Few data are available in France about implementation of guidelines for pathology reports of rectal cancer resections.Aim-The purpose of this study was to audit quality and completeness of histopathology reports of re...Few data are available in France about implementation of guidelines for pathology reports of rectal cancer resections.Aim-The purpose of this study was to audit quality and completeness of histopathology reports of rectal cancer resections in Brittany by comparing results with French guidelines published in 1998.Methods-All inhabitants in Brittany who were beneficiaries of the general health insurance system and who underwent surgery for rectal cancer between February 1999 and January 2000 were included in the study.Twenty-one pathology laboratories,including 14 private laboratories,participated in this study.All pathology reports were examined by two physician-consultants of the health insurance system trained in the analysis of pathology reports(search for consigned or missing data).Results were compared with guidelines published in 1998.Results-Of 234 pathology reports,204(84%)mentioned the number of examined lymph nodes and 217(93 %)the number of those found positive.The criterion of at least 8 examined lymph nodes was noted in 53.4 %of reports.Longitudinal margin involvement was recorded in 92 %of reports and circumferential margin involvement in 27 %only.Venous and/or lymphatic and neural invasion were recorded in 34 %and 18 %of reports,respectively.Tumor staging was made by using UICC(pTNM)in 67%of reports.Conclusion-This study shows that the quality and completeness of histopathology reports of rectal cancer resections could be improved in Brittany.Despite its documented value as an important predictor of local recurrence,circumferential margin involvement is too frequently omitted.Standardisation of the examination procedures and exhaustive reporting would be useful to improve practice quality.展开更多
Objectives: To examine the histopathologic features of iridectomy specimens from patients undergoing glaucoma surgery and to compare histologic abnormalities in a group of patients with a history of latanoprost therap...Objectives: To examine the histopathologic features of iridectomy specimens from patients undergoing glaucoma surgery and to compare histologic abnormalities in a group of patients with a history of latanoprost therapy with those in a group of patients who had no history of prostaglandin therapy (controls). Methods: Iridectomy specimens and patient history forms were submitted to the central Latanoprost Pathology Center. These were independently examined by 3 ophthalmic pathologists in a masked fashion. Specimens were evaluated for malignant, premalignant, and other changes including differences in levels of pigmentation, degrees of cellularity, inflammation, vascular abnormalities, and changes in the iris pigment epithelium. Results: Specimens were received from 449 patients with a history of latanoprost treatment and 142 patients who had no history of treatment with latanoprost or other prostaglandin analogues. No evidence of malignant or premalignant changes was found. In latanoprost- treated irides, the prevalence of iris freckles was higher (P=.001) than in control irides, as was the combined number of stromal fibroblasts and melanocytes (P < .001). In a subgroup of specimens received through June 2002, there was no significant difference in mean melanocyte counts (P=.35)- obtained by immunohistochemical staining techniques between the latanoprost- treated and control groups. Conclusions: These findings support previous studies indicating that latanoprost- in- duced eye color changes are due to an increased amount of melanin within the iris stromal melanocytes. The increased numbers of freckles may be a focal manifestation of this effect.展开更多
文摘Few data are available in France about implementation of guidelines for pathology reports of rectal cancer resections.Aim-The purpose of this study was to audit quality and completeness of histopathology reports of rectal cancer resections in Brittany by comparing results with French guidelines published in 1998.Methods-All inhabitants in Brittany who were beneficiaries of the general health insurance system and who underwent surgery for rectal cancer between February 1999 and January 2000 were included in the study.Twenty-one pathology laboratories,including 14 private laboratories,participated in this study.All pathology reports were examined by two physician-consultants of the health insurance system trained in the analysis of pathology reports(search for consigned or missing data).Results were compared with guidelines published in 1998.Results-Of 234 pathology reports,204(84%)mentioned the number of examined lymph nodes and 217(93 %)the number of those found positive.The criterion of at least 8 examined lymph nodes was noted in 53.4 %of reports.Longitudinal margin involvement was recorded in 92 %of reports and circumferential margin involvement in 27 %only.Venous and/or lymphatic and neural invasion were recorded in 34 %and 18 %of reports,respectively.Tumor staging was made by using UICC(pTNM)in 67%of reports.Conclusion-This study shows that the quality and completeness of histopathology reports of rectal cancer resections could be improved in Brittany.Despite its documented value as an important predictor of local recurrence,circumferential margin involvement is too frequently omitted.Standardisation of the examination procedures and exhaustive reporting would be useful to improve practice quality.
文摘Objectives: To examine the histopathologic features of iridectomy specimens from patients undergoing glaucoma surgery and to compare histologic abnormalities in a group of patients with a history of latanoprost therapy with those in a group of patients who had no history of prostaglandin therapy (controls). Methods: Iridectomy specimens and patient history forms were submitted to the central Latanoprost Pathology Center. These were independently examined by 3 ophthalmic pathologists in a masked fashion. Specimens were evaluated for malignant, premalignant, and other changes including differences in levels of pigmentation, degrees of cellularity, inflammation, vascular abnormalities, and changes in the iris pigment epithelium. Results: Specimens were received from 449 patients with a history of latanoprost treatment and 142 patients who had no history of treatment with latanoprost or other prostaglandin analogues. No evidence of malignant or premalignant changes was found. In latanoprost- treated irides, the prevalence of iris freckles was higher (P=.001) than in control irides, as was the combined number of stromal fibroblasts and melanocytes (P < .001). In a subgroup of specimens received through June 2002, there was no significant difference in mean melanocyte counts (P=.35)- obtained by immunohistochemical staining techniques between the latanoprost- treated and control groups. Conclusions: These findings support previous studies indicating that latanoprost- in- duced eye color changes are due to an increased amount of melanin within the iris stromal melanocytes. The increased numbers of freckles may be a focal manifestation of this effect.
