with the treated tumors From Day 10 to Day 14, the ADC map showed a progressive decrease in the central region of tumors in the treated and control groups. However, this change is more significant in the treated groups. Conclusions： Early changes in mean ADC correlated with sorafenib treatment in HCC, which are promising indicators for predicting sorafenib response in this carcinoma.展开更多
基金Supported by Clinical research grant from Pusan National University Hospital
文摘Diffusion-weighted magnetic resonance imaging(DWI)is a well established method for the evaluation of intracranial diseases,such as acute stroke.DWI for extracranial application is more difficult due to physiological motion artifacts and the heterogeneous composition of the organs.However,thanks to the newer technical development of DWI,DWI has become increasingly used over the past few years in extracranial organs including the abdomen and pelvis.Most previous studies of DWI have been limited to the evaluation of diffuse parenchymal abnormalities and focal lesions in abdominal organs,whereas there are few studies about DWI for the evaluation of the biliopancreatic tract.Although further studies are needed to determine its performance in evaluating bile duct,gallbladder and pancreas diseases,DWI has potential in the assessment of the functional information on the biliopancreatic tract concerning the status of tissue cellularity,because increased cellularity is associated with impeded diffusion,as indicated by a reduction in the apparent diffusion coefficient.The detection of malignant lesions and their differentiation from benign tumor-like lesions in the biliopancreatic tract could be improved using DWI in conjunction with findings obtained with conventional magnetic resonance cholagiopancreatography.Additionally,DWI can be useful for the assessment of the biliopancreatic tract in patients with renal impairment because contrast-enhanced computed tomography or magnetic resonance scans should be avoided in these patients.
文摘Objective： The aim of our study was to investigate the value of Diffusion-weighted MR imaging （DWl） for evaluating differential diagnosis of pulmonary isolated lesions. Methods： Twenty-seven consecutive patients enrolled in this study, all of whom underwent single direction DWl examinations and received a histologic and clinical diagnosis. Diffusion factor B value was 300, 500, 800 s/mm2, respectively. DWl images of twenty cases could be satisfied to measurement and diagnosis and success rate was percent 74. Among these, lung tuberculoma 5 cases, harmatoma 3 cases, peripheral lung cancer 12 cases. The apparent diffusion coefficient （ADC） values of the lesions were measured. Statistical analyses were performed with the independent samples t test for comparing difference of ADC values between malignant nodules and benign nodules at different 8 value. Results： DWI images of twenty cases could be satisfied and its success rate was percent 74. When B value was 300 s/mm2, ADC values of malignant nodules and benign nodules were 0.002192±0.0006091 mm2/s, 0.002454 ± 0.0007892 mm2/s, respectively, and P = 0.442. When B value was 500 s/mm2, ADC value of malignant nodules and benign nodules were 0.002065 ± 0.0006769 mm2/s, 0.002871± 0.0007746 mm2/s, respectively, and P = 0.033. When B value was 800 s/mm2, ADC value of malignant nodules and benign nodules were 0.001646 ± 0.0004292 mm2/s, 0.002651 ＋ 0.0008041 mm2/s, respectively, and P = 0.009. There were the most different between malignant nodules and benign nodules at B value 800 and statistical significance. Conclusion： Lung DWl imaging is helpful to diagnosis and differential diagnosis between malignant and benign isolated nodules. The ADC value of benign lesions was statistically higher than that of malignant tumors.
基金supported by the National Natural Science Foundation of China(No.81071960)the New Teacher Foundation of the Ministry of Education,China(No.20100101120129)the Zhejiang Provincial Medical Science Research Foundation(No.2010KYA064),China
文摘Objective： The relationship between apparent diffusion coefficient （ADC） and chemotherapy has been established. However, whether ADC could be considered as a measure for monitoring response to sorafenib in hepatocellular carcinoma （HCC） has not been demonstrated. This study was to investigate the ADC changes of ad- vanced HCC under sorafenib treatment. Methods： Athymic mice with HepG2 xenografts were allocated to two groups： control and sorafenib （40 mg/kg, bid）. T2 and diffusion images were acquired at each time point （0, 10, 14, and 18 d post-therapy）. Tumor volume and changes in ADC were calculated. Results： Tumor volumes on Days 10, 14, and 18 after treatment showed significant decreases in the sorafenib-treated group compared with the control. Pretreatment ADC values were not significantly different between the control and treated groups. A slow increase in ADC in the peripheral zone of tumors appeared in the treated group, which was significantly higher compared with the control group on Days 10, 14, and 18. In the central part of tumors on Day 10 after treatment, an increase in ADC appeared in the treated and control groups, the ADC of the control group being significantly lower compared with the treated tumors From Day 10 to Day 14, the ADC map showed a progressive decrease in the central region of tumors in the treated and control groups. However, this change is more significant in the treated groups. Conclusions： Early changes in mean ADC correlated with sorafenib treatment in HCC, which are promising indicators for predicting sorafenib response in this carcinoma.
