Juvenile xanthogranuloma is a benign histiocytic cutaneous disorder mainly occ urring in infants which may affect the eye. Ocular manifestations usually presen t in the form of iris lesions with secondary hyphema and ...Juvenile xanthogranuloma is a benign histiocytic cutaneous disorder mainly occ urring in infants which may affect the eye. Ocular manifestations usually presen t in the form of iris lesions with secondary hyphema and glaucoma, but juvenile xanthogranuloma may also present as a corneoscleral limbal mass. We present the case of an 18-month-old female infant with ocular juvenile xanthogranuloma occ urring as a corneoscleral limbal mass without associated cutaneous or systemic f indings. The limbal mass lesion was excised by lamellar dissection and histopath ological studies revealed histiocytes admixed with lymphocytes, plasma cells, an d eosinophils; foreign body and Touton giant cells present throughout the specim en confirmed the diagnosis of juvenile xanthogranuloma. At 14-month fol-low-u p, there was no recurrence of the limbal mass. The natural history of this uncom mon ocular condition is discussed and the relevant literature reviewed. Juvenile xanthogranuloma should be considered in the differential diagnosis of any corne oscleral limbal mass lesion, particularly in children.展开更多
文摘Juvenile xanthogranuloma is a benign histiocytic cutaneous disorder mainly occ urring in infants which may affect the eye. Ocular manifestations usually presen t in the form of iris lesions with secondary hyphema and glaucoma, but juvenile xanthogranuloma may also present as a corneoscleral limbal mass. We present the case of an 18-month-old female infant with ocular juvenile xanthogranuloma occ urring as a corneoscleral limbal mass without associated cutaneous or systemic f indings. The limbal mass lesion was excised by lamellar dissection and histopath ological studies revealed histiocytes admixed with lymphocytes, plasma cells, an d eosinophils; foreign body and Touton giant cells present throughout the specim en confirmed the diagnosis of juvenile xanthogranuloma. At 14-month fol-low-u p, there was no recurrence of the limbal mass. The natural history of this uncom mon ocular condition is discussed and the relevant literature reviewed. Juvenile xanthogranuloma should be considered in the differential diagnosis of any corne oscleral limbal mass lesion, particularly in children.
