OBJECTIVE: To investigate the characteristics of multifocal electroretinograms (mf-ERG) of different phases in diabetic retinopathy (DR) and its clinical significance. METHODS: Multifocal electroretinograms in patient...OBJECTIVE: To investigate the characteristics of multifocal electroretinograms (mf-ERG) of different phases in diabetic retinopathy (DR) and its clinical significance. METHODS: Multifocal electroretinograms in patients with DR (I - II stage) were tested with VERIS IV system. RESULTS: In I - II stage, the absolute values of N1, P1 and N2 response densities, and the N1-P1 and P1-N2 response densities were attenuated is a field of about 45 degrees in diameter. CONCLUSION: As a new objective and quantitative examination for spatial visual function, multifocal electroretinograms may be valuable in the diagnosis of diabetic retinopathy.展开更多
To investigate the characteristics of multifocal electroretinograms (mf ERG) o f different phases in diabetic retinopathy (DR) and its clinical significance Methods Multifocal electroretinograms in patients with D...To investigate the characteristics of multifocal electroretinograms (mf ERG) o f different phases in diabetic retinopathy (DR) and its clinical significance Methods Multifocal electroretinograms in patients with DR (Ⅰ-Ⅱ stage) were tested with VERIS Ⅳ system Results In Ⅰ-Ⅱ stage, the absolute values of N1, P1 and N2 response densities, and the N1 P1 and P1 N2 response densities were attenuated is a field of about 45 deg rees in diameter Conclusion As a new ABSTRACT and quantitative examination for spatial visual function, mul tifocal electroretinograms may be valuable in the diagnosis of diabetic retinopa thy展开更多
To investigate the pathological morphology alteration of the splanchnic vascular wall in portal hypertensive patients Methods Splenic arteries, veins and gastric coronary veins from portal hypertensive pati ents (n...To investigate the pathological morphology alteration of the splanchnic vascular wall in portal hypertensive patients Methods Splenic arteries, veins and gastric coronary veins from portal hypertensive pati ents (n=50) were removed during esophagogastric devascularization with splenecto my and were observed under optic and electron microscopes The expression of iN OS in the splenic artery wall was analysed with immunohistochemistry Results The internal elastic membrane and medial elastic fibers of the splenic artery wa ll were broken and degenerated Atrophy, apoptosis and phenotypic changes were seen in smooth muscle cells of splenic arteries Positive staining for iNOS was seen in the cytoplasm of smooth muscle cells and iNOS activity was elevated com pared with the non cirrhotic patients ( P 【0 01) In the splenic and gastri c coronary veins of cirrhotic patients, we found proliferative intima, extensive thrombi adhering to the venous wall, mimicked arteriosclerosis plaques accompan ied with hypertrophy of smooth muscle cells, and thickened muscle fibers of vein s with increase in extracelluar matrix Conclusion Portal hypertension may be complicated by splanchnic arterial and venous vasculo pathy There may be an interactive relationship among portal hypertension, spla nchnic hyperdynamic disturbances and splanchnic vasculopathy in the pathogenesis of portal hypertension展开更多
文摘OBJECTIVE: To investigate the characteristics of multifocal electroretinograms (mf-ERG) of different phases in diabetic retinopathy (DR) and its clinical significance. METHODS: Multifocal electroretinograms in patients with DR (I - II stage) were tested with VERIS IV system. RESULTS: In I - II stage, the absolute values of N1, P1 and N2 response densities, and the N1-P1 and P1-N2 response densities were attenuated is a field of about 45 degrees in diameter. CONCLUSION: As a new objective and quantitative examination for spatial visual function, multifocal electroretinograms may be valuable in the diagnosis of diabetic retinopathy.
文摘To investigate the characteristics of multifocal electroretinograms (mf ERG) o f different phases in diabetic retinopathy (DR) and its clinical significance Methods Multifocal electroretinograms in patients with DR (Ⅰ-Ⅱ stage) were tested with VERIS Ⅳ system Results In Ⅰ-Ⅱ stage, the absolute values of N1, P1 and N2 response densities, and the N1 P1 and P1 N2 response densities were attenuated is a field of about 45 deg rees in diameter Conclusion As a new ABSTRACT and quantitative examination for spatial visual function, mul tifocal electroretinograms may be valuable in the diagnosis of diabetic retinopa thy
基金theNationalNaturalScienceFoundationofChina (No 3 0 170 92 0 )
文摘To investigate the pathological morphology alteration of the splanchnic vascular wall in portal hypertensive patients Methods Splenic arteries, veins and gastric coronary veins from portal hypertensive pati ents (n=50) were removed during esophagogastric devascularization with splenecto my and were observed under optic and electron microscopes The expression of iN OS in the splenic artery wall was analysed with immunohistochemistry Results The internal elastic membrane and medial elastic fibers of the splenic artery wa ll were broken and degenerated Atrophy, apoptosis and phenotypic changes were seen in smooth muscle cells of splenic arteries Positive staining for iNOS was seen in the cytoplasm of smooth muscle cells and iNOS activity was elevated com pared with the non cirrhotic patients ( P 【0 01) In the splenic and gastri c coronary veins of cirrhotic patients, we found proliferative intima, extensive thrombi adhering to the venous wall, mimicked arteriosclerosis plaques accompan ied with hypertrophy of smooth muscle cells, and thickened muscle fibers of vein s with increase in extracelluar matrix Conclusion Portal hypertension may be complicated by splanchnic arterial and venous vasculo pathy There may be an interactive relationship among portal hypertension, spla nchnic hyperdynamic disturbances and splanchnic vasculopathy in the pathogenesis of portal hypertension
