1 INTRODUCTIONMicroemulsion and micelle systems are wide-spread in the industry and agriculture applications,e.g.the petroleum exploitation,food industry chemical engineering and biological engineering,but so far,thei...1 INTRODUCTIONMicroemulsion and micelle systems are wide-spread in the industry and agriculture applications,e.g.the petroleum exploitation,food industry chemical engineering and biological engineering,but so far,their properties are still not very well understood.Both micelle and microemulsion systems are dispersed systems and consist of the aggregationsof the surfactant.The difference between them is that there is dispered liquid phase in the coreof the aggregation in the case of the microemulsion,but in the micelle there is not any展开更多
The interaction of cationic gemini surfactants(alkanediyl-α,ω-bis(alkyl dimethylammonium bromide)) with an antipsychotic drug(chlorpromazine hydrochloride(CPZ)) has been investigated. Various micellar and interfacia...The interaction of cationic gemini surfactants(alkanediyl-α,ω-bis(alkyl dimethylammonium bromide)) with an antipsychotic drug(chlorpromazine hydrochloride(CPZ)) has been investigated. Various micellar and interfacial parameters have been deliberated by surface tension measurement to report the nature of interactions between drug and novel surfactant mixtures. The behavior of mixed systems, their compositions and activities of components have been analyzed in the light of Rubingh's theory. The results indicate synergism in the binary mixtures.The binding study between CPZ and surfactants has been done by spectroscopic techniques such as UV–visible and fluorescence. The results are discussed in the light of the use of gemini surfactants as promising drug delivery agents for phenothiazine drugs, and hence, improve their bioavailability.展开更多
基金Supported by the National Nature Science Foundation of China(No.29736170).
文摘1 INTRODUCTIONMicroemulsion and micelle systems are wide-spread in the industry and agriculture applications,e.g.the petroleum exploitation,food industry chemical engineering and biological engineering,but so far,their properties are still not very well understood.Both micelle and microemulsion systems are dispersed systems and consist of the aggregationsof the surfactant.The difference between them is that there is dispered liquid phase in the coreof the aggregation in the case of the microemulsion,but in the micelle there is not any
基金Chemistry Department and Centre of Excellence for Advanced Materials Research, King Abdulaziz University
文摘The interaction of cationic gemini surfactants(alkanediyl-α,ω-bis(alkyl dimethylammonium bromide)) with an antipsychotic drug(chlorpromazine hydrochloride(CPZ)) has been investigated. Various micellar and interfacial parameters have been deliberated by surface tension measurement to report the nature of interactions between drug and novel surfactant mixtures. The behavior of mixed systems, their compositions and activities of components have been analyzed in the light of Rubingh's theory. The results indicate synergism in the binary mixtures.The binding study between CPZ and surfactants has been done by spectroscopic techniques such as UV–visible and fluorescence. The results are discussed in the light of the use of gemini surfactants as promising drug delivery agents for phenothiazine drugs, and hence, improve their bioavailability.
