班公湖—怒江成矿带西段角西独立黑钨矿床的发现及其地质意义

角西石英脉型黑钨矿床系班公湖—怒江成矿带西段发现的首个独立黑钨矿床。文章通过对其矿体产出形式、矿化特征、蚀变类型等方面的研究,认为矿床成因类型属与岩浆热液有关的石英脉型黑钨矿。基于矿床现有的激电剖面测量和土壤地球化学剖面结果并结合矿床成因类型分析,笔者认为矿区尚具有一定找矿潜力,尤其云英岩型钨矿体应为下一步找矿工作部署的重点。角西石英脉型黑钨矿的发现将会丰富班公湖—怒江成矿带矿床成矿系列,完善区域成矿规律,拓展区域找矿方向,具有重要的区域成矿学与找矿意义,值得进一步研究。

陕西西沟钼矿床辉钼矿Re-Os年代学和同位素地球化学特征及其地质意义

西沟钼矿床是东秦岭黄龙铺地区近些年新发现和勘查的碳酸岩脉型钼矿床。钼矿体主要赋存于新太古界太华群变质岩内的石英方解石碳酸岩脉中,呈脉状、似层状或透镜状产出。辉钼矿主要呈浸染状、薄膜状、团块状分布于石英方解石碳酸岩脉中,成矿有关的围岩蚀变有钾长石化、硅化、黄铁矿化、萤石化、硬石膏化等。为查明西沟钼矿床的成矿时代、成矿物质来源、成矿机制、确定矿床类型,文章开展了辉钼矿Re-Os同位素测年,同位素地球化学分析。6件辉钼矿样品Re-Os同位素测年结果,模式年龄为(222.3±3.4)Ma^(226.6±3.7)Ma;加权平均年龄为(225.1±1.4)Ma;等时线年龄为(224.6±9.1)Ma,表明该矿床形成于晚三叠世。硫化物和硫酸盐的S同位素组成、重晶石和方解石Sr-Nd同位素组成及方解石C-O同位素组成均指示:西沟钼矿的成矿物质可能主要来源于地幔。根据其与华北陆块南缘其他碳酸岩型钼矿床地质特征、成矿时代和成矿物质来源等对比,确定西沟钼矿床属碳酸岩型脉状矿床。成矿作用发生于扬子板块与华北板块碰撞造山的后碰撞伸展环境,由于软流圈物质上涌诱发富集岩石圈地幔发生低程度部分熔融,所形成的碳酸质流体携带钼等成矿物质上升,在NW-NWW向深断裂带沉淀富集成矿。

陕西华县西沟钼矿地质、地球化学特征及其对矿床成因的制约

为了研究西沟钼矿床的成矿物质来源及矿床成因,对西沟钼矿床进行了地质、地球化学及稳定同位素研究。结果表明,西沟钼矿床的矿体主要以石英-方解石脉、石英脉类分布于太华岩群内,少量长石-石英脉型,辉钼矿、方铅矿、黄铁矿是主要矿石矿物,方解石和石英是主要的脉石矿物;含矿方解石具有较高的Sr、Ba和稀土含量,稀土元素及其特征值具火成碳酸岩组分特征,与黄龙铺矿田碳酸岩脉型钼矿床相似;成矿物质和成矿流体主要来源于深源或上地幔,成矿过程中有少量壳源物质或地下水参与。研究认为西沟矿床为石英-碳酸岩脉型钼铅矿床。

新疆哈密市野马泉西金矿床地质特征及找矿标志

野马泉西金矿床位于阿齐山—雅满苏铁铜金成矿带东段北部的苦水断裂带上。该断裂带是东天山晚古生代重要的铁铜金成矿带,已发现多个铁铜金矿。文章拟通过分析矿床地层、断裂、韧性剪切带、岩浆岩、地球物理、地球化学、矿石矿物、围岩蚀变等特征,阐明野马泉西金矿床的地质特征,简述其矿床成因,初步建立找矿标志。

新疆东天山三岔口西铜矿床中辉钼矿Re-Os定年结果及其意义

新疆东天山三岔口西铜矿床位于大南湖—头苏泉岛弧带的东段,为近年来新发现的1个中型矿床。矿区蚀变和矿化可分为三个阶段:黑云母-磁铁矿化阶段(Ⅰ)、绢英岩化阶段(Ⅱ)和后期脉体阶段(Ⅲ)。阶段Ⅰ蚀变普遍分布在石英闪长岩中;阶段Ⅱ蚀变零星分布在石英闪长岩中,并叠加在黑云母-磁铁矿化蚀变之上;阶段Ⅲ脉体偶见于石英闪长岩中,且切穿黑云母-磁铁矿化、绢英岩化蚀变的石英闪长岩。矿区铜钼矿化出现在石英闪长岩中,与阶段Ⅱ绢英岩化蚀变关系密切。辉钼矿Re-Os年龄显示,三岔口西矿集区内至少存在两期成矿作用:第一期形成于早古生代[(416.3±6.4)]Ma,该期矿化仅出现在三岔口矿床,与区内石英闪长岩关系密切;第二期形成于晚古生代(360~350Ma),该期矿化在玉海、玉海西、三岔口西、三岔口地区广发分布,是该区的主矿化期,可能是由玉海西泥盆纪花岗岩侵入而引起。

山东省乳山市西涝口金矿床金矿物学特征及其意义

西涝口金矿是胶莱盆地东北缘地区典型的金矿床,该区金矿物以单颗粒的自然金为主,有少量的银金矿。粒度多集中在1~37μm;形态多为星点状、角粒状、圆粒状、细脉状、枝杈状等。主要以包体金、粒间金、裂隙金存在于黄铁矿、石英等颗粒中。化学成分中除含Au和Ag以外,还含有Fe、S、Te、Se、Ni、Co等元素检出,其中Fe、S、Te元素普遍存在,推断为中浅成矿作用产物。金矿物成色平均值为864.49,金成色包体金(896.00)→晶隙金(861.79)→裂隙金(846.93),其中黄铁矿中包体金主要是自然金,成色最高,反映形成温度也最高。

追上唔西·迪西的小床

依古·比古还找到谁了呢？哈哈，她喜欢小花。猜到是谁了吗？赶快把她贴在依古·比古旁边，然后帮她去追小床吧！

《召南·小星》在怨谁?——兼评胡适的解说

胡适在他的《谈谈诗经》里认为,《小星》“是写妓女生活的最早记载。我们试看《老残游记》,可见黄河流域的妓女送铺盖上店陪客人的情形。再看原文,我们看她抱衾禂以宵征,就可以知道她为何事了”(《胡适论说文选》)。 别的先不说,单说胡适这种研究《诗经》的方法,也实在可笑。《老残游记》写于清之末季,距《诗经》时代相去约两千年,社会形态,包括男女之间关系的形态。

胶东郭城地区龙口——土堆金矿区深部成矿潜力及找矿方向

龙口-土堆金矿区位于胶莱盆地东北缘,控制矿体主要赋存在-400 m标高以上的浅部,矿体规模相对较小、不连续,而其周边的辽上、西涝口金矿区在-500 m标高以下均实现了找矿突破,且矿体规模厚大。通过对比龙口-土堆金矿床与辽上、西涝口金矿床的地质特征,并结合区域成矿背景,认为龙口-土堆金矿区深部具有较大的成矿潜力,且深部找矿应以牧牛山岩体与荆山群地层接触带为主。

Ore-forming material of Dachang tin deposit in Guangxi, China:Lead isotope evidence

For revealing the ore sources of the Dachang tin?polymetallic ore deposit, the lead isotopes were analyzed systematically by using the single minerals of sulphides, including pyrite, pyrrhotite, sphalerite, and galena. Then, the mineral sources and their characteristics were discussed based on the classical lead isotope discriminating model. The results show that the lead isotope ratios of206Pb/204Pb,207Pb/204Pb, and208Pb/204Pb range from 17.478 to 18.638, 15.440 to 15.858, and 37.556 to 39.501, respectively. According to Zartman lead model, the ore lead contains the upper crust composition; however, the granite does not provide all ore leads, and other material sources exist. Obviously, the ore deposit belongs to the result of the combined effect of crust?mantle. The source rocks are characterized by a certain degree of similarity with the island arc material. Moreover, its distant origin in the upper and lower crusts may be related to the subduction island arc material or oceanic crust. The mantle-derived material may have a certain status in the source region. Meanwhile, based on the lead isotope three-dimensional topology projection vectors, the ore leads are concentrated in zoneA, which indicates the characteristics of Yangtze lead isotope province and a possible genetic relationship with Yangtze block.

贾岛苦吟诗风的形成和特色

贾岛是唐代苦吟诗派的代表作家,人们之所以称他为苦吟诗人,主要基于三个方面的原因,一是生活苦.贾岛早年出家当和尚,以后还俗久举进士不第,生活无着,穷愁潦倒.贫困到何等地步呢?他有诗为证:“市中有樵山,此舍朝无烟.井底有甘泉,釜中乃空然.我要见白日,雪来塞青天.坐闻西床琴,冻折两三弦”(《朝饥》)“鬓边虽有丝,不堪织寒衣”(《客喜》)“近日营家计,”绳悬一小瓢”(《寄乔侍郎》).

Comparison of Traditional Chinese Medicine with Western Medicine Cancer Therapy

The interactions among drugs,tumor and host are critical for a response to therapy and for outcome.Anticancer herbs used in Chinese medicine are classified into 4 groups based on their target (tumor,patient and drug) as follows:eliminating pathogenic factors,strengthening the body resistance,enhancing effects of chemotherapy and detoxication of chemotherapy. Correspondingly,anticancer drugs used in Western medicine can be classified into 4 groups as follows:cytotoxic drugs,biological response modifiers,chemosensitizers and chemoprotectants. Based on the theory of Chinese medicinal formulas,prescriptions are composed of four constituents,namely,primary constituent (main component of the formula prescription),minister constituent (second component of formula prescription),adjuvant constituent (adjuvant component of the formula prescription) and messenger constituent (component making the formula prescription targeting pathological tissues).To control the interaction among drugs and to modulate the interaction among the tumor,patient and drugs,we suggest that combined therapy for Western medicine might include 4 constituents,i.e.,primary,cooperative,adjuvant and modulatory constituent. Cytotoxic drugs frequently are used as primary and cooperative constituents,whereas biological response modifiers and biochemical modulators are usually regarded respectively as adjuvant drugs and modulatory constituents. We believe these new concepts may be helpful for the aim of appropriately designing,evaluating or providing combination therapy.

Early Cretaceous precious fossil-bearing beds in Weijialing—Yaolugou of Jianchang Basin,western Liaoning

The Jianchang Basin is one of the main localities of the precious fossils of Jehol Biota in western Liaoning.The fossil-bearing horizons are mainly in the Yixian-and Jiufotang formations.In the Weijialing--Yaolugou of southwest Jianchang Basin,many precious fossils have been found at Luojiagou Bed of the 2nd Member of the Yixian Formation and at Xidian Bed of the 1st member of the Jiufotang Formation.The geologic setting,sedimentary environment and paleogeography of the precious fossil-bearing beds were also studied.

Order of sphalerite and galena precipitation: A case study from lead-zinc deposits in southwest China

Most of the lead and zinc deposits in Southwest China, are characterized by mineral zoning, which is especially true for the Huize and Zhaotong deposits. The mineral assemblage zoning is consistent for both horizontal and vertical zoning, from the base(center) of the ore body to the top(outermost), the mineral zones are as follows. I-1: coarse-grained pyrite and a little puce sphalerite;I-2: brown sphalerite, galena, and ferro-dolomite;I-3: galena, sandy beige and pale yellow sphalerite, and calcite;and I-4: fine-grained pyrite, dolomite, and calcite. Among them, sphalerite is the landmark mineral of different zoning. From I-1 to I-3, the color of sphalerite changes from dark to light, its crystalline size changes from coarse to fine, and its structure changes from disseminated to veinlet. This mineral zoning is seen not only on a microscopic scale, but is also clear on a mesoscopic and macroscopic scale. It is caused by the order of the sphalerite and galena precipitation. We studied the metallic minerals and fluid inclusions using a thermodynamic phase diagram method, such as lgfO2–lgfS2, pH–lgfO2, pH–lg[Pb^2+] and pH–lg[HS^-], discussed the constraints on the order of the sphalerite and galena precipitation in the migration and precipitation process of lead and zinc under different pH values, oxygen fugacity, sulfur fugacity, and ionic activity. We also explain the formation mechanism and propose that the main controlling factor of the order of the sphalerite and galena precipitation is sulfur fugacity.

A functional variant in the CD209 promoter is associated with DQ2-negative celiac disease in the Spanish population

AIM： To address the role of CD209 in celiac disease （CD） patients. Non-human leukocyte antigen （HLA） genetic factors in CD predisposition are poorly understood, and environmental factors like infectious pathogens may play a role. CD209 is a dendritic and macrophage surface molecule involved in pathogen recognition and immune activation. Recently, a functional variant in the promoter of the CD209 gene （-336A/G） has been shown to affect the transcriptional CD209 activity in vitro and it has been associated with a higher susceptibility to/or severity of infection. METHODS： The study population was composed of two case-control cohorts of 103 and 386 CD patients and 312 y 419 healthy controls as well as a panel of 257 celiac families. Genotyping for the -336A/G CD209 promoter polymorphism was performed using a TaqMan 5＇ allelic discrimination assay. HLA-DQ was determined by hybridization with allele specific probes. RESULTS： Initially, the case-control and familial studies did not find any association of the -336 A/G CD209 genetic variant with CD susceptibility. However, the stratification by HLA-DQ2 did reveal a significant association of CD209 promoter polymorphism in the HLA-DQ2 （-） group （carrier A vs GG in DQ2 （-） vs DQ2 （＋） patients （P = 0.026, OR = 3.71）. CONCLUSION： The -336G CD209 allele seems to be involved in CD susceptibility in HLA-DQ2 （-） patients. Our results might suggest a possible role of pathogens in the onset of a minor group of CD patients.

Clinical characteristics and type of antithrombotic treatment in a Spanish cohort of elderly patients with atrial fibrillation according to dependency, frailty and cognitive impairment

Background Available data regarding clinical profile and management of elderly patients with atrial fibrillation （AF） according to dependency, fragility and cognitive impairment are scarce. The objective of the study was to analyze the biodemographic data, clinical profile and antithrombotic treatment according to dependency, fragility and cognitive impairment in elderly AF patients. Methods Cross- sectional and multi-center study performed in consecutive AF patients ≥ 75 years treated with oral anticoagulants ≥ 3 months attended in Internal Medicine Departments in Spain. Results A total of 837 patients （83.0 ± 5.0 years; CHA2DS2-VASc： 5.0 ± 1.4; HAS-BLED： 2.1 ± 0.9） were included. 44.4% of patients had some degree of dependency, 43.3% were fragile, and 32.3% had cognitive impairment. Patients with any of these conditions were older, had a worse clinical profile, with more comorbidities and higher risks of thromboembolic and bleeding events. All these conditions were independently associated among them. Overall, 70.8% of patients were taking vitamin K antagonists, the remaining 29.2% direct oral anticoagulants and 9.7% oral antiplatelets. This distribution was independent of the presence of dependency or fragility, but there was a trend to a higher prescription of vitamin K antagonists in those patients with cognitive impairment （75.2% vs. 68.8%; P = 0.05）. Conclusions Approximately 32%-44% of elderly anticoagulated AF patients attended have some degree of dependency, fragility and/or cognitive impairment. Patients with any of these conditions are older and have a worse clinical profile. Ap？proximately 71% of patients are taking vitamin K antagonists, regardless dependency or frailty, but with a trend to higher prescription in patients with cognitive impairment.

Clinical usefulness of adherence to gastro-esophageal reflux disease guideline by Spanish gastroenterologists

AIM:To investigate usefulness of adherence to gastroesophageal reflux disease(GERD) guideline established by the Spanish Association of Gastroenterology.METHODS:Prospective,observational and multicentre study of 301 patients with typical symptoms of GERD who should be managed in accordance with guidelines and were attended by gastroenterologists in daily practice.Patients(aged > 18 years) were eligible for inclusion if they had typical symptoms of GERD(heartburn and/or acid regurgitation) as the major complaint in the presence or absence of accompanying atypical symptoms,such as dyspeptic symptoms and/or supraesophageal symptoms.Diagnostic and therapeutic decisions should be made based on specific recommendations of the Spanish clinical practice guideline for GERD which is a widely disseminated and well known instrument among Spanish in digestive disease specialists.RESULTS:Endoscopy was indicated in 123(41%) patients:50 with alarm symptoms,32 with age > 50 years without alarm symptom.Seventy-two patients(58.5%) had esophagitis(grade A,23,grade B,28,grade C,18,grade D,3).In the presence of alarm symptoms,endoscopy was indicated consistently with recommendations in 98% of cases.However,in the absence of alarm symptoms,endoscopy was indicated in 33% of patients > 50 years(not recommended by the guideline).Adherence for proton pump inhibitors(PPIs) therapy was 80%,but doses prescribed were lower(half) in 5% of cases and higher(double) in 15%.Adherence regarding duration of PPI therapy was 69%;duration was shorter than recommended in 1%(4 wk in esophagitis grades C-D) or longer in 30%(8 wk in esophagitis grades A-B or in patients without endoscopy).Treatment response was higher when PPI doses were consistent with guidelines,although differences were not significant(95% vs 85%).CONCLUSION:GERD guideline compliance was quite good although endoscopy was over indicated in patients > 50 years without alarm symptoms;PPIs were prescribed at higher doses and longer duration.

山东栖霞台前—陡崖断裂带构造特征及找矿方向浅谈

台前-陡崖断裂带为胶西北地区4条S形断裂之一,是西林-陡崖S形断裂的一部分,控制着西陡崖-笏山金矿床、台前金矿床等多处金矿床的产出,已探明金金属量超过20t。通过分析该断裂带地质特征及所赋存的金矿床矿体特征,认为西陡崖-笏山金矿床东南侧一带深部具有较大的找矿空间。

The clinical effects of DC-CIK cells combined with chemotherapy in the treatment of advanced NSCLC

Objective: The aim of the study was to evaluate the safety and therapeutic effects of autologous dendritic cells co-cultured with cytokine-induced killer cells (DC-CIK) combined with chemotherapy in advanced non-small cell lung cancer (NSCLC) patients. Methods: Fifty patients with advanced NSCLC (stages III to IV), who had received therapies in our Center (Department of Biotherapy, Affiliated to Cancer Hospital of Shanxi Medical University, Taiyuan, China) from August 2008 to January 2010, were treated by DC-CIK + chemotherapy as the combined treatment group; fifty advanced NSCLC patients treated with chemotherapy at the same time served as controls. The immunologic function, short-term therapeutic effects, the 1-year survival rate, the life quality, the chemotherapy side effects were compared between the two groups, the safety and therapeutic effects of DC-CIK cells therapy were observed too. Results: There was no obvious change of subsets of T cells in peripheral blood before and after therapy in DC-CIK + chemotherapy group, and IFN-γ was improved after therapy in this group (P < 0.05); in chemotherapy alone group, the ratios of CD3+CD4+, CD3+CD8+, CD3-CD56+ cells and the secretion of IL-2, TNF-α decreased significantly after therapy (P < 0.05); the ratios of CD3+CD8+, CD3+CD56+ were improved after cell culture (P < 0.05). The disease control rate (DCR) of DC-CIK + chemotherapy group was higher than that in the chemotherapy alone group (78.0% vs 56.0%, P < 0.05); the 1-year survival rates of DC-CIK + chemotherapy group and chemotherapy alone group were 50% and 44% respectively, had no significant difference. Compared with chemotherapy alone group, the occurrence of chemotherapy side effects (including bone marrow suppression, nausea and vomiting, peripheral nerve toxicity) was less in the DC-CIK + chemotherapy group (P < 0.05). The physical and appetite were better in DC-CIK + chemotherapy group after therapy. Conclusion: To compare with simple chemotherapy, DC-CIK + chemotherapy for advanced NSCLC is safe and effective, and it can improve patients' life quality and remission rate, and prolong their survival time.

Geology and fluid inclusion of Wadi Sharis Neoproterozoic orogenic gold deposits in northwestern Yemen

The Wadi Sharis orogenic gold deposit in northwestern Yemen is related to the fault and shear zones vein at medium depth in the crust in the Neoprotcrozoic meta-sedimentary and meta-volcanosedimentary succes- sion of greenschist to amphibolite facies metamorphism. Three distinct fluid inclusion types have been identified in the gold-bearing quartz sulphide veins of the deposit： （1） type I： vapour-liquid two-phase （VH2O-LH2O ）, （2） type II ： three-phase CO2 （ VCO2 - LH2O - LCO2 ） and （3） type III： vapour-rich （LCO2 - VCO2 ） inclusions. Six analysis of individual fluid inclusion indicate the fluid inclusions comprise mainly of H2O and CO2. Forma- tion P-T conditions recorded by fluid inclusions in quartz crystals correspond to 180℃-380℃ and up to 130 MPa, as indicated by high-density CO2 bubbles （up to 0. 98 g/cm3 ） observed in some inclusions. The esti- mated crystallization pressures correspond to approximately 4-10 km of overburden, assuming a lithostatic load. The salinity ranges from 0 to 22 wt%. The deposit holds at 0.2-5 g/t Au and contains low-moderate salinity.