In a surface plasmon resonant (SPR) configuration, real part in refraction coefficient of modulation layer material is monotonic with resonant wave length, while imaginary part is monotonic with resonant magnitude. Ba...In a surface plasmon resonant (SPR) configuration, real part in refraction coefficient of modulation layer material is monotonic with resonant wave length, while imaginary part is monotonic with resonant magnitude. Based on the fact above, a new type of display is proposed and designed. Firstly, a display pixel with either controllable color or controllable brightness is discussed, and then a display pixel with both controllable color and brightness is proposed in detail. At last, an SPR display with 8×8 pixels is developed and simulated. The results show that color and brightness of each display pixel in an SPR display can be tuned directly, with no need of synthesizing three basic colors, traditionally. Moreover, the display has many merits, such as high color resolution, high contrast, high brightness, fast re-sponse, etc. Yet practical usage of SPR display demands deeper study on properties of modulation layer material and fabrication techniques.展开更多
Surface plasmon resonance(SPR)technology is a powerful and sensitive tool for investigating molecular interactions.Technical improvements in recent years have brought new functionality to SPR apparatuses that can be w...Surface plasmon resonance(SPR)technology is a powerful and sensitive tool for investigating molecular interactions.Technical improvements in recent years have brought new functionality to SPR apparatuses that can be widely applied at multiple stages of the drug discovery process.The technology allows users to conduct ligand fishing and offers rich and in-depth information regarding the affinity,specificity,kinetics,concentration and identification of covalent/allosteric/competitive binding behaviors.The present review highlights the principle,sample types,detection ranges,experimental methods,strengths,limitations,and the latest research progress on the application of SPR technology in the drug discovery process.展开更多
基金the National Natural Science Foundation of China (Grant No. 60621002)
文摘In a surface plasmon resonant (SPR) configuration, real part in refraction coefficient of modulation layer material is monotonic with resonant wave length, while imaginary part is monotonic with resonant magnitude. Based on the fact above, a new type of display is proposed and designed. Firstly, a display pixel with either controllable color or controllable brightness is discussed, and then a display pixel with both controllable color and brightness is proposed in detail. At last, an SPR display with 8×8 pixels is developed and simulated. The results show that color and brightness of each display pixel in an SPR display can be tuned directly, with no need of synthesizing three basic colors, traditionally. Moreover, the display has many merits, such as high color resolution, high contrast, high brightness, fast re-sponse, etc. Yet practical usage of SPR display demands deeper study on properties of modulation layer material and fabrication techniques.
基金supported by State Key Laboratory of Natural and Biomimetic Drugs,Peking University。
文摘Surface plasmon resonance(SPR)technology is a powerful and sensitive tool for investigating molecular interactions.Technical improvements in recent years have brought new functionality to SPR apparatuses that can be widely applied at multiple stages of the drug discovery process.The technology allows users to conduct ligand fishing and offers rich and in-depth information regarding the affinity,specificity,kinetics,concentration and identification of covalent/allosteric/competitive binding behaviors.The present review highlights the principle,sample types,detection ranges,experimental methods,strengths,limitations,and the latest research progress on the application of SPR technology in the drug discovery process.
