目的探讨薄荷醇对皮肤角质层结构影响的作用机制。方法大鼠皮肤角质层样本和健康志愿者皮肤给予薄荷醇后,测定全衰减反射傅里叶变换红外光谱(ATR-FTIR)在皮肤角质层的变化,以确定皮肤角质层结构是否改变。结果在大鼠皮肤实验中,与对照...目的探讨薄荷醇对皮肤角质层结构影响的作用机制。方法大鼠皮肤角质层样本和健康志愿者皮肤给予薄荷醇后,测定全衰减反射傅里叶变换红外光谱(ATR-FTIR)在皮肤角质层的变化,以确定皮肤角质层结构是否改变。结果在大鼠皮肤实验中,与对照组和溶剂组相比,氮酮组大鼠角质层中的CH2对称振动(2 854 cm 1)发生了相对位移,角蛋白NH-C=O振动I峰(1 659 cm 1)及II峰(1 637 cm 1)发生了位移,NH-C=O振动I峰发生了裂峰;薄荷醇组大鼠角质层中CH2非对称振动(2 925 cm 1)、CH2对称振动(2 854 cm 1)发生相对位移。在人体皮肤试验中,与对照区和溶剂区相比,氮酮组CH2非对称振动(2 921.5 cm 1)和CH2对称振动(2 852.1 cm 1)发生了3～4个波长位移;薄荷醇组CH2非对称振动(2 922.7 cm 1)和CH2对称振动(2 853.8 cm 1)发生了3～4个波长位移。结论薄荷醇可能是通过改变角质层中脂质的构象,使角质层脂质双分子层的流动性增加、有序致密结构改变,降低皮肤屏障作用,从而使药物的透过性增加。展开更多
Numerous leaf compressions of Glyptostrobus europaeus (Brongn.) Ung. (Taxodiaceae) are found in Aquitanian (Lower Miocene) lignified clay localities Bolattam and Akzhar in the Southern Turgay, on the right bank of the...Numerous leaf compressions of Glyptostrobus europaeus (Brongn.) Ung. (Taxodiaceae) are found in Aquitanian (Lower Miocene) lignified clay localities Bolattam and Akzhar in the Southern Turgay, on the right bank of the Dulygaly-Zhilanshik river (Central Kazakhstan). The finely preserved lignified compression remains of leafy shoots make micro-morphological investigation feasible. Comparative studies of the epidermal features both living G. pensilis C. Koch and a new finding of G. europaeus from Early Miocene of Kazakhstan and illustrate their certain difference. The cuticular organization and epidermal features of fossil leaves, which have been compared with these of 'the nearest living relative', G. pensilis, were studied by scanning electron microscopy (SEM) and light microscopy (LM). The fossil leaves of G. europaeus from Kazakhstan are distinguished by stronger, than in living species, G. pensilis, developed 'micro-papillae' ('Kristallucken'), visible in SEM as ring-like structures left on the outer surface of cuticle in both nonstomatal and stomatal zones.展开更多
文摘目的探讨薄荷醇对皮肤角质层结构影响的作用机制。方法大鼠皮肤角质层样本和健康志愿者皮肤给予薄荷醇后,测定全衰减反射傅里叶变换红外光谱(ATR-FTIR)在皮肤角质层的变化,以确定皮肤角质层结构是否改变。结果在大鼠皮肤实验中,与对照组和溶剂组相比,氮酮组大鼠角质层中的CH2对称振动(2 854 cm 1)发生了相对位移,角蛋白NH-C=O振动I峰(1 659 cm 1)及II峰(1 637 cm 1)发生了位移,NH-C=O振动I峰发生了裂峰;薄荷醇组大鼠角质层中CH2非对称振动(2 925 cm 1)、CH2对称振动(2 854 cm 1)发生相对位移。在人体皮肤试验中,与对照区和溶剂区相比,氮酮组CH2非对称振动(2 921.5 cm 1)和CH2对称振动(2 852.1 cm 1)发生了3～4个波长位移;薄荷醇组CH2非对称振动(2 922.7 cm 1)和CH2对称振动(2 853.8 cm 1)发生了3～4个波长位移。结论薄荷醇可能是通过改变角质层中脂质的构象,使角质层脂质双分子层的流动性增加、有序致密结构改变,降低皮肤屏障作用,从而使药物的透过性增加。
文摘Numerous leaf compressions of Glyptostrobus europaeus (Brongn.) Ung. (Taxodiaceae) are found in Aquitanian (Lower Miocene) lignified clay localities Bolattam and Akzhar in the Southern Turgay, on the right bank of the Dulygaly-Zhilanshik river (Central Kazakhstan). The finely preserved lignified compression remains of leafy shoots make micro-morphological investigation feasible. Comparative studies of the epidermal features both living G. pensilis C. Koch and a new finding of G. europaeus from Early Miocene of Kazakhstan and illustrate their certain difference. The cuticular organization and epidermal features of fossil leaves, which have been compared with these of 'the nearest living relative', G. pensilis, were studied by scanning electron microscopy (SEM) and light microscopy (LM). The fossil leaves of G. europaeus from Kazakhstan are distinguished by stronger, than in living species, G. pensilis, developed 'micro-papillae' ('Kristallucken'), visible in SEM as ring-like structures left on the outer surface of cuticle in both nonstomatal and stomatal zones.
