The interactions among drugs,tumor and host are critical for a response to therapy and for outcome.Anticancer herbs used in Chinese medicine are classified into 4 groups based on their target (tumor,patient and drug) ...The interactions among drugs,tumor and host are critical for a response to therapy and for outcome.Anticancer herbs used in Chinese medicine are classified into 4 groups based on their target (tumor,patient and drug) as follows:eliminating pathogenic factors,strengthening the body resistance,enhancing effects of chemotherapy and detoxication of chemotherapy. Correspondingly,anticancer drugs used in Western medicine can be classified into 4 groups as follows:cytotoxic drugs,biological response modifiers,chemosensitizers and chemoprotectants. Based on the theory of Chinese medicinal formulas,prescriptions are composed of four constituents,namely,primary constituent (main component of the formula prescription),minister constituent (second component of formula prescription),adjuvant constituent (adjuvant component of the formula prescription) and messenger constituent (component making the formula prescription targeting pathological tissues).To control the interaction among drugs and to modulate the interaction among the tumor,patient and drugs,we suggest that combined therapy for Western medicine might include 4 constituents,i.e.,primary,cooperative,adjuvant and modulatory constituent. Cytotoxic drugs frequently are used as primary and cooperative constituents,whereas biological response modifiers and biochemical modulators are usually regarded respectively as adjuvant drugs and modulatory constituents. We believe these new concepts may be helpful for the aim of appropriately designing,evaluating or providing combination therapy.展开更多
Quercus rugosa and Q.laurina are species that presents a wide geographical distribution range in temperate forests of Mexico. Oak canopies contain a considerable portion of arthropod diversity and the arthropods fauna...Quercus rugosa and Q.laurina are species that presents a wide geographical distribution range in temperate forests of Mexico. Oak canopies contain a considerable portion of arthropod diversity and the arthropods fauna fulfill a wide variety of ecological roles. We examined the effect of oak species and seasonal changes on some community structure parameters (diversity,composition,similarity,biomass,rare species,and density of arthropod fauna) of canopy arthropods. In total,40 oak canopies were fogged during rainy and dry season. A total of 614 identified arthropod morphospecies were recognized belonging to 22 orders associated with tree canopies. A separation of host tree species during both seasons,suggesting a different community structure on host plants species was demonstrated by the principal component analyses (PCA),therefore,differences between oak species results in phenotypes that structure the composition of the arthropod community. Q.laurina registered the highest densities,diversity index and number of rare species in comparison with Q.rugosa. While arthropod biomass showed an inverse pattern. Trees more close to one another (spatial distance) register a more similar canopy arthropod fauna. This study suggests that the trees of Q.laurina could act as a center of biodiversity by the accumulation of arthropod fauna with a considerable number of rare species,which presents wide ecological roles or is involved in critical processes that maintain forest ecosystems.展开更多
Conductivity-temperature-depth(CTD)data obtained during the 2010 La Nina winter and the 2012 normal winter,combined with concurrent Argo profiling float data,provide a quasi-synoptic description of the water mass di...Conductivity-temperature-depth(CTD)data obtained during the 2010 La Nina winter and the 2012 normal winter,combined with concurrent Argo profiling float data,provide a quasi-synoptic description of the water mass distributions and their variations in the far western equatorial Pacific Ocean.The water mass connection between the western Pacific and the east Indonesian seas is emphasized.Analysis indicates that the North Pacific Tropical Water(NPTW,S〉34.9)carried by the Mindanao Current southward and the South Pacific Tropical Water(SPTW,S〉35.1)from the southern hemisphere meet in the area.Observations suggest that the southward transport of the NPTW is stronger in 2010 than in 2012 due to enhanced advection of the Mindanao Current.The distribution of SPTW,which crosses the equator in the northwest direction and retroflects back to the interior Pacific Ocean,is found to retreat from 4°–5°N in2012 to 2°–3°N in 2010 La Ni?a peak in the 130°E section.A relatively fresh tropical subsurface water is identified in between the NPTW and the SPTW,moving eastward with the North Equatorial Countercurrent into the equatorial Pacific Ocean.However,the salinity maximum of this subsurface fresh water is found to decrease eastward,suggesting that the salinity maximum is generated either by strong diapycnal mixing or by isopycnal mixing of temporally entrained Indonesian sea water into the area.展开更多
The Shanxi Institute of Coal Chemistry,Chinese Academy of Sciences has designed and prepared a multiple confined-zone-based nickel hydrogenation catalyst by means of the atomic layer deposition(ALD)technology.In compa...The Shanxi Institute of Coal Chemistry,Chinese Academy of Sciences has designed and prepared a multiple confined-zone-based nickel hydrogenation catalyst by means of the atomic layer deposition(ALD)technology.In comparison with the non-confined-zone based catalyst,the multiple confined-zone-based nickel catalyst possesses an enhanced catalytic reactivity and catalytic stability for hydrogenation of cinnamaldehyde and nitrobenzene.展开更多
Using ELLS-1/2 radar satellite data, we generated a Digital Elevation Model by Interferometric Synthetic Aperture Radar, and the ERS-1/2 DEM that we generated is obviously superior to both the 1/25 ten thousand-scale ...Using ELLS-1/2 radar satellite data, we generated a Digital Elevation Model by Interferometric Synthetic Aperture Radar, and the ERS-1/2 DEM that we generated is obviously superior to both the 1/25 ten thousand-scale DEM of the National Fundamental Geographic Information System of China and the 90-m spatial resolution's SRTM DEM that America published in 2004 when it showed the characteristics of tiny structure relief. By analyzing the relief characteristics of the Bengcuo fault zone based on ERS-1/2 DEM, we find that the relief on the connection location of the Bengcuo and Pengcuo fault zones has complex characteristics. A structure relief that is similar to the Pengcuo fault zone crosses through the Dazi-Dasha fault on the the Bengcuo fault zone, while the Dazi-Dasha fault crosses through a gully at this place. This indicates that the Dazi-Dasha fault has been active at this place recently. At the same time, the Naka-Naduiduo fault is severed by the gully which was cut through by the Dazi-Dasha fault. Therefore, the Naka-Naduiduo fault was formed earlier than the Dazi-Dasha fault.展开更多
The Federal Commission for Protection against Health Risks in Mexico (COFEPRIS) is responsible for the regulation and health promotion of the production, commercialization, import, export, publicity or involuntary e...The Federal Commission for Protection against Health Risks in Mexico (COFEPRIS) is responsible for the regulation and health promotion of the production, commercialization, import, export, publicity or involuntary exposure of medicines and technologies for health. For its part, the Mexican Institute of Industrial Property (IMPI) is a decentralized public body with legal personality, own property and legal authority to administer the industrial property system in our country. In the year 2000, on September 19, the official journal published the linking of patents related to allopathic medicines and the sanitary registry. Objectives: To publicize the process of linking the Sanitary-Patent Registry as a case study to delimit the scope of the new pharmaceutical products. Methodology: Request the information to COFEPRIS for the registration of a new pharmaceutical product; Establish flow diagrams for the registration of: innovative products, generic products, biotech products and bio similar products; Integrate the documents in the dossier of the pharmaceutical product for sanitary registration; Elaborate sworn letter of non-invasion of patents and study of patents; Submit the Health Registry; Intergovernmental consultation. Sanitary Registry Results: Search of patents in databases to elaborate state of the art, to write letter under protest to say truth that is not invading any patent, when developing a composition of cetuximab, as generic product since the patent molecule expired in 2016 and 11 patents related to compositions, preparations and finished product preparation processes. Conclusions: COFEPRIS will determine through intergovernmental consultation with the IMPI whether or not a patent is invaded, according to the case it will grant the registration or send the corresponding prevention for cetuximab, in case that invading can also be a refusal of grant.展开更多
This paper reports the results acquired in a research work about "questionable" practices and behaviors in the academic production of researches and postgraduate social sciences and humanities studies of the program...This paper reports the results acquired in a research work about "questionable" practices and behaviors in the academic production of researches and postgraduate social sciences and humanities studies of the programs that are appointed by the National Program of Quality Postgraduate Studies (PNPC, by its acronym in Spanish) in Mexico. Through a qualitative methodology, the authors interpreted some of the arguments that explain and/or justify certain practices in relation to doubled production, authorship, and coauthorship of academic products. In this paper, the authors present and analyze the results that they obtained after reviewing documents produced by professors and students of six postgraduate programs that are taught in two Mexican public universities. At the same time, the authors examine some of the practices that take place within said programs, given the institutional demands of improving finished studies efficiency. One of the hypotheses of this work is the demands that are imposed by external evaluations of academic processes on professors and their programs in order to reach desirable rates with the purpose of maintaining or increasing the levels of productivity, gives way to certain practices that must be analyzed. This work's theoretic framework is constituted by the contributions of career sociology and professional ethics.展开更多
This paper presents some thoughts about the Maison du Bresil. The objective is to research this temporary residency for researchers through the meanings that characterize it as a Brazilian territory in Paris and throu...This paper presents some thoughts about the Maison du Bresil. The objective is to research this temporary residency for researchers through the meanings that characterize it as a Brazilian territory in Paris and through the very belonging to the category elite as a peculiarity of its residents. The author wish to analyze the international circulation of students and researchers that live there and have an educational experience of multiple dimensions as experiences of deterritorialization of identities and its consequences in a housing space which is at the same time in public and private. Based on documental analysis and ethnographic fieldwork, the paper presents some aspects of the history and the everyday life of the Maison du Bresil and Paris' Cite Internationale Universitaire. Also, it intends to show how the meanings of Brazilianness are used as support for the identity crisis lived by the members of a supposed Brazilian elite in Paris, as it analyzes the particularities of the mediations established by the residents of the Maison du Bresil, in the formation and international insertion of some researchers.展开更多
From May 4 to May 30, 2011, a field exploration of the Ashikule basin in the Western Kunlun Mountains area was conducted by a research team from the Institute of Geology, China Earthquake Administration and Earthquake...From May 4 to May 30, 2011, a field exploration of the Ashikule basin in the Western Kunlun Mountains area was conducted by a research team from the Institute of Geology, China Earthquake Administration and Earthquake Administration of Xinjiang Uygur Autonomous Region. This work is financially supported by the special fund for China earthquake research project "The Comprehensive Scientific Exploration of the MS7.3 Yutian Earthquake in 2008 and the Ashikule Volcano Group". Through detailed field survey on geological and geomorphological features of the Ashikule volcano group, which is one of the highest altitude volcanic plateaus (about 5000m) in the world, we have determined the total number of volcanoes, the eruption type and structural parameters, and approximate active history of the volcano group. Our studies have provided field evidence for resolving past controversies such as the authenticity of the news report about the eruption event on May 27, 1951, the eruption pattern of the Daheishan volcano, and the reality of the Gaotaishan volcano.展开更多
A research report on the environmental changes of the Tibetan Plateau from the past 2,000 years to a century ahead has been released by the Institute of Tibetan Plateau Research,Chinese Academy of Sciences.After a thr...A research report on the environmental changes of the Tibetan Plateau from the past 2,000 years to a century ahead has been released by the Institute of Tibetan Plateau Research,Chinese Academy of Sciences.After a three-year investigation into the plateau areas in southwest China’s Tibet Autonomous Region with an average altitude of over 4,500 meters,展开更多
The development of philosophy in contemporary China requires correct understanding and solving prominent practical problems in China's process of social development, providing proper rational thinking, value ideal an...The development of philosophy in contemporary China requires correct understanding and solving prominent practical problems in China's process of social development, providing proper rational thinking, value ideal and life orientation for the Chinese, and playing its role of guiding, regulating and promoting social progress. To achieve the goal, philosophy needs to shift from "system consciousness" to "problem consciousness," so as to fulfill a paradigm transformation; to shift from "local horizon" to "world horizon," so as to expand the horizon of our philosophy; and to shift from the tripartite division of Chinese, Western and Marxist philosophies to a "common horizon" for the three, so as to gradually establish the concept of "macro-philosophy."展开更多
The tomato fruit fly Dacus punctatifrons is a pest of tomato, Lycopersicon esculentum Mill in Cameroon. Oviposition behavior, developmental durations for the life stages, pupal and adult weights as well as adult longe...The tomato fruit fly Dacus punctatifrons is a pest of tomato, Lycopersicon esculentum Mill in Cameroon. Oviposition behavior, developmental durations for the life stages, pupal and adult weights as well as adult longevities were investigated on tomato. The peak period of oviposition was recorded between the hours of 10:30-11:30 and 14:30-5:30. The number of eggs per clutch varied from 3-12. Although the development period was similar for both sexes, the pupal weights, adult weights as well as adult longevities were significantly different.展开更多
文摘The interactions among drugs,tumor and host are critical for a response to therapy and for outcome.Anticancer herbs used in Chinese medicine are classified into 4 groups based on their target (tumor,patient and drug) as follows:eliminating pathogenic factors,strengthening the body resistance,enhancing effects of chemotherapy and detoxication of chemotherapy. Correspondingly,anticancer drugs used in Western medicine can be classified into 4 groups as follows:cytotoxic drugs,biological response modifiers,chemosensitizers and chemoprotectants. Based on the theory of Chinese medicinal formulas,prescriptions are composed of four constituents,namely,primary constituent (main component of the formula prescription),minister constituent (second component of formula prescription),adjuvant constituent (adjuvant component of the formula prescription) and messenger constituent (component making the formula prescription targeting pathological tissues).To control the interaction among drugs and to modulate the interaction among the tumor,patient and drugs,we suggest that combined therapy for Western medicine might include 4 constituents,i.e.,primary,cooperative,adjuvant and modulatory constituent. Cytotoxic drugs frequently are used as primary and cooperative constituents,whereas biological response modifiers and biochemical modulators are usually regarded respectively as adjuvant drugs and modulatory constituents. We believe these new concepts may be helpful for the aim of appropriately designing,evaluating or providing combination therapy.
文摘Quercus rugosa and Q.laurina are species that presents a wide geographical distribution range in temperate forests of Mexico. Oak canopies contain a considerable portion of arthropod diversity and the arthropods fauna fulfill a wide variety of ecological roles. We examined the effect of oak species and seasonal changes on some community structure parameters (diversity,composition,similarity,biomass,rare species,and density of arthropod fauna) of canopy arthropods. In total,40 oak canopies were fogged during rainy and dry season. A total of 614 identified arthropod morphospecies were recognized belonging to 22 orders associated with tree canopies. A separation of host tree species during both seasons,suggesting a different community structure on host plants species was demonstrated by the principal component analyses (PCA),therefore,differences between oak species results in phenotypes that structure the composition of the arthropod community. Q.laurina registered the highest densities,diversity index and number of rare species in comparison with Q.rugosa. While arthropod biomass showed an inverse pattern. Trees more close to one another (spatial distance) register a more similar canopy arthropod fauna. This study suggests that the trees of Q.laurina could act as a center of biodiversity by the accumulation of arthropod fauna with a considerable number of rare species,which presents wide ecological roles or is involved in critical processes that maintain forest ecosystems.
基金Supported by the Chinese Academy of Sciences(No.XDA11010205)the National Natural Science Foundation of China(Nos.41421005,U1606402,41720104008,41376032)+1 种基金the Qingdao Marine Science National Laboratory(Nos.2016ASKJ04,2016SAKJ12)the Shandong Provincial Project(No.2014GJJS0101)
文摘Conductivity-temperature-depth(CTD)data obtained during the 2010 La Nina winter and the 2012 normal winter,combined with concurrent Argo profiling float data,provide a quasi-synoptic description of the water mass distributions and their variations in the far western equatorial Pacific Ocean.The water mass connection between the western Pacific and the east Indonesian seas is emphasized.Analysis indicates that the North Pacific Tropical Water(NPTW,S〉34.9)carried by the Mindanao Current southward and the South Pacific Tropical Water(SPTW,S〉35.1)from the southern hemisphere meet in the area.Observations suggest that the southward transport of the NPTW is stronger in 2010 than in 2012 due to enhanced advection of the Mindanao Current.The distribution of SPTW,which crosses the equator in the northwest direction and retroflects back to the interior Pacific Ocean,is found to retreat from 4°–5°N in2012 to 2°–3°N in 2010 La Ni?a peak in the 130°E section.A relatively fresh tropical subsurface water is identified in between the NPTW and the SPTW,moving eastward with the North Equatorial Countercurrent into the equatorial Pacific Ocean.However,the salinity maximum of this subsurface fresh water is found to decrease eastward,suggesting that the salinity maximum is generated either by strong diapycnal mixing or by isopycnal mixing of temporally entrained Indonesian sea water into the area.
文摘The Shanxi Institute of Coal Chemistry,Chinese Academy of Sciences has designed and prepared a multiple confined-zone-based nickel hydrogenation catalyst by means of the atomic layer deposition(ALD)technology.In comparison with the non-confined-zone based catalyst,the multiple confined-zone-based nickel catalyst possesses an enhanced catalytic reactivity and catalytic stability for hydrogenation of cinnamaldehyde and nitrobenzene.
基金This project was sponsored bythe Special Programof Social Public Welfare Research of the Ministry of Science and Technology of PRC(2002D1A10001)
文摘Using ELLS-1/2 radar satellite data, we generated a Digital Elevation Model by Interferometric Synthetic Aperture Radar, and the ERS-1/2 DEM that we generated is obviously superior to both the 1/25 ten thousand-scale DEM of the National Fundamental Geographic Information System of China and the 90-m spatial resolution's SRTM DEM that America published in 2004 when it showed the characteristics of tiny structure relief. By analyzing the relief characteristics of the Bengcuo fault zone based on ERS-1/2 DEM, we find that the relief on the connection location of the Bengcuo and Pengcuo fault zones has complex characteristics. A structure relief that is similar to the Pengcuo fault zone crosses through the Dazi-Dasha fault on the the Bengcuo fault zone, while the Dazi-Dasha fault crosses through a gully at this place. This indicates that the Dazi-Dasha fault has been active at this place recently. At the same time, the Naka-Naduiduo fault is severed by the gully which was cut through by the Dazi-Dasha fault. Therefore, the Naka-Naduiduo fault was formed earlier than the Dazi-Dasha fault.
文摘The Federal Commission for Protection against Health Risks in Mexico (COFEPRIS) is responsible for the regulation and health promotion of the production, commercialization, import, export, publicity or involuntary exposure of medicines and technologies for health. For its part, the Mexican Institute of Industrial Property (IMPI) is a decentralized public body with legal personality, own property and legal authority to administer the industrial property system in our country. In the year 2000, on September 19, the official journal published the linking of patents related to allopathic medicines and the sanitary registry. Objectives: To publicize the process of linking the Sanitary-Patent Registry as a case study to delimit the scope of the new pharmaceutical products. Methodology: Request the information to COFEPRIS for the registration of a new pharmaceutical product; Establish flow diagrams for the registration of: innovative products, generic products, biotech products and bio similar products; Integrate the documents in the dossier of the pharmaceutical product for sanitary registration; Elaborate sworn letter of non-invasion of patents and study of patents; Submit the Health Registry; Intergovernmental consultation. Sanitary Registry Results: Search of patents in databases to elaborate state of the art, to write letter under protest to say truth that is not invading any patent, when developing a composition of cetuximab, as generic product since the patent molecule expired in 2016 and 11 patents related to compositions, preparations and finished product preparation processes. Conclusions: COFEPRIS will determine through intergovernmental consultation with the IMPI whether or not a patent is invaded, according to the case it will grant the registration or send the corresponding prevention for cetuximab, in case that invading can also be a refusal of grant.
文摘This paper reports the results acquired in a research work about "questionable" practices and behaviors in the academic production of researches and postgraduate social sciences and humanities studies of the programs that are appointed by the National Program of Quality Postgraduate Studies (PNPC, by its acronym in Spanish) in Mexico. Through a qualitative methodology, the authors interpreted some of the arguments that explain and/or justify certain practices in relation to doubled production, authorship, and coauthorship of academic products. In this paper, the authors present and analyze the results that they obtained after reviewing documents produced by professors and students of six postgraduate programs that are taught in two Mexican public universities. At the same time, the authors examine some of the practices that take place within said programs, given the institutional demands of improving finished studies efficiency. One of the hypotheses of this work is the demands that are imposed by external evaluations of academic processes on professors and their programs in order to reach desirable rates with the purpose of maintaining or increasing the levels of productivity, gives way to certain practices that must be analyzed. This work's theoretic framework is constituted by the contributions of career sociology and professional ethics.
文摘This paper presents some thoughts about the Maison du Bresil. The objective is to research this temporary residency for researchers through the meanings that characterize it as a Brazilian territory in Paris and through the very belonging to the category elite as a peculiarity of its residents. The author wish to analyze the international circulation of students and researchers that live there and have an educational experience of multiple dimensions as experiences of deterritorialization of identities and its consequences in a housing space which is at the same time in public and private. Based on documental analysis and ethnographic fieldwork, the paper presents some aspects of the history and the everyday life of the Maison du Bresil and Paris' Cite Internationale Universitaire. Also, it intends to show how the meanings of Brazilianness are used as support for the identity crisis lived by the members of a supposed Brazilian elite in Paris, as it analyzes the particularities of the mediations established by the residents of the Maison du Bresil, in the formation and international insertion of some researchers.
基金sponsored by the Special Fund for China Earthquake Research (201008004)the Special Projects of the Fundamental Scientific Research of the Institute of Geology,CEA (IGCEA1101)
文摘From May 4 to May 30, 2011, a field exploration of the Ashikule basin in the Western Kunlun Mountains area was conducted by a research team from the Institute of Geology, China Earthquake Administration and Earthquake Administration of Xinjiang Uygur Autonomous Region. This work is financially supported by the special fund for China earthquake research project "The Comprehensive Scientific Exploration of the MS7.3 Yutian Earthquake in 2008 and the Ashikule Volcano Group". Through detailed field survey on geological and geomorphological features of the Ashikule volcano group, which is one of the highest altitude volcanic plateaus (about 5000m) in the world, we have determined the total number of volcanoes, the eruption type and structural parameters, and approximate active history of the volcano group. Our studies have provided field evidence for resolving past controversies such as the authenticity of the news report about the eruption event on May 27, 1951, the eruption pattern of the Daheishan volcano, and the reality of the Gaotaishan volcano.
文摘A research report on the environmental changes of the Tibetan Plateau from the past 2,000 years to a century ahead has been released by the Institute of Tibetan Plateau Research,Chinese Academy of Sciences.After a three-year investigation into the plateau areas in southwest China’s Tibet Autonomous Region with an average altitude of over 4,500 meters,
文摘The development of philosophy in contemporary China requires correct understanding and solving prominent practical problems in China's process of social development, providing proper rational thinking, value ideal and life orientation for the Chinese, and playing its role of guiding, regulating and promoting social progress. To achieve the goal, philosophy needs to shift from "system consciousness" to "problem consciousness," so as to fulfill a paradigm transformation; to shift from "local horizon" to "world horizon," so as to expand the horizon of our philosophy; and to shift from the tripartite division of Chinese, Western and Marxist philosophies to a "common horizon" for the three, so as to gradually establish the concept of "macro-philosophy."
文摘The tomato fruit fly Dacus punctatifrons is a pest of tomato, Lycopersicon esculentum Mill in Cameroon. Oviposition behavior, developmental durations for the life stages, pupal and adult weights as well as adult longevities were investigated on tomato. The peak period of oviposition was recorded between the hours of 10:30-11:30 and 14:30-5:30. The number of eggs per clutch varied from 3-12. Although the development period was similar for both sexes, the pupal weights, adult weights as well as adult longevities were significantly different.