航空食品装运车

QYJ5110JSPO4型(简称SPO4)航空食品装运车,系采用东风EQP142L/38十一吨级专用汽车底盘进行改装设计,属民航机场对客机进行食品供应的专用中型车辆。整车由底盘改装总成、副大梁、传动系统、液压、电气系统、平台总成、应急装置、窗式空调机等部件组成。基本结构形式为:剪叉式举行、H型垂直支腿、合金铝蒙皮食品厢,前后为大型助力平板式卷帘门。

巨型路沿石杠杆法快速铺装施工技术

依为了解决传统路沿石安装施工过程中主要依靠人工进行搬运、安装的难题,设计了一种路沿石简易装运杠杆车。简易装运杠杆车能够使路沿石的移动、安装、摆放、调校、固定变得轻松、快捷,有效地提高工作效率,减少劳动力。为了使施工技术更趋于规范、标准,在实践工程应用的基础上,经进一步改进、创新,总结形成了巨型路沿石杠杆法快速铺装施工技术,保证了工程质量、工期和安全,为类似工程提供参考依据。

Cinnamon extract suppresses experimental colitis through modulation of antigen-presenting cells

AIM:To investigate the anti-inflammatory effects of cinnamon extract and elucidate its mechanisms for targeting the function of antigen presenting cells.METHODS:Cinnamon extract was used to treat murine macrophage cell line(Raw 264.7),mouse primary antigen-presenting cells(APCs,MHCII+) and CD11c+dendritic cells to analyze the effects of cinnamon extract on APC function.The mechanisms of action of cinnamon extract on APCs were investigated by analyzing cytokine production,and expression of MHC antigens and co-stimulatory molecules by quantitative real-time PCR and flow cytometry.In addition,the effect of cinnamon extract on antigen presentation capacity and APC-dependent T-cell differentiation were analyzed by [H3]-thymidine incorporation and cytokine analysis,respectively.To confirm the anti-inflammatory effects of cinnamon extract in vivo,cinnamon or PBS was orally administered to mice for 20 d followed by induction of experimental colitis with 2,4,6 trinitrobenzenesulfonic acid.The protective effects of cinnamon extract against experimental colitis were measured by checking clinical symptoms,histological analysis and cytokine expression prof iles in inflamed tissue.RESULTS:Treatment with cinnamon extract inhibited maturation of MHCII+ APCs or CD11c+ dendritic cells(DCs) by suppressing expression of co-stimulatory molecules(B7.1,B7.2,ICOS-L),MHCII and cyclooxygenase(COX)-2.Cinnamon extract induced regulatory DCs(rDCs) that produce low levels of pro-inflammatory cytokines [interleukin(IL)-1β,IL-6,IL-12,interferon(IFN)-γ and tumor necrosis factor(TNF)-α] while expressing high levels of immunoregulatory cytokines(IL-10 and transforming growth factor-β).In addition,rDCs generated by cinnamon extract inhibited APC-dependent T-cell proliferation,and converted CD4+ T cells into IL-10high CD4+ T cells.Furthermore,oral administration of cinnamon extract inhibited development and progression of intestinal colitis by inhibiting expression of COX-2 and pro-inflammatory cytokines(IL-1β,IFN-γ and TNF-α),while enhancing IL-10 levels.CONCLUSION:Our study suggests the potential of cinnamon extract as an anti-inflammatory agent by targeting the generation of regulatory APCs and IL-10+ regulatory T cells.

The role of Langerhans cells in oral squamous cell carcinoma

During the initiation, promotion, and progression of multi-step carcinogenesis, changes in specific host immuno- logical factors have been observed. Although immunology of oral cancer has long been focused on antigens and lymphocytes, the fact remains that the antigen presenting cells, like the Langerhans cells （LCs） of the epithelium are initiators and modulators of the immune response. LCs as sentinels of immune response, have been investigated in several orai mucosal diseases, including cancer. Inadequate presentation of tumor antigens by host dendritic cells is one potential mechanism that allows tumor progression, tn this review, the role of LCs in OSCC is discussed. Elucidation of the role of APCs, in particular LCs, may help to better understand the mechanisms underlying anti-tumour immune responses and, improve the effectiveness of anti-cancer immunity in tumour-bearing hosts. This section focuses on the roles LCs in the immunity of cancer and how cancer bypasses the dendritic cell-mediated immune responses, are discussed. Subsequently, the effects of tumor microenviornment on LC＇s and their therapeutic implications are elaborated.

Operator health risk evaluation of off-highway dump truck under shovel loading condition

To evaluate the operator health risk exposed to whole-body vibration(WBV) while the electric-shovel loads the ore on the truck body, the semi-truck mathematical model and 3-D virtual prototype were built to simulate the high shockwave of truck cab under the shovel loading. Discrete element method was utilized to accurately estimate the impacting force on the truck body. Based on the ISO 2631-5 criteria, the Sed is about 0.56 MPa in both models, which means that the dump operators have a high probability of adverse health effects over long-term exposure to these vibrations. The 4-DOF operator model was built to investigate the biodynamic response of seated-human body exposed to WBV in terms of the transmission of vibrations through the body. The results show that the response peak is in the frequency range of 4-6 Hz corresponding to the primary body resonant frequency.

An Apparatus Design for the Vehicle Control Scheme in Personal Rapid Transit System

A new transportation technology known as personal rapid transit （PRT） is being developed by multiple different companies around the world, and one system is under commercial operations in the United Kingdom. Each design is different, but they all share a need to operate many automated transit vehicles at very close headways. Safe operation will require a level of control an order of magnitude above any current transit system. As a result, new techniques will be needed for the development and testing of the mechanical and control systems. In this paper an apparatus for developing and testing a PRT vehicle control scheme is demonstrated. This system is composed of independent modules that represent virtual vehicles, a central control system, a man-machine interface and a monitoring device. It can be used to implement and to evaluate the designed vehicle control algorithm. The vehicle control algorithm is designed and simulated in a combined simulation platform that consists of Matlab/Simulink and Labview Simulation Interface Toolkit. Simple operational scenarios are proposed for the testing of the proposed vehicle control apparatus.

Aerodynamic drag analysis of double-deck container vehicles with different structures

To study the aerodynamic performance of a new six-axis X2K double-deck container vehicle, numerical simulation was done based on three-dimensional, steady Navier-Stokes equations and k-e turbulence model. The results show that the pressure on the front surface of vehicle is positive, and others are negative. The maximum negative one appears as a ＂gate＂ shape on front surfaces. The pressure on vehicle increases with train speed, and pressure on vehicles with cross-loaded structure is smaller than that without it. The airflow around vehicles is symmetrical about train vertical axis, and the flow velocity decreases gradually along the axis to ground. Airflow around vehicles with cross-loaded structure is weaker than that without the structure. The aerodynamic drag increases linearly with the train speed, and it is minimum for the mid-vehicle. The linear coefficient for mid-vehicle without cross-loaded structure is 29.75, nearly one time larger than that with the structure valued as 15.425. So, from the view-point of aerodynamic drag, the cross-loaded structure is more reasonable for the six-axis X2K double-deck container vehicle.

Use of Xinfeng capsule to treat abarticular pathologic changes in patients with rheumatoid arthritis

OBJECTIVE: To observe the influence of Xinfengcapsule(XFC) on abarticular pathologic changes(APCs) and other indices of patients with rheumatoid arthritis(RA) and explore the mechanism of action of XFC in improving such changes.METHODS: Three-hundred RA patients were divided randomly into a treatment group(n=150) and control group(n=150). A normal control(NC)group(n=90) was also created. Changes in cardiac function, pulmonary function, anemia indices and platelet parameters of RA patients were measured.Curative effects of the two groups were compared,and comparison carried out with the NC group.RESULTS: In 300 RA patients, late diastolic peak flow velocity(A peak) was much higher(P<0.01)and early diastolic peak flow velocity(E peak), E/A,and left ventricular fraction shortening much lower(P<0.01) than those in the NC group. Vital capacity(VC), forced vital capacity in one second, forced vital capacity(FVC), maximal voluntary ventilation(MVV), maximal expiratory flow in 50% of VC(FEF50) and FEF75 were lowered remarkably(P<0.05 or P<0.01). Platelet count(PLT), plateletcrit(PCT) and mean platelet volume(MPV) increased markedly(P<0.05 or P<0.01), and hemoglobin(Hb)level decreased significantly(P<0.05). After XFC treatment, the A peak and PLT and PCT were much lower(P<0.05), and E/A and the number of red blood cells as well as Hb level were much higher(P<0.05), as were FVC, MVV and FEF50(P<0.05 or P<0.01), in the treatment group than those in the NC group. Total score of pain and swelling in joints,uric-acid level and high-sensitivity C-reactive protein level were much lower, and superoxide dismutase level as well as the number of CD4 +CD25+ regulation T cells(Treg) and CD4+CD25+CD127- Treg were much higher(P<0.05 or P<0.01)in the treatment group than those in the NC group.CONCLUSION: RA patients with pathologic changes in joints also suffer from lower cardiac and pulmonary functions and from parameters of anemia and platelet factors. XFC can improve the symptoms of RA patients, ameliorate their cardiac and pulmonary functions and reduce the parameters of anemia and platelet factors. XFC lowers the immune inflammatory reaction to improve APCs in RA patients.