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三黄凝胶对大鼠耳廓痤疮模型的抗角化作用 被引量:7
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作者 王思农 张娅茹 +1 位作者 张博 柳文红 《中国麻风皮肤病杂志》 2012年第11期785-788,共4页
目的:观察三黄凝胶对大鼠耳廓痤疮模型的抗角化作用。方法:大鼠右耳廓皮内涂抹油酸,连续造模3 w。造模成功后,模型组、正常组不涂抹任何药物,三黄凝胶高、中、低剂量组分别在大鼠耳廓造模处涂抹不同剂量的三黄凝胶,阳性组涂抹0.025%维A... 目的:观察三黄凝胶对大鼠耳廓痤疮模型的抗角化作用。方法:大鼠右耳廓皮内涂抹油酸,连续造模3 w。造模成功后,模型组、正常组不涂抹任何药物,三黄凝胶高、中、低剂量组分别在大鼠耳廓造模处涂抹不同剂量的三黄凝胶,阳性组涂抹0.025%维A酸乳膏,连续治疗2 w后,肉眼和组织学观察三黄凝胶抗痤疮作用。结果:低、中、高剂量组、阳性对照组与模型组相比较均有差异;与阳性对照组相比较,低中剂量组与其无差异(P>0.05),而高剂量组治疗效果进一步增强,具有统计学意义(P<0.05)。结论:三黄凝胶可减轻油酸致大鼠耳廓痤疮模型的过度角化和表皮层厚度,并有一定的量效关系。 展开更多
关键词 三黄凝胶 痤疮模型 角化作用 油酸
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茶多酚乳膏对痤疮动物模型的实验研究 被引量:6
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作者 隋丽华 宋顺鹏 +5 位作者 张天艳 汤新强 李传勋 韩国柱 杨彤 李楠 《临床皮肤科杂志》 CAS CSCD 北大核心 2007年第8期487-489,共3页
目的:研究茶多酚(tea polyphenols,TP)乳膏外用对实验性痤疮动物模型的治疗效果。方法:采用煤焦油外涂致兔耳实验性角化和金黄地鼠皮脂腺斑增生模型,于动物模型的病变部位外搽一定剂量的12%、6%和3%TP乳膏,结合组织病理学检查和其他量... 目的:研究茶多酚(tea polyphenols,TP)乳膏外用对实验性痤疮动物模型的治疗效果。方法:采用煤焦油外涂致兔耳实验性角化和金黄地鼠皮脂腺斑增生模型,于动物模型的病变部位外搽一定剂量的12%、6%和3%TP乳膏,结合组织病理学检查和其他量化指标观察TP乳膏的抗痤疮作用。结果:家兔耳郭涂煤焦油2周后,肉眼可见兔耳皮肤粗糙、增厚、有粉刺样皮损,组织病理检查示其病变与人类粉刺相似。TP乳膏涂搽后可明显减少毛囊角化物,减轻皮肤增厚;金黄地鼠皮脂腺斑涂搽TP乳膏后,能明显减轻皮脂腺斑增厚,并使其变得柔软,表明TP乳膏对皮脂腺增生有抑制作用。结论:TP乳膏可抑制实验性毛囊上皮角化过度和皮脂腺增生,表明该制剂具有抗实验性痤疮的作用。 展开更多
关键词 茶多酚 痤疮 角化作用 动物模型
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治愈青春痘要多管齐下
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作者 曹来安 《求医问药》 2005年第10期14-14,共1页
关键词 丙酸杆菌 角化作用 药物 青春痘 炎症性皮肤病 抗雄性激素 蠕虫感染 女性患者 美满霉素胶囊 甲氰咪胍
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阴道脱落细胞检诊对临床医疗的启示
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作者 李维 《西北国防医学杂志》 CAS 1991年第4期79-80,共2页
利用阴道分泌物涂片检查发现妇女疾病及性激素紊乱,虽在一百多年前就已开始,但真正被广泛应用于临床还是由Papanicolaou的研究工作才奠定了基础。他对涂片的制作,染色技术的改进,观察阴道脱落细胞的周期性变化,生殖器官癌瘤的早期发现... 利用阴道分泌物涂片检查发现妇女疾病及性激素紊乱,虽在一百多年前就已开始,但真正被广泛应用于临床还是由Papanicolaou的研究工作才奠定了基础。他对涂片的制作,染色技术的改进,观察阴道脱落细胞的周期性变化,生殖器官癌瘤的早期发现等做了大量工作,均对这项技术的临床价值作出了确切的论证,并为其他脏器的细胞学诊断开拓了新途径。近年来由于细胞生物学、细胞化学、电子细胞分析等新技术的发展,为这一技术增加了丰富的内容并赋于了新的活力及发展前景。根据目前的认识水平,从一张阴道涂片中脱落细胞所显示的细胞形态、细胞内部结构、细胞代谢及功能性改变等。 展开更多
关键词 阴道脱落细胞 临床医疗 检诊 细胞代谢 生殖器官 妇女疾病 癌瘤 细胞学诊断 阴道分泌物涂片 角化作用
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Discussion on storm-induced liquefaction of the superficial stratum in the Yellow River subaqueous delta 被引量:5
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作者 许国辉 孙永福 +4 位作者 于月倩 林霖 胡光海 赵庆鹏 郭秀军 《Marine Science Bulletin》 2012年第1期80-89,共10页
Geological disasters on the superficial seafloor were revealed in geological investigation on the Yellow River subaqueous delta. Combined with dynamic triaxial tests and wave flume experiments, occurring conditions an... Geological disasters on the superficial seafloor were revealed in geological investigation on the Yellow River subaqueous delta. Combined with dynamic triaxial tests and wave flume experiments, occurring conditions and forming patterns of liquefaction as well as motion of the liquefied soil were explained in this paper. Based on the viewpoint that the geological disasters were formed due to silty soil liquefaction under storm waves, re-stratification issue of the superficial stratum was analyzed. Movement of the liquefied soil agreed with the wave, leading to differentiation of the soil particles. Research issues in respect of geological, environment and engineering of storm-induced liquefaction were also discussed. 展开更多
关键词 Yellow River subaqueous delta LIQUEFACTION re-stratification storm wave action
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绵羊口腔上皮角化过程中透明角质颗粒的超微结构观察
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作者 王石平 《解剖学报》 CAS 1988年第3期319-322,353,共5页
本实验用3种不同固定液固定不同年龄的绵羊口腔上皮,用透射电镜观察上皮细胞中透明角质颗粒的超微结构。本文的结果表明:1.绵羊口腔上皮存在两种类型透明角质颗粒。Ⅰ型颗粒的形态结构随上皮发育而变化,它从圆形颗粒变成与张力细丝束结... 本实验用3种不同固定液固定不同年龄的绵羊口腔上皮,用透射电镜观察上皮细胞中透明角质颗粒的超微结构。本文的结果表明:1.绵羊口腔上皮存在两种类型透明角质颗粒。Ⅰ型颗粒的形态结构随上皮发育而变化,它从圆形颗粒变成与张力细丝束结合后的不规则形颗粒,最后颗粒从成年动物口腔上皮的某些部位消失。Ⅱ型颗粒呈圆形或椭圆形,周边有游离核蛋白体围绕,其形态结构不随上皮发育而变化。自发生后这种颗粒始终存在于成年动物口腔上皮中。2.根据两型颗粒与不同固定液的反应,Ⅰ型颗粒的组成成分具有脂蛋白性质,而Ⅱ型颗粒除有脂蛋白性质外,还具有不饱和脂类的性质。 展开更多
关键词 口腔上皮 透明角质颗粒 绵羊 角化作用 超微结构
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皮脂腺及皮下脂肪疾病
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《中国医学文摘(皮肤科学)》 2013年第2期120-121,共2页
20130537三黄凝胶对大鼠耳廓痤疮模型的抗角化作用/王思农(甘肃中医学院),张娅茹,张博…∥中国麻风皮肤病杂志.-2012,28(11).-785~788予大鼠右耳廓皮内涂抹油酸,连续造模3周。造模成功后,模型组、正常组不涂抹任何药物,三黄凝胶高、中... 20130537三黄凝胶对大鼠耳廓痤疮模型的抗角化作用/王思农(甘肃中医学院),张娅茹,张博…∥中国麻风皮肤病杂志.-2012,28(11).-785~788予大鼠右耳廓皮内涂抹油酸,连续造模3周。造模成功后,模型组、正常组不涂抹任何药物,三黄凝胶高、中、低剂量组分别在大鼠耳廓造模处涂抹不同剂量的三黄凝胶,阳性组涂抹0.025%维A酸乳膏,连续治疗2周,肉眼和组织学观察三黄凝胶抗痤疮作用。 展开更多
关键词 皮下脂肪 大鼠 模型组 三黄 娅茹 甘肃中医学院 强脉冲光 寻常痤疮 角化作用 痤疮患者
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Effects of Reclamation on Soil Carbon and Nitrogen in Coastal Wetlands of Liaohe River Delta,China 被引量:5
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作者 WAN Siang MOU Xiaojie LIU Xingtu 《Chinese Geographical Science》 SCIE CSCD 2018年第3期443-455,共13页
To evaluate the influence of wetland reclamation on vertical distribution of carbon and nitrogen in coastal wetland soils, we measured the soil organic carbon(SOC), soil total nitrogen(STN) and selected soil propertie... To evaluate the influence of wetland reclamation on vertical distribution of carbon and nitrogen in coastal wetland soils, we measured the soil organic carbon(SOC), soil total nitrogen(STN) and selected soil properties at five sampling plots(reed marsh, paddy field, corn field, forest land and oil-polluted wetland) in the Liaohe River estuary in September 2013. The results showed that reclamation significantly changed the contents of SOC and STN in the Liaohe River estuary(P < 0.001). The SOC concentrations were in the order: oil-polluted wetland > corn field > paddy field > forest land > reed marsh, with mean values of 52.17, 13.14, 11.46, 6.44 and 6.16 g/kg, respectively. STN followed a similar order as SOC, with mean values of 1351.14, 741.04, 632.32, 496.17 and 390.90 mg/kg, respectively. Interaction of reclamation types and soil depth had significant effects on SOC and STN, while soil depth had significant effects on SOC, but not on STN. The contents of SOC and STN were negatively correlated with pH and redox potential(Eh) in reed marsh and corn field, while the SOC and STN in paddy field had positive correlations with electrical conductivity(EC). Dissolved organic carbon(DOC), ammonium nitrogen(NH_4^+-N) and nitrate nitrogen(NO_3~–-N) were also significantly changed by human activities. NH_4^+-N and NO_3~–-N increased to different degrees, and forest land had the highest NO_3~–-N concentration and lowest DOC concentration, which could have been caused by differences in soil aeration and fertilization. Overall, the results indicate that reed harvest increased soil carbon and nitrogen release in the Liaohe River Estuary, while oil pollution significantly increased the SOC and STN; however, these cannot be used as indicators of soil fertility and quality because of the serious oil pollution. 展开更多
关键词 coastal wetlands reclamation soil carbon soil nitrogen Liaohe River Delta
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Purification and identification of natural antikeratin autoantibody from normal human sera and its effects on the cultured keratinocytes
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作者 李承新 刘玉峰 +1 位作者 刘彦仿 张泰山 《Journal of Medical Colleges of PLA(China)》 CAS 2001年第1期4-7,共4页
Objective: To purify the natural antikeratin autoantibody (AK auto-Ab) and observe its effects on the prolif eration of the cultured keratinocytes. Methods: Natural AK auto-Ab was purified by using keratin affinity co... Objective: To purify the natural antikeratin autoantibody (AK auto-Ab) and observe its effects on the prolif eration of the cultured keratinocytes. Methods: Natural AK auto-Ab was purified by using keratin affinity column, and then the titre and specificity of the Abs were studied by ELISA, immunoperoxidase staining and immuno-electronicmicroscope. The effect of the purified Abs on the cultured keratino-cytes was assayed by 3H-TdR incorporation. Results: Natural AK auto-Ab was obtained. The binding activity of IgG AK auto-Ab in purified Ah remained similar to that in pooled human sera. and the specificity of the obtained antibody is strong. The purified antibody could decrease the Il-TdR incorporation of the cultured keratinocytes in a dose-dependent manner. Conclusion: The method of punning AK auto-Ab is simple, practicable and reliable. Natural AK auto-Ab, existing in normal human individuals, has inhibitory etiect on the proliferation of the cultured keratinocytes. 展开更多
关键词 antikeratin autoantibody PURIFICATION proliferation
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