In this study the authors aimed to evaluate the oxidative stress enzymes indicative of liver damage in rats exposed to malathion （M）, subchronic form using cimetidine （C） and cimetidine plus malathion （M ＋ C）. ...In this study the authors aimed to evaluate the oxidative stress enzymes indicative of liver damage in rats exposed to malathion （M）, subchronic form using cimetidine （C） and cimetidine plus malathion （M ＋ C）. Malathion, widely used organophosphorus insecticide worldwide, induces oxidative liver damage type; cimetidine is an antagonist of histamine H2-receptor, it has been shown to be an inhibitor of various CYP45o isoforms. Male Wistar rats weighing 200-250 g were studied, exposed to malathion orally for 3 weeks （0.15 mg/kg/day, 2 mg/kg/day, 15 mg/kg/day） and cimetidine 10 mg/kg/day. Malathion plus cimetidine affect susceptibility to oxidative stress and possibly modifies the antioxidant defense capacity directly or indirectly.展开更多
目的:评价西咪匹韦治疗基因1型丙型肝炎的疗效和安全性。方法:检索EMBASE、PubMed、The Cochrane Central Register of Controlled Trials、clinicaltrials.gov、CNKI全文数据库、万方数据库中关于西咪匹韦治疗基因1型丙型肝炎的疗效和...目的:评价西咪匹韦治疗基因1型丙型肝炎的疗效和安全性。方法:检索EMBASE、PubMed、The Cochrane Central Register of Controlled Trials、clinicaltrials.gov、CNKI全文数据库、万方数据库中关于西咪匹韦治疗基因1型丙型肝炎的疗效和安全性的随机对照试验,检索起始日期为2000年1月1日,截止时间为2016年8月8日。采用RevMan5.3对纳入的研究进行Meta分析。结果:共7项研究符合纳入标准入选本Meta分析,共纳入2 301例患者。分析结果显示西咪匹韦快速病毒学应答(RVR)、持续早期病毒应答(SVR12)、持续病毒学应答(SVR24)等获得率均明显高于对照组(P<0.000 1),病毒复发率明显低于对照组(P<0.000 1);100 mg组西咪匹韦RVR,SVR12,SVR24,病毒复发率等指标明显优于对照组(P<0.001),而150 mg组除了SVR24与对照组对比,差异无统计学意义外(P>0.05),其余指标均优于对照组(P<0.001)。西咪匹韦组一般不良反应发生率与对照组相比,差异无统计学意义(P>0.05),与临床治疗相关的不良反应中除了对光敏感发生率高于对照组,其余不良反应如皮疹、瘙痒、中性粒细胞减少、贫血事件发生率均与对照组对比无统计学差异(P>0.05)。结论:西咪匹韦用于治疗基因1型丙肝具有较好疗效及安全性。100 mg西咪匹韦较150 mg西咪匹韦用于治疗基因1型丙肝疗效更佳。展开更多
Although rare,death from amanitin exposure poses a significant health risk and a diagnostic challenge to the clinician due to its rarity.This is one of the few conditions to be voluntarily reported by healthcare profe...Although rare,death from amanitin exposure poses a significant health risk and a diagnostic challenge to the clinician due to its rarity.This is one of the few conditions to be voluntarily reported by healthcare professionals.No antidote exists for this poisoning and,perhaps due to its rarity or lack of attention,the United States has lagged behind Europe for almost three decades in treatment,diagnostics and experimentation.This regrettable fact warrants the formation of a centralized agency for education,the advancement of research and the collection of data,to provide better treatment for the population.展开更多
文摘In this study the authors aimed to evaluate the oxidative stress enzymes indicative of liver damage in rats exposed to malathion （M）, subchronic form using cimetidine （C） and cimetidine plus malathion （M ＋ C）. Malathion, widely used organophosphorus insecticide worldwide, induces oxidative liver damage type; cimetidine is an antagonist of histamine H2-receptor, it has been shown to be an inhibitor of various CYP45o isoforms. Male Wistar rats weighing 200-250 g were studied, exposed to malathion orally for 3 weeks （0.15 mg/kg/day, 2 mg/kg/day, 15 mg/kg/day） and cimetidine 10 mg/kg/day. Malathion plus cimetidine affect susceptibility to oxidative stress and possibly modifies the antioxidant defense capacity directly or indirectly.
文摘Although rare,death from amanitin exposure poses a significant health risk and a diagnostic challenge to the clinician due to its rarity.This is one of the few conditions to be voluntarily reported by healthcare professionals.No antidote exists for this poisoning and,perhaps due to its rarity or lack of attention,the United States has lagged behind Europe for almost three decades in treatment,diagnostics and experimentation.This regrettable fact warrants the formation of a centralized agency for education,the advancement of research and the collection of data,to provide better treatment for the population.
