PURPOSE: To describe retinal pigment epithelial tear following photodynamic therapy (PDT) for subfoveal choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD). Design: Retrospective int...PURPOSE: To describe retinal pigment epithelial tear following photodynamic therapy (PDT) for subfoveal choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD). Design: Retrospective interventional case series. Methods: A retrospective study in an institutional practice. We describe seven cases of retinal pigment epithelial (RPE) tear, which developed in seven eyes of seven patients following PDT. All eyes had subfoveal CNV secondary to AMD. Results: Six eyes had occult subfoveal CNV, and one eye had recurrent classic subfoveal CNV. In five patients, the eye that developed the tear was the second eye, whereas the first eye had a disciform scar. In four eyes, the RPE tear developed after one PDT, in one eye the RPE tear developed after the second PDT, and in two eyes the RPE tear developed after the third PDT. In five of seven cases, there was a significant visual deterioration following the RPE tear. Conclusions: RPE tear is a complication that may occur following PDT in particular when the PDT is applied to an occult subfoveal CNV.展开更多
PURPOSE:To report two cases of a retinal pigment epithelial tear after intravitreal injection of pegaptanib sodium.To our knowledge,this is the first report of this finding after intraocular antivascular endothelial g...PURPOSE:To report two cases of a retinal pigment epithelial tear after intravitreal injection of pegaptanib sodium.To our knowledge,this is the first report of this finding after intraocular antivascular endothelial growth factor therapy.DESIGN:Observational case reports.METHODS:Two patients presented with occult choroidal neovascularization and associated serous pigment epithelial detachment that was a result of agerelated macular degeneration.Both patients were treated with an intravitreal injection of pegaptanib sodium.RESULTS:One patient developed a retinal pigment epithelium tear one week after the intravitreal injection.The second patient developed a retinal pigment epithelium tear eight weeks after treatment.CONCLUSIONS:Although these cases may represent natural history,there should be a high index of suspicion for retinal pigment epithelium tears in patients who report significant visual deterioration after intravitreal injection of pegaptanib sodium.Further studies are needed to determine whether angiographic subtypes of choroidal neovascular membranes are more susceptible to developing retinal pigment epithelium tears after treatmentwith antivascular endothelial growth factor agents.展开更多
患者男,72岁。因颜面部及四肢水肿5个月,双眼视物模糊3 d到河南省立眼科医院就诊。既往糖尿病史12年,胰岛素治疗,随机血糖12.8 mmol/L;糖尿病肾病半年;高血压史5年,血压控制差,波动在170~180/100~110 mm Hg(1 mm Hg=0.133 kPa)之间;低...患者男,72岁。因颜面部及四肢水肿5个月,双眼视物模糊3 d到河南省立眼科医院就诊。既往糖尿病史12年,胰岛素治疗,随机血糖12.8 mmol/L;糖尿病肾病半年;高血压史5年,血压控制差,波动在170~180/100~110 mm Hg(1 mm Hg=0.133 kPa)之间;低蛋白血症半年。肝功能检测,总蛋白38.9 mmol/L,白蛋白19.0 mmol/L。尿常规检测,尿蛋白(+++),尿糖(++)。24 h尿蛋白定量检测,尿蛋白4.54 g/L,24 h尿蛋白7.72 g/24 h。眼部检查:右眼视力眼前数指,左眼视力0.1。右眼、左眼眼压分别为18.0、16.2 mm Hg。展开更多
文摘PURPOSE: To describe retinal pigment epithelial tear following photodynamic therapy (PDT) for subfoveal choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD). Design: Retrospective interventional case series. Methods: A retrospective study in an institutional practice. We describe seven cases of retinal pigment epithelial (RPE) tear, which developed in seven eyes of seven patients following PDT. All eyes had subfoveal CNV secondary to AMD. Results: Six eyes had occult subfoveal CNV, and one eye had recurrent classic subfoveal CNV. In five patients, the eye that developed the tear was the second eye, whereas the first eye had a disciform scar. In four eyes, the RPE tear developed after one PDT, in one eye the RPE tear developed after the second PDT, and in two eyes the RPE tear developed after the third PDT. In five of seven cases, there was a significant visual deterioration following the RPE tear. Conclusions: RPE tear is a complication that may occur following PDT in particular when the PDT is applied to an occult subfoveal CNV.
文摘PURPOSE:To report two cases of a retinal pigment epithelial tear after intravitreal injection of pegaptanib sodium.To our knowledge,this is the first report of this finding after intraocular antivascular endothelial growth factor therapy.DESIGN:Observational case reports.METHODS:Two patients presented with occult choroidal neovascularization and associated serous pigment epithelial detachment that was a result of agerelated macular degeneration.Both patients were treated with an intravitreal injection of pegaptanib sodium.RESULTS:One patient developed a retinal pigment epithelium tear one week after the intravitreal injection.The second patient developed a retinal pigment epithelium tear eight weeks after treatment.CONCLUSIONS:Although these cases may represent natural history,there should be a high index of suspicion for retinal pigment epithelium tears in patients who report significant visual deterioration after intravitreal injection of pegaptanib sodium.Further studies are needed to determine whether angiographic subtypes of choroidal neovascular membranes are more susceptible to developing retinal pigment epithelium tears after treatmentwith antivascular endothelial growth factor agents.
