The tension property of aluminum-alloy sheet with different microstructures is measured, and the surface and tension fracture morphology of tension sample with and without orange peel are observed by using scanning el...The tension property of aluminum-alloy sheet with different microstructures is measured, and the surface and tension fracture morphology of tension sample with and without orange peel are observed by using scanning electron microscope （SEM）. Surface roughness and nano hardness of tension sample are measured. The results show that the average elongation of the samples with orange peel is lower than that without orange peel ; especially the r value of per- pendicular to the rolling direction is much lower than that without orange peel. The tension surface of the orange peel samples is very rough; various parameters of surface roughness are higher. Under the observation of SEM, a wider slid- ing band with a micro crack on the surface of orange peel sample can be found. The various parameters of surface rough- ness without orange peel sample are near to zero, the sliding band is narrow and without micro cracks. The dimple width in tensile fracture of orange peel sample is larger than that without orange peel sample, but shear lip is narrower. The nano hardness testing results show that samples with orange peel behave high elastic modulus, high hardness, and high maximum load, but low plastic deformation depth. These mentioned features can completely describe surface and frac- ture morphology of tension samt31es with oranze peel.展开更多
Objective:The aim of this study was to evaluate the response rate,time to progression(TTP),overall survival,and safety of the combination of capecitabine plus oxaliplatin in treatment of advanced gastric cancer(AGC).M...Objective:The aim of this study was to evaluate the response rate,time to progression(TTP),overall survival,and safety of the combination of capecitabine plus oxaliplatin in treatment of advanced gastric cancer(AGC).Methods:All the patients with advanced gastric cancer who were not received any prior chemotherapy or radiotherapy were treated with combination of capecitabine(1250 mg/m2 twice daily,days 1-14) plus oxaliplatin(130 mg/m2 as a 2-h intravenous infusion on day 1) every 3 weeks.Results:Two cases of complete response(CR) and 34 cases of partial response(PR) were confirmed,giving an overall response rate of 52.9%,of the 68 patients with advanced gastric cancer.The median TTP and overall survival for all patients were 7.3 and 11.9 months,respectively.Grade 3 leukopenia,thrombocytopenia,nausea/vomiting,and diarrhea were observed in 3,5,1,and 4 patients,respectively.Yet,no grade 4 toxicity was observed.Conclusion:Capecitabine/ oxaliplatin combination chemotherapy is active in patients with advanced gastric cancer.展开更多
Objective： The aim of the study was to investigate the efficacy and safety of raltitrexed/bevacizumab in combination with irinotecan or oxaliplation for advanced colorectal cancer as the second-line and second-line a...Objective： The aim of the study was to investigate the efficacy and safety of raltitrexed/bevacizumab in combination with irinotecan or oxaliplation for advanced colorectal cancer as the second-line and second-line above treatments. Metho ods： Fifteen cases of advanced colorectal cancer were enrolled to receive regimens including raltitrexed/bevacizumab combined with irinotecan or oxaliplation. Two cases were treated with raltitrexed ＋ bavacizumab regimen, 9 cases with raltitrexed ＋ bavacizumab ＋ irinotecan regimen, and 4 cases with raltitrexed ＋ bevacizumab ＋ oxaliplation regimen. The doses of the drugs were as follows： bevacizumab 5 mg/kg ivgtt, d 1; raltitrexed 2.0 mg/m2 ivgtt 15 min, d2; irinotecan 180 mg/m2 ivgtt 1 h, d2; and oxaliplatin 85 mg/m2 ivgtt 2 h, d2. Two weeks was a cycle for each regimen. Results： The efficacy of the 15 patients could be evaluated. Two cases were in PR ,10 cases in SD, 3 cases in PD, the response rate was 13.3%, and the disease control rate was 80.0%. The median progress-free survival was 5.1 months （95% CI： 3.404-6.813 months）, and the median overall survival was 11.5 months （95% CI： 8.985-13.930 months）. The adverse effects included anorexia, nausea/vomiting, fatigue, leucopenia, thrombocytopenia, etc, and the main 3-4 grades adverse effects were anorexia, nausea/vomiting, fatigue, and thrombocytopenia. Conclusion： Raltitrexed/bevacizumab combined with irinotecan or oxaliplatin as the secondline and second-line above treatments for advanced colorectal cancer has high disease control rates, and the adverse effect is well tolerated. The combined regimen can be recommended as a phase III clinical research and second-line and secondlines above treatments for advanced colorectal cancer.展开更多
Objective: To sutdy the mechanical properties and the clinical results of minimum-contact plate in the treatment of fractures. Methods: Four-point bending and torsion tests were conducted to compare the new minimum co...Objective: To sutdy the mechanical properties and the clinical results of minimum-contact plate in the treatment of fractures. Methods: Four-point bending and torsion tests were conducted to compare the new minimum contact plate (MCP) with dynamic compression plate (DCP) and limited contact dynamic compression plate (LC-DCP). The fracture healing time and growth of bony callus were observed in 29 cases of long bone fracture fixed with MCP to evaluate the advantages of this kind of plate. Results: The 29 patients who underwent MCP were followed up from 6 to 14 months. The average healing time for femoral, tibial and humeral fractures was 12, 13 and 10 weeks, respectively. All fractures were healed. No displacement of fracture, screw pullout, deformation or break of the plate were found. Conclusions: The bending stiffness of MCP is significantly greater than that of DCP and LC-DCP (P< 0.05). MCP can protect the periosteal blood supply against avascular osseous necrosis and accelerate bone healing. It is a kind of reliable and effective plate in treatment of fractures.展开更多
文摘The tension property of aluminum-alloy sheet with different microstructures is measured, and the surface and tension fracture morphology of tension sample with and without orange peel are observed by using scanning electron microscope （SEM）. Surface roughness and nano hardness of tension sample are measured. The results show that the average elongation of the samples with orange peel is lower than that without orange peel ; especially the r value of per- pendicular to the rolling direction is much lower than that without orange peel. The tension surface of the orange peel samples is very rough; various parameters of surface roughness are higher. Under the observation of SEM, a wider slid- ing band with a micro crack on the surface of orange peel sample can be found. The various parameters of surface rough- ness without orange peel sample are near to zero, the sliding band is narrow and without micro cracks. The dimple width in tensile fracture of orange peel sample is larger than that without orange peel sample, but shear lip is narrower. The nano hardness testing results show that samples with orange peel behave high elastic modulus, high hardness, and high maximum load, but low plastic deformation depth. These mentioned features can completely describe surface and frac- ture morphology of tension samt31es with oranze peel.
文摘Objective:The aim of this study was to evaluate the response rate,time to progression(TTP),overall survival,and safety of the combination of capecitabine plus oxaliplatin in treatment of advanced gastric cancer(AGC).Methods:All the patients with advanced gastric cancer who were not received any prior chemotherapy or radiotherapy were treated with combination of capecitabine(1250 mg/m2 twice daily,days 1-14) plus oxaliplatin(130 mg/m2 as a 2-h intravenous infusion on day 1) every 3 weeks.Results:Two cases of complete response(CR) and 34 cases of partial response(PR) were confirmed,giving an overall response rate of 52.9%,of the 68 patients with advanced gastric cancer.The median TTP and overall survival for all patients were 7.3 and 11.9 months,respectively.Grade 3 leukopenia,thrombocytopenia,nausea/vomiting,and diarrhea were observed in 3,5,1,and 4 patients,respectively.Yet,no grade 4 toxicity was observed.Conclusion:Capecitabine/ oxaliplatin combination chemotherapy is active in patients with advanced gastric cancer.
文摘Objective： The aim of the study was to investigate the efficacy and safety of raltitrexed/bevacizumab in combination with irinotecan or oxaliplation for advanced colorectal cancer as the second-line and second-line above treatments. Metho ods： Fifteen cases of advanced colorectal cancer were enrolled to receive regimens including raltitrexed/bevacizumab combined with irinotecan or oxaliplation. Two cases were treated with raltitrexed ＋ bavacizumab regimen, 9 cases with raltitrexed ＋ bavacizumab ＋ irinotecan regimen, and 4 cases with raltitrexed ＋ bevacizumab ＋ oxaliplation regimen. The doses of the drugs were as follows： bevacizumab 5 mg/kg ivgtt, d 1; raltitrexed 2.0 mg/m2 ivgtt 15 min, d2; irinotecan 180 mg/m2 ivgtt 1 h, d2; and oxaliplatin 85 mg/m2 ivgtt 2 h, d2. Two weeks was a cycle for each regimen. Results： The efficacy of the 15 patients could be evaluated. Two cases were in PR ,10 cases in SD, 3 cases in PD, the response rate was 13.3%, and the disease control rate was 80.0%. The median progress-free survival was 5.1 months （95% CI： 3.404-6.813 months）, and the median overall survival was 11.5 months （95% CI： 8.985-13.930 months）. The adverse effects included anorexia, nausea/vomiting, fatigue, leucopenia, thrombocytopenia, etc, and the main 3-4 grades adverse effects were anorexia, nausea/vomiting, fatigue, and thrombocytopenia. Conclusion： Raltitrexed/bevacizumab combined with irinotecan or oxaliplatin as the secondline and second-line above treatments for advanced colorectal cancer has high disease control rates, and the adverse effect is well tolerated. The combined regimen can be recommended as a phase III clinical research and second-line and secondlines above treatments for advanced colorectal cancer.
文摘Objective: To sutdy the mechanical properties and the clinical results of minimum-contact plate in the treatment of fractures. Methods: Four-point bending and torsion tests were conducted to compare the new minimum contact plate (MCP) with dynamic compression plate (DCP) and limited contact dynamic compression plate (LC-DCP). The fracture healing time and growth of bony callus were observed in 29 cases of long bone fracture fixed with MCP to evaluate the advantages of this kind of plate. Results: The 29 patients who underwent MCP were followed up from 6 to 14 months. The average healing time for femoral, tibial and humeral fractures was 12, 13 and 10 weeks, respectively. All fractures were healed. No displacement of fracture, screw pullout, deformation or break of the plate were found. Conclusions: The bending stiffness of MCP is significantly greater than that of DCP and LC-DCP (P< 0.05). MCP can protect the periosteal blood supply against avascular osseous necrosis and accelerate bone healing. It is a kind of reliable and effective plate in treatment of fractures.
